About this data
Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.
Lactulose
- Company
- General Hospital of Shenyang Military Region
- Mechanism
- Mechanism not yet reported
- Route
- Route not yet reported
- Recruiting trials
- 17 recruiting
Efficacy results: Not yet reported
17 recruiting studies currently listed on ClinicalTrials.gov.
Data source: ClinicalTrials.gov · trial data as of Sep 26, 2026
Find a Clinical Trial Near Me
See recruiting studies for Lactulose and check eligibility with the study team.
Trial details
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Recruiting NCT NCT04073290
Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose
Not yet reported Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 238 participants Est. completion 2026-12-31 6 sitesOther conditions: Hepatic Encephalopathy, Cirrhosis, Liver, Portal Hypertension, Liver Diseases, Pathological ProcessesView official trial listing → -
Recruiting NCT NCT05054361
Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children
Institut National de la Santé Et de la Recherche Médicale, France 180 participants Est. completion 2027-08-14 2 sitesOther conditions: Type1diabetesView official trial listing → -
Recruiting NCT NCT05849012
A Pilot Study Examining Low Sulfur Diet as Treatment for Persistent Symptoms in Quiescent Crohn's Disease
Not yet reported University of Michigan 20 participants Est. completion 2027-04-30 1 site Stand-aloneOther conditions: Crohn's Disease in RemissionView official trial listing → -
Recruiting NCT NCT06317441
The Safety And Efficacy Of A Probiotic Intervention On Lactulose Hydrogen Breath Test-Positive Patients And Related Gastrointestinal Symptoms
Not yet reported Nimble Science Ltd. 105 participants Est. completion 2026-12 1 siteOther conditions: Small Intestinal Bacterial Overgrowth, SIBOView official trial listing → -
Recruiting NCT NCT06483737
Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)
Not yet reported General Hospital of Shenyang Military Region 174 participants Est. completion 2027-06-30 1 site Stand-aloneOther conditions: Overt Hepatic EncephalopathyView official trial listing → -
Recruiting NCT NCT06538077
BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HE
Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 336 participants Est. completion 2027-08 1 site Stand-aloneOther conditions: Hepatic Encephalopathy, Decompensated Cirrhosis, Minimal Hepatic EncephalopathyView official trial listing → -
Recruiting NCT NCT06768827
New Mechanisms of Obesity
Not yet reported Yale University 55 participants Est. completion 2030-03-31 1 site Stand-aloneOther conditions: Obesity and Overweight, Insulin Resistance, Obesity and Obesity-related Medical ConditionsView official trial listing → -
Recruiting NCT NCT06802042
Effect of Lactobacillus DSM17938+ on Functional Constipation and Intestinal Flora in Pregnant Women
Not yet reported Peking Union Medical College Hospital 40 participants Est. completion 2026-12-31 2 sitesOther conditions: Functional Constipation (FC)View official trial listing → -
Recruiting NCT NCT06835361
Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Women with Candidal Vaginitis/Vulvovaginitis
Not yet reported, Not yet reported AVVA Pharmaceuticals Ltd. 264 participants Est. completion 2025-11-30 7 sites Stand-aloneOther conditions: Candidal Vulvovaginitis (ICD-10 Code: B37.3), Vulvovaginal Candidiasis (VVC)View official trial listing → -
Recruiting NCT NCT07002827
Effect of Single vs Repeated Cycles of a Combination of Granulocyte Colony Stimulating Factor and Darbepoetin vs Standard Medical Treatment on Immunometabolic Profile in Patient With Early Decompensated Cirrhosis.
Not yet reported Institute of Liver and Biliary Sciences, India 60 participants Est. completion 2026-12-30 1 site Stand-aloneOther conditions: Decompensated Liver CirrhosisView official trial listing → -
Recruiting NCT NCT07060222
Intestinal Preparation in Colonoscopy: Lactulose vs Sodium Phosphate.
