Naltrexone-Bupropion

• Recruiting NCT NCT05919797

  Weight Loss Study: Genetics and Response to Naltrexone/Bupropion

  Not yet reported Columbia University 120 participants Est. completion 2027-06-30 1 site Stand-alone
  Other conditions: Obesity
  View official trial listing →
• Recruiting NCT NCT05925959

  Preoperative Weight Loss for Open Abdominal Wall Reconstruction

  Not yet reported Benjamin T. Miller 258 participants Est. completion 2027-06-01 2 sites
  Other conditions: Abdominal Wall Hernia
  View official trial listing →
• Recruiting NCT NCT06620562

  Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release Tablet

  Not yet reported Laval University 108 participants Est. completion 2028-08 1 site
  Other conditions: Obesity; Drug, Obesity, Morbid
  View official trial listing →
• Recruiting NCT NCT06809166

  Metabolic and Behavioural Effects of CONTRAVE as Potential Mechanisms of Weight Loss in Adults With Obesity

  Not yet reported The Royal's Institute of Mental Health Research 40 participants Est. completion 2026-07-31 3 sites Stand-alone
  Other conditions: Obesity, Weight Loss, Weight Management, Dietary Intervention, Obesity/Therapy
  View official trial listing →
• Recruiting NCT NCT06881485

  Naltrexone/Bupropion With or Without Very Low Calorie Ketogenic Diet for Weight Regain After Bariatric Surgery

  Not yet reported Universitaire Ziekenhuizen KU Leuven 62 participants Est. completion 2027-01-01 2 sites
  Other conditions: Weight Regain Post Bariatric Surgery, Obesity (Disorder)
  View official trial listing →
• Recruiting NCT NCT07213466

  Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

  Not yet reported Mayo Clinic 100 participants Est. completion 2029-02-01 1 site Stand-alone
  Other conditions: Bipolar I Disorder, Bipolar II Disorder, Schizo Affective Disorder, Obesity, Weight Loss, GLP - 1
  View official trial listing →
• Recruiting NCT NCT07269873

  Safety and PK Study of BICX104 With or Without Bupropion Compared to Vivitrol

  Not yet reported BioCorRx Pharmaceuticals Inc 30 participants Est. completion 2026-12-05 1 site
  Other conditions: Healthy Adult Male and Female Volunteers
  View official trial listing →
• Completed NCT NCT00129246

  Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain

  Not yet reported, Not yet reported Yale University 40 participants Est. completion 2005-12 1 site
  Other conditions: Smoking, Nicotine Dependence
  View official trial listing →
• Completed NCT NCT00364871

  Efficacy and Safety Study of Combination Therapy to Treat Uncomplicated Obesity

  Not yet reported Orexigen Therapeutics, Inc 410 participants Est. completion 2007-03 7 sites
  Other conditions: Obesity
  View official trial listing →
• Status unknown NCT NCT00419731

  Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation

  Not yet reported, Not yet reported University of Minnesota 120 participants Est. completion 2010-07 1 site
  Other conditions: Tobacco Use Disorder
  View official trial listing →
• Completed NCT NCT00456521

  A Safety and Efficacy Study of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects Participating in an Intensive Behavior Modification Program

  Not yet reported Orexigen Therapeutics, Inc 793 participants Est. completion 2008-12 9 sites
  Other conditions: Obesity, Overweight
  View official trial listing →
• Completed NCT NCT00474630

  A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes

  Not yet reported Orexigen Therapeutics, Inc 505 participants Est. completion 2009-06 53 sites
  Type 2 diabetes Other conditions: Obesity, Overweight
  View official trial listing →
• Completed NCT NCT00532779

  A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects

  Not yet reported Orexigen Therapeutics, Inc 1742 participants Est. completion 2009-05 34 sites
  Other conditions: Obesity, Overweight
  View official trial listing →
• Completed NCT NCT00563563

  A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent

  Not yet reported Orexigen Therapeutics, Inc 30 participants Est. completion 2008-09 3 sites
  Other conditions: Nicotine Dependence, Overweight, Obesity
  View official trial listing →
• Completed NCT NCT00567255

