About this data
Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.
Polypill
- Company
- University of Texas Southwestern Medical Center
- Mechanism
- Mechanism not yet reported
- Route
- Route not yet reported
- Recruiting trials
- 8 recruiting
Efficacy results: Not yet reported
8 recruiting studies currently listed on ClinicalTrials.gov.
Data source: ClinicalTrials.gov · trial data as of Sep 23, 2026
Find a Clinical Trial Near Me
See recruiting studies for Polypill and check eligibility with the study team.
Trial details
-
Recruiting NCT NCT05030818
Cross-over Study of Coronary Risk Factors With a Polypill
Not yet reported Fundación EPIC 88 participants Est. completion 2026-04-30 1 site Stand-aloneCardiovascular diseaseView official trial listing → -
Recruiting NCT NCT05155137
Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE)
Not yet reported Hospital Moinhos de Vento 8518 participants Est. completion 2030-12-14 2 sites Stand-aloneCardiovascular disease Other conditions: Cognitive DeclineView official trial listing → -
Recruiting NCT NCT05963568
Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment II Study (SMAART II)
Not yet reported Northern California Institute of Research and Education 1000 participants Est. completion 2029-02-01 4 sites Stand-aloneCardiovascular disease Other conditions: Medication AdherenceView official trial listing → -
Recruiting NCT NCT06143566
Polypill for Prevention of Cardiomyopathy
Not yet reported, Not yet reported University of Texas Southwestern Medical Center 200 participants Est. completion 2027-12-01 1 site Stand-aloneType 2 diabetes Other conditions: High Blood PressureView official trial listing → -
Recruiting NCT NCT06930885
Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease
Not yet reported Hospital do Coracao 7713 participants Est. completion 2031-05 13 sites Stand-aloneCardiovascular disease Other conditions: Atherothrombotic DiseasesView official trial listing → -
Recruiting NCT NCT07032389
A Polypill for Acute Coronary Syndrome
Not yet reported University of Texas Southwestern Medical Center 1000 participants Est. completion 2030-07-31 2 sites Stand-aloneOther conditions: Acute Coronary SyndromeView official trial listing → -
Recruiting NCT NCT07569640
HFrEF Polypill in Sri Lanka RCT
Not yet reported Washington University School of Medicine 1672 participants Est. completion 2029-04 11 sites Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT07679828
Polypills Approach for Multiple Cardiovascular Risk Factors
Not yet reported China Medical University, China 8252 participants Est. completion 2030-03-01 15 sites Stand-aloneOther conditions: Hypertension, Dyslipidemia, DiabetesView official trial listing → -
Completed NCT NCT00567307
Polypill For Prevention of Cardiovascular Disease
Not yet reported Wake Forest University Health Sciences 216 participants Est. completion 2010-01 3 sites Stand-aloneCardiovascular diseaseView official trial listing → -
Completed NCT NCT00603590
Phase II Study of Heart Polypill Safety and Efficacy in Primary Prevention of Cardiovascular Disease
Not yet reported Tehran University of Medical Sciences 475 participants Est. completion 2008-07 1 site Stand-aloneCardiovascular disease Other conditions: Hypertension, Hyperlipidemia, Heart DiseaseView official trial listing → -
Completed NCT NCT00982189
Cardiovascular Prevention for Persons With HIV
Not yet reported Hennepin Healthcare Research Institute 37 participants Est. completion 2011-05 1 siteCardiovascular disease Other conditions: HIV InfectionView official trial listing → -
Completed NCT NCT01057537
UMPIRE - Use of a Multidrug Pill In Reducing Cardiovascular Events
Not yet reported Imperial College London 2004 participants Est. completion 2012-09 7 sites Stand-aloneCardiovascular diseaseView official trial listing → -
Completed NCT NCT01245608
Prevention of Cardiovascular Disease Using a Single PolyPill in an Urban Population - Focus on Liver-Related Variables.
Not yet reported Tehran University of Medical Sciences 2400 participants Est. completion 2018-09 1 site Stand-aloneCardiovascular diseaseView official trial listing → -
Completed NCT NCT01271985
Prevention of Cardiovascular Disease in Middle-aged and Elderly Iranians Using a Single PolyPill
Not yet reported Tehran University of Medical Sciences 8410 participants Est. completion 2019-01 1 siteCardiovascular diseaseView official trial listing → -
Withdrawn NCT NCT01313702
Single Pill to Avert Cardiovascular Events
Not yet reported Hospital do Coracao Est. completion 2014-07 1 siteCardiovascular diseaseView official trial listing → -
Completed NCT NCT01321255
Fixed Dose Combination Drug (Polypill)for Secondary Cardiovascular Prevention.