Not yet reported Hospital Civil de Guadalajara 300 participants Est. completion 2026-12-31 4 sitesOther conditions: Bowel Preparation for ColonoscopyView official trial listing → -
Recruiting NCT NCT07065942
Effects of Lactulose on Gut Microbiota and Metabolism in Diabetic Constipated Patients
Not yet reported Peking Union Medical College Hospital 60 participants Est. completion 2026-07-30 1 site Stand-aloneOther conditions: Diabetes Mellitus, Constipation - FunctionalView official trial listing → -
Recruiting NCT NCT07354100
Lactulose to Improve Gut Health in Cancer Patients Receiving Immunotherapy
Not yet reported, Not yet reported University of Chicago 55 participants Est. completion 2029-04-13 1 site Stand-aloneOther conditions: CancerView official trial listing → -
Recruiting NCT NCT07501078
Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation
Not yet reported Muhammad N Aslam, MD 52 participants Est. completion 2029-06 1 site Stand-aloneOther conditions: Ulcerative Colitis, Ileal PouchView official trial listing → -
Recruiting NCT NCT07589465
Oral Lactulose for Gastrointestinal Recovery After Complex Appendectomy
Not yet reported Nanchong Central Hospital 150 participants Est. completion 2029-06-30 1 site Stand-aloneOther conditions: Ileus Postoperative, Gastrointestinal Function, Complicated AppendicitisView official trial listing → -
Recruiting NCT NCT07683936
Fecal Microbiota Transplantation for the Treatment of Refractory Hepatic Encephalopathy After TIPS Surgery
Not yet reported Air Force Military Medical University, China 26 participants Est. completion 2028-06-01 1 site Stand-aloneOther conditions: Hepatic Encephalopathy, Fecal Microbiota Transplantation, TIPS, Refractory Hepatic EncephalopathyView official trial listing → -
Recruiting NCT NCT07813975
Evaluating the Impact of Vitamin D Supplementation on Healing Bed Sores in ICU.
Not yet reported Maha Salah 50 participants Est. completion 2027-03 1 siteOther conditions: Bed SoresView official trial listing → -
Completed NCT NCT00001337
Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma
Not yet reported National Cancer Institute (NCI) 348 participants Est. completion 2024-05-24 5 sites Stand-aloneOther conditions: Diffuse Large B-Cell Lymphoma (DLBCL), Primary Mediastinal Large B-cell Lymphoma, Burkitt Lymphoma, Anaplastic Large-Cell Lymphoma, Gray Zone LymphomaView official trial listing → -
Completed NCT NCT00004796
Phase II Study of Lactulose and Circadian Rhythms in Patients With Cirrhosis
Not yet reported National Center for Research Resources (NCRR) 16 participants Est. completion 1997-02Other conditions: Portal Hypertension, Hepatic Encephalopathy, CirrhosisView official trial listing → -
Completed NCT NCT00083382
Combination Bisphosphonate and Anti-Angiogenesis Therapy With Pamidronate and Thalidomide
Not yet reported University of Arkansas 83 participants Est. completion 2014-05 1 site Stand-aloneOther conditions: Multiple MyelomaView official trial listing → -
Completed NCT NCT00160264
Study to Investigate if Adding Lactulose to Vitamin D and Calcium Has an Effect on the Preservation of Bone in Postmenopausal Women
Not yet reported Solvay Pharmaceuticals 40 participants 3 sitesOther conditions: OsteopeniaView official trial listing → -
Terminated NCT NCT00160290
Trial to Evaluate Effect of Lactulose on Hard Stools in Patients With Hemorrhoids or Anal Fissures
Not yet reported Solvay Pharmaceuticals 97 participants Est. completion 2006-06 8 sites Stand-aloneOther conditions: Hemorrhoids, Anal FissuresView official trial listing → -
Status unknown NCT NCT00227487
Intestinal Inflammation and Carbohydrate Digestion in Autistic Children
Not yet reported Massachusetts General Hospital 115 participants Est. completion 2017-12 2 sitesOther conditions: Autism, InflammationView official trial listing → -
Completed NCT NCT00255372
To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence.
