GLP-1 Market
LLY $1149.85 ▼ -0.6% NVO $37.40 ▼ -1.3% PFE $28.12 ▼ -1.4% VKTX $30.51 ▼ -6.4% KLRA $11.03 ▼ -3.4% GPCR $28.98 ▼ -7.3% RHHBY $52.35 ▲ +0.9%
Market data delayed up to 20 min · Source: Twelve Data

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About this data Sourced primarily from ClinicalTrials.gov — a listing isn't proof of safety or FDA approval.

Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.

Not yet reported

Naltrexone Hydrochloride

Company
Johns Hopkins University
Mechanism
Mechanism not yet reported
Route
Oral
Recruiting trials
30 recruiting

Efficacy results: Not yet reported

Find a Clinical Trial Near Me

30 recruiting studies currently listed on ClinicalTrials.gov.

Data source: ClinicalTrials.gov · trial data as of Oct 2, 2026

Find a Clinical Trial Near Me

See recruiting studies for Naltrexone Hydrochloride and check eligibility with the study team.

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Treatment type

"Added to GLP-1" means the investigational treatment is being studied on top of an existing GLP-1-based therapy.

Your ZIP code is only used to calculate distance to trial sites — it isn't stored.

Trial details
  • Recruiting NCT NCT02502162

    Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome

    Not yet reported Stanford University 120 participants Est. completion 2027-07 1 site Stand-alone
    Other conditions: Complex Regional Pain Syndrome
    View official trial listing →
  • Recruiting NCT NCT04649892

    Predicting Response to Naltrexone With Eye Tracking in Gaming Disorder

    Not yet reported University of Sao Paulo 40 participants Est. completion 2027-07 1 site Stand-alone
    Other conditions: Gaming Disorder
    View official trial listing →
  • Recruiting NCT NCT04678895

    Low-Dose Naltrexone for the Treatment of Painful Diabetic Neuropathy

    Not yet reported Dartmouth-Hitchcock Medical Center 35 participants Est. completion 2026-12 1 site Stand-alone
    Other conditions: Painful Diabetic Neuropathy
    View official trial listing →
  • Recruiting NCT NCT05011266

    Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

    Not yet reported, Not yet reported New York State Psychiatric Institute 180 participants Est. completion 2027-01-01 2 sites
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Recruiting NCT NCT05028062

    Naltrexone in AUD Reward Drinkers

    Not yet reported University of Pennsylvania 60 participants Est. completion 2028-07 1 site
    Alcohol use disorder Other conditions: Alcoholism
    View official trial listing →
  • Recruiting NCT NCT05509257

    Naltrexone Neuroimaging in Teens With Eating Disorders

    Not yet reported Children's Mercy Hospital Kansas City 60 participants Est. completion 2027-06 1 site Stand-alone
    Obstructive sleep apnea Other conditions: Eating Disorders, Binge Eating, Purging (Eating Disorders)
    View official trial listing →
  • Recruiting NCT NCT05537935

    Low Dose Naltrexone for Pain in Patients With HIV

    Not yet reported Emory University 60 participants Est. completion 2027-06-30 3 sites Stand-alone
    Other conditions: Human Immunodeficiency Virus, Chronic Neuropathic Pain
    View official trial listing →
  • Recruiting NCT NCT05620940

    A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.

    Not yet reported Inventage Lab., Inc. 40 participants Est. completion 2025-12-30 1 site Stand-alone
    Alcohol use disorder Other conditions: Opioid Dependence, Multiple Sclerosis
    View official trial listing →
  • Recruiting NCT NCT05827159

    Emergency Department-Initiated Medications for Alcohol Use Disorder

    Not yet reported Yale University 240 participants Est. completion 2029-02-01 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Recruiting NCT NCT05919797

    Weight Loss Study: Genetics and Response to Naltrexone/Bupropion

    Not yet reported Columbia University 120 participants Est. completion 2027-06-30 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Recruiting NCT NCT05925959

    Preoperative Weight Loss for Open Abdominal Wall Reconstruction

    Not yet reported Benjamin T. Miller 258 participants Est. completion 2027-06-01 2 sites
    Other conditions: Abdominal Wall Hernia
    View official trial listing →
  • Recruiting NCT NCT05940324

    Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)

    Not yet reported Stanford University 150 participants Est. completion 2028-11 1 site Stand-alone
    Other conditions: Obsessive-Compulsive Disorder
    View official trial listing →
  • Recruiting NCT NCT05955313

    Effectiveness of Low-dose Naltrexone in Patients With Different Types of Vulvodynia

    Not yet reported Medical University of Lublin 300 participants Est. completion 2026-12-31 1 site Stand-alone
    Other conditions: Vulvodynia, Naltrexone, Quality of Life
    View official trial listing →
  • Recruiting NCT NCT05968690

    Naltrexone and Propranolol Combined With Immunotherapy

    Not yet reported Sarah Weiss 12 participants Est. completion 2027-09-30 1 site Stand-alone
    Other conditions: Advanced Melanoma
    View official trial listing →
  • Recruiting NCT NCT06104280

    Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

    University of Alabama at Birmingham 200 participants Est. completion 2029-01-01 1 site
    Substance use disorder Other conditions: Sleep Disturbance
    View official trial listing →
  • Recruiting NCT NCT06303778

    Combining a Smartphone App With Medications to Manage Heavy Drinking

    Not yet reported VA Office of Research and Development 330 participants Est. completion 2028-11-01 15 sites
    Alcohol use disorder
    View official trial listing →
  • Recruiting NCT NCT06366724

    LIFT: Life Improvement Trial

    Not yet reported Brigham and Women's Hospital 160 participants Est. completion 2026-11 1 site
    Other conditions: ME/CFS, Long COVID, PASC
    View official trial listing →
  • Recruiting NCT NCT06426303

    Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder

    Not yet reported Milky Kohno 100 participants Est. completion 2028-12-31 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Recruiting NCT NCT06488586

    IV Ketamine vs. IN Esketamine for MDD TRD

    Gustavo Vazquez 80 participants Est. completion 2026-10-20 1 site
    Other conditions: Treatment Resistant Depression
    View official trial listing →
  • Recruiting NCT NCT06500793

    Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With Nafamostat (PF614-MPAR-102)

    Not yet reported Ensysce Biosciences 54 participants Est. completion 2027-04-28 1 site Stand-alone
    Other conditions: Pharmacokinetics, Healthy Volunteer
    View official trial listing →
  • Recruiting NCT NCT06620562

    Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release Tablet

    Not yet reported Laval University 108 participants Est. completion 2028-08 1 site Stand-alone
    Other conditions: Obesity; Drug, Obesity, Morbid
    View official trial listing →
  • Recruiting NCT NCT06633900

    Naltrexone for Overdose Prevention

    Not yet reported, Not yet reported University of California, San Francisco 100 participants Est. completion 2027-04-15 1 site Stand-alone
    Other conditions: Overdose Accidental
    View official trial listing →
  • Recruiting NCT NCT06774248

    Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD

    Not yet reported Potomac Health Foundations 80 participants Est. completion 2027-08-01 1 site
    Substance use disorder
    View official trial listing →
  • Recruiting NCT NCT06845124

    A Trial to Investigate the Effects of Cannabidiol Plus Naltrexone on Alcohol Craving in Patients With Alcohol Dependence

    Not yet reported Central Institute of Mental Health, Mannheim 150 participants Est. completion 2028-09-30 2 sites Stand-alone
    Other conditions: Alcohol Addiction, Alcoholism
    View official trial listing →
  • Recruiting NCT NCT06881485

    Naltrexone/Bupropion With or Without Very Low Calorie Ketogenic Diet for Weight Regain After Bariatric Surgery

    Not yet reported Universitaire Ziekenhuizen KU Leuven 62 participants Est. completion 2027-01-01 2 sites
    Other conditions: Weight Regain Post Bariatric Surgery, Obesity (Disorder)
    View official trial listing →
  • Recruiting NCT NCT07092618

    Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation

    Not yet reported, Not yet reported AgelessRx 150 participants Est. completion 2025-08 1 site Stand-alone
    Other conditions: Longevity, GLP-1, Geroscience, Aging
    View official trial listing →
  • Recruiting NCT NCT07213466

    Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

    Not yet reported Mayo Clinic 100 participants Est. completion 2029-02-01 1 site Stand-alone
    Other conditions: Bipolar I Disorder, Bipolar II Disorder, Schizo Affective Disorder, Obesity, Weight Loss, GLP - 1
    View official trial listing →
  • Recruiting NCT NCT07224009

    Low Dose Naltrexone (LDN) for Management of Fatigue in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT)

    Not yet reported University of Arkansas 60 participants Est. completion 2030-01 1 site Stand-alone
    Other conditions: Metastatic Prostate Cancer
    View official trial listing →
  • Recruiting NCT NCT07262190

    NavSTAR Implementation Effectiveness Trial Across a Health System

    Not yet reported Friends Research Institute, Inc. 720 participants Est. completion 2029-08-01 1 site
    Substance use disorder
    View official trial listing →
  • Recruiting NCT NCT07269873

    Safety and PK Study of BICX104 With or Without Bupropion Compared to Vivitrol

    Not yet reported BioCorRx Pharmaceuticals Inc 30 participants Est. completion 2026-12-05 1 site Stand-alone
    Other conditions: Healthy Adult Male and Female Volunteers
    View official trial listing →
  • Withdrawn NCT NCT00000195

    Neurobiology of Opioid Dependence: 4 - 4

    Not yet reported Yale University Est. completion 1998-01 1 site
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Withdrawn NCT NCT00000196

    Neurobiology of Opioid Dependence: 5 - 5

    Not yet reported Yale University Est. completion 1998-01 1 site
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT00000299

    Rapid Opiate Detoxification and Naltrexone Induction Using Buprenorphine - 2

    Not yet reported University of California, Los Angeles 12 participants Est. completion 2009-11 1 site
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT00000307

    Naltrexone as Adjunct in Alcoholic Cocaine Dependent Patients - 4

    Not yet reported National Institute on Drug Abuse (NIDA) Est. completion 2007-04 1 site
    Other conditions: Alcohol-Related Disorders, Cocaine-Related Disorders
    View official trial listing →
  • Completed NCT NCT00000437

    Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)

    Not yet reported The Scripps Research Institute 60 participants Est. completion 2005-09-15 1 site Stand-alone
    Other conditions: Alcoholism, Smoking
    View official trial listing →
  • Completed NCT NCT00000438

    Naltrexone Treatment for Alcoholism

    Not yet reported Johns Hopkins University 192 participants Est. completion 2003-03 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00000440

    Sertraline and Naltrexone for Alcohol Dependence

    Not yet reported National Institute on Alcohol Abuse and Alcoholism (NIAAA) 124 participants Est. completion 2002-09 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00000442

    Naltrexone for Relapse Prevention

    Not yet reported UConn Health 57 participants Est. completion 2002-12 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00000445

    Use of Naltrexone in a Clinical Setting

    Not yet reported National Institute on Alcohol Abuse and Alcoholism (NIAAA) 300 participants Est. completion 2002-09 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00000447

    Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)

    Not yet reported The University of Texas Health Science Center, Houston 200 participants Est. completion 2003-05 1 site
    Other conditions: Alcoholism, Smoking
    View official trial listing →
  • Completed NCT NCT00000448

    Naltrexone Treatment for Alcoholic Women

    Not yet reported Yale University 160 participants Est. completion 2000-12 1 site Stand-alone
    Other conditions: Alcoholism, Eating Disorder
    View official trial listing →
  • Completed NCT NCT00000450

    Naltrexone Maintenance Treatment of Alcoholism

    Not yet reported The Scripps Research Institute 159 participants Est. completion 2002-02-13 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00000451

    Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)

    Not yet reported Yale University 198 participants Est. completion 2005-11 1 site Stand-alone
    Alcohol use disorder Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00000452

    Naltrexone Treatment of Alcohol Dependence

    Not yet reported National Institute on Alcohol Abuse and Alcoholism (NIAAA) 240 participants Est. completion 2003-01 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00000455

    Naltrexone for Early Problem Drinkers

    Not yet reported UConn Health 160 participants Est. completion 2002-09 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00000456

    Behavioral Therapy Plus Naltrexone for Alcoholism

    Not yet reported Medical University of South Carolina 160 participants Est. completion 2002-08 1 site
    Alcohol use disorder Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00004554

    Sertraline for Alcohol Dependence and Depression

    Not yet reported University of Pennsylvania 171 participants Est. completion 2006-02 1 site Stand-alone
    Other conditions: Alcoholism, Depression
    View official trial listing →
  • Completed NCT NCT00006203

    Naltrexone, Craving, and Drinking

    Not yet reported Brown University 180 participants Est. completion 2005-05 1 site Stand-alone
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00006204

    Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)

    Not yet reported National Institute on Alcohol Abuse and Alcoholism (NIAAA) 106 participants Est. completion 2006-01 1 site
    Alcohol use disorder Other conditions: Alcoholism, Depression
    View official trial listing →
  • Completed NCT NCT00006206

    COMBINE (Acamprosate/Naltrexone)

    Not yet reported University of North Carolina, Chapel Hill 1375 participants Est. completion 2006-05 12 sites
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00006449

    Post-Treatment Effects of Naltrexone

    Not yet reported Indiana University 160 participants Est. completion 2006-07 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00006489

    Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)

    Not yet reported University of Pennsylvania 165 participants Est. completion 2011-02 1 site
    Alcohol use disorder Other conditions: Alcoholism, Post-Traumatic Stress Disorder
    View official trial listing →
  • Completed NCT NCT00015080

    Naltrexone in Treatment of Cocaine Dependence - 5

    Not yet reported National Institute on Drug Abuse (NIDA) Est. completion 1996-07 1 site
    Other conditions: Cocaine-Related Disorders
    View official trial listing →
  • Completed NCT NCT00018213

    Naltrexone and Patch for Smokers

    Not yet reported US Department of Veterans Affairs Est. completion 2001-03 1 site
    Other conditions: Smoking
    View official trial listing →
  • Completed NCT NCT00018824

    Treating Alcohol Use In Older Adults With Depression

    Not yet reported US Department of Veterans Affairs 74 participants Est. completion 2005-01 1 site Stand-alone
    Other conditions: Alcoholism, Depression
    View official trial listing →
  • Completed NCT NCT00027079

    Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron)

    Not yet reported National Institute on Alcohol Abuse and Alcoholism (NIAAA) 360 participants Est. completion 2004-08 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00042536

    Effects of Yohimbine and Naltrexone on Sexual Function

    National Institute of Mental Health (NIMH) 40 participants Est. completion 2004-04 1 site
    Other conditions: Erectile Dysfunction
    View official trial listing →
  • Completed NCT NCT00053677

    Drug Treatment for Pathologic Gambling Disorder

    Not yet reported University of Chicago 83 participants Est. completion 2005-11 1 site
    Other conditions: Gambling
    View official trial listing →
  • Status unknown NCT NCT00065936

    Self-Injury: Diagnosis and Treatment

    Not yet reported Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 37 participants Est. completion 2002-06 2 sites
    Other conditions: Self-Injurious Behavior, Mental Retardation
    View official trial listing →
  • Completed NCT NCT00105482

    Targeted Interventions for Weight-Concerned Smokers

    Not yet reported Yale University 172 participants Est. completion 2009-10 1 site Stand-alone
    Other conditions: Nicotine Dependence
    View official trial listing →
  • Completed NCT NCT00115037

    Managing Alcoholism in People Who Do Not Respond to Naltrexone

    Not yet reported University of Pennsylvania 302 participants Est. completion 2008-07 1 site Stand-alone
    Other conditions: Alcoholism
    View official trial listing →
  • Status unknown NCT NCT00120601

    Trial for the Treatment of Alcohol Dependence

    Not yet reported University of Sydney 200 participants Est. completion 2005-06 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Terminated NCT NCT00124839

    Naltrexone in Borderline Personality Disorder

    Not yet reported Central Institute of Mental Health, Mannheim 48 participants Est. completion 2008-03 5 sites
    Other conditions: Borderline Personality Disorder
    View official trial listing →
  • Completed NCT NCT00125515

    Memantine and Naltrexone Treatment for Opioid Dependence

    Not yet reported New York State Psychiatric Institute 81 participants Est. completion 2008-08 1 site
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT00129246

    Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain

    Not yet reported, Not yet reported Yale University 40 participants Est. completion 2005-12 1 site Stand-alone
    Other conditions: Smoking, Nicotine Dependence
    View official trial listing →
  • Completed NCT NCT00135759

    Addition of Naltrexone to Methadone Taper

    Not yet reported National Institute on Drug Abuse (NIDA) 174 participants Est. completion 2006-07 1 site Stand-alone
    Substance use disorder Other conditions: Heroin Dependence, Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT00142818

    Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence

    Not yet reported Kyle Kampman 164 participants Est. completion 2013-08 1 site Stand-alone
    Other conditions: Alcohol-Related Disorders, Alcoholism, Cocaine-Related Disorders
    View official trial listing →
  • Completed NCT NCT00142844

    Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1

    Not yet reported University of Pennsylvania 208 participants Est. completion 2008-01 1 site Stand-alone
    Other conditions: Alcohol-Related Disorders, Alcoholism, Cocaine-Related Disorders
    View official trial listing →
  • Completed NCT NCT00142909

    Effectiveness of Lofexidine to Prevent Stress-Related Opiate Relapse During Naltrexone Treatment - 1

    Not yet reported Yale University 86 participants Est. completion 2009-01 1 site
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT00142948

    Naltrexone and Adrenergic Agents to Reduce Heroin Use in Heroin Addicts

    Not yet reported Baylor College of Medicine 301 participants Est. completion 2011-05 1 site Stand-alone
    Other conditions: Heroin Dependence
    View official trial listing →
  • Completed NCT NCT00145847

    Naltrexone Treatment of Alcohol Abuse in Schizophrenia

    Not yet reported State University of New York - Upstate Medical University 90 participants Est. completion 2008-05 4 sites
    Other conditions: Schizophrenia, Mental Disorders, Alcohol Abuse, Alcoholism, Alcohol-related Disorders
    View official trial listing →
  • Completed NCT NCT00147576

    Study To Examine Effect Of CP-866,087 On Consumption And Craving Of Alcohol In Alcohol Dependent Subjects.

