GLP-1 Market
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About this data Sourced primarily from ClinicalTrials.gov — a listing isn't proof of safety or FDA approval.

Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.

Not yet reported

Phentermine-Topiramate

Company
The Cleveland Clinic
Mechanism
Mechanism not yet reported
Route
Route not yet reported
Recruiting trials
6 recruiting

Efficacy results: Not yet reported

Find a Clinical Trial Near Me

6 recruiting studies currently listed on ClinicalTrials.gov.

Data source: ClinicalTrials.gov · trial data as of Oct 1, 2026

Find a Clinical Trial Near Me

See recruiting studies for Phentermine-Topiramate and check eligibility with the study team.

Select conditions
Match
Treatment type

"Added to GLP-1" means the investigational treatment is being studied on top of an existing GLP-1-based therapy.

Your ZIP code is only used to calculate distance to trial sites — it isn't stored.

Trial details
  • Recruiting NCT NCT04721873

    Pharmacologic Weight Loss as Adjunct Therapy for Ulcerative Colitis in Obese Patients

    Not yet reported University of California, San Diego 40 participants Est. completion 2024-06-30 1 site Stand-alone
    Other conditions: Colitis, Ulcerative, Obesity
    View official trial listing →
  • Recruiting NCT NCT05925959

    Preoperative Weight Loss for Open Abdominal Wall Reconstruction

    Not yet reported Benjamin T. Miller 258 participants Est. completion 2027-06-01 2 sites
    Other conditions: Abdominal Wall Hernia
    View official trial listing →
  • Recruiting NCT NCT05975580

    Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery

    Not yet reported University of California, Irvine 120 participants Est. completion 2028-01-31 1 site
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT06299891

    Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity

    Not yet reported Seattle Children's Hospital 24 participants Est. completion 2026-05-31 2 sites Stand-alone
    Other conditions: Hypothalamic Obesity, Hypothalamic Tumor, Craniopharyngioma
    View official trial listing →
  • Recruiting NCT NCT07058155

    Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

    Not yet reported The Cleveland Clinic 70 participants Est. completion 2034-02-01 1 site
    Other conditions: Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity, TIPS
    View official trial listing →
  • Recruiting NCT NCT07213466

    Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

    Not yet reported Mayo Clinic 100 participants Est. completion 2029-02-01 1 site Stand-alone
    Other conditions: Bipolar I Disorder, Bipolar II Disorder, Schizo Affective Disorder, Obesity, Weight Loss, GLP - 1
    View official trial listing →
  • Completed NCT NCT00486291

    Study of VI-0521 Compared to Placebo in the Glycemic Management of Obese Diabetics

    Not yet reported VIVUS LLC 210 participants Est. completion 2008-04 9 sites
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT00518466

    Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults

    Not yet reported VIVUS LLC 64 participants Est. completion 2007-12 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT00553787

    Study of VI-0521 Compared to Placebo in Treatment of Diabetes and Obesity in Adults With Obesity-Related Co-Morbid Conditions

    Not yet reported VIVUS LLC 2487 participants Est. completion 2009-06 6 sites
    Type 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT00554216

    Study of VI-0521 Compared to Placebo in Treatment of Obesity in Adults

    Not yet reported VIVUS LLC 1267 participants Est. completion 2009-05 5 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT00563368

    A Study Comparing Multiple Doses of VI-0521 With Placebo and Their Single-agent Constituents for Treatment of Obesity in Adults

    Not yet reported VIVUS LLC 756 participants Est. completion 2008-09 2 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT00600067

    A VI-0521 Study to Evaluate the Long-term Safety and Efficacy in Type 2 Diabetic Adults

    Not yet reported VIVUS LLC 130 participants Est. completion 2008-11 9 sites
    Other conditions: Diabetes
    View official trial listing →
  • Terminated NCT NCT00737633

    Open-Label Study to Evaluate the Long-Term Safety and Efficacy of VI-0521 in Type 2 Diabetic Adults

    Not yet reported VIVUS LLC 101 participants Est. completion 2009-06 9 sites
    Other conditions: Diabetes
    View official trial listing →
  • Completed NCT NCT00745251

    A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults

    Not yet reported, Not yet reported VIVUS LLC 45 participants Est. completion 2009-12 1 site
    Other conditions: Sleep Apnea
    View official trial listing →
  • Completed NCT NCT00768209

    A Study to Evaluate the Pharmacokinetics of VI-0521 in Subjects With Hepatic Impairment

    Not yet reported VIVUS LLC 18 participants Est. completion 2009-07 2 sites
    Other conditions: Hepatic Impairment
    View official trial listing →
  • Completed NCT NCT00768404

    A Study to Evaluate the Pharmacokinetics of VI-0521 Subjects With Renal Impairment

    Not yet reported VIVUS LLC 32 participants Est. completion 2009-07 4 sites
    Other conditions: Renal Impairment
    View official trial listing →
  • Completed NCT NCT00796367

    A Safety and Efficacy Study of VI-0521 to Evaluate the Long Term Treatment of Obesity in Adults With Obesity-Related Co-Morbid Conditions. An Extension Study of Protocol OB-303 (NCT00553787)

    Not yet reported VIVUS LLC 676 participants Est. completion 2010-07
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT00806260

    A Study to Evaluate How VI-0521 Affect Psychomotor Performance in Healthy Overweight and Obese Subjects.