Not yet reported Ipsen 88 participants Est. completion 2008-05-20 2 sitesOther conditions: Chronic ConstipationView official trial listing → -
Status unknown NCT NCT00273949
Lactulose for the Prevention of Nosocomial Infections in Children
Not yet reported Bnai Zion Medical Center 100 participants Est. completion 2007-01 1 siteOther conditions: Nosocomial InfectionView official trial listing → -
Completed NCT NCT00276354
Study of Long-term Use of Forlax® in Elderly Patients With Chronic Constipation
Not yet reported Ipsen 246 participants Est. completion 2001-11-20 146 sitesOther conditions: ConstipationView official trial listing → -
Terminated NCT NCT00364689
RICE Trial: Rifaximin In Chronic Hepatic Encephalopathy - A Randomized, Controlled Trial
Not yet reported University of Miami 13 participants Est. completion 2008-07 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT00375375
Effect of Lactulose on Minimal Hepatic Encephalopathy and Health-Related Quality of Life
Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 80 participants Est. completion 2004-12 1 siteOther conditions: Minimal Hepatic Encephalopathy, Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT00403858
Movicol in Childhood Constipation (ProMotion Study)
Not yet reported Norgine 60 participants Est. completion 2002-04 1 siteOther conditions: Feces, ImpactedView official trial listing → -
Completed NCT NCT00404040
Movicol in Childhood Constipation (ProMotion Study)
Not yet reported Norgine 60 participants Est. completion 2002-07 1 siteOther conditions: Chronic ConstipationView official trial listing → -
Completed NCT NCT00508482
A Clinical Standardization Study of the Preferred Acupuncture Treatment Protocol to Treat Functional Constipation
Not yet reported Guang'anmen Hospital of China Academy of Chinese Medical Sciences 475 participants Est. completion 2011-11 1 siteOther conditions: ConstipationView official trial listing → -
Status unknown NCT NCT00553423
Lactulose for the Prevention of Hepatic Encephalopathy in Cirrhotic Patients With Upper Gastrointestinal Hemorrhage
Not yet reported Aga Khan University 128 participants Est. completion 2008-11 2 sites Stand-aloneOther conditions: Hepatocerebral Encephalopathy, Portal-Systemic Encephalopathy, Encephalopathy, Hepatic, Encephalopathy, HepatocerebralView official trial listing → -
Completed NCT NCT00558038
Safety and Efficacy of AST-120 Compared to Lactulose in Patients With Hepatic Encephalopathy
Not yet reported Ocera Therapeutics 40 participants Est. completion 2009-06 17 sitesOther conditions: Hepatic EncephalopathyView official trial listing → -
Terminated NCT NCT00577772
Transit Time and Bacterial Overgrowth Using SmartPill Capsule
Not yet reported Mayo Clinic 17 participants Est. completion 2010-07 1 siteOther conditions: Small Bowel Bacterial Overgrowth, Gastrointestinal Diseases, Stomach Diseases, Digestive System DiseasesView official trial listing → -
Completed NCT NCT00616876
Lactulose Supplementation in Premature Infants
Not yet reported Bnai Zion Medical Center 28 participants Est. completion 2007-01 1 site Stand-aloneOther conditions: Necrotizing Enterocolitis, SepsisView official trial listing → -
Completed NCT NCT00619970
Is Chronic Abdominal Pain in Pediatric Patients Due to Small Intestinal Bacterial Overgrowth?
