About this data
Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.
Vericiguat
- Company
- University Medical Centre Ljubljana
- Mechanism
- Mechanism not yet reported
- Route
- Route not yet reported
- Recruiting trials
- 10 recruiting
Efficacy results: Not yet reported
10 recruiting studies currently listed on ClinicalTrials.gov.
Data source: ClinicalTrials.gov · trial data as of Sep 23, 2026
Find a Clinical Trial Near Me
See recruiting studies for Vericiguat and check eligibility with the study team.
Trial details
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Recruiting NCT NCT05666518
A Study to Learn More About the Safety of the Drug Vericiguat in Japanese People With Chronic Heart Failure Who Will be Receiving Vericiguat Under Real-world Conditions
Bayer 1400 participants Est. completion 2028-12-31 1 siteHeart failureView official trial listing → -
Recruiting NCT NCT05714085
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Not yet reported, Not yet reported Merck Sharp & Dohme LLC 342 participants Est. completion 2032-04-15 109 sites Stand-aloneHeart failure Other conditions: Left Ventricular Systolic DysfunctionView official trial listing → -
Recruiting NCT NCT05812755
SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery
Not yet reported Vanderbilt University Medical Center 170 participants Est. completion 2029-07 1 siteOther conditions: Endothelial Dysfunction, Vascular Diseases, Kidney Injury, Brain Disease, Vascular InflammationView official trial listing → -
Recruiting NCT NCT06148935
An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting
Bayer 1350 participants Est. completion 2027-10-31 1 siteHeart failureView official trial listing → -
Recruiting NCT NCT06239974
Vericiguat in Patients With Coronary Microvascular Dysfunction Causing Stable Chest Pain (V-COM)
Not yet reported The University of Hong Kong 94 participants Est. completion 2027-08-31 1 site Stand-aloneOther conditions: Chest PainView official trial listing → -
Recruiting NCT NCT06601465
COgnitioN With VERiciGuat Evaluation in Heart Failure
Not yet reported University of Alberta 120 participants Est. completion 2028-07-16 4 sites Stand-aloneHeart failure Other conditions: Cognitive ImpairmentView official trial listing → -
Recruiting NCT NCT07047547
A Study of Real-world Events of Vericiguat in Patients With Chronic Kidney Disease and Heart Failure
Not yet reported Guangdong Provincial People's Hospital 118 participants Est. completion 2026-06-01 1 site Stand-aloneHeart failure Other conditions: Hemodialysis ComplicationView official trial listing → -
Recruiting NCT NCT07335900
A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis
Not yet reported RenJi Hospital 25 participants Est. completion 2027-05-30 1 site Stand-aloneOther conditions: Severe Aortic Valve StenosisView official trial listing → -
Recruiting NCT NCT07405944
Vericiguat and Reverse Remodeling Indices in Heart Failure
Not yet reported University Medical Centre Ljubljana 60 participants Est. completion 2027-12-31 4 sites Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT07444398
Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG Trial
Not yet reported Khawaja Danish Ali 130 participants Est. completion 2026-03-31 1 site Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT01951625
Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure With Reduced Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-REDUCED)
Not yet reported Bayer 456 participants Est. completion 2015-06-09 157 sites Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT01951638
Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure and Preserved Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-PRESERVED)
Not yet reported Bayer 477 participants Est. completion 2015-09-16 158 sites Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT02617550
Vericiguat Drug-drug Interaction With Nitroglycerin in Stable Coronary Artery Disease Patients
Not yet reported Bayer 36 participants Est. completion 2016-08-11 6 sites Stand-aloneCardiovascular diseaseView official trial listing → -
Completed NCT NCT02861534
A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001)
Not yet reported Merck Sharp & Dohme LLC 5050 participants Est. completion 2019-09-02 Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT03145038
Relative Bioavailability and Food Effect Study With Vericiguat to Characterize the Pediatric Formulation in Adult Healthy Subjects
Not yet reported Bayer 30 participants Est. completion 2017-10-09 1 site Stand-aloneOther conditions: PharmacokineticsView official trial listing → -
Completed NCT NCT03255512
Vericiguat Drug-drug Interaction Study With Isosorbite Mononitrate in Stable Coronary Artery Disease Patients
Not yet reported Bayer 41 participants Est. completion 2018-03-23 6 sites Stand-aloneCardiovascular diseaseView official trial listing → -
Completed NCT NCT03504982
Study to Evaluate the QT / QTc Interval Prolongation Potential of Vericiguat
Not yet reported Bayer 74 participants Est. completion 2019-02-26 8 sites Stand-aloneCardiovascular diseaseView official trial listing → -