    Not yet reported Pfizer 88 participants Est. completion 2004-12 11 sites
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00149669

    Employment-based Reinforcement of Naltrexone Ingestion and Abstinence

    Not yet reported Johns Hopkins University 67 participants Est. completion 2010-12 1 site Stand-alone
    Other conditions: Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
    View official trial listing →
  • Terminated NCT NCT00156936

    ALK21-006EXT: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol- or Opioid-dependent Adults (Extension of Study ALK21-006 [NCT01218997])

    Not yet reported Alkermes, Inc. 108 participants Est. completion 2007-01 Stand-alone
    Other conditions: Alcoholism, Opiate Dependence
    View official trial listing →
  • Completed NCT NCT00167232

    Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence

    Not yet reported University of Pennsylvania 164 participants Est. completion 2003-07 1 site
    Other conditions: Cocaine Dependence, Alcoholism
    View official trial listing →
  • Status unknown NCT NCT00182572

    Science-Based Treatment for Opioid-Dependent Adolescents

    Not yet reported National Development and Research Institutes, Inc. 80 participants 1 site
    Other conditions: Opioid-Dependence Among Adolescents
    View official trial listing →
  • Completed NCT NCT00183196

    Effectiveness of Gabapentin When Used With Naltrexone to Treat Alcohol Dependence Compared to Placebo and Naltrexone Alone

    Not yet reported Medical University of South Carolina 150 participants Est. completion 2009-06 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00183222

    Effectiveness of Naltrexone and/or Ondansetron to Reduce Craving for Alcohol and Drinking

    Not yet reported Medical University of South Carolina 160 participants Est. completion 2005-12 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00204243

    Naltrexone Implants vs. MMT Among Inmates in the Norwegian Correctional Services

    Not yet reported University of Oslo 46 participants Est. completion 2008-12 1 site Stand-alone
    Other conditions: Opiate Addiction
    View official trial listing →
  • Completed NCT NCT00218023

    Medications for Stopping Cocaine Dependence and Preventing Relapse

    Not yet reported The University of Texas Health Science Center, Houston 101 participants Est. completion 2012-04 1 site Stand-alone
    Other conditions: Cocaine Abuse, Cocaine-Related Disorders
    View official trial listing →
  • Completed NCT NCT00218153

    Naltrexone Augmentation of Nicotine Patch Therapy - 1

    Not yet reported National Institute on Drug Abuse (NIDA) 200 participants Est. completion 2004-04 2 sites
    Other conditions: Tobacco Use Disorder
    View official trial listing →
  • Completed NCT NCT00218426

    Addiction Treatment in Russia: Oral vs. Naltrexone Implant

    Not yet reported, Not yet reported University of Pennsylvania 306 participants Est. completion 2010-11-04 2 sites
    Other conditions: Heroin Dependence, Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT00218530

    Effectiveness of Naltrexone and Lofexidine in Treating Detoxified Heroin Addicts - 1

    Not yet reported National Institute on Drug Abuse (NIDA) Est. completion 2004-09 1 site
    Other conditions: Heroin Dependence
    View official trial listing →
  • Completed NCT NCT00218660

    Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1

    Not yet reported University of Pennsylvania 164 participants Est. completion 2007-11 1 site Stand-alone
    Other conditions: Alcoholism, Cocaine Dependence
    View official trial listing →
  • Completed NCT NCT00223275

    Naltrexone for Bipolar Disorder and Alcohol Dependence

    Not yet reported University of Texas Southwestern Medical Center 50 participants Est. completion 2007-09 1 site
    Alcohol use disorder Other conditions: Bipolar Disorder
    View official trial listing →
  • Completed NCT NCT00234689

    Efficacy of Naltrexone Treatment as Augmentation to SSRI in OCD Patients

    Not yet reported Sheba Medical Center Est. completion 2004-12 1 site
    Other conditions: Obsessive Compulsive Disorder
    View official trial listing →
  • Completed NCT NCT00238914

    Opiate Dependence: Combined Naltrexone/Behavior Therapy - 1

    Not yet reported New York State Psychiatric Institute 12 participants Est. completion 2002-07 1 site
    Other conditions: Heroin Dependence
    View official trial listing →
  • Completed NCT NCT00254670

    Naltrexone Effects on Alcohol Intake

    Not yet reported University of California, San Francisco Est. completion 2006-12 1 site
    Other conditions: Social Drinker
    View official trial listing →
  • Completed NCT NCT00256451

    Endophenotype for Alcohol Misuse in Healthy Minority Populations

    Not yet reported University of Pennsylvania 43 participants Est. completion 2008-05 1 site Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Terminated NCT NCT00269607

    Naltrexone Implants as Relapse Prevention

    Not yet reported, Not yet reported University of Oslo 12 participants Est. completion 2006-12
    Other conditions: Opioid Dependency
    View official trial listing →
  • Completed NCT NCT00270231

    Effects of Naltrexone on Nicotine Reinforcement

    Not yet reported University of Pennsylvania 64 participants Est. completion 2005-10 1 site
    Other conditions: Tobacco Dependence
    View official trial listing →
  • Completed NCT NCT00271024

    Efficacy of Naltrexone in Women's Smoking Cessation

    Not yet reported University of Chicago 333 participants Est. completion 2010-03 1 site Stand-alone
    Other conditions: Smoking, Smoking Cessation
    View official trial listing →
  • Completed NCT NCT00302133

    Optimizing Pharmacotherapy for Bipolar Alcoholics

    Not yet reported, Not yet reported University of Miami 88 participants Est. completion 2013-07 1 site Stand-alone
    Alcohol use disorder Other conditions: Bipolar Disorder
    View official trial listing →
  • Completed NCT NCT00317031

    Individually Adapted Therapy of Alcoholism

    Not yet reported Central Institute of Mental Health, Mannheim 435 participants Est. completion 2008-06 5 sites
    Other conditions: Alcoholism
    View official trial listing →
  • Status unknown NCT NCT00318162

    Trial of Low-Dose Naltrexone for Children With Pervasive Developmental Disorder (PDD)

    Not yet reported, Not yet reported Hadassah Medical Organization 50 participants 1 site
    Other conditions: Pervasive Developmental Disorder
    View official trial listing →
  • Completed NCT NCT00326807

    Naltrexone in the Treatment of Concurrent Alcohol Dependence and Pathological Gambling

    Not yet reported Centre for Addiction and Mental Health 50 participants Est. completion 2004-06 2 sites
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00332228

    Behavioral Naltrexone Therapy: A Novel Treatment for Heroin Dependence

    Not yet reported New York State Psychiatric Institute 125 participants Est. completion 2007-12 2 sites Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT00332579

    Double-Blind Naltrexone in Kleptomania

    Not yet reported University of Minnesota 25 participants Est. completion 2008-09-01 1 site
    Other conditions: Kleptomania
    View official trial listing →
  • Completed NCT NCT00332605

    N-Acetyl Cysteine Plus Naltrexone in Methamphetamine Dependence

    Not yet reported University of Chicago 45 participants Est. completion 2010-01 1 site Stand-alone
    Other conditions: Methamphetamine Dependence
    View official trial listing →
  • Completed NCT NCT00338962

    Naltrexone & SSRI in Alcoholics With Depression/PTSD

    Not yet reported Yale University 88 participants Est. completion 2015-07 1 site
    Other conditions: Alcoholism, Depression, PTSD
    View official trial listing →
  • Completed NCT NCT00364871

    Efficacy and Safety Study of Combination Therapy to Treat Uncomplicated Obesity

    Not yet reported Orexigen Therapeutics, Inc 410 participants Est. completion 2007-03 7 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT00366626

    Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.

    Not yet reported Medical University of South Carolina 83 participants Est. completion 2010-01 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00369408

    Targeted Naltrexone for Problem Drinkers

    Not yet reported UConn Health 163 participants Est. completion 2008-03 1 site Stand-alone
    Alcohol use disorder Other conditions: Alcoholism
    View official trial listing →
  • Terminated NCT NCT00379197

    Phase II of Naltrexone in Hormone-Refractory Metastatic Breast Cancer

    Not yet reported Masonic Cancer Center, University of Minnesota 13 participants Est. completion 2013-05 1 site Stand-alone
    Other conditions: Breast Cancer
    View official trial listing →
  • Completed NCT NCT00383045

    HIV Risk Reduction and Drug Abuse Treatment in Malaysia

    Not yet reported Yale University 180 participants Est. completion 2007-08 2 sites
    Other conditions: Opiate Dependence
    View official trial listing →
  • Withdrawn NCT NCT00398008

    HIV Risk Reduction and Drug Abuse Treatment in Iran

    Not yet reported Yale University Est. completion 2008-12 2 sites Stand-alone
    Other conditions: Opiate Dependence, HIV Infections
    View official trial listing →
  • Completed NCT NCT00398957

    An Open-Label Evaluation of the Dose Proportionality of OROS� Hydromorphone HCL Tablets 8mg, 16mg, 32mg, 64mg

    Not yet reported Alza Corporation, DE, USA 32 participants Est. completion 1998-09
    Other conditions: Analgesia
    View official trial listing →
  • Completed NCT NCT00399295

    An Open-Label Evaluation of the Independent Effects of Coadministration of a High-Fat Meal and Naltrexone Blockade on the Pharmacokinetic Profile of Dilaudid OROS (Hydromorphone HCI) 16mg

    Not yet reported Alza Corporation, DE, USA 30 participants Est. completion 1997-06
    Other conditions: Analgesia
    View official trial listing →
  • Completed NCT NCT00403117

    Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana

    Not yet reported New York State Psychiatric Institute 49 participants Est. completion 2010-08 Stand-alone
    Other conditions: Marijuana Use
    View official trial listing →
  • Completed NCT NCT00415597

    Study of Embeda (Kadian NT, ALO-01) in Subjects With Chronic Moderate to Severe Nonmalignant Pain

    Not yet reported Pfizer 467 participants Est. completion 2008-03 58 sites Stand-alone
    Other conditions: Pain
    View official trial listing →
  • Status unknown NCT NCT00419731

    Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation

    Not yet reported, Not yet reported University of Minnesota 120 participants Est. completion 2010-07 1 site Stand-alone
    Other conditions: Tobacco Use Disorder
    View official trial listing →
  • Completed NCT NCT00420992

    A Study of Embeda (Kadian NT, ALO-01) in Subjects With Pain Due to Osteoarthritis of the Hip or Knee

    Not yet reported Pfizer 547 participants Est. completion 2007-11 81 sites Stand-alone
    Osteoarthritis Other conditions: Chronic Pain
    View official trial listing →
  • Completed NCT NCT00435435

    Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence

    Not yet reported Finnish Institute for Health and Welfare 243 participants Est. completion 2005-04 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00444418

    Medication and Counseling for Controlled Drinking (Project SMART)

    Not yet reported National Institute on Alcohol Abuse and Alcoholism (NIAAA) 200 participants Est. completion 2010-06 1 site Stand-alone
    Alcohol use disorder Other conditions: Alcohol-related Disorders, Alcoholism, Alcohol Abuse
    View official trial listing →
  • Completed NCT NCT00453609

    Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)

    Not yet reported State University of New York - Upstate Medical University 15 participants Est. completion 2008-10 3 sites
    Alcohol use disorder Other conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
    View official trial listing →
  • Completed NCT NCT00456521

    A Safety and Efficacy Study of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects Participating in an Intensive Behavior Modification Program

    Not yet reported Orexigen Therapeutics, Inc 793 participants Est. completion 2008-12 9 sites Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Terminated NCT NCT00461890

    Long-Acting Injectable Naltrexone Treatment of Alcohol Dependence in Primary Care vs. in Specialized Chemical Dependence Treatment: A Pilot Trial

    Not yet reported State University of New York - Upstate Medical University 20 participants Est. completion 2007-12 1 site
    Alcohol use disorder Other conditions: Veterans
    View official trial listing →
  • Withdrawn NCT NCT00467454

    Naltrexone in the Treatment of Pyromania

    Not yet reported University of Minnesota Est. completion 2010-04 1 site
    Other conditions: Pyromania
    View official trial listing →
  • Completed NCT NCT00467558

    Double-Blind Naltrexone in Compulsive Sexual Behavior

    Not yet reported University of Minnesota 7 participants Est. completion 2010-06 1 site
    Other conditions: Compulsive Sexual Behavior
    View official trial listing →
  • Completed NCT NCT00474630

    A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes

    Not yet reported Orexigen Therapeutics, Inc 505 participants Est. completion 2009-06 53 sites Stand-alone
    Type 2 diabetes Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT00501631

    ALK21-014: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) After Enforced Abstinence

    Not yet reported Alkermes, Inc. 300 participants Est. completion 2011-03
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00501696

    A Randomized Placebo-Controlled, Crossover-Design Study of the Effects of Low Dose Naltrexone

    Not yet reported University of California, San Francisco 80 participants Est. completion 2007-11 1 site
    Other conditions: Multiple Sclerosis
    View official trial listing →
  • Completed NCT NCT00511836

    ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults

    Not yet reported Alkermes, Inc. 31 participants Est. completion 2009-10 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00521157

    Naltrexone Implants as an Aid in Preventing Relapse Following Inpatient Treatment for Opioid Addiction

    Not yet reported, Not yet reported University of Oslo 56 participants Est. completion 2008-12 1 site Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT00523133

    Research on Individualized Treatment for Alcoholism

    Not yet reported Indiana University 185 participants Est. completion 2005-07 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00532779

    A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects

    Not yet reported Orexigen Therapeutics, Inc 1742 participants Est. completion 2009-05 34 sites Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT00537745

    Vivitrol for Reducing Driving While Impaired Behavior Among Repeat Offenders

    Not yet reported Pacific Institute for Research and Evaluation 14 participants Est. completion 2009-05 1 site
    Other conditions: Alcohol Consumption
    View official trial listing →
  • Completed NCT NCT00555425

    Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence

    Not yet reported Yale University 113 participants Est. completion 2013-05 2 sites Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT00563563

    A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent

    Not yet reported Orexigen Therapeutics, Inc 30 participants Est. completion 2008-09 3 sites Stand-alone
    Other conditions: Nicotine Dependence, Overweight, Obesity
    View official trial listing →
  • Completed NCT NCT00567034

    Augmenting Zyprexa With Naltrexone to Ameliorate Metabolic Side-Effects

    Not yet reported Mclean Hospital 30 participants Est. completion 2011-12 1 site
    Other conditions: Schizophrenia, Psychotic Disorders
    View official trial listing →
  • Completed NCT NCT00567255

    A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects

    Not yet reported Orexigen Therapeutics, Inc 1496 participants Est. completion 2009-06 36 sites Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT00568555

    Effects of Low Dose Naltrexone in Fibromyalgia

    Not yet reported Stanford University 53 participants Est. completion 2010-01 1 site Stand-alone
    Other conditions: Fibromyalgia, Persian Gulf Syndrome
    View official trial listing →
  • Completed NCT NCT00568958

    Naltrexone for Heavy Drinking in Young Adults

    Not yet reported Yale University 140 participants Est. completion 2012-12 1 site Stand-alone
    Other conditions: Alcohol Consumption, Alcoholic Intoxication, Alcoholism, Alcohol-induced Disorders
    View official trial listing →
  • Completed NCT NCT00614328

    Combination of Naltrexone and Baclofen for Alcohol Dependence:A Pilot Study.