Not yet reported Children's Hospital Los Angeles 115 participants Est. completion 2008-09 1 siteOther conditions: Chronic Abdominal Pain, Small Intestinal Bacterial OvergrowthView official trial listing → -
Completed NCT NCT00701792
Liver Transplantation Versus Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis
Not yet reported Centre Hospitalier Universitaire de Besancon 120 participants Est. completion 2006-11 13 sitesOther conditions: CirrhosisView official trial listing → -
Completed NCT NCT00712543
A Preference Study Comparing Kristalose® and Liquid Lactulose
Not yet reported Cumberland Pharmaceuticals 50 participants Est. completion 2009-09 3 sites Stand-aloneOther conditions: ConstipationView official trial listing → -
Withdrawn NCT NCT00732108
Is Topiramate Effective in Treating Dizziness in Patient's With Migraine-Associated Dizziness
Not yet reported University of California, San Francisco 1 siteOther conditions: Migraine, Headache, DizzinessView official trial listing → -
Completed NCT NCT00740142
Efficacy of Combined Oral L-ornithine-L-aspartate and Lactulose in Patients With Hepatic Encephalopathy
Not yet reported Mahidol University 35 participants Est. completion 2011-10 1 siteOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT00745147
Comparison of TCM and Laxatives for Adults With Chronic Constipation
Not yet reported National Taiwan University Hospital 93 participants Est. completion 2010-04 1 siteOther conditions: Chronic ConstipationView official trial listing → -
Withdrawn NCT NCT00748904
Rifaximin Versus Lactulose in Renal Failure
Not yet reported Weill Medical College of Cornell University Est. completion 2009-07 1 site Stand-aloneOther conditions: Liver Cirrhosis, Renal FailureView official trial listing → -
Completed NCT NCT00781131
Trial of Pregabalin for Post-operative Pain in Women Undergoing Abdominal Hysterectomy
Not yet reported IWK Health Centre 101 participants Est. completion 2011-01 1 siteOther conditions: Postoperative Pain, Opioid UseView official trial listing → -
Completed NCT NCT00785382
Pregabalin for Postoperative Pain in Women Undergoing Breast Cancer Surgery
Not yet reported IWK Health Centre 62 participants Est. completion 2011-12 1 siteOther conditions: Postoperative PainView official trial listing → -
Status unknown NCT NCT00785603
Paroxetines Effect on Tramadols Metabolism and Pharmakodynamics: a Dose Response Study
Not yet reported University of Southern Denmark 12 participants Est. completion 2009-02Other conditions: Depression, PainView official trial listing → -
Terminated NCT NCT00811434
Study of Lactulose in Children With Chronic Liver Disease
Not yet reported Indiana University 16 participants Est. completion 2010-11 1 siteOther conditions: Minimal Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT00829777
Safety Study of Intravenous 6β-Naltrexol (AIKO-150) in Opioid-Dependent Subjects
Not yet reported California Pacific Medical Center Research Institute 8 participants Est. completion 2009-09 1 siteOther conditions: Opiate AddictionView official trial listing → -
Completed NCT NCT00914056
A Study of Controlled Lactulose Withdrawal
Not yet reported Hunter Holmes Mcguire Veteran Affairs Medical Center 7 participants Est. completion 2012-05 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Status unknown NCT NCT00956150
Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex
Not yet reported Henry C. Lin, MD 210 participants 1 site Stand-aloneOther conditions: Gulf War SyndromeView official trial listing → -
Completed NCT NCT00956397
Does Small Intestinal Bacterial Overgrowth Contribute to Functional Dyspepsia
Not yet reported Henry C. Lin, MD 55 participants 1 siteOther conditions: Functional Dyspepsia, Small Intestinal Bacterial Overgrowth, Chronic Abdominal DiscomfortView official trial listing → -
Completed NCT NCT01008293
Effect of Probiotics in Treatment of Minimal Hepatic Encephalopathy (MHE) and Health Related Quality of Life
Not yet reported, Not yet reported CD Pharma India Pvt. Ltd. 120 participants Est. completion 2012-10 1 siteOther conditions: Chronic Liver Disease, Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT01070212
