About this data
Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.
Virus-Specific Cytotoxic T Lymphocytes
- Company
- Children's Hospital of Philadelphia
- Mechanism
- Mechanism not yet reported
- Route
- Route not yet reported
- Recruiting trials
- 10 recruiting
Efficacy results: Not yet reported
10 recruiting studies currently listed on ClinicalTrials.gov.
Data source: ClinicalTrials.gov · trial data as of Oct 15, 2026
Find a Clinical Trial Near Me
See recruiting studies for Virus-Specific Cytotoxic T Lymphocytes and check eligibility with the study team.
Trial details
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Recruiting NCT NCT02007356
A Study to Assess Safety and Feasibility of Direct Infusions of Donor-derived Virus-specific T-cells in Recipients of Hematopoietic Stem Cell Transplantation With Post-transplant Viral Infections Using the Cytokine Capture System®
Not yet reported University Hospital, Basel, Switzerland 30 participants Est. completion 2026-12 1 siteOther conditions: Adenovirus Infection, EBV, Cytomegalovirus Infections, Cytokine Capture System, Allogenic DiseaseView official trial listing → -
Recruiting NCT NCT03266640
Virus Specific Cytotoxic T-Lymphocytes (CTLs) for Refractory Cytomegalovirus (CMV)
Not yet reported New York Medical College 20 participants Est. completion 2027-12-31 9 sitesOther conditions: Cytomegalovirus Infections, Primary Immune Deficiency DisorderView official trial listing → -
Recruiting NCT NCT03394365
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
Not yet reported Pierre Fabre Medicament 115 participants Est. completion 2030-08 71 sitesOther conditions: Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant ComplicationsView official trial listing → -
Recruiting NCT NCT03665675
Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT
Not yet reported Sumithira Vasu 20 participants Est. completion 2027-06-20 2 sitesOther conditions: Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Cytomegalovirus, Donor, Solid Organ Transplantation Recipient, AdenovirusView official trial listing → -
Recruiting NCT NCT04293042
Treatment of BK Virus Infection With CTL Cells in Immunocompromised Transplant Patients
Not yet reported Children's Hospital of Philadelphia 20 participants Est. completion 2029-01-30 1 siteOther conditions: BK PolyomavirusView official trial listing → -
Recruiting NCT NCT05183490
R-MVST Cells for Treatment of Viral Infections
Not yet reported Columbia University 36 participants Est. completion 2028-06 1 siteOther conditions: Epstein-Barr Virus Infections, Cytomegalovirus Infections, Adenovirus, BK Virus InfectionView official trial listing → -
Recruiting NCT NCT07670468
Evaluation of the Safety and Efficacy of LB-DTK-MV in Patients Diagnosed With Antiviral-Resistant CMV, BKV, or EBV Infection or Associated Diseases Following Anticancer Therapy or Allogeneic Hematopoietic Stem Cell Transplantation.
Not yet reported, Not yet reported LucasBio 27 participants Est. completion 2027-06-04 1 siteOther conditions: BKV Infection, EBV Infection, CMV InfectionView official trial listing → -
Recruiting NCT NCT07679412
Evaluation of Safety and Efficacy of Autologous LB-DTK-CMV in Patients With Antiviral-Resistant and Refractory Cytomegalovirus Retinitis.
Not yet reported LucasBio 5 participants Est. completion 2027-08-14 1 siteOther conditions: CMV RetinitisView official trial listing → -
Recruiting NCT NCT07685457
Evaluation of Safety and Efficacy of Virus Specific T-Cell Administration in Pediatric Patients With Systemic Viral Infection Following Allogeneic Hematopoietic Stem Cell Transplantation.