    Not yet reported University of North Carolina, Chapel Hill 40 participants Est. completion 2010-01
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00620750

    Extended-release Naltrexone for Alcohol Dependence in Primary Care

    Not yet reported NYU Langone Health 72 participants Est. completion 2010-02 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00624858

    A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression

    Not yet reported Orexigen Therapeutics, Inc 25 participants Est. completion 2009-07 1 site Stand-alone
    Other conditions: Depression
    View official trial listing →
  • Completed NCT NCT00650182

    A Study to Evaluate the Safety of D-TRANS Fentanyl With Naltrexone in Adult Patients With Chronic Pain and Who Are Opioid Tolerant

    Not yet reported Alza Corporation, DE, USA 406 participants Est. completion 2003-07
    Other conditions: Chronic Pain
    View official trial listing →
  • Completed NCT NCT00656630

    Medication Development in Alcoholism: Acamprosate Versus Naltrexone

    Not yet reported The Scripps Research Institute 68 participants Est. completion 2010-01 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00663117

    The Effects of Naltrexone on Active Crohn's Disease

    Not yet reported Milton S. Hershey Medical Center 40 participants Est. completion 2009-10 1 site
    Other conditions: Inflammation, Crohn's Disease
    View official trial listing →
  • Completed NCT NCT00667771

    The Effect of Naltrexone on Alcohol Craving and on Brain Activity During Alcohol Infusion

    Not yet reported National Institute on Alcohol Abuse and Alcoholism (NIAAA) 70 participants Est. completion 2011-04-04 1 site
    Alcohol use disorder Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00667875

    An Exploratory Study of Naltrexone Plus Aripiprazole for Alcohol Dependence

    Not yet reported Medical University of South Carolina 65 participants Est. completion 2011-05 1 site
    Alcohol use disorder
    View official trial listing →
  • Withdrawn NCT NCT00675532

    Testing a Primary Care Model for the Treatment of Opioid Dependence Using Long-acting Injectable Naltrexone (Vivitrol).

    Not yet reported Yale University Est. completion 2013-08 1 site
    Other conditions: Drug Dependence
    View official trial listing →
  • Completed NCT NCT00675961

    Effectiveness of Alcohol Interventions Among Tuberculosis (TB) Patients in Tomsk Oblast, Russia

    Not yet reported Brigham and Women's Hospital 400 participants Est. completion 2011-06 1 site Stand-alone
    Alcohol use disorder Other conditions: Tuberculosis
    View official trial listing →
  • Completed NCT NCT00678418

    ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence

    Not yet reported Alkermes, Inc. 250 participants Est. completion 2010-11 1 site
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT00684775

    Employment-Based Depot Naltrexone Clinical Trial II

    Not yet reported Johns Hopkins University 38 participants Est. completion 2010-04-30 1 site Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT00684788

    Employment-Based Depot Naltrexone Clinical Trial

    Not yet reported Johns Hopkins University 35 participants Est. completion 2009-05-03 1 site Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT00711477

    A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese Subjects

    Not yet reported Orexigen Therapeutics, Inc 46 participants Est. completion 2010-06 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT00714558

    Pharmacokinetics of Fentanyl Following Intravenous and Oral Routes of Administration in Healthy Volunteers

    Not yet reported Alza Corporation, DE, USA 18 participants Est. completion 2003-05
    Other conditions: Biological Availability
    View official trial listing →
  • Completed NCT NCT00714584

    Pharmacokinetics of Naltrexone Following Intravenous and Oral Routes of Administration in Healthy Volunteers

    Not yet reported Alza Corporation, DE, USA 18 participants Est. completion 2003-06
    Other conditions: Biological Availability
    View official trial listing →
  • Completed NCT NCT00715117

    The Efficacy of Low Dose Naltrexone Therapy in Children With Crohn's Disease

    Not yet reported Milton S. Hershey Medical Center 14 participants Est. completion 2010-08 1 site Stand-alone
    Other conditions: Crohn's Disease
    View official trial listing →
  • Completed NCT NCT00719095

    Effective Treatment for Prescription Opioid Abuse

    Not yet reported University of Vermont Medical Center 105 participants Est. completion 2010-03 1 site Stand-alone
    Other conditions: Prescription Opioid Dependence
    View official trial listing →
  • Completed NCT NCT00733720

    Buprenorphine Naltrexone-P1 A-Cocaine

    Not yet reported National Institute on Drug Abuse (NIDA) 8 participants Est. completion 2009-01 1 site
    Other conditions: Cocaine-related Disorders
    View official trial listing →
  • Completed NCT NCT00743145

    Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana

    Not yet reported New York State Psychiatric Institute 23 participants Est. completion 2009-09 1 site Stand-alone
    Other conditions: Marijuana Smoking
    View official trial listing →
  • Completed NCT NCT00751478

    Study to Determine the Bioavailability, Pharmacodynamic Effects, and Safety of Whole and Crushed ALO-01 Compared to Morphine Sulfate Immediate Release (MSIR)

    Not yet reported, Not yet reported Pfizer 32 participants Est. completion 2007-05 1 site
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT00756990

    Depot Naltrexone Treatment of Opioid Dependent Parolees

    Not yet reported University of Pennsylvania 61 participants Est. completion 2011-08 1 site Stand-alone
    Other conditions: Opioid Dependence
    View official trial listing →
  • Terminated NCT NCT00758966

    Naltrexone SR and Fluoxetine Combination Therapy in Subjects With Obsessive-Compulsive Disorder

    Not yet reported Orexigen Therapeutics, Inc 8 participants Est. completion 2008-12 11 sites Stand-alone
    Other conditions: Obsessive-Compulsive Disorder
    View official trial listing →
  • Completed NCT NCT00768508

    Combined Pharmacotherapies for Alcoholism

    Not yet reported Bankole Johnson 300 participants Est. completion 2012-12 2 sites Stand-alone
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00769158

    Combining Medications for the Treatment of Alcohol Dependence: An Inpatient Preliminary Study

    Not yet reported Bankole Johnson 4 participants Est. completion 2010-12 2 sites Stand-alone
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT00773422

    The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking Lapse

    Not yet reported Yale University 30 participants Est. completion 2016-11 1 site Stand-alone
    Other conditions: Smoking
    View official trial listing →
  • Completed NCT NCT00777062

    VIVITROL as a Treatment for Cocaine and Alcohol Dependence

    Not yet reported University of Pennsylvania 80 participants Est. completion 2013-09 1 site Stand-alone
    Alcohol use disorder Other conditions: Cocaine Dependence
    View official trial listing →
  • Completed NCT NCT00781898

    Treatment Study Using Depot Naltrexone (1/6) Philadelphia Coord/Data Mgmt Site

    Not yet reported, Not yet reported University of Pennsylvania 308 participants Est. completion 2015-08 1 site
    Other conditions: Opiate Addiction
    View official trial listing →
  • Completed NCT NCT00793780

    Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia

    Not yet reported Yale University 24 participants Est. completion 2010-11 1 site
    Other conditions: Obesity, Schizophrenia, Schizoaffective Disorder
    View official trial listing →
  • Completed NCT NCT00831272

    Pharmacogenetic Response to Naltrexone For Alcohol Dependence

    Not yet reported David Oslin 221 participants Est. completion 2014-01-15 4 sites Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00834080

    ALK21-021: A Safety Study of Medisorb® Naltrexone (VIVITROL®) Administered to Health Care Professionals

    Not yet reported Alkermes, Inc. 38 participants Est. completion 2012-05 11 sites Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Withdrawn NCT NCT00854230

    Pharmacotherapy for HIV Infected Patients With Alcohol Problems

    Not yet reported VA Connecticut Healthcare System Est. completion 2010-01 Stand-alone
    Other conditions: HIV Infection, Heavy Alcoholic Consumption, HIV Infections
    View official trial listing →
  • Withdrawn NCT NCT00855972

    Low Dose Naltrexone for the Treatment of Juvenile Primary Fibromyalgia Syndrome

    Not yet reported Stanford University Est. completion 2011-12
    Other conditions: Fibromyalgia
    View official trial listing →
  • Status unknown NCT NCT00908089

    TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis

    Not yet reported University of Helsinki 100 participants Est. completion 2015-12 13 sites
    Other conditions: Rheumatoid Arthritis
    View official trial listing →
  • Completed NCT NCT00920829

    Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism

    Not yet reported Medical University of South Carolina 358 participants Est. completion 2015-12 2 sites
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT00938886

    Naltrexone for At-Risk and Problem Drinking in Smoking Cessation Treatment

    Not yet reported Brown University 150 participants Est. completion 2015-12 1 site Stand-alone
    Other conditions: Hazardous Drinking, Cigarette Smoking
    View official trial listing →
  • Completed NCT NCT00976066

    [11C]Carfentanil PET Study of GSK1521498

    Not yet reported GlaxoSmithKline 26 participants Est. completion 2009-12-07 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT00984360

    Study of Naltrexone for Methamphetamine Addiction

    Not yet reported California Pacific Medical Center Research Institute 22 participants Est. completion 2012-09 1 site Stand-alone
    Other conditions: Methamphetamine Dependence
    View official trial listing →
  • Completed NCT NCT00992095

    Bioequivalency Study of Buprenorphine Hydrochloride 8 mg Tablet Under Fasted Conditions

    Not yet reported Roxane Laboratories 48 participants Est. completion 2006-09 1 site
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Withdrawn NCT NCT01015066

    Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents

    Not yet reported State University of New York at Buffalo Est. completion 2014-06 1 site Stand-alone
    Other conditions: Opiate Addiction
    View official trial listing →
  • Completed NCT NCT01024335

    Dronabinol Naltrexone Treatment for Opioid Dependence

    Not yet reported, Not yet reported New York State Psychiatric Institute 60 participants Est. completion 2012-12 1 site Stand-alone
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT01032135

    Adaptive Treatment for Alcohol and Cocaine Dependence

    Not yet reported, Not yet reported University of Pennsylvania 500 participants Est. completion 2013-12 3 sites Stand-alone
    Substance use disorder
    View official trial listing →
  • Completed NCT NCT01052831

    Naltrexone for Impulse Control Disorders in Parkinson's Disease

    Not yet reported University of Pennsylvania 50 participants Est. completion 2012-12 1 site
    Other conditions: Impulse Control Disorder, Parkinson Disease
    View official trial listing →
  • Completed NCT NCT01053078

    Naltrexone and Hypoglycemia in Type 1 Diabetes

    Not yet reported, Not yet reported University of Minnesota 29 participants Est. completion 2014-06 1 site Stand-alone
    Other conditions: Type 1 Diabetes, Hypoglycemia Unawareness
    View official trial listing →
  • Completed NCT NCT01057862

    Investigation of Naltrexone for Pathological Gambling

    Not yet reported Yale University 9 participants Est. completion 2017-01 3 sites Stand-alone
    Other conditions: Pathological Gambling
    View official trial listing →
  • Completed NCT NCT01077310

    Alcohol Pharmacotherapy for HIV+ Prisoners

    Not yet reported Yale University 100 participants Est. completion 2015-08 1 site
    Alcohol use disorder Other conditions: Problem Drinking, Hazardous Drinking, Human Immunodeficiency Virus, AIDS
    View official trial listing →
  • Terminated NCT NCT01100437

    Safety Study to Assess Opiate Withdrawal Signs and Symptoms in Opioid Dependent Patients

    Not yet reported Pfizer 14 participants Est. completion 2011-03 1 site Stand-alone
    Other conditions: Chronic Pain
    View official trial listing →
  • Completed NCT NCT01100853

    Extended Release Naltrexone for Treating Amphetamine Dependence in Iceland

    Not yet reported University of Pennsylvania 100 participants Est. completion 2013-02 1 site
    Other conditions: Amphetamine Dependence
    View official trial listing →
  • Completed NCT NCT01101815

    Adherence to HIV Therapy in Heroin Addicts: Oral vs XR-NTX

    Not yet reported University of Pennsylvania 200 participants Est. completion 2016-12 2 sites
    Other conditions: HIV, Substance Abuse, HIV Infections
    View official trial listing →
  • Status unknown NCT NCT01115894

    Medication and Counseling for Controlled Drinking

    Not yet reported Research Foundation for Mental Hygiene, Inc. 200 participants 1 site Stand-alone
    Alcohol use disorder Other conditions: Alcohol Abuse
    View official trial listing →
  • Completed NCT NCT01133301

    Naltrexone in the Treatment of Dissociative Symptoms in Patients With Borderline Personality Disorder

    Not yet reported Central Institute of Mental Health, Mannheim 30 participants Est. completion 2001-10 1 site
    Other conditions: Borderline Personality Disorder, Dissociation
    View official trial listing →
  • Terminated NCT NCT01155869

    Pilot Study of Depot NTX in Homeless Veterans

    Not yet reported US Department of Veterans Affairs 7 participants Est. completion 2012-06 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT01174914

    Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+

    Not yet reported The Ojai Foundation 171 participants Est. completion 2010-03 1 site Stand-alone
    Other conditions: HIV Seropositivity
    View official trial listing →
  • Completed NCT NCT01175512

    Stress, Hormones, and Eating

    Not yet reported University of California, San Francisco 42 participants Est. completion 2011-12
    Other conditions: Food Addiction, How Opioid Tone Was Related to Self Reported, Drive to Eat Using a Measure of Food Addiction
    View official trial listing →
  • Terminated NCT NCT01179191

    Conversion to Embeda With Rescue Trial

    Not yet reported Pfizer 684 participants Est. completion 2011-04 166 sites Stand-alone
    Other conditions: Chronic Disease, Pain
    View official trial listing →
  • Completed NCT NCT01210638

    Bioequivalency Study of Oxymorphone Hydrochloride 10 mg Tablets Under Fasted Conditions

    Not yet reported Roxane Laboratories 42 participants Est. completion 2008-06 1 site
    Other conditions: Pain
    View official trial listing →
  • Completed NCT NCT01211769

    Effects of Omegas 3 and 6 on Alcohol Dependence

    Not yet reported Federal University of São Paulo 80 participants Est. completion 2008-06 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT01214083

    N-acetylcysteine Plus Naltrexone for the Treatment of Alcohol Dependence

    Not yet reported VA Office of Research and Development 111 participants Est. completion 2016-10-30 2 sites Stand-alone
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT01218971

    ALK21-003EXT: An Extension of Study ALK21-003 (NCT01218958) to Test the Long-term Safety of Medisorb® Naltrexone (VIVITROL®)

    Not yet reported Alkermes, Inc. 332 participants Est. completion 2004-09 Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT01218984

    ALK21-004: Single-dose Opiate Challenge of Medisorb® Naltrexone (VIVITROL®) in Adults Who Use Opioids

    Not yet reported Alkermes, Inc. 27 participants Est. completion 2003-05 Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT01218997

    ALK21-006: Long-Term Study of Medisorb® Naltrexone (VIVITROL®)

    Not yet reported Alkermes, Inc. 436 participants Est. completion 2005-03 Stand-alone
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT01220414

    Attenuation of Pain in Men and Women

    Not yet reported University of Wisconsin, Madison 60 participants Est. completion 2013-01 1 site
    Other conditions: Pain
    View official trial listing →
  • Completed NCT NCT01227044

    Reducing Heavy Drinking to Optimize HIV/AIDS Treatment and Prevention

    Not yet reported, Not yet reported Yale University 51 participants Est. completion 2017-08 2 sites
    Other conditions: Reduction in Heavy Drinking in Patients With HIV
    View official trial listing →
  • Completed NCT NCT01245647

    Will Having Alcohol Treatment Improve Functioning?