Completed NCT NCT03547583
Patient-reported Outcomes in Vericiguat-treated Patients With HFpEF
Not yet reported Bayer 789 participants Est. completion 2019-11-04 177 sites Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT04722484
A Trial to Learn How Safe Vericiguat (BAY1021189) is and the Way the Body Absorbs, Distributes and Gets Rid of Vericiguat in Participants With Kidney Disease and in Age-, Weight- and Gender-matched Healthy Participants
Not yet reported Bayer 39 participants Est. completion 2015-01-22 1 site Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT04722562
A Trial to Learn How Safe Vericiguat (BAY1021189) is and the Way the Body Absorbs, Distributes and Gets Rid of Vericiguat in Participants With Liver Disease and in Age-, Weight- and Gender-matched Healthy Participants
Not yet reported Bayer 27 participants Est. completion 2015-04-30 1 site Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT05086952
A Study in Healthy Adult Male Participants to Learn the Way Vericiguat is Absorbed With and Without Food When Taken as a Single Dose in Liquid Form Suitable for Children Compared to a 10 Milligram (mg) Tablet That Releases the Active Substance Immediately
Not yet reported Bayer 36 participants Est. completion 2022-02-15 1 site Stand-aloneHeart failure Other conditions: ChildrenView official trial listing → -
Completed NCT NCT05093933
A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
Not yet reported Merck Sharp & Dohme LLC 6106 participants Est. completion 2025-02-05 519 sites Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT05420012
The Effect of Vericiguat on Peripheral Vascular Function, Patient Health Status and Inflammation
Not yet reported Josef Stehlik 26 participants Est. completion 2024-10-24 2 sites Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT05658458
A Study to Learn How Well the Drug Vericiguat Works and How Safe it is Under Real World Conditions in Indian Participants After Worsening of a Long-term Heart Condition in Which the Left Side of the Heart Does Not Pump Blood as Well as it Should (Chronic Heart Failure With Reduced Ejection Fraction)
Not yet reported Bayer 205 participants Est. completion 2024-09-19 12 sites Stand-aloneHeart failureView official trial listing → -
Active, not recruiting NCT NCT05697640
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome
Not yet reported Charite University, Berlin, Germany 104 participants Est. completion 2026-12-31 1 siteOther conditions: Post-COVID ME/CFSView official trial listing → -
Active, not recruiting NCT NCT05704478
Impact of Vericiguat on Hemodynamics of Heart Failure
Not yet reported University of Colorado, Denver 30 participants Est. completion 2027-03-31 1 siteHeart failureView official trial listing → -
Completed NCT NCT05711719
Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction
Not yet reported Johns Hopkins University 45 participants Est. completion 2025-11-18 1 site Stand-aloneMetabolic syndrome Other conditions: Coronary Microvascular DysfunctionView official trial listing → -
Completed NCT NCT05728502
An Observational Study, Called VERI-China, to Learn More About How Well Vericiguat Works and How Safe it is in Real-world Setting in People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in China
Bayer 2400 participants Est. completion 2025-12-26 1 siteHeart failureView official trial listing → -
Completed NCT NCT05799638
Strategy, Efficacy and Safety of Medication Usage in Heart Failure Patients Who Were Intolerable to GDMT
Chongqing Medical University 263 participants Est. completion 2024-06-30 1 siteHeart failureView official trial listing → -
Active, not recruiting NCT NCT05806138
A Study of Vericiguat in People With Breast Cancer and Cancer Therapy-Related Cardiac Dysfunction
Not yet reported Memorial Sloan Kettering Cancer Center 21 participants Est. completion 2028-07-17 1 site Stand-aloneOther conditions: Breast Cancer, Cardiac DysfunctionView official trial listing → -
Completed NCT NCT05974189
The VERIFY Study: An Observational Study Called VERIFY to Learn More About the Use of Vericiguat in People With Chronic Heart Failure With Reduced Ejection Fraction
Bayer 1391 participants Est. completion 2024-10-08 1 siteHeart failureView official trial listing → -
Completed NCT NCT06195930
A Study to Learn How Safe Starting Vericiguat at a Dose of 5 Milligrams is in Participants With Chronic Heart Failure With Reduced Ejection Fraction
Not yet reported Bayer 106 participants Est. completion 2024-07-29 35 sites Stand-aloneHeart failureView official trial listing → -
Not yet recruiting NCT NCT06320951
VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway
Not yet reported University of Alabama at Birmingham 200 participants Est. completion 2029-04-30 1 site Stand-aloneCardiovascular disease Other conditions: Insulin Sensitivity/Resistance, Metabolic Disease, Metabolism, Energy Expenditure, ObesityView official trial listing → -
Completed NCT NCT06321094
Effect of Vericiguat on Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45%