  A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects

  Not yet reported Orexigen Therapeutics, Inc 1496 participants Est. completion 2009-06 36 sites
  Other conditions: Obesity, Overweight
  View official trial listing →
• Completed NCT NCT00624858

  A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression

  Not yet reported Orexigen Therapeutics, Inc 25 participants Est. completion 2009-07 1 site
  Other conditions: Depression
  View official trial listing →
• Completed NCT NCT00711477

  A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese Subjects

  Not yet reported Orexigen Therapeutics, Inc 46 participants Est. completion 2010-06 1 site
  Other conditions: Obesity
  View official trial listing →
• Completed NCT NCT01359930

  Phase 1 Naltrexone-Bupropion-Methamphetamine Interaction Study

  Not yet reported National Institute on Drug Abuse (NIDA) 16 participants Est. completion 2012-06 1 site
  Other conditions: Methamphetamine Dependence
  View official trial listing →
• Terminated NCT NCT01601704

  Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)

  Not yet reported Orexigen Therapeutics, Inc 8910 participants Est. completion 2015-08 224 sites
  Other conditions: Obesity, Overweight
  View official trial listing →
• Completed NCT NCT01739192

  A Novel Anti-Obesity Drug Combination as a Pharmacotherapy for Cocaine Dependence

  Not yet reported Craig Rush 34 participants Est. completion 2018-06 1 site
  Other conditions: Cocaine Use Disorders
  View official trial listing →
• Completed NCT NCT01764386

  Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects

  Not yet reported Orexigen Therapeutics, Inc 242 participants Est. completion 2014-09 15 sites
  Other conditions: Obesity, Overweight
  View official trial listing →
• Completed NCT NCT01982643

  Accelerated Development of Additive Pharmacotherapy Treatment for Methamphetamine Use Disorder

  Not yet reported, Not yet reported Walter Ling 49 participants Est. completion 2015-02 3 sites
  Other conditions: Methamphetamine Use Disorder
  View official trial listing →
• Completed NCT NCT02259179

  Bioequivalence Study Comparing Naltrexone SR/Bupropion SR Trilayer Tablets From Two Manufacturers

  Not yet reported Orexigen Therapeutics, Inc 80 participants Est. completion 2014-12 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT02317744

  Treatment of Binge Eating Disorder in Obesity: Naltrexone/ Bupropion Combination Versus Placebo

  Not yet reported Yale University 22 participants Est. completion 2016-09 1 site
  Other conditions: Binge Eating Disorder
  View official trial listing →
• Withdrawn NCT NCT02616315

  Efficacy of Naltrexone HCl/Bupropion HCl Extended Release Versus Placebo for Treatment of Weight Regain in Participants Post Bariatric Surgery

  Not yet reported Takeda Est. completion 2017-12 2 sites
  Other conditions: Weight Regain Post Bariatric Surgery
  View official trial listing →
• Terminated NCT NCT02638129

  Naltrexone/Bupropion Cardiovascular Outcomes Study

  Not yet reported Orexigen Therapeutics, Inc 67 participants Est. completion 2016-06 139 sites
  Cardiovascular disease Other conditions: Obesity
  View official trial listing →
• Completed NCT NCT02735603

  Study to Evaluate the Effect of Naltrexone and Bupropion Extended-Release Combination on Cardiac Repolarization in Healthy Participants

  Not yet reported Orexigen Therapeutics, Inc 84 participants Est. completion 2016-10 1 site
  Other conditions: Heart Repolarization
  View official trial listing →
• Completed NCT NCT02736474

  Naltrexone and Bupropion Combination on Obese,Smoking Patients With Schizophrenia

  Not yet reported Shanghai Mental Health Center 22 participants Est. completion 2018-07
  Other conditions: Obese, Cigarette-smoking, Schizophrenia
  View official trial listing →
• Completed NCT NCT02745912

  Study to Evaluate the Effect of Naltrexone and Bupropion Combination on the Pharmacokinetics of Metformin in Healthy Participants

  Not yet reported Orexigen Therapeutics, Inc 30 participants Est. completion 2016-08
  Other conditions: Healthy Subjects
  View official trial listing →
• Completed NCT NCT02842073

  An Open Label Trial of Bupropion and Naltrexone for Binge Drinking

  Not yet reported University of North Carolina, Chapel Hill 12 participants Est. completion 2017-12-13 1 site
  Other conditions: Binge Drinking
  View official trial listing →
• Completed NCT NCT03045341

  Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment

  Not yet reported, Not yet reported Yale University 136 participants Est. completion 2022-12-16 1 site
  Other conditions: Binge-eating Disorder, Obesity
  View official trial listing →
• Completed NCT NCT03047005

  Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy

  Not yet reported, Not yet reported Yale University 68 participants Est. completion 2022-12-16 1 site
  Other conditions: Binge-Eating Disorder, Obesity
  View official trial listing →
• Completed NCT NCT03063606

  Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment

  Not yet reported, Not yet reported Yale University 31 participants Est. completion 2022-12-16 1 site
  Other conditions: Binge-Eating Disorder, Obesity
  View official trial listing →
• Completed NCT NCT03078075

  Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT-2) for Methamphetamine Use Disorder

  Not yet reported University of Texas Southwestern Medical Center 403 participants Est. completion 2019-07-25 8 sites
  Other conditions: Methamphetamine Use Disorder
  View official trial listing →
• Terminated NCT NCT03132571

  Naltrexone-Bupropion Versus Placebo-Bupropion for Weight Loss in Schizophrenia

  Not yet reported Yale University 5 participants Est. completion 2018-07-31 1 site
  Type 2 diabetes Other conditions: Schizophrenia, Obesity
  View official trial listing →
• Completed NCT NCT03374956

  Individualized Obesity Pharmacotherapy

  Not yet reported Mayo Clinic 193 participants Est. completion 2022-05-26 1 site
  Other conditions: Obesity
  View official trial listing →
• Completed NCT NCT03431831

  Assessment of and Treatment Applied to Food Addiction in a Rural Healthy Behaviors Clinic

  Not yet reported University of Nebraska 86 participants Est. completion 2022-07-01 2 sites Stand-alone
  Other conditions: Obesity
  View official trial listing →
• Completed NCT NCT03539900

  Efficacy and Mechanisms of Naltrexone+Bupropion for Binge Eating Disorder

  Not yet reported, Not yet reported Yale University 89 participants Est. completion 2023-03-22 1 site
  Other conditions: Binge-Eating Disorder
  View official trial listing →
• Completed NCT NCT03581630

  Effects of Mediterranean Diet and Naltrexone/Bupropion Treatment in Obese Breast Cancer Patients

  Not yet reported Gangnam Severance Hospital 72 participants Est. completion 2018-07-22 1 site
  Other conditions: Breast Cancer, Obesity, Overweight
  View official trial listing →
• Completed NCT NCT03799198

  Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity

  Not yet reported Novo Nordisk A/S 200 participants Est. completion 2020-05-22 1 site Stand-alone
  Other conditions: Obesity
  View official trial listing →
• Completed NCT NCT03946111

  Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders

  Not yet reported, Not yet reported Yale University 3 participants Est. completion 2024-12-05 1 site
  Other conditions: Binge-Eating Disorder, Obesity
  View official trial listing →
• Withdrawn NCT NCT04399395

  Naltrexone/Bupropion (Mysimba) to Optimize Weight Outcomes After Obesity Surgery

  Not yet reported Oslo University Hospital Est. completion 2022-12-31
  Other conditions: Obesity
  View official trial listing →
• Completed NCT NCT04499950

  Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study

  Not yet reported Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 53 participants Est. completion 2024-01-10 1 site Stand-alone
  Other conditions: Breast Cancer, Overweight or Obesity
  View official trial listing →
• Terminated NCT NCT04531176

  EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial

  Not yet reported The Cleveland Clinic 74 participants Est. completion 2023-08-04 1 site
  Type 2 diabetes Other conditions: Obesity
  View official trial listing →
• Withdrawn NCT NCT04553263

  Relapse Prevention in Stimulant Use Disorder

  Not yet reported University of California, Los Angeles Est. completion 2025-01-11 1 site Stand-alone
  Other conditions: Stimulant Use, Relapse, Cognitive Function, ADHD
  View official trial listing →
• Status unknown NCT NCT04575194

  Study of the Cardiometabolic Effects of Obesity Pharmacotherapy

  Not yet reported National and Kapodistrian University of Athens 40 participants Est. completion 2023-05-30 1 site
  Other conditions: Obesity, Blood Pressure
  View official trial listing →
• Status unknown NCT NCT04587843