    Not yet reported University of Florida 19 participants Est. completion 2012-10 3 sites
    Other conditions: HIV, Alcoholism
    View official trial listing →
  • Completed NCT NCT01246401

    Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populations

    Not yet reported, Not yet reported Yale University 151 participants Est. completion 2016-07 3 sites
    Other conditions: HIV, AIDS, Opioid Dependence, Drug Dependence
    View official trial listing →
  • Completed NCT NCT01296646

    Sweet Preference and Alcohol Craving

    Not yet reported University of North Carolina, Chapel Hill 80 participants Est. completion 2012-06 1 site
    Alcohol use disorder Other conditions: Alcohol Abuse
    View official trial listing →
  • Completed NCT NCT01303835

    Low Dose Naltrexone for Glioma Patients

    Not yet reported Katy Peters 110 participants Est. completion 2015-05 1 site Stand-alone
    Other conditions: Malignant Glioma
    View official trial listing →
  • Completed NCT NCT01319266

    A Study to Assess the Pharmacokinetics of the Hydrocodone Extended-Release Tablet (CEP-33237) in Subjects With Normal Renal Function and Subjects With Varying Degrees of Renal Impairment

    Not yet reported Cephalon 55 participants Est. completion 2011-10 4 sites Stand-alone
    Other conditions: Renal Impairment
    View official trial listing →
  • Withdrawn NCT NCT01327326

    Role of the Endogenous Opioid System Underlying Modulation of Experimental Pain

    Not yet reported University of Florida Est. completion 2012-07
    Other conditions: Temporomandibular Disorder, Facial Pain
    View official trial listing →
  • Completed NCT NCT01342549

    Treatment Strategy for Alcohol Use Disorders in Veterans With TBI

    Not yet reported VA Office of Research and Development 62 participants Est. completion 2015-06 2 sites
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT01349985

    Adaptive Goal-Directed Adherence Tracking and Enhancement

    Not yet reported Talaria, Inc 136 participants Est. completion 2013-02 1 site Stand-alone
    Other conditions: Alcohol Abuse
    View official trial listing →
  • Completed NCT NCT01359930

    Phase 1 Naltrexone-Bupropion-Methamphetamine Interaction Study

    Not yet reported National Institute on Drug Abuse (NIDA) 16 participants Est. completion 2012-06 1 site
    Other conditions: Methamphetamine Dependence
    View official trial listing →
  • Completed NCT NCT01377168

    Naltrexone for Medication Compliance Among HIV-infected Men With Alcohol Use Disorder

    Not yet reported Fred Hutchinson Cancer Center 159 participants Est. completion 2017-06 1 site
    Alcohol use disorder Other conditions: HIV
    View official trial listing →
  • Completed NCT NCT01377610

    Improved Strategies for Outpatient Opioid Detoxification

    Not yet reported New York State Psychiatric Institute 150 participants Est. completion 2017-12 1 site
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT01380093

    Abuse Potential of Orally Administered Crushed Embeda Compared to Crushed Controlled-Release Morphine and Placebo in Non-Dependent Recreational Opioid Users

    Not yet reported Pfizer 80 participants Est. completion 2011-05 1 site Stand-alone
    Other conditions: Nondependent Opioid Abuse, Episodic
    View official trial listing →
  • Completed NCT NCT01389167

    Naltrexone and Behavioral Drug and HIV Risk Reduction Counseling in Russia

    Not yet reported Yale University 320 participants Est. completion 2017-05 1 site Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT01402492

    Cocaine Use Reduction With Buprenorphine

    Not yet reported, Not yet reported University of California, Los Angeles 302 participants Est. completion 2013-03 11 sites Stand-alone
    Other conditions: Cocaine Dependence
    View official trial listing →
  • Completed NCT NCT01415895

    Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain

    Not yet reported Annette C. Toledano MD 78 participants Est. completion 2013-02 1 site Stand-alone
    Other conditions: Back Pain, Lower Back Pain, Cervical Pain
    View official trial listing →
  • Completed NCT NCT01422837

    ALK21-025: Vivitrol's Cost and Treatment Outcomes Registry

    Alkermes, Inc. 403 participants Est. completion 2013-10 31 sites
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT01428583

    Safety Study of Oxycodone Hydrochloride and Naltrexone Hydrochloride Extended-Release Capsules in Subjects With Moderate to Severe Chronic Noncancer Pain

    Not yet reported Pfizer 395 participants Est. completion 2012-05 32 sites Stand-alone
    Other conditions: Chronic Noncancer Pain
    View official trial listing →
  • Completed NCT NCT01449565

    Extended-Release Naltrexone to Treat Methamphetamine Dependence in Men Who Have Sex With Men (MSM)

    Not yet reported San Francisco Department of Public Health 100 participants Est. completion 2016-03 1 site
    Other conditions: Amphetamine-Related Disorders
    View official trial listing →
  • Completed NCT NCT01453374

    A Study of VIVITROL in the Prevention of Re-arrest and Re-incarceration

    Not yet reported Alkermes, Inc. 27 participants Est. completion 2014-05 1 site
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT01456507

    Healthy Volunteers Study to Estimate the Effects of Food on the Bioavailability of Oxycodone and Naltrexone/6- Β -Naltrexol From a Extended Release Formulation of Oxycodone With Sequestered Naltrexone

    Not yet reported Pfizer 24 participants Est. completion 2012-01 1 site Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT01462227

    Effect of Naltrexone on Counterregulatory Mechanisms in Hypoglycemia

    Not yet reported Yale University 17 participants Est. completion 2013-10 1 site Stand-alone
    Other conditions: Hypoglycemia
    View official trial listing →
  • Completed NCT NCT01471145

    Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECT

    Not yet reported Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 40 participants Est. completion 2014-10 1 site Stand-alone
    Other conditions: Opioid-Related Disorders, Heroin Dependence
    View official trial listing →
  • Completed NCT NCT01519063

    Naltrexone and Memantine Effects on Alcohol Drinking Behaviors

    Not yet reported Yale University 75 participants Est. completion 2017-05-01 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT01528007

    Treatment of Pathological Gambling With Naltrexone Pharmacotherapy and Brief Intervention

    Not yet reported Finnish Institute for Health and Welfare 100 participants Est. completion 2013-09 1 site
    Other conditions: Pathological Gambling
    View official trial listing →
  • Completed NCT NCT01552850

    Pharmacokinetics And Relative Bioavailability Study Of Oxycodone

    Not yet reported Pain Therapeutics 18 participants Est. completion 2012-06 1 site Stand-alone
    Other conditions: Pain
    View official trial listing →
  • Completed NCT NCT01552863

    A Study To Characterize The Pharmacokinetics Of Oxycodone In Healthy Volunteers

    Not yet reported Pain Therapeutics 21 participants Est. completion 2012-09 1 site Stand-alone
    Other conditions: Pain
    View official trial listing →
  • Completed NCT NCT01556425

    The Separate and Combined Effects of Vivitrol and Opiate Abstinence Reinforcement in the Treatment of Opioid Dependence

    Not yet reported Johns Hopkins University 84 participants Est. completion 2017-08-06 1 site
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT01557257

    Pharmacokinetics Study of ALO-02 and OxyContin

    Not yet reported Pfizer 13 participants Est. completion 2012-05 1 site Stand-alone
    Other conditions: Management of Moderate to Severe Pain
    View official trial listing →
  • Status unknown NCT NCT01560013

    The Effects of Treatment With Naltrexone in Alcohol and Cannabis-dependent Patients

    Not yet reported Tel-Aviv Sourasky Medical Center 24 participants Est. completion 2014-10 1 site Stand-alone
    Other conditions: Alcohol-dependence
    View official trial listing →
  • Completed NCT NCT01563718

    Pre-Release VIVITROL for Opioid Dependent Inmates

    Not yet reported Rhode Island Hospital 26 participants Est. completion 2015-08 1 site Stand-alone
    Substance use disorder
    View official trial listing →
  • Completed NCT NCT01571362

    A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back Pain

    Not yet reported Pfizer 410 participants Est. completion 2013-06 52 sites
    Other conditions: Chronic Pain, Low Back Pain, Analgesia
    View official trial listing →
  • Completed NCT NCT01587196

    CURE Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery

    Not yet reported University of Pennsylvania 72 participants Est. completion 2021-01-01 1 site Stand-alone
    Other conditions: Prescription Opiate/Medication Dependence
    View official trial listing →
  • Completed NCT NCT01595867

    Abuse Potential Assessment of Intranasally Administered EMBEDA Compared To Morphine Sulfate Controlled Release And Placebo

    Not yet reported Pfizer 33 participants Est. completion 2011-01 Stand-alone
    Other conditions: Narcotic Abuse, Opioid-related Disorders, Analgesia, Chronic Pain
    View official trial listing →
  • Terminated NCT NCT01601704

    Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)

    Not yet reported Orexigen Therapeutics, Inc 8910 participants Est. completion 2015-08 224 sites Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT01623440

    Food Reward in Native American Women

    University of Minnesota 69 participants Est. completion 2015-07 1 site
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT01625091

    Clinical Trial to Reduce Drinking in Women With HIV

    Not yet reported University of Florida 194 participants Est. completion 2016-07 2 sites
    Other conditions: HIV Infection
    View official trial listing →
  • Completed NCT NCT01625611

    Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors

    Not yet reported Yale University 59 participants Est. completion 2021-06-30 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Terminated NCT NCT01638377

    Pharmacotherapy for Alcohol Dependence in Convicted Drinking Drivers

    Not yet reported Centre for Addiction and Mental Health 2 participants Est. completion 2014-03 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Terminated NCT NCT01650350

    Low Dose Naltrexone for Metastatic Melanoma, Castrate Resistant Prostate Cancer and Renal Cancer

    Not yet reported Brown University 7 participants Est. completion 2013-10 1 site Stand-alone
    Other conditions: Melanoma, Prostate Cancer, Renal Cancer
    View official trial listing →
  • Completed NCT NCT01672723

    Neuropharmacological Basis of Social Connection: The Role of Opioids

    Not yet reported University of California, Los Angeles 34 participants Est. completion 2014-02 1 site Stand-alone
    Other conditions: Psychology, Social
    View official trial listing →
  • Completed NCT NCT01673594

    Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist

    Not yet reported Massachusetts General Hospital 37 participants Est. completion 2015-06 1 site Stand-alone
    Other conditions: ADHD, Stimulant-Induced Euphoria
    View official trial listing →
  • Completed NCT NCT01677039

    Study to Determine the Effects of Co-Administration of Alcohol on the Absorption of Oxycodone From a Proprietary Controlled-Release Formulation

    Not yet reported Pfizer 19 participants Est. completion 2012-12 1 site
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT01677065

    A Randomized, Two-way, Crossover Study to Estimate the Relative Bioavailability of a Controlled-release Formulation of Oxycodone (40 mg) With Sequestered Naltrexone Compared With Immediate-release Oxycodone Tablets (20 mg) in Healthy Volunteers

    Pfizer 14 participants Est. completion 2012-10 1 site
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT01690546

    Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid Dependence

    Not yet reported Paolo Mannelli 38 participants Est. completion 2015-02 1 site Stand-alone
    Other conditions: Opiate Dependence
    View official trial listing →
  • Completed NCT NCT01717027

    Pharmacokinetics And Relative Bioavailability Study Of Oxycodone in Healthy Volunteers

    Not yet reported Pain Therapeutics 19 participants Est. completion 2013-01 1 site Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT01717963

    Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in Norway

    Not yet reported University of Oslo 166 participants Est. completion 2018-04-30 5 sites Stand-alone
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT01721070

    Effect of Ketoconazole on Sufentanil NanoTab Pharmacokinetics

    Not yet reported Talphera, Inc 19 participants Est. completion 2012-12 1 site Stand-alone
    Other conditions: Pharmacokinetics
    View official trial listing →
  • Terminated NCT NCT01721330

    A Double-Blind Comparison of Naltrexone and Placebo in Adults With Attention Deficit Hyperactivity Disorder

    Not yet reported Massachusetts General Hospital 3 participants Est. completion 2015-02 1 site
    Other conditions: ADHD, Attention Deficit Hyperactivity Disorder
    View official trial listing →
  • Completed NCT NCT01723384

    Intermittent Naltrexone Among Polysubstance Users

    Not yet reported University of California, San Francisco 30 participants Est. completion 2014-11 1 site
    Other conditions: Methamphetamine, Alcohol
    View official trial listing →
  • Completed NCT NCT01738867

    To Evaluate the Influence of the A118G Polymorphism in the mu Opioid Receptor Gene (OPRM1) on Effects of GSK1521498 and Naltrexone on Physiological and Behavioural Markers of Brain Function in Healthy Social Drinkers

    Not yet reported GlaxoSmithKline 56 participants Est. completion 2014-05-27 1 site Stand-alone
    Other conditions: Alcoholism
    View official trial listing →
  • Completed NCT NCT01739192

    A Novel Anti-Obesity Drug Combination as a Pharmacotherapy for Cocaine Dependence

    Not yet reported Craig Rush 34 participants Est. completion 2018-06 1 site Stand-alone
    Other conditions: Cocaine Use Disorders
    View official trial listing →
  • Completed NCT NCT01746901

    A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers

    Not yet reported Pfizer 81 participants Est. completion 2013-08-09 1 site
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT01750060

    Pharmacokinetic Characterization of the Active, Separated System With PK Controller (Fentanyl Iontophoretic Transdermal System, 40 Mcg Fentanyl Per Activation).

    Not yet reported Incline Therapeutics, Inc. 54 participants Est. completion 2013-03 1 site Stand-alone
    Other conditions: Pain, Postoperative
    View official trial listing →
  • Completed NCT NCT01764386

    Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects

    Not yet reported Orexigen Therapeutics, Inc 242 participants Est. completion 2014-09 15 sites Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT01775189

    A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Users When ALO-02 Capsules Are Crushed and Snorted

    Not yet reported Pfizer 45 participants Est. completion 2013-07 1 site
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT01780233

    Pharmacokinetic Study of Fentanyl 400 µg Sublingual Spray, Actiq® 400 µg Transmucosally, and Fentanyl Citrate Injection 100 µg Intravenously (iv)

    Not yet reported INSYS Therapeutics Inc 40 participants Est. completion 2007-05 1 site Stand-alone
    Other conditions: Pain
    View official trial listing →
  • Withdrawn NCT NCT01810185

    Low Dose Naltrexone in Symptomatic Inflammatory Bowel Disease

    Not yet reported Santa Barbara Cottage Hospital Est. completion 2014-03 1 site Stand-alone
    Other conditions: Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
    View official trial listing →
  • Completed NCT NCT01822132

    Risky Decision Making in Methamphetamine Users: The Role of Opioid Blockade

    Not yet reported Oregon Health and Science University 76 participants Est. completion 2015-03 2 sites Stand-alone
    Other conditions: Methamphetamine Abuse, HIV
    View official trial listing →
  • Completed NCT NCT01825447

    A Study to Characterize the Abuse Liability of Intravenous Oxycodone Alone or in Combination With Intravenous Naltrexone in Healthy, Non-Dependent, Recreational Opioid Users

    Not yet reported Pfizer 89 participants Est. completion 2013-09 1 site Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT01843023

    Extended Release Naltrexone for Opioid-Dependent Youth

    Not yet reported Friends Research Institute, Inc. 288 participants Est. completion 2019-07 2 sites Stand-alone
    Other conditions: Drug Dependence
    View official trial listing →
  • Completed NCT NCT01856712

    Oral vs. Injectable Naltrexone for Hospitalized Veterans With Alcohol Dependence

    Not yet reported University of Wisconsin, Madison 54 participants Est. completion 2016-01 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT01866098

    Naltrexone for Antipsychotic-Induced Weight Gain

    Not yet reported Yale University 144 participants Est. completion 2019-04-07 1 site Stand-alone
    Other conditions: Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Bipolar Disorder, Severe Major Depression With Psychotic Features
    View official trial listing →
  • Completed NCT NCT01873729

    An Open-Label Study of Naltrexone in Adults With Attention Deficit Hyperactivity Disorder.