Not yet reported Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III 2118 participants Est. completion 2014-06 69 sitesCardiovascular diseaseView official trial listing → -
Withdrawn NCT NCT01326676
Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial
Not yet reported Imperial College London Est. completion 2012-09 3 sites Stand-aloneCardiovascular diseaseView official trial listing → -
Terminated NCT NCT01362218
Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL Cholesterol
Not yet reported Ferrer Internacional S.A. 107 participants Est. completion 2012-04 1 siteOther conditions: Elevated LDL CholesterolView official trial listing → -
Completed NCT NCT01506505
The Evening Versus Morning Polypill Utilization Study
Not yet reported UMC Utrecht 78 participants Est. completion 2013-07 1 site Stand-aloneCardiovascular disease Other conditions: Cerebrovascular Disease, Peripheral Arterial DiseaseView official trial listing → -
Completed NCT NCT02278471
The SCCS Polypill Pilot Trial
Not yet reported Vanderbilt University 303 participants Est. completion 2018-06-27 1 site Stand-aloneOther conditions: Hypertension, HyperlipidemiaView official trial listing → -
Completed NCT NCT02596126
Secondary Prevention of Cardiovascular Disease in the Elderly Trial
Not yet reported Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III 2499 participants Est. completion 2022-03-31 113 sites Stand-aloneCardiovascular diseaseView official trial listing → -
Status unknown NCT NCT02791958
Pharmacodynamic Equivalence of Ramipril 10 mg and Atorvastatin 40 mg Administered as a Cardiovascular (CV) Polypill Acetylsalicylic Acid-Atorvastatin-Ramipril (AAR) as Compared to Monotherapy
Not yet reported Ferrer Internacional S.A. 528 participants Est. completion 2017-10 36 sitesOther conditions: HypertensionView official trial listing → -
Completed NCT NCT03329599
Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment
Not yet reported Northern California Institute of Research and Education 148 participants Est. completion 2022-03-30 1 site Stand-aloneOther conditions: Atherosclerosis, Adherence, Medication, ToleranceView official trial listing → -
Status unknown NCT NCT03459560
Prevention of Cardiovascular Disease With Polypill Among Pars Cohort Participants
Not yet reported Tehran University of Medical Sciences 4415 participants Est. completion 2022-03-20 1 site Stand-aloneCardiovascular diseaseView official trial listing → -
Status unknown NCT NCT03541109
A Polypill for Secondary Prevention of Ischemic Heart Disease
Not yet reported Isfahan University of Medical Sciences 1200 participants Est. completion 2024-08 2 sites Stand-aloneCardiovascular diseaseView official trial listing → -
Completed NCT NCT04633005
Polypill Strategy for Heart Failure With Reduced Ejection Fraction
Not yet reported University of Texas Southwestern Medical Center 212 participants Est. completion 2025-10-31 1 site Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT05514938
Polypill in Acute Coronary Syndrome
Not yet reported University of Texas Southwestern Medical Center 140 participants Est. completion 2025-06-05 2 sites Stand-aloneCardiovascular disease Other conditions: Acute Coronary Syndrome, Lipid DisorderView official trial listing → -
Withdrawn NCT NCT05833958
Polypill Versus Metformin in New Onset Type 2 Diabetes
Not yet reported George Medicines PTY Limited Est. completion 2025-09 Stand-aloneType 2 diabetesView official trial listing → -
Completed NCT NCT06029712
Heart Failure Polypill at a Safety Net Hospital
Not yet reported University of California, San Francisco 35 participants Est. completion 2025-01-29 1 site Stand-aloneHeart failure Other conditions: HIV InfectionsView official trial listing → -
Completed NCT NCT06597058
Phase 2 Estimation Study of Fixed Dose Drugs Combination Type of Polypill
Not yet reported Noah Pharmaceuticals, Inc. 121 participants Est. completion 2025-12-15 16 sitesOther conditions: Alzheimer DiseaseView official trial listing → -
Completed NCT NCT06831864
Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy in Sri Lanka
Not yet reported Washington University School of Medicine 40 participants Est. completion 2025-05-05 2 sites Stand-aloneHeart failureView official trial listing →
Efficacy history
Not yet reported.
Safety
Not yet reported.
Sources
Related On The Pen coverage
No related coverage yet.
This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.