Not yet reported LucasBio 6 participants Est. completion 2027-05-20 1 siteOther conditions: BKV Infection, CMV Infection, EBV InfectionView official trial listing → -
Recruiting NCT NCT07688759
CMV-CMI in csCMVi After HSCT
The First Affiliated Hospital of Soochow University 40 participants Est. completion 2028-08-31 1 siteOther conditions: Cytomegalovirus Infections, Hematopoietic Stem Cell Transplantation (HSCT), Immune ReconstitutionView official trial listing → -
Completed NCT NCT00002663
Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies
Not yet reported, Not yet reported Atara Biotherapeutics 58 participants Est. completion 2019-07 1 site Stand-aloneOther conditions: EBV-induced Lymphomas, EBV-associated Malignancies, Transplant Patients With EBV Viremia at High Risk of Developing a Recurrent EBV LymphomaView official trial listing → -
Withdrawn NCT NCT00002956
Immunotherapy for Lymphoproliferative Diseases Associated With Epstein-Barr Virus in Patients Who Have Undergone Organ Transplants
Not yet reported University of Alabama at Birmingham Est. completion 2002-02 1 site Stand-aloneOther conditions: Leukemia, LymphomaView official trial listing → -
Completed NCT NCT00005606
Peripheral Blood Lymphocyte Therapy to Prevent Lymphoproliferative Disorders Caused by Epstein-Barr Virus in Patients Who Have Undergone Transplantation
Not yet reported Northwestern University Est. completion 2003-09 1 siteOther conditions: Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell NeoplasmView official trial listing → -
Status unknown NCT NCT00006100
Allogeneic Epstein Barr Virus-Specific Cytotoxic T-Lymphocytes in Treating Patients With Progressive, Relapsed, or Refractory Hodgkin's Lymphoma
Not yet reported Milton S. Hershey Medical Center 1 siteOther conditions: LymphomaView official trial listing → -
Completed NCT NCT00063648
Detection and Cytotoxic T Lymphocyte Therapy of Post-Transplant Lymphoproliferative Disorder After Liver Transplant
Not yet reported National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 50 participants Est. completion 2007-12 1 siteOther conditions: Liver Disease, Lymphoproliferative DisordersView official trial listing → -
Completed NCT NCT00078533
Cytotoxic T-Lymphocytes for the Prophylaxis of Cytomegalovirus After Allogeneic Stem Cell Transplant
Not yet reported Baylor College of Medicine 26 participants Est. completion 2011-06 2 sitesOther conditions: Cytomegalovirus InfectionsView official trial listing → -
Completed NCT NCT00590083
Administration of Virus-Specific Cytotoxic T-Lymphocytes
Not yet reported Baylor College of Medicine 14 participants Est. completion 2011-01 3 sitesOther conditions: Adenovirus InfectionView official trial listing → -
Status unknown NCT NCT00690872
Gemcitabine and Carboplatin Followed By Laboratory-Treated T Lymphocytes in Treating Patients With Metastatic or Locally Recurrent Epstein-Barr Virus-Positive Nasopharyngeal Cancer
Not yet reported National Cancer Centre, Singapore 35 participants 1 siteOther conditions: Head and Neck CancerView official trial listing → -
Completed NCT NCT00706316
Administration of Epstein Barr Virus - Specific Cytotoxic T-Lymphocytes to Metastatic EBV-Positive Nasopharygneal Cancer
Not yet reported University Health Network, Toronto 5 participants Est. completion 2012-11 1 siteOther conditions: Nasopharyngeal CancerView official trial listing → -
Completed NCT NCT00711035
Most Closely HLA Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL)
Not yet reported, Not yet reported Baylor College of Medicine 50 participants Est. completion 2013-08 8 sitesOther conditions: Adenovirus Infection, EBV InfectionView official trial listing → -
Active, not recruiting NCT NCT00840853