    Not yet reported Massachusetts General Hospital 3 participants Est. completion 2016-06 1 site Stand-alone
    Other conditions: Attention Deficit Hyperactivity Disorder
    View official trial listing →
  • Completed NCT NCT01874951

    Low-Dose Naltrexone (LDN) for Depression Relapse and Recurrence

    Not yet reported Massachusetts General Hospital 12 participants Est. completion 2015-06 1 site Stand-alone
    Other conditions: Major Depressive Disorder, Depression, Unipolar, Recurrence, Relapse
    View official trial listing →
  • Completed NCT NCT01882361

    Opioid Relapse & HIV Risk: 48 Versus 24 Weeks of Injectable Extended Release Naltrexone

    Not yet reported, Not yet reported University of Pennsylvania 77 participants Est. completion 2020-07-31 1 site
    Other conditions: Opiate Dependence, Human Immunodeficiency Virus
    View official trial listing →
  • Completed NCT NCT01893827

    Extended-Release vs. Oral Naltrexone Alcohol Treatment in Primary Care

    Not yet reported NYU Langone Health 237 participants Est. completion 2018-10-03 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT01895036

    Nalrexone Facilitated Discontinuation of Buprenorphine

    Not yet reported, Not yet reported New York State Psychiatric Institute 6 participants Est. completion 2013-09 1 site Stand-alone
    Other conditions: Stable Opioid Dependence
    View official trial listing →
  • Completed NCT NCT01908062

    Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study

    Not yet reported Oregon Health and Science University 51 participants Est. completion 2015-03 2 sites Stand-alone
    Substance use disorderAlcohol use disorder
    View official trial listing →
  • Completed NCT NCT01932801

    Harm Reduction With Pharmacotherapy (HaRP)

    Not yet reported University of Washington 308 participants Est. completion 2019-06-30 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT01940588

    Neuropsychoanalytic Treatment of Failed Back Surgery Syndrome-Opioid Dependence

    State University of New York - Upstate Medical University 30 participants Est. completion 2013-06
    Other conditions: Pain
    View official trial listing →
  • Completed NCT NCT01950520

    Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

    Not yet reported National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 47 participants Est. completion 2024-06-11 1 site Stand-alone
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT01967381

    Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse

    Not yet reported University of Kentucky 24 participants Est. completion 2018-09 1 site Stand-alone
    Other conditions: Methamphetamine Abuse, Methamphetamine Dependence
    View official trial listing →
  • Completed NCT NCT01982643

    Accelerated Development of Additive Pharmacotherapy Treatment for Methamphetamine Use Disorder

    Not yet reported, Not yet reported Walter Ling 49 participants Est. completion 2015-02 3 sites Stand-alone
    Other conditions: Methamphetamine Use Disorder
    View official trial listing →
  • Completed NCT NCT01993108

    Control of Cognition (Naltrexone, Methylphenidate, and ADHD Study (NMAS))

    Not yet reported University of Michigan 23 participants Est. completion 2017-02 1 site Stand-alone
    Other conditions: Healthy, Attention Deficit Hyperactivity Disorder
    View official trial listing →
  • Completed NCT NCT01999114

    The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) at Doses up to 80 Micrograms/Hour (mcg/hr) and Naltrexone on Electrocardiogram (ECG) Intervals in Healthy Volunteers

    Not yet reported Purdue Pharma LP 328 participants Est. completion 2012-10 1 site Stand-alone
    Other conditions: ECG Effects
    View official trial listing →
  • Completed NCT NCT01999946

    Extended-Release Naltrexone Opioid Treatment at Jail Re-Entry

    Not yet reported NYU Langone Health 217 participants Est. completion 2020-12-24 2 sites Stand-alone
    Other conditions: Heroin Dependence, Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT02026011

    Naltrexone for Individuals of East Asian Descent

    Not yet reported University of California, Los Angeles 87 participants Est. completion 2016-09 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT02059915

    Single-Dose, Crossover Study To Compare Bioavailability Of Two Formulations Under Fed And Fasted Conditions

    Not yet reported Pain Therapeutics 134 participants Est. completion 2014-07 1 site Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT02088177

    Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence

    Not yet reported, Not yet reported New York State Psychiatric Institute 12 participants Est. completion 2016-03 2 sites Stand-alone
    Other conditions: Cannabis Dependence
    View official trial listing →
  • Completed NCT NCT02089295

    Dose Proportionality Study Of PF-00345439 Formulation Under Fed Conditions

    Not yet reported Pain Therapeutics 18 participants Est. completion 2014-06 2 sites Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT02107014

    Low Dose Naltrexone (LDN) Immune Monitoring

    Not yet reported University of Alabama at Birmingham 9 participants Est. completion 2014-07 1 site
    Other conditions: Fibromyalgia
    View official trial listing →
  • Completed NCT NCT02107352

    Effect of Anti-craving Medication on Cognitive Functions in Alcohol Dependence: an ERP Study

    Brugmann University Hospital 80 participants Est. completion 2018-01-29 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT02110264

    Injectable Pharmacotherapy for Opioid Use Disorders (IPOD)

    Not yet reported University of California, Los Angeles 151 participants Est. completion 2019-05 1 site Stand-alone
    Substance use disorder
    View official trial listing →
  • Completed NCT NCT02117583

    Effects of Food on Oxycodone Pharmacokinetics in Healthy Volunteers

    Not yet reported Pain Therapeutics 34 participants Est. completion 2014-08 2 sites Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Terminated NCT NCT02137252

    Naltrexone RCT for Treatment-Emergent Fatigue in Patients Receiving Radiation Therapy for Breast Cancer

    Not yet reported Dana-Farber Cancer Institute 3 participants Est. completion 2015-08-01 2 sites Stand-alone
    Other conditions: Invasive Breast Cancer (Stage I-III), Ductal Carcinoma in Situ, Lobular Carcinoma in Situ, Lobular Carcinoma, Fatigue Related to Cancer Treatment
    View official trial listing →
  • Completed NCT NCT02138396

    Exploratory Bioavailability of Fentanyl Sublingual Spray Under Fasting Conditions

    Not yet reported INSYS Therapeutics Inc 12 participants Est. completion 2014-01 1 site Stand-alone
    Other conditions: Bioavailability
    View official trial listing →
  • Completed NCT NCT02165930

    Effects of Ethanol on Oxycodone Pharmacokinetics in Healthy Volunteers

    Not yet reported Pain Therapeutics 17 participants Est. completion 2014-08 2 sites Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT02194764

    An Adherence Tool to Manage Narcotic -Addicted HIV Patients

    Not yet reported Xhale Assurance 8 participants Est. completion 2014-07 1 site Stand-alone
    Other conditions: Healthy Adults
    View official trial listing →
  • Completed NCT NCT02206490

    Trial of Naltrexone and Dextromethorphan for Gulf War Illness

    Not yet reported East Carolina University 60 participants Est. completion 2016-01 1 site
    Other conditions: Gulf War Illness
    View official trial listing →
  • Completed NCT NCT02259179

    Bioequivalence Study Comparing Naltrexone SR/Bupropion SR Trilayer Tablets From Two Manufacturers

    Not yet reported Orexigen Therapeutics, Inc 80 participants Est. completion 2014-12 1 site
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT02268448

    Treatment of Chronic Itch in Atopic Dermatitis (Eczema): Nerve Function

    Not yet reported University of Minnesota 8 participants Est. completion 2022-09 1 site Stand-alone
    Other conditions: Cutaneous Nerves CNS Itch
    View official trial listing →
  • Completed NCT NCT02294253

    Buprenorphine/Naloxone Stabilization and Induction Onto Injection Naltrexone

    Not yet reported, Not yet reported New York State Psychiatric Institute 30 participants Est. completion 2017-12 1 site
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT02317744

    Treatment of Binge Eating Disorder in Obesity: Naltrexone/ Bupropion Combination Versus Placebo

    Not yet reported Yale University 22 participants Est. completion 2016-09 1 site Stand-alone
    Other conditions: Binge Eating Disorder
    View official trial listing →
  • Completed NCT NCT02322047

    Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

    Not yet reported Seattle Institute for Biomedical and Clinical Research 31 participants Est. completion 2018-10-10 1 site Stand-alone
    Alcohol use disorder Other conditions: Posttraumatic Stress Disorder (PTSD)
    View official trial listing →
  • Completed NCT NCT02324725

    Biomarkers of Injectable Extended Release Naltrexone Treatment

    Not yet reported University of Pennsylvania 32 participants Est. completion 2021-12 1 site Stand-alone
    Other conditions: Heroin Dependence, Opioid Dependence
    View official trial listing →
  • Completed NCT NCT02330419

    Better Than Study: Targeting Heavy Alcohol Use With Naltrexone Among Men Who Have Sex With Men (MSM)

    Not yet reported University of California, San Francisco 120 participants Est. completion 2021-01 1 site
    Other conditions: Binge Drinking, HIV
    View official trial listing →
  • Completed NCT NCT02362256

    The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism

    Not yet reported Vilnius University 60 participants Est. completion 2014-09 1 site Stand-alone
    Other conditions: Opiate Addiction
    View official trial listing →
  • Completed NCT NCT02391571

    A Study to Evaluate Withdrawal Effects Following Dosing of Oxycodone/Naltrexone in Methadone-Maintained Subjects

    Not yet reported Elite Laboratories, Inc 26 participants Est. completion 2015-03 1 site Stand-alone
    Other conditions: Withdrawal Symptoms
    View official trial listing →
  • Completed NCT NCT02401750

    A Study to Evaluate Safety and Efficacy Following Dosing of Oxycodone/Naltrexone for Treatment of Adults With Pain Following Bunionectomy Surgery

    Not yet reported Elite Laboratories, Inc 163 participants Est. completion 2015-09 5 sites Stand-alone
    Other conditions: Pain
    View official trial listing →
  • Completed NCT NCT02445339

    Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users

    Not yet reported NYU Langone Health 50 participants Est. completion 2019-02-08 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT02446002

    Assessment of the Effect of Naltrexone on Lofexidine Single Dose Pharmacokinetics in Healthy Subjects

    Not yet reported USWM, LLC (dba US WorldMeds) 25 participants Est. completion 2015-06 1 site Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT02454712

    Study of PF614 Compared to OxyContin® in Healthy Volunteers (PF614-101)

    Not yet reported Ensysce Biosciences 64 participants Est. completion 2018-01-18 1 site Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT02478489

    Alcohol Disorder hOsPital Treatment Trial

    Not yet reported Boston University 248 participants Est. completion 2020-10 1 site Stand-alone
    Alcohol use disorder Other conditions: Heavy Drinking
    View official trial listing →
  • Completed NCT NCT02537197

    The Effect of Regular Naltrexone Dosing on Disordered Gamblers

    Not yet reported University of Calgary 35 participants Est. completion 2022-05-26 1 site Stand-alone
    Other conditions: Gambling
    View official trial listing →
  • Completed NCT NCT02537574

    Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)

    Not yet reported Alkermes, Inc. 380 participants Est. completion 2017-01-09 20 sites Stand-alone
    Substance use disorder
    View official trial listing →
  • Completed NCT NCT02543944

    Improving Treatment Outcomes for Prescription Opioid Dependence

    Not yet reported, Not yet reported University of Arkansas 117 participants Est. completion 2021-05-31 1 site
    Other conditions: Drug Dependence
    View official trial listing →
  • Completed NCT NCT02557984

    Dopamine and Opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward Impulsivity

    Not yet reported University of Zurich 121 participants Est. completion 2014-04 1 site Stand-alone
    Other conditions: Addiction
    View official trial listing →
  • Completed NCT NCT02593474

    Medication-Assisted Treatment for Youth With Substance Use Disorders

    Not yet reported New York State Psychiatric Institute 11 participants Est. completion 2018-04 2 sites
    Substance use disorder Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT02602795

    Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence

    Not yet reported Rhode Island Hospital 14 participants Est. completion 2018-06 1 site
    Other conditions: Opiate Dependence, Sexually Transmitted Diseases, HIV
    View official trial listing →
  • Completed NCT NCT02603471

    Cell Phone Technology Targeting ART and Naltrexone Adherence and Alcohol Use

    Not yet reported University of California, Los Angeles 35 participants Est. completion 2016-12 1 site
    Alcohol use disorder Other conditions: HIV Infections
    View official trial listing →
  • Withdrawn NCT NCT02616315

    Efficacy of Naltrexone HCl/Bupropion HCl Extended Release Versus Placebo for Treatment of Weight Regain in Participants Post Bariatric Surgery

    Not yet reported Takeda Est. completion 2017-12 2 sites Stand-alone
    Other conditions: Weight Regain Post Bariatric Surgery
    View official trial listing →
  • Completed NCT NCT02617628

    Outcomes of Opioid Addicted Prisoners With Extended-Release Injectable Naltrexone

    Not yet reported, Not yet reported University of Pennsylvania 146 participants Est. completion 2018-12-31 1 site
    Other conditions: Opiate Dependence
    View official trial listing →
  • Terminated NCT NCT02638129

    Naltrexone/Bupropion Cardiovascular Outcomes Study

    Not yet reported Orexigen Therapeutics, Inc 67 participants Est. completion 2016-06 139 sites
    Cardiovascular disease Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT02652585

    Validation of a Test System for Development of Medications for Alcoholism

    Not yet reported Technische Universität Dresden 46 participants Est. completion 2017-09-04 1 site
    Other conditions: Alcoholism
    View official trial listing →
  • Terminated NCT NCT02680847

    Safety and Pharmacokinetic Study of ALO-02 in Children Ages 7-17 With Pain

    Not yet reported Pfizer 32 participants Est. completion 2018-01-24 16 sites
    Other conditions: Moderate-severe Pain
    View official trial listing →
  • Status unknown NCT NCT02696512

    A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness

    Not yet reported, Not yet reported International Brain Research Foundation 30 participants Est. completion 2017-04 1 site Stand-alone
    Other conditions: Brain Injury
    View official trial listing →
  • Completed NCT NCT02698215

    Combining Varenicline and Naltrexone for Smoking Cessation

    Not yet reported University of California, Los Angeles 165 participants Est. completion 2019-12 1 site Stand-alone
    Alcohol use disorder Other conditions: Nicotine Dependence
    View official trial listing →
  • Completed NCT NCT02712034

    Impact on Opioid Use of Bundling Medication-assisted Treatment With mHealth

    Not yet reported University of Wisconsin, Madison 417 participants Est. completion 2020-04-08 1 site
    Substance use disorder
    View official trial listing →
  • Withdrawn NCT NCT02726035

    Evaluation of Naltrexone as a Treatment for Self-injurious Behavior

    Not yet reported Western Michigan University School of Medicine Est. completion 2017-01-04 1 site Stand-alone
    Other conditions: Self-injurious Behavior, Self Mutilation
    View official trial listing →
  • Completed NCT NCT02735603

    Study to Evaluate the Effect of Naltrexone and Bupropion Extended-Release Combination on Cardiac Repolarization in Healthy Participants

    Not yet reported Orexigen Therapeutics, Inc 84 participants Est. completion 2016-10 1 site Stand-alone
    Other conditions: Heart Repolarization
    View official trial listing →
  • Completed NCT NCT02736474

    Naltrexone and Bupropion Combination on Obese,Smoking Patients With Schizophrenia

    Not yet reported Shanghai Mental Health Center 22 participants Est. completion 2018-07 Stand-alone
    Other conditions: Obese, Cigarette-smoking, Schizophrenia
    View official trial listing →
  • Completed NCT NCT02745912

    Study to Evaluate the Effect of Naltrexone and Bupropion Combination on the Pharmacokinetics of Metformin in Healthy Participants

    Not yet reported Orexigen Therapeutics, Inc 30 participants Est. completion 2016-08 Stand-alone
    Other conditions: Healthy Subjects
    View official trial listing →
  • Completed NCT NCT02750748

    Pharmacokinetic Evaluation of Intranasal, Intramuscular, and Oral Naltrexone in Healthy Volunteers

    Not yet reported National Institute on Drug Abuse (NIDA) 14 participants Est. completion 2016-09 1 site Stand-alone
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT02792140

    The Impact of the Opiate Antagonist Naltrexone on the Emotional Valence of Dreams

    Not yet reported University of Bern 32 participants Est. completion 2016-11 1 site Stand-alone
    Other conditions: Neuroscience of Dreaming, Healthy
    View official trial listing →
  • Completed NCT NCT02806440

    Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism?