    Not yet reported VIVUS LLC 80 participants Est. completion 2009-05 1 site
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT00842400

    A Drug Interaction Study of VI-0521 With Metformin, Sitagliptan and Probenecid in Healthy Subjects.

    Not yet reported VIVUS LLC 20 participants Est. completion 2009-04 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT01087736

    Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy

    Not yet reported University of California, San Francisco 30 participants Est. completion 2013-12 1 site
    Other conditions: PTSD, Alcohol Abuse, Alcoholism
    View official trial listing →
  • Completed NCT NCT01834404

    Peripheral Pharmacodynamics of Phentermine-Topiramate in Obese Patients

    Not yet reported Mayo Clinic 24 participants Est. completion 2014-03 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT01922934

    A Toolbox Approach to Obesity Treatment in Primary Care

    Not yet reported Denver Health and Hospital Authority 4730 participants Est. completion 2016-08 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT01950520

    Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

    Not yet reported National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 47 participants Est. completion 2024-06-11 1 site Stand-alone
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Withdrawn NCT NCT01970566

    Comparison of the Effect of Intense-Exercise/Moderate-Calorie, Topiramate-Phentermine and Cognitive Behavioral Therapy on Obesity

    Not yet reported US Department of Veterans Affairs Est. completion 2017-11 1 site
    Other conditions: Obesity, Diabetes Mellitus
    View official trial listing →
  • Completed NCT NCT02229214

    Effect of VI-0521 (Qsymia®) on Glomerular Filtration Rate (GFR) in Overweight or Obese Healthy Subjects

    Not yet reported VIVUS LLC 51 participants Est. completion 2014-11 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT02239913

    Topiramate-Phentermine Combinations for Cocaine Dependence

    Not yet reported University of Kentucky 38 participants Est. completion 2019-09 1 site
    Other conditions: Cocaine Use Disorder
    View official trial listing →
  • Completed NCT NCT02301416

    Qsymia as an Adjunct to Surgical Therapy in the Superobese

    Not yet reported Wake Forest University Health Sciences 25 participants Est. completion 2018-06-27 1 site Stand-alone
    Other conditions: Obesity, Metabolic Surgery, Weight Loss, Bariatric Surgery Procedures
    View official trial listing →
  • Completed NCT NCT02553824

    FDA Approved Medication to Reduce Binge Eating and/or Purging

    Not yet reported Stanford University 22 participants Est. completion 2017-04-15 1 site Stand-alone
    Obstructive sleep apnea Other conditions: Binge Eating Disorder
    View official trial listing →
  • Completed NCT NCT02635386

    EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)

    Not yet reported Woman's 119 participants Est. completion 2020-10-09 1 site
    Other conditions: Polycystic Ovary Syndrome, Obesity
    View official trial listing →
  • Completed NCT NCT02659475

    Phentermine/Topiramate Extended Release in Binge Eating Disorder (BED)

    Not yet reported Lindner Center of HOPE 10 participants Est. completion 2016-09 1 site Stand-alone
    Other conditions: Binge Eating Disorder
    View official trial listing →
  • Completed NCT NCT02714062

    A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents

    Not yet reported VIVUS LLC 42 participants Est. completion 2016-11 4 sites
    Other conditions: Pediatric Obesity, Childhood Obesity
    View official trial listing →
  • Completed NCT NCT03374956

    Individualized Obesity Pharmacotherapy

    Not yet reported Mayo Clinic 193 participants Est. completion 2022-05-26 1 site Added to GLP-1
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT03799198

    Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity

    Not yet reported Novo Nordisk A/S 200 participants Est. completion 2020-05-22 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT03922945

    A Phase IV Safety and Efficacy Study of VI-0521 in Adolescents With Obesity

    Not yet reported VIVUS LLC 223 participants Est. completion 2021-04-16 1 site
    Other conditions: Adolescent Obesity, Obesity in Adolescence, Adolescent Overweight
    View official trial listing →
  • Completed NCT NCT04007393

    SMART Use of Medication for the Treatment of Adolescent Severe Obesity

    Not yet reported University of Minnesota 150 participants Est. completion 2025-03-11 1 site
    Other conditions: Adolescent Obesity
    View official trial listing →
  • Completed NCT NCT04095104