Multi-virus CTLs Expressing CD19 Chimeric Receptors, CD19 Positive Malignancies Post SCT, MULTIPRAT
Not yet reported Baylor College of Medicine 68 participants Est. completion 2031-04 2 sitesOther conditions: Acute Lymphoblastic Leukemia (ALL), Chronic Lymphocytic Leukemia (CLL), Non Hodgkin's LymphomaView official trial listing → -
Completed NCT NCT01070797
Administration of Rapidly Generated Multivirus-specific Cytotoxic T-Lymphocytes (VIRAGE)
Not yet reported Baylor College of Medicine 10 participants Est. completion 2014-04 2 sitesOther conditions: Adenovirus Infection, Epstein-Barr Virus Infections, Cytomegalovirus Infections, Stem Cell TransplantView official trial listing → -
Active, not recruiting NCT NCT01430390
In Vitro Expanded Allogeneic Epstein-Barr Virus Specific Cytotoxic T-Lymphocytes (EBV-CTLs) Genetically Targeted to the CD19 Antigen in B-cell Malignancies
Not yet reported Memorial Sloan Kettering Cancer Center 19 participants Est. completion 2027-09 1 siteOther conditions: Acute Lymphocytic Leukemia, LymphomaView official trial listing → -
Completed NCT NCT01460901
Study of Donor Derived, Multi-virus-specific, Cytotoxic T-Lymphocytes for Relapsed/Refractory Neuroblastoma
Not yet reported Children's Mercy Hospital Kansas City 5 participants Est. completion 2015-01 1 siteOther conditions: NeuroblastomaView official trial listing → -
Completed NCT NCT01475058
CD19 CAR T Cells for B Cell Malignancies After Allogeneic Transplant
Not yet reported, Not yet reported Fred Hutchinson Cancer Center 1 participants Est. completion 2014-07 1 site Stand-aloneOther conditions: Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia, Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Immunoblastic Large Cell Lymphoma, Recurrent Mantle Cell Lymphoma, Refractory Chronic Lymphocytic LeukemiaView official trial listing → -
Status unknown NCT NCT01823718
Cell Bank of Epstein Barr Virus Specific Cytotoxic T Lymphocytes
Not yet reported Nantes University Hospital 18 participants Est. completion 2014-08 7 sitesOther conditions: EBV Associated LymphomaView official trial listing → -
No Longer Available NCT NCT01945619
Allogeneic Virus-Specific Cytotoxic T-Lymphocytes(CTL), Persistent/Recurrent Viral Infection Post-HSCT (EAP CHALLAH)
Baylor College of Medicine 2 sitesOther conditions: EBV Infection, CMV Infection, Adenoviral InfectionView official trial listing → -
Completed NCT NCT02108522
Multivirus-specific T Cells for the Treatment of Virus Infections After Stem Cell Transplant
Not yet reported AlloVir 82 participants Est. completion 2019-12 2 sitesOther conditions: InfectionView official trial listing → -
Withdrawn NCT NCT02276820
Most Closely Human Leukocyte Antigen (HLA)-Matched Adenovirus-specific T Lymphocytes (Viralym-A)
Not yet reported AlloVir Est. completion 2019-12 2 sitesOther conditions: Adenovirus InfectionView official trial listing → -
Withdrawn NCT NCT02313844
Most Closely Human Leukocyte Antigen (HLA)-Matched BK Virus-specific T Lymphocytes (Viralym-B)
Not yet reported AlloVir Est. completion 2019-12 2 sitesOther conditions: BK Virus InfectionView official trial listing → -
Completed NCT NCT02313857
Most Closely Human Leukocyte Antigen (HLA)-Matched CMV-specific T Lymphocytes (Viralym-C)
Not yet reported AlloVir 10 participants Est. completion 2018-02 2 sitesOther conditions: CMV InfectionsView official trial listing → -
Completed NCT NCT02379520
HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA
Not yet reported Baylor College of Medicine 35 participants Est. completion 2026-01 1 siteOther conditions: Human Papillomavirus-Related Carcinoma, Human Papillomavirus Positive Oropharyngeal Carcinoma, Human Papillomavirus Positive Cervical Carcinoma, Human Papillomavirus Positive Anal Carcinoma, Human Papillomavirus Positive Vulvar Carcinoma, Human Papillomavirus Positive Penile CarcinomaView official trial listing → -