    Not yet reported Copenhagen University Hospital, Rigshospitalet 58 participants Est. completion 2022-09-01 1 site
    Other conditions: Fibromyalgia
    View official trial listing →
  • Completed NCT NCT02818036

    An fMRI Study of Opioid-related Changes in Neural Activity

    Not yet reported Tristen Inagaki 82 participants Est. completion 2018-06-21 1 site Stand-alone
    Other conditions: Social Acceptance
    View official trial listing →
  • Completed NCT NCT02842073

    An Open Label Trial of Bupropion and Naltrexone for Binge Drinking

    Not yet reported University of North Carolina, Chapel Hill 12 participants Est. completion 2017-12-13 1 site Stand-alone
    Other conditions: Binge Drinking
    View official trial listing →
  • Completed NCT NCT02867124

    Long-acting Naltrexone for Pre-release Prisoners

    Not yet reported Friends Research Institute, Inc. 240 participants Est. completion 2026-01-01 1 site Stand-alone
    Other conditions: Opiate Addiction
    View official trial listing →
  • Completed NCT NCT02885311

    Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home

    Not yet reported, Not yet reported Northwell Health 27 participants Est. completion 2018-10 1 site
    Alcohol use disorder Other conditions: Alcohol-Related Disorders, Alcoholism, Alcohol Abuse
    View official trial listing →
  • Completed NCT NCT02926482

    Intervention to Expand Opioid Use Disorder Treatment Pharmacotherapy Prescribers

    Not yet reported University of Wisconsin, Madison 76 participants Est. completion 2019-10 3 sites
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT02978417

    Feasibility Study of Extended-release Naltrexone (Vivitrol) in Drug Court Settings

    Not yet reported Duke University 14 participants Est. completion 2019-06-30 1 site
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT03008590

    Low Dose Naltrexone for Chronic Pain From Arthritis

    Not yet reported VA Office of Research and Development 29 participants Est. completion 2019-12-31 1 site
    Osteoarthritis Other conditions: Arthritis, Rheumatoid, Arthritis, Psoriatic
    View official trial listing →
  • Status unknown NCT NCT03023540

    Assessing Long Term Safety and Tolerability of PXT3003 in Patients With Charcot-Marie-Tooth Disease Type 1A

    Not yet reported Pharnext S.C.A. 187 participants Est. completion 2024-12-31 23 sites
    Other conditions: Charcot-Marie-Tooth Disease, Type IA
    View official trial listing →
  • Completed NCT NCT03045341

    Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment

    Not yet reported, Not yet reported Yale University 136 participants Est. completion 2022-12-16 1 site Stand-alone
    Other conditions: Binge-eating Disorder, Obesity
    View official trial listing →
  • Completed NCT NCT03047005

    Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy

    Not yet reported, Not yet reported Yale University 68 participants Est. completion 2022-12-16 1 site Stand-alone
    Other conditions: Binge-Eating Disorder, Obesity
    View official trial listing →
  • Completed NCT NCT03061734

    Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine

    Not yet reported Allodynic Therapeutics, Inc 92 participants Est. completion 2018-02-08 1 site Stand-alone
    Other conditions: Migraine With or Without Aura
    View official trial listing →
  • Completed NCT NCT03078075

    Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT-2) for Methamphetamine Use Disorder

    Not yet reported University of Texas Southwestern Medical Center 403 participants Est. completion 2019-07-25 8 sites Stand-alone
    Other conditions: Methamphetamine Use Disorder
    View official trial listing →
  • Terminated NCT NCT03113409

    Buprenorphine as Adjunct to Outpatient Induction Onto Vivitrol

    Not yet reported, Not yet reported New York State Psychiatric Institute 10 participants Est. completion 2020-12-01 1 site Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Terminated NCT NCT03132571

    Naltrexone-Bupropion Versus Placebo-Bupropion for Weight Loss in Schizophrenia

    Not yet reported Yale University 5 participants Est. completion 2018-07-31 1 site Stand-alone
    Type 2 diabetes Other conditions: Schizophrenia, Obesity
    View official trial listing →
  • Completed NCT NCT03169816

    Lorcaserin in Combination With XR-Naltrexone for Relapse Prevention in Opioid Use Disorder

    Not yet reported, Not yet reported New York State Psychiatric Institute 60 participants Est. completion 2019-08-30 1 site
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT03194555

    The Preventive Treatment of Migraine With Low-Dose Naltrexone and Acetaminophen Combination

    Not yet reported Allodynic Therapeutics, Inc 12 participants Est. completion 2018-07-28 1 site Stand-alone
    Other conditions: Migraine With or Without Aura
    View official trial listing →
  • Completed NCT NCT03201393

    Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)

    Not yet reported Allodynic Therapeutics, Inc 12 participants Est. completion 2018-07-26 1 site Stand-alone
    Other conditions: Chronic Low Back Pain, Lumbar Radiculopathy
    View official trial listing →
  • Completed NCT NCT03226223

    Pharmacogenetics of Naltrexone for Stimulant Abuse

    Not yet reported New York State Psychiatric Institute 18 participants Est. completion 2020-07-30 1 site Stand-alone
    Substance use disorder Other conditions: Methamphetamine Abuse
    View official trial listing →
  • Completed NCT NCT03232346

    A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders

    Not yet reported New York State Psychiatric Institute 11 participants Est. completion 2021-06-30 1 site Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT03275350

    Comparing Treatments for HIV-Infected Opioid Users in an Integrated Care Effectiveness Study (CHOICES) Scale-Up

    Not yet reported, Not yet reported Oregon Health and Science University 114 participants Est. completion 2019-11-08 5 sites
    Other conditions: Opioid-use Disorder, Hiv
    View official trial listing →
  • Completed NCT NCT03278886

    St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Nalmefene

    Not yet reported, Not yet reported Boston Medical Center 11 participants Est. completion 2018-12-19 1 site Stand-alone
    Other conditions: HIV Infection, Alcohol Use, Pain
    View official trial listing →
  • Completed NCT NCT03290391

    Linking Infectious and Narcology Care-Part II

    Not yet reported Boston Medical Center 225 participants Est. completion 2022-04-06 2 sites Stand-alone
    Other conditions: HIV Infection, Drug Use
    View official trial listing →
  • Completed NCT NCT03306368

    Youth Opioid Recovery Support: A Developmentally-specific Intervention for Home Delivery of Extended Release Naltrexone

    Not yet reported Potomac Health Foundations 40 participants Est. completion 2019-12-01 1 site
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Active, not recruiting NCT NCT03345173

    Facilitating Rapid Naltrexone Initiation

    Not yet reported New York State Psychiatric Institute 100 participants Est. completion 2024-10 1 site Stand-alone
    Other conditions: Opioid Dependence
    View official trial listing →
  • Withdrawn NCT NCT03367234

    Patient-Centered Care for Opioid Use Disorders in Federally Qualified Healthcare Centers and Specialty Care Settings

    Not yet reported Public Health Management Corporation Est. completion 2022-06-30 Stand-alone
    Substance use disorder Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT03374956

    Individualized Obesity Pharmacotherapy

    Not yet reported Mayo Clinic 193 participants Est. completion 2022-05-26 1 site Added to GLP-1
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT03386448

    The Safety and Efficacy of Naltrexone and Scopolamine Utilized in the Treatment of Major Depression

    Not yet reported The Taub Group 14 participants Est. completion 2018-11-20 1 site Stand-alone
    Other conditions: Depression
    View official trial listing →
  • Completed NCT NCT03407638

    PRimary Care Opioid Use Disorders Treatment (PROUD) Trial

    Not yet reported Kaiser Permanente 377373 participants Est. completion 2020-02-29 6 sites
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT03431831

    Assessment of and Treatment Applied to Food Addiction in a Rural Healthy Behaviors Clinic

    Not yet reported University of Nebraska 86 participants Est. completion 2022-07-01 2 sites
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT03447743

    Re-entry XR-NTX for Rural Individuals With Opioid Use Disorder

    Not yet reported Michele Staton 9 participants Est. completion 2022-03-09 1 site
    Other conditions: Opioid Dependence
    View official trial listing →
  • Completed NCT NCT03447782

    Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children

    Not yet reported, Not yet reported Boston Children's Hospital 45 participants Est. completion 2020-11-20 1 site Stand-alone
    Other conditions: New Daily Persistent Headache (NDPH)
    View official trial listing →
  • Status unknown NCT NCT03479086

    Defining the Clinical Role of Topiramate in the Treatment of Alcohol Dependence in Australia

    Not yet reported South West Sydney Local Health District 180 participants Est. completion 2020-11-01 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT03482479

    Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis

    Not yet reported University of Pennsylvania 60 participants Est. completion 2025-12-31 7 sites Stand-alone
    Obstructive sleep apnea Other conditions: Eosinophilic Granulomatosis With Polyangiitis (EGPA), Churg-Strauss Syndrome (CSS), Giant Cell Arteritis, Granulomatosis With Polyangiitis, Microscopic Polyangiitis, Takayasu Arteritis
    View official trial listing →
  • Completed NCT NCT03539900

    Efficacy and Mechanisms of Naltrexone+Bupropion for Binge Eating Disorder

    Not yet reported, Not yet reported Yale University 89 participants Est. completion 2023-03-22 1 site Stand-alone
    Other conditions: Binge-Eating Disorder
    View official trial listing →
  • Withdrawn NCT NCT03547882

    Addiction Treatment in Primary Care Expansion

    VA Office of Research and Development Est. completion 2021-09-30 2 sites
    Substance use disorder Other conditions: Chronic Pain
    View official trial listing →
  • Completed NCT NCT03581630

    Effects of Mediterranean Diet and Naltrexone/Bupropion Treatment in Obese Breast Cancer Patients

    Not yet reported Gangnam Severance Hospital 72 participants Est. completion 2018-07-22 1 site Stand-alone
    Other conditions: Breast Cancer, Obesity, Overweight
    View official trial listing →
  • Completed NCT NCT03647774

    Long Acting Naltrexone for Opioid Addiction: Focus on Sustained Abstinence and Recovery

    Not yet reported Lars Tanum 317 participants Est. completion 2022-10-13 1 site Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT03658330

    Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

    Not yet reported VA Connecticut Healthcare System 5 participants Est. completion 2018-06 Stand-alone
    Alcohol use disorder Other conditions: Major Depressive Disorder
    View official trial listing →
  • Completed NCT NCT03660475

    Effect of Topical Naltrexone Ophthalmic Solution on the Signs and Symptoms of Dry Eye in Diabetic Subjects

    Not yet reported Sassani, Joseph S., MD, MHA 60 participants Est. completion 2018-11-15 1 site Stand-alone
    Other conditions: Dry Eye Disease
    View official trial listing →
  • Withdrawn NCT NCT03678792

    Comparison of Three Opioid Detoxification Treatment Regimens

    Not yet reported University of Alabama at Birmingham Est. completion 2020-10-25 1 site
    Other conditions: Opioid-Related Disorders, Opioid Withdrawal
    View official trial listing →
  • Terminated NCT NCT03711318

    Buprenorphine Stabilization and Induction Onto Vivitrol for Heroin-dependent Individuals

    Not yet reported New York State Psychiatric Institute 8 participants Est. completion 2021-12-31 1 site
    Other conditions: Heroin Dependence
    View official trial listing →
  • Completed NCT NCT03715634

    Study of a Novel Subcutaneous Depot Formulation of Buprenorphine

    Not yet reported Indivior Inc. 12 participants Est. completion 2018-06-07 1 site
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT03718104

    MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study

    Boston Medical Center 46 participants Est. completion 2024-05-08 2 sites
    Alcohol use disorder Other conditions: Opioid-use Disorder, Neonatal Abstinence Syndrome, Pregnancy, High Risk
    View official trial listing →
  • Withdrawn NCT NCT03762798

    Can The Bridge Transition Opiate Use Disorder Patients in Stable Recovery From Buprenorphine to Naltrexone

    Not yet reported The Cleveland Clinic Est. completion 2020-12-01 1 site
    Substance use disorder Other conditions: Substance Abuse, Substance Use, Substance Dependence
    View official trial listing →
  • Completed NCT NCT03766893

    Medication Maintenance Therapy in Community Pharmacy Settings

    Not yet reported Lifespan 11 participants Est. completion 2018-12-31 1 site Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT03769064

    Study for Naltrexone on the Abuse Potential of Methylphenidate

    Not yet reported Avekshan LLC 94 participants Est. completion 2018-06-20 1 site Stand-alone
    Other conditions: Naltrexone, Methylphenidate Abuse
    View official trial listing →
  • Completed NCT NCT03799198

    Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity

    Not yet reported Novo Nordisk A/S 200 participants Est. completion 2020-05-22 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT03810495

    The O'Neil Long Acting Naltrexone Implant (OLANI) Pharmacokinetic (PK)/Safety Study in Healthy Volunteers

    Not yet reported Go Medical Industries Pty Ltd 20 participants Est. completion 2021-03-22 1 site Stand-alone
    Substance use disorder
    View official trial listing →
  • Completed NCT NCT03851731

    Evaluation of Intranasal Naltrexone and Naloxone

    Not yet reported National Institute on Drug Abuse (NIDA) 12 participants Est. completion 2015-11-07 Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Terminated NCT NCT03852628

    Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD

    Not yet reported Pharmacotherapies for Alcohol and Substance Use Disorders Alliance 69 participants Est. completion 2023-01-30 2 sites
    Other conditions: Post Traumatic Stress Disorder, Alcohol Abuse
    View official trial listing →
  • Terminated NCT NCT03854942

    Study of the Opioid Modulation of the Effect of Alcohol on the Dopaminergic Reward System

    Not yet reported RWTH Aachen University 43 participants Est. completion 2017-12-13 1 site
    Other conditions: Alcohol Addiction
    View official trial listing →
  • Completed NCT NCT03879460

    The Evaluation of Safety and Tolerance of Commercially Available Naltrexone Administered Daily - Assessment for CBRN Operations

    Not yet reported Timothy Smith 15 participants Est. completion 2019-03-31 1 site Stand-alone
    Other conditions: Opioid Intoxication
    View official trial listing →
  • Completed NCT NCT03902821

    Reducing Overdose After Release From Incarceration

    Oregon Health and Science University 65 participants Est. completion 2023-11-30 1 site
    Other conditions: Overdose, Drug
    View official trial listing →
  • Completed NCT NCT03946111

    Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders

    Not yet reported, Not yet reported Yale University 3 participants Est. completion 2024-12-05 1 site Stand-alone
    Other conditions: Binge-Eating Disorder, Obesity
    View official trial listing →
  • Terminated NCT NCT03970330

    Low-Dose Naltrexone in Combination With Standard Treatment in Women With Endometriosis

    Not yet reported Milton S. Hershey Medical Center 9 participants Est. completion 2021-06-21 1 site Stand-alone
    Other conditions: Endometriosis
    View official trial listing →
  • Status unknown NCT NCT03975010

    Buprenorphine Transdermal Patches Pharmacokinetic Study

    Not yet reported Mundipharma (China) Pharmaceutical Co. Ltd 45 participants Est. completion 2020-03-31 1 site Stand-alone
    Other conditions: Chronic Pain
    View official trial listing →
  • Completed NCT NCT03976258

    Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV

    MetroHealth Medical Center 190 participants Est. completion 2022-12-31 2 sites
    Cardiovascular disease Other conditions: HIV Infection, Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT04015115

    Youth Opioid Recovery Support: Improving Care Systems

    Not yet reported University of Maryland, Baltimore 44 participants Est. completion 2020-10-31 1 site
    Other conditions: Opioid-Related Disorders
    View official trial listing →
  • Completed NCT NCT04052139

    St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Gabapentin

    Not yet reported Boston Medical Center 45 participants Est. completion 2021-12-15 1 site
    Other conditions: Chronic Pain, Alcohol Use, Unspecified, HIV Infections
    View official trial listing →
  • Completed NCT NCT04056182

    Lofexidine for Management of Opioid Withdrawal With XR-NTX Treatment

    Not yet reported New York State Psychiatric Institute 20 participants Est. completion 2021-01-29 1 site
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Terminated NCT NCT04094584

    Emergency Department Initiated Extended-Release Naltrexone and Case Management for the Treatment of Alcohol Use Disorder