  A Trial Evaluating the Effectiveness of Contrave in Patients Who Have Weight Recidivism Following Bariatric Surgery

  Not yet reported St. Joseph's Healthcare Hamilton 18 participants Est. completion 2023-12-31 4 sites Stand-alone
  Other conditions: Obesity
  View official trial listing →
• Status unknown NCT NCT04589130

  Evaluating Contrave for Weight Maintenance in Adults With BMI >= 27 Kg/m2, After 6 Month Behaviour Modification Program.

  Not yet reported St. Joseph's Healthcare Hamilton 89 participants Est. completion 2023-12-31 3 sites Stand-alone
  Other conditions: Obesity
  View official trial listing →
• Completed NCT NCT04599478

  Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1)

  Not yet reported, Not yet reported Yale University 92 participants Est. completion 2026-06-04 1 site
  Other conditions: Loss-of-control Eating, Obesity/Overweight
  View official trial listing →
• Completed NCT NCT04605081

  Pharmacological and Behavioral Treatments After Bariatric Surgery: Maintenance Treatment (Stage 2a)

  Not yet reported, Not yet reported Yale University 24 participants Est. completion 2026-06-04 1 site
  Other conditions: Loss-of-Control Eating, Obesity/Overweight
  View official trial listing →
• Completed NCT NCT04662801

  Weight Regain Treatment Post-Bariatric Surgery

  Not yet reported, Not yet reported Yale University 26 participants Est. completion 2022-09-13 1 site
  Other conditions: Obesity, Overweight
  View official trial listing →
• Status unknown NCT NCT04902625

  Use of Mysimba in Patients With Weight Regain After Bariatric Surgery

  Not yet reported Zuyderland Medisch Centrum 116 participants Est. completion 2025-03 1 site
  Other conditions: Obesity, Morbid, Bariatric Surgery Candidate, Medication Persistence
  View official trial listing →
• Completed NCT NCT05157698

  Pharmacological and Behavioral Treatment After Bariatric Surgery

  Not yet reported Yale University 84 participants Est. completion 2026-05-25 1 site
  Other conditions: Obesity
  View official trial listing →
• Enrolling by invitation NCT NCT05503927

  A Study to Evaluate the Safety of Exposure to Wegovy During Pregnancy

  Novo Nordisk A/S 2701 participants Est. completion 2027-08-15 2 sites
  Other conditions: Pregnancy, Obesity, Overweight
  View official trial listing →
• Completed NCT NCT05579249

  A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America

  Not yet reported Novo Nordisk A/S 500 participants Est. completion 2024-11-27 1 site
  Other conditions: Obesity
  View official trial listing →
• Active, not recruiting NCT NCT05756764

  Anti-obesity Pharmacotherapy and Inflammation

  Louisiana State University Health Sciences Center in New Orleans 30 participants Est. completion 2026-02-20 2 sites
  Other conditions: Obesity
  View official trial listing →
• Withdrawn NCT NCT05812183

  Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity

  Not yet reported University of California, Los Angeles Est. completion 2025-02-12 Stand-alone
  Other conditions: Dyspnea, Quality of Life
  View official trial listing →
• Completed NCT NCT06089824

  Drug Utilisation of Mysimba/Contrave

  Currax Pharmaceuticals 43324 participants Est. completion 2022-10 1 site
  Other conditions: Obesity
  View official trial listing →
• Completed NCT NCT06090461

  Real-World Evidence on the Cardiovascular Safety of CONTRAVE® in the United States (U.S.)

  Currax Pharmaceuticals 31889 participants Est. completion 2022-12 1 site
  Other conditions: Obesity
  View official trial listing →
• Active, not recruiting NCT NCT06098079

  Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)

  Not yet reported Currax Pharmaceuticals 8600 participants Est. completion 2029-07 140 sites
  Other conditions: Obesity
  View official trial listing →
• Active, not recruiting NCT NCT06233799

  Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder

  Not yet reported National Institute on Drug Abuse (NIDA) 360 participants Est. completion 2027-04-30 11 sites
  Other conditions: Methamphetamine-dependence, Methamphetamine Abuse
  View official trial listing →
• Terminated NCT NCT06374290

  Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia

  Not yet reported The University of Texas Health Science Center, Houston 2 participants Est. completion 2024-12-04 1 site
  Other conditions: Smoking Cessation
  View official trial listing →
• Completed NCT NCT06482411

  Risk Factors Affect Weight Loss Outcomes After Treatment.