The First Affiliated Hospital with Nanjing Medical University 149 participants Est. completion 2025-12-01 1 siteHeart failure Other conditions: Acute Coronary SyndromeView official trial listing → -
Completed NCT NCT06363110
An Observational Study to Learn More About Vericiguat Treatment Patterns and Its Safety in People With Chronic Heart Failure With Reduced Ejection Fraction in Routine Medical Care in the United States
Bayer 1400 participants Est. completion 2024-06-24 1 siteHeart failureView official trial listing → -
Completed NCT NCT06415227
The Impact of Vericiguat on Microvascular Function in Patients With Documented Vasospastic Angina Pectoris
Not yet reported Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 57 participants Est. completion 2026-07-13 1 site Stand-aloneOther conditions: Vasospastic AnginaView official trial listing → -
Completed NCT NCT06474208
A Study to Learn About the Taste of Vericiguat Given in Liquid Form in Healthy Male Participants Aged 18 to 45 Years
Not yet reported Bayer 19 participants Est. completion 2024-09-30 1 site Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT06486844
An Observational Study Called ROVER to Learn More About How Well Vericiguat Works in People Who Were Newly Treated With Vericiguat in Routine Medical Care in Germany
Bayer 500 participants Est. completion 2025-08-31 1 siteHeart failureView official trial listing → -
Active, not recruiting NCT NCT06632483
An Observational Study to Learn More About How Safe Vericiguat is and How Well it Works in Indian People With Chronic Heart Failure With Reduced Ejection Fraction and Worsening Chronic Heart Failure Under Real World Conditions
Bayer 604 participants Est. completion 2026-06-30 1 siteHeart failureView official trial listing → -
Not yet recruiting NCT NCT06671990
The CardioMEMS Vericiguat Heart Failure Trial
Not yet reported Finn Gustafsson 17 participants Est. completion 2026-01-31Heart failure Other conditions: Pulmonary Arterial HypertensionView official trial listing → -
Completed NCT NCT06697353
An Observational Study to Learn More About the Real-world Outcomes in Patients With Heart Failure Who Initiate Treatment With Vericiguat in Japan
Bayer 4936 participants Est. completion 2025-09-19 1 siteHeart failureView official trial listing → -
Not yet recruiting NCT NCT06717204
Vericiguat for Heart Failure With Reduced Ejection Fraction After Myocardial Infarction
Qilu Hospital of Shandong University 210 participants Est. completion 2027-12-31 3 sitesHeart failureCardiovascular diseaseView official trial listing → -
Not yet recruiting NCT NCT06812546
Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction
Not yet reported Dongying Zhang 200 participants Est. completion 2026-12-30 1 site Stand-aloneHeart failureCardiovascular diseaseView official trial listing → -
Completed NCT NCT07472595
Effect of Vericiguat on cardiAc Remodeling in Patients With Heart faiLure and Reduced Ejection fractioN (HFrEF): A Prospective sTudy usIng NOvel Echocardiographic Imaging Techniques (VALENTINO)
Chinese University of Hong Kong 40 participants Est. completion 2025-12-31 1 siteHeart failureView official trial listing → -
Not yet recruiting NCT NCT07594509
Perioperative Vericiguat in Patients Undergoing Cardiovascular Surgery
Not yet reported Nanjing Medical University 600 participants Est. completion 2030-12-31 1 site Stand-aloneOther conditions: Cardio Vascular Disease, Cardiopulmonary BypassView official trial listing → -
Not yet recruiting NCT NCT07668739
Efficacy of Verciguat in TR and RV Failure
Not yet reported Daejeon St. Mary's hospital 100 participants Est. completion 2028-05-31 1 site Stand-aloneOther conditions: HFrEF, Tricuspid Regurgitation (TR)View official trial listing → -
Not yet recruiting NCT NCT07678021
Micro-axial Flow Pump-Supported PCI in Complex Coronary Artery Disease With Ischemic LV Dysfunction
Not yet reported China National Center for Cardiovascular Diseases 452 participants Est. completion 2029-12-31 1 site Stand-aloneCardiovascular diseaseView official trial listing → -
Completed NCT NCT07697365
Vericiguat and Exercise Hemodynamics in Patients With HFrEF
Argyrios Ntalianis 40 participants Est. completion 2025-12-31 1 siteHeart failureView official trial listing → -
Not yet recruiting NCT NCT07697833
Comparing the Efficacy and Safety of Vericiguat With Standard Medical Treatment in Heart Failure Patients
Not yet reported National Institute of Cardiovascular Diseases, Pakistan 500 participants Est. completion 2027-07-31 Stand-aloneHeart failureView official trial listing → -
Not yet recruiting NCT NCT07715279
Vericiguat for the Inhibition of Calcific Aortic Valve Stenosis Progression
Not yet reported West China Hospital 238 participants Est. completion 2029-11-30Other conditions: Calcific Aortic Valve Disease, AORTIC VALVE DISEASES, Aortic Valve StenosisView official trial listing →
Efficacy history
Not yet reported.
Safety
Not yet reported.
Sources
Also known as: Vericiguat, VERQUVO, MK-1242
Related On The Pen coverage
No related coverage yet.
This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.