    Not yet reported University of California, San Francisco 179 participants Est. completion 2022-05-01 1 site Stand-alone
    Alcohol use disorder Other conditions: Substance Use, Alcohol Abuse or Dependence
    View official trial listing →
  • Withdrawn NCT NCT04115020

    Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis

    Not yet reported Brigham and Women's Hospital Est. completion 2020-01-07 1 site Stand-alone
    Osteoarthritis Other conditions: Arthritis, Rheumatoid, Arthritis, Psoriatic
    View official trial listing →
  • Status unknown NCT NCT04139213

    Medication Maintenance Therapy in Community Pharmacy Settings

    Not yet reported, Not yet reported Lifespan 250 participants Est. completion 2022-10-01 1 site Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Withdrawn NCT NCT04154033

    Treatment of Chronic Itch in Atopic Dermatitis With Topical Naltrexone

    Not yet reported University of Minnesota Est. completion 2024-03-31 1 site Stand-alone
    Other conditions: Atopic Dermatitis, Pruritus, Dermatitis
    View official trial listing →
  • Enrolling by invitation NCT NCT04166071

    Opioids and Social Support Enhanced Extinction Effects

    Not yet reported University of California, Los Angeles 60 participants Est. completion 2026-09 2 sites
    Other conditions: Fear
    View official trial listing →
  • Completed NCT NCT04218240

    Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal

    Not yet reported University of Pennsylvania 90 participants Est. completion 2023-08-31 3 sites
    Other conditions: Opioid Withdrawal
    View official trial listing →
  • Completed NCT NCT04219540

    Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved Adults

    Not yet reported NYU Langone Health 675 participants Est. completion 2025-02-28 6 sites Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT04245423

    The Whole Health Study: Collaborative Care for OUD and Mental Health Conditions

    Not yet reported University of Pennsylvania 567 participants Est. completion 2026-03-28 1 site Stand-alone
    Other conditions: Opioid-use Disorder, Mental Health Conditions
    View official trial listing →
  • Completed NCT NCT04250792

    Efficacy of Low Dose Naltrexone in Psoriasis

    Not yet reported Jinnah Postgraduate Medical Centre 42 participants Est. completion 2019-09-30 1 site Stand-alone
    Other conditions: Psoriasis
    View official trial listing →
  • Completed NCT NCT04270877

    Fibromyalgia and Naltrexone: The FINAL Study

    Not yet reported Odense University Hospital 99 participants Est. completion 2022-12-27 1 site Stand-alone
    Other conditions: Fibromyalgia
    View official trial listing →
  • Completed NCT NCT04276259

    Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses

    Not yet reported Marta Peciña, MD PhD 120 participants Est. completion 2026-03-31 1 site Stand-alone
    Other conditions: Major Depressive Disorder, Depression
    View official trial listing →
  • Terminated NCT NCT04287790

    Promoting Medications for Alcohol Use Disorder on the General Medicine Service

    Yale University 67 participants Est. completion 2021-02-01 1 site
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT04309565

    Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support

    Not yet reported Yale University 398 participants Est. completion 2025-12-30 5 sites Stand-alone
    Other conditions: Opioid Addiction
    View official trial listing →
  • Terminated NCT NCT04313972

    IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone

    Not yet reported Endeavor Health 3 participants Est. completion 2023-02-23 1 site Stand-alone
    Other conditions: Interstitial Cystitis, Painful Bladder Syndrome, Bladder Pain Syndrome, Low Dose Naltrexone, Low-dose Naltrexone, Naltrexone
    View official trial listing →
  • Completed NCT NCT04322526

    Study of Naltrexone-Induced Blockade of Antidepressant Effects

    Not yet reported Marta Peciña, MD PhD 25 participants Est. completion 2018-07-15 1 site Stand-alone
    Other conditions: Depression, Major Depressive Disorder
    View official trial listing →
  • Withdrawn NCT NCT04325802

    Treatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist Naltrexone

    Not yet reported University of Minnesota Est. completion 2024-06 1 site Stand-alone
    Other conditions: Atopic Dermatitis, Pruritus, Pruritus Chronic, Dermatitis
    View official trial listing →
  • Completed NCT NCT04345718

    EXHIT ENTRE Comparative Effectiveness Trial

    Not yet reported, Not yet reported Gavin Bart 344 participants Est. completion 2025-08-27 6 sites Stand-alone
    Substance use disorder
    View official trial listing →
  • Completed NCT NCT04363320

    Fostering MAT Use in Justice Populations

    Not yet reported University of Wisconsin, Madison 256 participants Est. completion 2024-02-28 1 site Stand-alone
    Other conditions: Opioid-use Disorder, Recidivism
    View official trial listing →
  • Terminated NCT NCT04365985

    Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19

    Not yet reported Corewell Health East 70 participants Est. completion 2021-04-01 1 site Stand-alone
    Other conditions: COVID-19, Acute Respiratory Distress Syndrome, Severe Acute Respiratory Syndrome (SARS), Coronavirus Infections
    View official trial listing →
  • Completed NCT NCT04391764

    Effect of Naltrexone in Achieving and Maintaining Abstinence From Alcohol in Patients With Cirrhosis.

    Not yet reported Institute of Liver and Biliary Sciences, India 100 participants Est. completion 2022-10-31 1 site Stand-alone
    Other conditions: Liver Cirrhosis
    View official trial listing →
  • Withdrawn NCT NCT04399395

    Naltrexone/Bupropion (Mysimba) to Optimize Weight Outcomes After Obesity Surgery

    Not yet reported Oslo University Hospital Est. completion 2022-12-31
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT04408313

    Extended Release Naltrexone Versus Extended Release Buprenorphine With Individuals Leaving Jail

    Not yet reported, Not yet reported Friends Research Institute, Inc. 240 participants Est. completion 2026-05-31 1 site
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT04409041

    Oral Low-Dose Naltrexone for Lichen Planopilaris and Frontal Fibrosing Alopecia

    Not yet reported Washington University School of Medicine 43 participants Est. completion 2020-12-31 1 site Stand-alone
    Other conditions: Lichen Planopilaris, Frontal Fibrosing Alopecia
    View official trial listing →
  • Terminated NCT NCT04450316

    Low-dose Naltrexone for Bladder Pain Syndrome

    Not yet reported Stanford University 29 participants Est. completion 2022-06-04 1 site
    Other conditions: Bladder Pain Syndrome, Interstitial Cystitis
    View official trial listing →
  • Terminated NCT NCT04454411

    Brain Mechanisms of Pharmacotherapy in Opioid Use Disorder

    Not yet reported University of Pennsylvania 3 participants Est. completion 2024-08-31 1 site
    Other conditions: Opioid Dependence
    View official trial listing →
  • Active, not recruiting NCT NCT04464980

    Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

    Not yet reported NYU Langone Health 1516 participants Est. completion 2027-01-31 21 sites Stand-alone
    Substance use disorder
    View official trial listing →
  • Terminated NCT NCT04480554

    Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1

    Not yet reported University of Pennsylvania 78 participants Est. completion 2025-06-30 2 sites Stand-alone
    Other conditions: Opioid-use Disorder, HIV-1-infection, Immune Activation, Inflammation, Methadone, Buprenorphine, Naltrexone, Antiretroviral Treatment
    View official trial listing →
  • Completed NCT NCT04499950

    Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study

    Not yet reported Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 53 participants Est. completion 2024-01-10 1 site
    Other conditions: Breast Cancer, Overweight or Obesity
    View official trial listing →
  • Completed NCT NCT04502251

    LDN and tDCS in Fibromyalgia

    Not yet reported, Not yet reported Centro Universitario La Salle 92 participants Est. completion 2020-07-01 1 site
    Other conditions: Fibromyalgia
    View official trial listing →
  • Terminated NCT NCT04547985

    Naltrexone Treatment for Prolonged Grief Disorder (PGD)

    Not yet reported Weill Medical College of Cornell University 9 participants Est. completion 2023-10-16 1 site
    Other conditions: Prolonged Grief Disorder
    View official trial listing →
  • Withdrawn NCT NCT04553263

    Relapse Prevention in Stimulant Use Disorder

    Not yet reported University of California, Los Angeles Est. completion 2025-01-11 1 site Stand-alone
    Other conditions: Stimulant Use, Relapse, Cognitive Function, ADHD
    View official trial listing →
  • Completed NCT NCT04562779

    Inpatient Single Dose Interventions for Alcohol Use Disorder

    Not yet reported Denver Health and Hospital Authority 44 participants Est. completion 2022-02-01 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Status unknown NCT NCT04575194

    Study of the Cardiometabolic Effects of Obesity Pharmacotherapy

    Not yet reported National and Kapodistrian University of Athens 40 participants Est. completion 2023-05-30 1 site
    Other conditions: Obesity, Blood Pressure
    View official trial listing →
  • Completed NCT NCT04575324

    Project STAMINA (Syringe Service Telemedicine Access for Medication-assisted Intervention Through NAvigation)

    Not yet reported Chestnut Health Systems 275 participants Est. completion 2022-12-30 1 site Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Terminated NCT NCT04581603

    CBT-I Augmentation of Medication for Drinking in AUD

    Not yet reported VA Office of Research and Development 82 participants Est. completion 2025-01-20 2 sites
    Alcohol use disorder
    View official trial listing →
  • Status unknown NCT NCT04587843

    A Trial Evaluating the Effectiveness of Contrave in Patients Who Have Weight Recidivism Following Bariatric Surgery

    Not yet reported St. Joseph's Healthcare Hamilton 18 participants Est. completion 2023-12-31 4 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Status unknown NCT NCT04589130

    Evaluating Contrave for Weight Maintenance in Adults With BMI >= 27 Kg/m2, After 6 Month Behaviour Modification Program.

    Not yet reported St. Joseph's Healthcare Hamilton 89 participants Est. completion 2023-12-31 3 sites Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Completed NCT NCT04599478

    Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1)

    Not yet reported, Not yet reported Yale University 92 participants Est. completion 2026-06-04 1 site Stand-alone
    Other conditions: Loss-of-control Eating, Obesity/Overweight
    View official trial listing →
  • Withdrawn NCT NCT04604678

    Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19

    Not yet reported AgelessRx Est. completion 2021-10 1 site Stand-alone
    Other conditions: Covid19
    View official trial listing →
  • Completed NCT NCT04604704

    Pilot Study Into LDN and NAD+ for Treatment of Patients With Post-COVID-19 Syndrome

    Not yet reported AgelessRx 36 participants Est. completion 2023-01-23 1 site Stand-alone
    Other conditions: Covid19, Long COVID-19, Post-COVID-19 Syndrome
    View official trial listing →
  • Completed NCT NCT04605081

    Pharmacological and Behavioral Treatments After Bariatric Surgery: Maintenance Treatment (Stage 2a)

    Not yet reported, Not yet reported Yale University 24 participants Est. completion 2026-06-04 1 site Stand-alone
    Other conditions: Loss-of-Control Eating, Obesity/Overweight
    View official trial listing →
  • Completed NCT NCT04662801

    Weight Regain Treatment Post-Bariatric Surgery

    Not yet reported, Not yet reported Yale University 26 participants Est. completion 2022-09-13 1 site Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Status unknown NCT NCT04708327

    Single-Blind Study of STAT-205 in Mild COVID-19

    Not yet reported Cytocom, Inc. 24 participants Est. completion 2022-09-30 2 sites Stand-alone
    Other conditions: COVID-19
    View official trial listing →
  • Completed NCT NCT04716881

    Pharmacokinetic Study of Vivitrol in Healthy Participants

    Not yet reported Go Medical Industries Pty Ltd 9 participants Est. completion 2022-04-04 1 site Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Status unknown NCT NCT04738773

    RCT for Gambling and Naltrexone, Using Use Eye-tracking Analysis to Predict Treatment Response

    Not yet reported University of Sao Paulo 40 participants Est. completion 2023-12
    Other conditions: Eye Tracking, Gambling Disorder, Naltrexone
    View official trial listing →
  • Status unknown NCT NCT04739995

    Cost-utility and Physiological Effects of LDN in Patients With Fibromyalgia

    Not yet reported Fundació Sant Joan de Déu 99 participants Est. completion 2024-12-31 1 site Stand-alone
    Other conditions: Randomized Controlled Trial
    View official trial listing →
  • Completed NCT NCT04757506

    An Investigation of the Effects of Opioid Receptor Blockade on Changes in Self-esteem and Social Attention

    Not yet reported McGill University 35 participants Est. completion 2013-03-15 Stand-alone
    Other conditions: Self Esteem
    View official trial listing →
  • Completed NCT NCT04762537

    Surmounting Withdrawal to Initiate Fast Treatment With Naltrexone

    Not yet reported New York State Psychiatric Institute 415 participants Est. completion 2022-12-21 6 sites Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Status unknown NCT NCT04762758

    Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients

    Not yet reported Pharnext S.C.A. 350 participants Est. completion 2024-04-19 50 sites Stand-alone
    Other conditions: Charcot-Marie-Tooth Disease
    View official trial listing →
  • Completed NCT NCT04791969

    Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM

    Not yet reported Glenn-Milo Santos 60 participants Est. completion 2024-07-01 1 site Stand-alone
    Other conditions: Methamphetamine Use Disorder
    View official trial listing →
  • Completed NCT NCT04817410

    ED Initiated Oral Naltrexone for AUD

    Not yet reported Icahn School of Medicine at Mount Sinai 30 participants Est. completion 2023-11-02 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT04828694

    Pharmacokinetic and Safety Study of Naltrexone Release From Subcutaneous BICX104 Pellets Compared to Vivitrol Injections

    Not yet reported BioCorRx Inc 24 participants Est. completion 2023-03-22 1 site Stand-alone
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT04854551

    Opioid Modulation and Neural Reward Activation in Healthy Adults

    Not yet reported, Not yet reported University of Colorado, Denver 13 participants Est. completion 2022-04-18 1 site Stand-alone
    Alcohol use disorder Other conditions: Opioid Use, Unspecified
    View official trial listing →
  • Status unknown NCT NCT04902625

    Use of Mysimba in Patients With Weight Regain After Bariatric Surgery

    Not yet reported Zuyderland Medisch Centrum 116 participants Est. completion 2025-03 1 site
    Other conditions: Obesity, Morbid, Bariatric Surgery Candidate, Medication Persistence
    View official trial listing →
  • Completed NCT NCT04935931

    Naltrexone Neuroimaging

    Not yet reported Children's Mercy Hospital Kansas City 13 participants Est. completion 2022-06-30 1 site Stand-alone
    Other conditions: Eating Disorders, Binge Eating, Purging (Eating Disorders)
    View official trial listing →
  • Completed NCT NCT04977674

    Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine

    Not yet reported King's College London 27 participants Est. completion 2023-02-20 1 site Stand-alone
    Other conditions: Depressive Disorder, Treatment-Resistant
    View official trial listing →
  • Completed NCT NCT05002946

    Pharmacokinetics of SP-104

    Not yet reported Scilex Pharmaceuticals, Inc. 18 participants Est. completion 2022-04-24 1 site
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT05007561

    Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences

    Not yet reported San Diego State University 217 participants Est. completion 2026-03-18 1 site Stand-alone
    Other conditions: Naltrexone, Placebo
    View official trial listing →
  • Completed NCT NCT05037032

    Effects of Naltrexone on Nocturnal Breathing Patterns at Altitude

    Not yet reported VA Loma Linda Health Care System 16 participants Est. completion 2021-10-17 1 site
    Other conditions: Altitude, Sleep Apnea, Central
    View official trial listing →
  • Completed NCT NCT05042388

    Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder

    Not yet reported West Chester University of Pennsylvania 105 participants Est. completion 2024-08-20 1 site
    Other conditions: Opioid-use Disorder
    View official trial listing →
  • Completed NCT NCT05043766

    Evaluation of Oral PF614 Relative to OxyContin (PF614-102)

    Not yet reported Ensysce Biosciences 84 participants Est. completion 2022-03-21 1 site Stand-alone
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT05053503

    Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder

    Not yet reported Spark Biomedical, Inc. 108 participants Est. completion 2025-04-04 4 sites Stand-alone
    Other conditions: Opioid-use Disorder, Opioid Withdrawal
    View official trial listing →
  • Terminated NCT NCT05073679