  E-DA Hospital 3602 participants Est. completion 2025-10-22 1 site
  Other conditions: Weight Regain
  View official trial listing →
• Completed NCT NCT06605703

  A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)

  Not yet reported WW International Inc 226 participants Est. completion 2026-02-05 1 site
  Other conditions: Obesity, Overweight
  View official trial listing →
• Enrolling by invitation NCT NCT06845345

  Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study)

  Not yet reported Carmen Dietvorst 70 participants Est. completion 2027-07 1 site
  Type 2 diabetesMASLD Other conditions: Liver Fibrosis, Liver Steatoses, Hepatic Steatosis, Hepatic Fibrosis, Overweight or Obesity, Cardio-metabolic Risk, Cardio-metabolic Health, Hypertension, Dyslipidaemia
  View official trial listing →
• Active, not recruiting NCT NCT06854614

  Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial)

  Not yet reported The Cleveland Clinic 150 participants Est. completion 2028-04-28 1 site Stand-alone
  Other conditions: Obesity
  View official trial listing →
• Active, not recruiting NCT NCT06877572

  Weight Loss Management in Endometrial Cancer Survivors

  University of Kansas Medical Center 50 participants Est. completion 2030-10 1 site
  Other conditions: Endometrial Cancer Survivors, Weight Management, Early Stage Endometrial Cancer
  View official trial listing →
• Not yet recruiting NCT NCT07001371

  Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study

  Not yet reported Loma Linda University 54 participants Est. completion 2027-08 1 site
  Substance use disorderAlcohol use disorder Other conditions: Cannabis Use Disorder, Stimulant Use Disorder, Tobacco Use Disorder, Sedative, Hypnotic, or Anxiolytic Use Disorders
  View official trial listing →
• Active, not recruiting NCT NCT07188545

  Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH)

  Ohio State University 23280000 participants Est. completion 2029-06-30 1 site
  Metabolic syndrome
  View official trial listing →
• Not yet recruiting NCT NCT07211724

  Methamphetamine Use Disorder Support in Heart Failure Pilot Study

  Not yet reported University of Southern California 50 participants Est. completion 2027-07 2 sites
  Heart failure Other conditions: Methamphetamine Use Disorder
  View official trial listing →
• Not yet recruiting NCT NCT07224087

  Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

  Not yet reported Medical University of South Carolina 20 participants Est. completion 2027-12-31 1 site
  Other conditions: Obesity, Smoking Cessation, Bariatric Surgery Patients
  View official trial listing →
• Not yet recruiting NCT NCT07398404

  A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

  Not yet reported, Not yet reported Medical University of South Carolina 64 participants Est. completion 2031-06-30 1 site
  Other conditions: Obesity, Smoking Cessation, Bariatric Surgery Patients
  View official trial listing →
• Not yet recruiting NCT NCT07728812

  Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy

  Not yet reported Phenomix Sciences 424 participants Est. completion 2029-01-01 Stand-alone
  Other conditions: Obesity & Overweight
  View official trial listing →
• Completed NCT NCT07753447

  Calorie Restricted Dietary Intervention in Type 2 Diabetes Patients With Obesity for Remission

  Not yet reported Yeouido St. Mary's Hospital 25 participants Est. completion 2026-02-28 1 site Stand-alone
  Other conditions: Diabetes, Type 2, Obesity &Amp; Overweight
  View official trial listing →
• Not yet recruiting NCT NCT07832084

  Comparing Different Medication Regimens to Maintaining Weight Loss Among Adults With Obesity Using GLP-1s

  Not yet reported Jing Luo 60 participants Est. completion 2028-09-30 1 site
  Other conditions: Obesity & Overweight, Cardiometabolic Health Indicators
  View official trial listing →

Not yet reported.

Not yet reported.

• ClinicalTrials.gov — NCT06854614

Also known as: Naltrexone-Bupropion, Contrave

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