    Adjunct Phentermine + Topiramate After Bariatric Surgery in 12-24 Year Olds

    Not yet reported University of Colorado, Denver 13 participants Est. completion 2022-01-25 1 site
    Other conditions: Obesity, Morbid, Bariatric Surgery, Adolescent, Young Adult, Drug Therapy
    View official trial listing →
  • Completed NCT NCT04298203

    Role of Pharmacotherapy in Counteracting Weight Regain in Adolescents With Severe Obesity

    Not yet reported University of Minnesota 100 participants Est. completion 2026-05-22 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT04408586

    Anti-Obesity Phentermine-Topiramate Extended Release Pharmacotherapy vs Placebo Among Patients Using a Wearable Activity Tracker

    Not yet reported Mayo Clinic 80 participants Est. completion 2022-10-11 1 site
    Other conditions: Obesity
    View official trial listing →
  • Terminated NCT NCT04531176

    EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial

    Not yet reported The Cleveland Clinic 74 participants Est. completion 2023-08-04 1 site
    Type 2 diabetes Other conditions: Obesity
    View official trial listing →
  • Withdrawn NCT NCT04572217

    Medications After Adolescent Bariatric Surgery

    Not yet reported Janey Pratt Est. completion 2022-06-01 1 site
    Other conditions: Pediatric Obesity
    View official trial listing →
  • Completed NCT NCT04621929

    Phentermine/Topiramate for Uric Acid Stones

    Not yet reported University of Florida 19 participants Est. completion 2024-11-14 1 site
    Type 2 diabetesPrediabetes Other conditions: Obesity, Uric Acid Stones
    View official trial listing →
  • Active, not recruiting NCT NCT04881799

    Phentermine/Topiramate in Adolescents With Type 2 Diabetes and Obesity

    Not yet reported University of Minnesota 13 participants Est. completion 2026-10-27 1 site Stand-alone
    Other conditions: Pediatric Obesity
    View official trial listing →
  • Completed NCT NCT05215418

    A Study of VI-0521 on Ambulatory Blood Pressure (ABPM) in Overweight or Obese Subjects

    Not yet reported VIVUS LLC 565 participants Est. completion 2023-04-17 28 sites
    Other conditions: Blood Pressure
    View official trial listing →
  • Completed NCT NCT05378503

    Phase IV Study of Qsymia in Obese Patients

    Not yet reported Alvogen Korea 232 participants Est. completion 2023-10-30 8 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT05579249

    A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America

    Not yet reported Novo Nordisk A/S 500 participants Est. completion 2024-11-27 1 site
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT05756764

    Anti-obesity Pharmacotherapy and Inflammation

    Louisiana State University Health Sciences Center in New Orleans 30 participants Est. completion 2026-02-20 2 sites
    Other conditions: Obesity
    View official trial listing →
  • Withdrawn NCT NCT05812183

    Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity

    Not yet reported University of California, Los Angeles Est. completion 2025-02-12 Stand-alone
    Other conditions: Dyspnea, Quality of Life
    View official trial listing →
  • Withdrawn NCT NCT05834062

    Phentermine/Topiramate as Preventive Pharmacotherapy for Obesity

    Not yet reported University of Minnesota Est. completion 2027-08 1 site Stand-alone
    Other conditions: Obesity, Adolescent
    View official trial listing →
  • Active, not recruiting NCT NCT06854614

    Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)

    Not yet reported The Cleveland Clinic 150 participants Est. completion 2028-04-28 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06877572

    Weight Loss Management in Endometrial Cancer Survivors

    University of Kansas Medical Center 50 participants Est. completion 2030-10 1 site
    Other conditions: Endometrial Cancer Survivors, Weight Management, Early Stage Endometrial Cancer
    View official trial listing →
  • Not yet recruiting NCT NCT06905626

    Weight Gain Prevention in Adolescents and Young Adults

    Not yet reported University of Minnesota 140 participants Est. completion 2031-10-31 Stand-alone
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Active, not recruiting NCT NCT07188545

    Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH)

    Ohio State University 23280000 participants Est. completion 2029-06-30 1 site
    Metabolic syndrome
    View official trial listing →
  • Not yet recruiting NCT NCT07728812

    Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy

    Not yet reported Phenomix Sciences 424 participants Est. completion 2029-01-01 Stand-alone
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07790913

    Obesity Treatment With Phentermine-Topiramate ER in AYA Surviving Leukemia and Lymphoma

    Not yet reported St. Jude Children's Research Hospital 100 participants Est. completion 2031-08 1 site Stand-alone
    Other conditions: Acute Lymphoblastic Leukemia in Remission, Hodgkin Lymphoma in Remission, Non-Hodgkin Lymphoma in Remission, Cancer Survivorship
    View official trial listing →
Efficacy history

Not yet reported.

Safety

Not yet reported.

Sources

Also known as: Phentermine-Topiramate, Qsymia

Related On The Pen coverage

No related coverage yet.

This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.