GLP-1 Market
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About this data Sourced primarily from ClinicalTrials.gov — a listing isn't proof of safety or FDA approval.

Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.

Not yet reported

NNC0487-0111

Company
Novo Nordisk A/S
Mechanism
Mechanism not yet reported
Route
Route not yet reported
Recruiting trials
11 recruiting

Efficacy results: Not yet reported

Find a Clinical Trial Near Me

11 recruiting studies currently listed on ClinicalTrials.gov.

Data source: ClinicalTrials.gov · trial data as of Sep 11, 2026

Find a Clinical Trial Near Me

See recruiting studies for NNC0487-0111 and check eligibility with the study team.

Select conditions
Match
Treatment type

"Added to GLP-1" means the investigational treatment is being studied on top of an existing GLP-1-based therapy.

Your ZIP code is only used to calculate distance to trial sites — it isn't stored.

Trial details
  • Recruiting NCT NCT07339423

    AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

    Not yet reported Novo Nordisk A/S 1150 participants Est. completion 2029-08-21 72 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07481630

    A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

    Not yet reported Novo Nordisk A/S 400 participants Est. completion 2028-08-14 82 sites Stand-alone
    Osteoarthritis Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07503210

    AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

    Not yet reported Novo Nordisk A/S 600 participants Est. completion 2028-07-04 72 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07508020

    A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity

    Not yet reported Novo Nordisk A/S 120 participants Est. completion 2028-01-22 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07509307

    AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

    Not yet reported Novo Nordisk A/S 400 participants Est. completion 2028-08-14 81 sites Stand-alone
    Osteoarthritis Other conditions: Obesity, Overweight
    View official trial listing →
  • Recruiting NCT NCT07533175

    AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

    Not yet reported Novo Nordisk A/S 630 participants Est. completion 2028-08-07 74 sites Stand-alone
    Other conditions: Diabetes Mellitus, Overweight, Obesity
    View official trial listing →
  • Recruiting NCT NCT07535307

    Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 80 participants Est. completion 2027-12-06 1 site Stand-alone
    Other conditions: Diabetes Mellitus
    View official trial listing →
  • Recruiting NCT NCT07567001

    A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

    Not yet reported Novo Nordisk A/S 5610 participants Est. completion 2029-08-15 838 sites Stand-alone
    Heart failure Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT07571005

    AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

    Not yet reported Novo Nordisk A/S 300 participants Est. completion 2028-10-04 80 sites Stand-alone
    Other conditions: Obesity, Overweight, Obstructive Sleep Apnoea
    View official trial listing →
  • Recruiting NCT NCT07571109

    AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

    Not yet reported Novo Nordisk A/S 300 participants Est. completion 2028-08-21 92 sites Stand-alone
    Other conditions: Obesity, Overweight, Obstructive Sleep Apnoea
    View official trial listing →
  • Recruiting NCT NCT07757087

    A Research Study to See How NNC0487-0111 Affects the Body's Energy Use After a Weight Loss in Adults Living With Obesity, Compared to a Low-calorie Diet or Placebo

    Not yet reported Novo Nordisk A/S 120 participants Est. completion 2028-09-18 2 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT05369390

    A Research Study on How NNC0487-0111 Works in People With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 144 participants Est. completion 2024-01-09 2 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06049329

    A Research Study of How a New Medicine Called Amycretin, Given as Tablets, Works in Japanese Men With Obesity

    Not yet reported Novo Nordisk A/S 36 participants Est. completion 2023-12-15 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06064006

    A Research Study to See How a New Medicine (NNC0487-0111) Works in People With Overweight or Obesity When Injected Under the Skin

    Not yet reported Novo Nordisk A/S 125 participants Est. completion 2024-11-27 2 sites Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT06461039

    A Research Study Looking at How the Compound NNC0487-0111 Works With Birth Control Pills and Affects Emptying of the Stomach in Women Not Able to Become Pregnant

    Not yet reported Novo Nordisk A/S 43 participants Est. completion 2025-04-04 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT06478563

    A Research Study Looking at Different Oral Formulations and the Effect of Food Intake on How the Medicine NNC0487-0111 Behaves in the Body of Participants Living With Overweight or Obesity

    Not yet reported Novo Nordisk A/S 133 participants Est. completion 2025-07-01 1 site Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT06542874

    A Research Study Comparing How Well Different Doses of the Medicine NNC0487-0111 Lower Blood Sugar in People With Type 2 Diabetes

    Not yet reported Novo Nordisk A/S 448 participants Est. completion 2025-10-24 137 sites Stand-alone
    Type 2 diabetes
    View official trial listing →
  • Completed NCT NCT06559527

    A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function

    Not yet reported Novo Nordisk A/S 42 participants Est. completion 2025-03-05 1 site Stand-alone
    Type 2 diabetes Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT06820476

    A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants After 10 Days of Oral Dosing

    Not yet reported Novo Nordisk A/S 29 participants Est. completion 2025-05-14 2 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT07121153

    A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants When Injected Under the Skin.

    Not yet reported Novo Nordisk A/S 36 participants Est. completion 2025-12-20 1 site Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
  • Not yet recruiting NCT NCT07400107

    AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

    Not yet reported Novo Nordisk A/S 1000 participants Est. completion 2029-01-26 120 sites Added to GLP-1
    Type 2 diabetes Other conditions: Obesity, Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07587710

    A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in People With Reduced Liver Function and Normal Liver Function

    Not yet reported Novo Nordisk A/S 35 participants Est. completion 2027-12-01 2 sites Stand-alone
    Other conditions: Overweight, Obesity
    View official trial listing →
Efficacy history

Not yet reported.

Safety

Not yet reported.

Sources

Also known as: NNC0487-0111, NNC0487-0111 (formulation D), NNC0487-0111 (formulation C)

Related On The Pen coverage

No related coverage yet.

This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.