Status unknown NCT NCT02456610
Administration of Virus Specific CTLs for the Prophylaxis and Treatment of EBV/CMV Infections After HSCT in China
Not yet reported Affiliated Hospital to Academy of Military Medical Sciences 30 participants Est. completion 2016-08 1 siteOther conditions: Viral InfectionView official trial listing → -
Withdrawn NCT NCT02702427
Virus-specific ImmunoTherapy Following Allogeneic Stem Cell Transplantation
Not yet reported, Not yet reported St. Anna Kinderkrebsforschung Est. completion 2019-04-01 1 siteOther conditions: Cytomegalovirus Infection, Adenovirus InfectionView official trial listing → -
Status unknown NCT NCT02779439
Partially HLA-matched Third Party Antigen Specific T-cells for Infection Post-stem Cell or Solid Organ Transplantation
Not yet reported University of Sydney 25 participants Est. completion 2018-03 1 siteOther conditions: CMV Infection, EBV, AdenovirusView official trial listing → -
Completed NCT NCT02973113
Nivolumab With Epstein Barr Virus Specific T Cells (EBVSTS), Relapsed/Refractory EBV Positive Lymphoma (PREVALE)
Not yet reported Baylor College of Medicine 8 participants Est. completion 2020-07-11 2 sitesOther conditions: NonHodgkin Lymphoma, Lymphoproliferative Disorders, EBV Related Lymphoma, EBV-Related PTLD, Hodgkin Lymphoma, EBV Related Non-Hodgkin's Lymphoma, EBV Related Hodgkin's LymphomaView official trial listing → -
Active, not recruiting NCT NCT03180216
T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation
Not yet reported Children's National Research Institute 32 participants Est. completion 2026-12 1 siteOther conditions: Viral Infections, Bone Marrow Transplant InfectionView official trial listing → -
Terminated NCT NCT03769467
Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)
Not yet reported, Not yet reported Atara Biotherapeutics 12 participants Est. completion 2021-08-19 7 sitesOther conditions: Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms, Epstein-Barr Virus Infections, Epstein-Barr Viraemia, Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)View official trial listing → -
Status unknown NCT NCT04389385
COVID-19 Specific T Cell Derived Exosomes (CSTC-Exo)
Not yet reported TC Erciyes University 60 participants Est. completion 2021-05-31 1 siteOther conditions: Corona Virus Infection, PneumoniaView official trial listing → -
Terminated NCT NCT04401410
Anti-SARS Cov-2 T Cell Infusions for COVID 19
Not yet reported Baylor College of Medicine 4 participants Est. completion 2021-10-12 1 siteOther conditions: SARS-CoV 2, Viral Infection, COVID 19View official trial listing → -
Terminated NCT NCT04933968
Study of ALVR106 in Patients With Respiratory Viral Infections After Hematopoietic Cell and Solid Organ Transplant
Not yet reported, Not yet reported AlloVir 17 participants Est. completion 2024-01-31 21 sitesOther conditions: Respiratory Tract Viral Infections, Human Metapneumovirus (hMPV) Infection, Parainfluenza (PIV) Infection, Respiratory Syncytial Viral (RSV) Infection, Influenza InfectionView official trial listing → -
Status unknown NCT NCT05075837
Adoptive T-cell Therapy for Resistant Viral Infections After Allogeneic HSCT
Not yet reported Istituto Giannina Gaslini 10 participants Est. completion 2025-07-25 Stand-aloneOther conditions: Viral Infection After HSCTView official trial listing → -
Terminated NCT NCT05101213
Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients
Not yet reported M.D. Anderson Cancer Center 12 participants Est. completion 2026-08-03 1 siteOther conditions: Adenovirus Infection, BK Virus Infection, Cytomegaloviral Infection, Hematopoietic and Lymphoid Cell Neoplasm, JC Virus Infection, Malignant Solid Neoplasm, Symptomatic COVID-19 Infection Laboratory-ConfirmedView official trial listing → -
Terminated NCT NCT05305040
Study of Posoleucel (ALVR105,Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant
Not yet reported, Not yet reported AlloVir 451 participants Est. completion 2024-01-30 88 sitesOther conditions: Adenovirus Infection, BK Virus Infection, Cytomegalovirus Infections, Epstein-Barr Virus Infections, Human Herpes Virus-6 Infection, JC Virus InfectionView official trial listing → -
Status unknown NCT NCT05447013
Generation of SARS-CoV-2-specific T Lymphocytes From Recovered Donors and Administration to High-risk COVID-19 Patients
Not yet reported, Not yet reported George Papanicolaou Hospital 182 participants Est. completion 2022-12-31 2 sitesOther conditions: Severe COVID-19View official trial listing → -
Completed NCT NCT05826496
Exercise-induced Effects on Immune Parameters in Healthy Participants
Not yet reported Per thor Straten 59 participants Est. completion 2025-02-10 1 siteOther conditions: HealthyView official trial listing → -
Status unknown NCT NCT06075927
Multivirus-specific T Cells in the Treatment of Refractory CMV and/or EBV Infection After Allo-HSCT
Not yet reported, Not yet reported Peking University People's Hospital 29 participants Est. completion 2025-10-30Other conditions: CMV Infection, EBV Infection, Stem Cell TransplantView official trial listing → -
Completed NCT NCT06256341
HHV-6-specific T-cell Reconstitution Among Children and Adolescents After Allogeneic Stem.
Medical University of Graz 53 participants Est. completion 2023-11-01Other conditions: Allogeneic Stem Cell TransplantationView official trial listing → -
Available NCT NCT07104591
TETRAVI Expanded Access Program
Baylor College of MedicineOther conditions: Epstein-Barr Virus Infection, Cytomegalovirus Infections, Adenovirus Infection, BK Virus Infection, JC Virus Infection, Viral Infections Post-Transplant, Post-Allogeneic Stem Cell Transplant ComplicationsView official trial listing → -
Not yet recruiting NCT NCT07638332
Evaluation of the Safety and Efficacy of LB-DTK-BKV in Patients With BK Virus-Associated Hemorrhagic Cystitis Following Allogeneic Hematopoietic Stem Cell Transplantation
Not yet reported, Not yet reported LucasBio 42 participants Est. completion 2028-03-01 9 sitesOther conditions: Hemorrhagic CystitisView official trial listing → -
Not yet recruiting NCT NCT07873970
25BT056: Basket Study of Viral Cytotoxic T Lymphocytes
Not yet reported Children's Hospital of Philadelphia 35 participants Est. completion 2037-11 Stand-aloneOther conditions: EBV Viremia, CMV Viremia, BK Viremia, Adenovirus, Post-transplant Lymphoproliferative Disorder, Viremia, Cytomegalovirus Enteritis, Adenovirus Infection, Epstein-Barr Virus Infection Reactivation, Epstein Barr Virus Infection, BK Virus Infection, Refractory Viral Infection, Opportunistic Viral Infection, Primary Immunodeficiency, Severe Combined Immunodeficiency (SCID), Inherited Immunodeficiency Diseases, Acquired Immunodeficiency, Stem Cell Transplant Complications, Solid Organ Transplant ComplicationsView official trial listing →
Efficacy history
Not yet reported.
Safety
Not yet reported.
Sources
Also known as: Virus-Specific Cytotoxic T Lymphocytes, Virus-Specific Cytotoxic T Lymphocytes (vCTLs), vCTLs, Virus-specific T cells, Cytotoxic T lymphocyte therapy, Gamma-Capture Virus-Specific Cytotoxic T Lymphocytes, CliniMACS-Manufactured Virus-Specific Cytotoxic T Lymphocytes, Donor-Derived Virus-Specific Cytotoxic T Lymphocytes
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