    Oral Naltrexone In Pediatric Eating Disorders

    Not yet reported, Not yet reported Rosemary Claire Roden 9 participants Est. completion 2024-05-21 1 site Stand-alone
    Obstructive sleep apnea Other conditions: Anorexia in Adolescence, Purging (Eating Disorders), Impulsive Behavior, Eating Disorders, Eating Disorders in Adolescence
    View official trial listing →
  • Withdrawn NCT NCT05087771

    In Hospital IM Naltrexone: A Pilot Study

    Not yet reported University of Colorado, Denver Est. completion 2023-06 Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT05090280

    Pharmacokinetics of Oxycodone and PF614 Co-Administered with Nafamostat (PF614-MPAR-101)

    Not yet reported Ensysce Biosciences 111 participants Est. completion 2023-04-26 1 site Stand-alone
    Other conditions: Pharmacokinetics
    View official trial listing →
  • Completed NCT NCT05092841

    A Study to Assess the Efficacy and Safety of PXT3003 in Charcot-Marie-Tooth Type 1A

    Not yet reported Tasly GeneNet Pharmaceuticals Co., Ltd 176 participants Est. completion 2024-03-18 25 sites
    Other conditions: Charcot-Marie-Tooth Type 1A
    View official trial listing →
  • Completed NCT NCT05093296

    Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder

    Not yet reported, Not yet reported Central Institute of Mental Health, Mannheim 62 participants Est. completion 2023-09-27 1 site Stand-alone
    Alcohol use disorder Other conditions: Alcoholism, Alcohol Addiction
    View official trial listing →
  • Completed NCT NCT05157698

    Pharmacological and Behavioral Treatment After Bariatric Surgery

    Not yet reported Yale University 84 participants Est. completion 2026-05-25 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Status unknown NCT NCT05228418

    Bridging ED to Outpatient AUD Therapy With Naltrexone

    Not yet reported Albert Einstein Healthcare Network 20 participants Est. completion 2025-07 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT05262270

    Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)

    Not yet reported University of Texas Southwestern Medical Center 427 participants Est. completion 2025-07-21 12 sites Stand-alone
    Other conditions: Cocaine Use Disorder
    View official trial listing →
  • Completed NCT NCT05304364

    Safety, Tolerability, and Pharmacokinetics of Naltrexone Implant (DLP-160)

    Not yet reported Delpor, Inc. 10 participants Est. completion 2022-11-19 1 site Stand-alone
    Other conditions: Opiod Use Disorder
    View official trial listing →
  • Withdrawn NCT NCT05307627

    The Effects of Low Dose Naltrexone (LDN) on Diseases of Aging

    AgelessRx Est. completion 2023-12-14 1 site
    Other conditions: Aging
    View official trial listing →
  • Completed NCT NCT05338151

    Promoting Alcohol Treatment Engagement Post-hospitalization

    Not yet reported Yale University 417 participants Est. completion 2026-08-31 1 site
    Alcohol use disorder
    View official trial listing →
  • Not yet recruiting NCT NCT05363514

    Low Dose Naltrexone Use in Patients With POTS

    Not yet reported University of Calgary 80 participants Est. completion 2030-12 Stand-alone
    Other conditions: Postural Orthostatic Tachycardia Syndrome
    View official trial listing →
  • Not yet recruiting NCT NCT05382091

    Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons

    Not yet reported Go Medical Industries Pty Ltd 250 participants Est. completion 2030-07-01 Stand-alone
    Substance use disorder
    View official trial listing →
  • Status unknown NCT NCT05415891

    The IMPROV Project: Improving Mental Health and Substance Use Treatment Provision (IMPROV) Among People Living With HIV (Human Immunodeficiency Virus) in Atlanta

    Not yet reported RTI International 333 participants Est. completion 2023-06 2 sites Stand-alone
    Substance use disorder Other conditions: Mental Health Disorder, Stigmatization, Implementation Science
    View official trial listing →
  • Completed NCT NCT05430152

    Low-dose Naltrexone for Post-COVID Fatigue Syndrome

    Not yet reported Luis Nacul 160 participants Est. completion 2026-02-28 1 site Stand-alone
    Other conditions: Post-Viral Fatigue Syndrome
    View official trial listing →
  • Completed NCT NCT05458609

    Lemborexant Augmentation of Naltrexone for Alcohol Craving and Sleep

    Not yet reported Baylor College of Medicine 8 participants Est. completion 2024-01-30 1 site
    Alcohol use disorder
    View official trial listing →
  • Enrolling by invitation NCT NCT05503927

    A Study to Evaluate the Safety of Exposure to Wegovy During Pregnancy

    Novo Nordisk A/S 2701 participants Est. completion 2027-08-15 2 sites
    Other conditions: Pregnancy, Obesity, Overweight
    View official trial listing →
  • Status unknown NCT NCT05536050

    Study of Low-dose Naltrexone in Chronic Migraine With Fibromyalgia

    Thomas Jefferson University 30 participants Est. completion 2023-12 1 site
    Other conditions: Chronic Migraine, Fibromyalgia, New Daily Persistent Headache
    View official trial listing →
  • Completed NCT NCT05569031

    Treatment of Withdrawal Symptoms and Prevention of Relapse in Patients With Tramadol Abuse

    Not yet reported Zagazig University 52 participants Est. completion 2022-06-15 1 site
    Other conditions: Opiate Withdrawal Syndrome
    View official trial listing →
  • Completed NCT NCT05579249

    A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America

    Not yet reported Novo Nordisk A/S 500 participants Est. completion 2024-11-27 1 site
    Other conditions: Obesity
    View official trial listing →
  • Withdrawn NCT NCT05685225

    Single-Site Study of Naltrexone/Acetaminophen for the Acute Treatment of Migraine: A Phase 2 Randomized Trial

    Not yet reported Allodynic Therapeutics, Inc Est. completion 2025-12-02 1 site Stand-alone
    Other conditions: Migraine
    View official trial listing →
  • Completed NCT NCT05748639

    Integrated Digital Intervention for Alcohol Use Disorder

    Not yet reported, Not yet reported Quit Genius 242 participants Est. completion 2025-07-15 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Withdrawn NCT NCT05812183

    Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity

    Not yet reported University of California, Los Angeles Est. completion 2025-02-12 Stand-alone
    Other conditions: Dyspnea, Quality of Life
    View official trial listing →
  • Status unknown NCT NCT05919017

    Exploring the PK of Different Doses of Naltrexone in Patients With AUD

    Not yet reported Shenzhen Sciencare Medical Industries Co., Ltd. 60 participants Est. completion 2024-05-01 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Completed NCT NCT05924893

    The Use of Naltrexone Hydrochloride to Promote Healing in Patients With Resistant Non-infectious Corneal Ulcer

    Not yet reported Minia University 50 participants Est. completion 2022-12-15 1 site Stand-alone
    Other conditions: Cornea Ulcer
    View official trial listing →
  • Active, not recruiting NCT NCT06021431

    Virtual Reality Cognitive-Affective Training for Opioid Use Disorder- A Phase 2 RCT

    Not yet reported BehaVR LLC 128 participants Est. completion 2025-09 2 sites Stand-alone
    Substance use disorder
    View official trial listing →
  • Completed NCT NCT06090461

    Real-World Evidence on the Cardiovascular Safety of CONTRAVE® in the United States (U.S.)

    Currax Pharmaceuticals 31889 participants Est. completion 2022-12 1 site
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06098079

    Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)

    Not yet reported Currax Pharmaceuticals 8600 participants Est. completion 2029-07 140 sites
    Other conditions: Obesity
    View official trial listing →
  • Terminated NCT NCT06140420

    Naltrexone for Prolonged Grief Disorder

    Not yet reported Texas Tech University 7 participants Est. completion 2025-02-01 1 site
    Other conditions: Naltrexone HCl 50 MG Oral Tablet, Placebo
    View official trial listing →
  • Status unknown NCT NCT06175507

    Efficacy of Baclofen Vs Naltrexon in Achieving & Maintaining Abstinence in Alcohol Dependence.

    Not yet reported Institute of Liver and Biliary Sciences, India 110 participants Est. completion 2025-03-31 1 site Stand-alone
    Other conditions: Alcohol Liver Disease
    View official trial listing →
  • Active, not recruiting NCT NCT06233799

    Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder

    Not yet reported National Institute on Drug Abuse (NIDA) 360 participants Est. completion 2027-04-30 11 sites Stand-alone
    Other conditions: Methamphetamine-dependence, Methamphetamine Abuse
    View official trial listing →
  • Completed NCT NCT06245902

    An Acute Migraine Factorial Study

    Not yet reported Allodynic Therapeutics, Inc 92 participants Est. completion 2018-02-08 1 site Stand-alone
    Other conditions: Migraine With or Without Aura
    View official trial listing →
  • Enrolling by invitation NCT NCT06306157

    Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome

    Not yet reported Hospital for Special Surgery, New York 40 participants Est. completion 2026-11 1 site Stand-alone
    Other conditions: Complex Regional Pain Syndrome, Chronic Pain, Causalgia, Complex Regional Pain Syndrome Type I, Complex Regional Pain Syndrome Type II
    View official trial listing →
  • Terminated NCT NCT06374290

    Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia

    Not yet reported The University of Texas Health Science Center, Houston 2 participants Est. completion 2024-12-04 1 site Stand-alone
    Other conditions: Smoking Cessation
    View official trial listing →
  • Status unknown NCT NCT06434818

    Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders

    Not yet reported Evon Medics LLC 300 participants Est. completion 2025-06-30 3 sites Stand-alone
    Substance use disorderAlcohol use disorder Other conditions: Cocaine Use Disorder, Methamphetamine-dependence
    View official trial listing →
  • Completed NCT NCT06605703

    A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)

    Not yet reported WW International Inc 226 participants Est. completion 2026-02-05 1 site Stand-alone
    Other conditions: Obesity, Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT06622239

    Trial to Evaluate the Effects of Naltrexone in Nonsuicidal Self-injury

    Not yet reported Seoul National University Hospital 150 participants Est. completion 2027-05-31 1 site Stand-alone
    Other conditions: Nonsuicidal Self-Injury
    View official trial listing →
  • Active, not recruiting NCT NCT06723561

    Treating Central Neuropathic Pain With Low Dose Naltrexone for People With Spinal Cord Injury

    Not yet reported Medical College of Wisconsin 10 participants Est. completion 2026-12-31 1 site Stand-alone
    Other conditions: Central Neuropathic Pain, Spinal Cord Injury
    View official trial listing →
  • Enrolling by invitation NCT NCT06845345

    Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study)

    Not yet reported Carmen Dietvorst 70 participants Est. completion 2027-07 1 site
    Type 2 diabetesMASLD Other conditions: Liver Fibrosis, Liver Steatoses, Hepatic Steatosis, Hepatic Fibrosis, Overweight or Obesity, Cardio-metabolic Risk, Cardio-metabolic Health, Hypertension, Dyslipidaemia
    View official trial listing →
  • Active, not recruiting NCT NCT06854614

    Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)

    Not yet reported The Cleveland Clinic 150 participants Est. completion 2028-04-28 1 site Stand-alone
    Other conditions: Obesity
    View official trial listing →
  • Active, not recruiting NCT NCT06877572

    Weight Loss Management in Endometrial Cancer Survivors

    University of Kansas Medical Center 50 participants Est. completion 2030-10 1 site
    Other conditions: Endometrial Cancer Survivors, Weight Management, Early Stage Endometrial Cancer
    View official trial listing →
  • Not yet recruiting NCT NCT07001371

    Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study

    Not yet reported Loma Linda University 54 participants Est. completion 2027-08 1 site Stand-alone
    Substance use disorderAlcohol use disorder Other conditions: Cannabis Use Disorder, Stimulant Use Disorder, Tobacco Use Disorder, Sedative, Hypnotic, or Anxiolytic Use Disorders
    View official trial listing →
  • Completed NCT NCT07014644

    A Randomized, Double-Blind, Single-Center Clinical Study on the Efficacy of Naltrexone Implant in Antagonizing Opioid Agonist Hydromorphone

    Not yet reported Shenzhen Sciencare Medical Industries Co., Ltd. 31 participants Est. completion 2020-05-19 1 site Stand-alone
    Other conditions: Opioid Dependence
    View official trial listing →
  • Active, not recruiting NCT NCT07064564

    iSTEP-N 101b: Pharmacokinetics and Safety Study of Low- and High-Dose Naltrexone Implants vs Monthly Vivitrol in Healthy Volunteers

    Not yet reported Akyso Therapeutics, LLC 33 participants Est. completion 2029-12-31 1 site Stand-alone
    Substance use disorder
    View official trial listing →
  • Completed NCT NCT07132177

    Targeted Naltrexone to Support Individuals Participating in Dry January

    Not yet reported Brigham and Women's Hospital 19 participants Est. completion 2026-04-01 1 site Stand-alone
    Other conditions: Alcohol Misuse
    View official trial listing →
  • Active, not recruiting NCT NCT07188545

    Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH)

    Ohio State University 23280000 participants Est. completion 2029-06-30 1 site
    Metabolic syndrome
    View official trial listing →
  • Not yet recruiting NCT NCT07211724

    Methamphetamine Use Disorder Support in Heart Failure Pilot Study

    Not yet reported University of Southern California 50 participants Est. completion 2027-07 2 sites
    Heart failure Other conditions: Methamphetamine Use Disorder
    View official trial listing →
  • Not yet recruiting NCT NCT07224087

    Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

    Not yet reported Medical University of South Carolina 20 participants Est. completion 2027-12-31 1 site Stand-alone
    Other conditions: Obesity, Smoking Cessation, Bariatric Surgery Patients
    View official trial listing →
  • Not yet recruiting NCT NCT07249554

    Combination Therapy for Alcohol Use Disorder

    Not yet reported Johns Hopkins University 45 participants Est. completion 2028-09 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Not yet recruiting NCT NCT07285473

    Low-Dose Naltrexone For ME/CFS: Dose-Finding

    Not yet reported University of Alabama at Birmingham 75 participants Est. completion 2028-04-01 1 site Stand-alone
    Other conditions: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
    View official trial listing →
  • Completed NCT NCT07333638

    Phase II Clinical Study on the Efficacy and Safety of Naltrexone Implant in Patients With Alcohol Use Disorder

    Not yet reported Shenzhen Sciencare Medical Industries Co., Ltd. 210 participants Est. completion 2024-10-10 1 site Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Not yet recruiting NCT NCT07398404

    A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

    Not yet reported, Not yet reported Medical University of South Carolina 64 participants Est. completion 2031-06-30 1 site Stand-alone
    Other conditions: Obesity, Smoking Cessation, Bariatric Surgery Patients
    View official trial listing →
  • Not yet recruiting NCT NCT07433413

    Evaluate the Efficacy and Safety of Naltrexone Hydrochloride Implant in Patients With Alcohol Use Disorder

    Not yet reported Shenzhen Sciencare Medical Industries Co., Ltd. 240 participants Est. completion 2027-05-01 Stand-alone
    Alcohol use disorder
    View official trial listing →
  • Active, not recruiting NCT NCT07475546

    Combination Gerotherapeutic Interventions for Healthspan Improvement

    Not yet reported AgelessRx 30 participants Est. completion 2026-04 1 site Stand-alone
    Other conditions: Healthspan Improvement, Aging, Longevity
    View official trial listing →
  • Not yet recruiting NCT NCT07641283

    Naltrexone for Nonsuicidal Self-Injury

    Not yet reported Seoul National University Hospital 150 participants Est. completion 2028-06 3 sites Stand-alone
    Other conditions: Nonsuicidal Self-Injury, Self-Injurious Behavior
    View official trial listing →
  • Not yet recruiting NCT NCT07728812

    Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy

    Not yet reported Phenomix Sciences 424 participants Est. completion 2029-01-01 Stand-alone
    Other conditions: Obesity & Overweight
    View official trial listing →
  • Not yet recruiting NCT NCT07832084

    Comparing Different Medication Regimens to Maintaining Weight Loss Among Adults With Obesity Using GLP-1s

    Not yet reported Jing Luo 60 participants Est. completion 2028-09-30 1 site Stand-alone
    Other conditions: Obesity & Overweight, Cardiometabolic Health Indicators
    View official trial listing →
Efficacy history

Not yet reported.

Safety

Not yet reported.

Sources

Also known as: Naltrexone Hydrochloride, Naltrexone, Naltrexone (oral tablets)

Related On The Pen coverage

No related coverage yet.

This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.