Effects of Gum Chewing on Appetite and Digestion
Not yet reported Purdue University 60 participants Est. completion 2012-01 2 sites Stand-aloneOther conditions: The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices, The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake, It is Hypothesized That the Effects of Mastication Will be Less Evident in Obese Compared to Lean IndividualsView official trial listing → -
Completed NCT NCT01084473
Effect of Dexmedetomidine on Gastric Emptying and Gastrointestinal Transit
Not yet reported University of Turku 12 participants Est. completion 2010-06 1 site Stand-aloneOther conditions: Gastric Emptying, HealthyView official trial listing → -
Completed NCT NCT01090193
Human Kidney Histopathology in Obstructive Jaundice
Not yet reported Turkish Ministry of Health Izmir Teaching Hospital 20 participants Est. completion 2010-03 1 siteOther conditions: Patients With Obstructive JaundiceView official trial listing → -
Completed NCT NCT01124318
A Pilot Study of Lactofiltrum to Treat Atopic Dermatitis in Adults
Not yet reported, Not yet reported Avva Rus, JSC 90 participants Est. completion 2010-09 2 sitesOther conditions: Atopic DermatitisView official trial listing → -
Status unknown NCT NCT01175538
Primary Prophylaxis of Hepatic Encephalopathy in Patients With Cirrhosis
Not yet reported Govind Ballabh Pant Hospital Est. completion 2010-09 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Status unknown NCT NCT01178372
Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhosis
Not yet reported Govind Ballabh Pant Hospital Est. completion 2010-09 1 siteOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT01190020
Effect of Lubiprostone on Methanogenesis and Bowel Function in Chronic Constipation.
Not yet reported Augusta University 41 participants Est. completion 2012-03 2 sitesOther conditions: Chronic Constipation, MethanogenesisView official trial listing → -
Completed NCT NCT01218568
Rifaximin Plus Lactulose Versus Lactulose Alone for the Treatment of Hepatic Encephalopathy: a Double Blind Randomized Trial
Not yet reported Institute of Liver and Biliary Sciences, India 120 participants Est. completion 2012-10 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT01231828
Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies.
Not yet reported University Hospital, Caen 55 participants Est. completion 2012-12 1 site Stand-aloneOther conditions: CirrhosisView official trial listing → -
Completed NCT NCT01252550
Effects of Activia in IBS
Not yet reported Sahlgrenska University Hospital 100 participants Est. completion 2014-08 3 sitesOther conditions: Irritable Bowel SyndromeView official trial listing → -
Completed NCT NCT01256541
Kristalose as Bowel Evacuant Prior to Colonoscopy
Not yet reported Benaroya Research Institute 20 participants Est. completion 2011-09 1 siteOther conditions: Bowel Evacuant Prior to ColonoscopyView official trial listing → -
Completed NCT NCT01283152
Efficacy Study of Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®) Versus Lactulose in Patients With Hepatic Encephalopathy.
Not yet reported University of Texas Southwestern Medical Center 50 participants Est. completion 2012-06 1 siteOther conditions: Hepatic Encephalopathy, Cirrhosis, Portosystemic Encephalopathy, PSEView official trial listing → -
Status unknown NCT NCT01295138
Pilot Study of the Effect of Lactulose on Post Caesarean Section Constipation
Not yet reported NHS Fife 30 participants Est. completion 2012-07 1 site Stand-aloneOther conditions: Constipation, Abdominal Pain, Nausea, VomitingView official trial listing → -
Completed NCT NCT01380366
rHGH and Intestinal Permeability in Intestinal Failure
Not yet reported Northwestern University 15 participants Est. completion 2015-02 1 siteOther conditions: Short Bowel SyndromeView official trial listing → -
Completed NCT NCT01446523
S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE
Not yet reported Govind Ballabh Pant Hospital 60 participants Est. completion 2012-02 1 siteOther conditions: Hepatic EncephalopathyView official trial listing → -
Status unknown NCT NCT01587846
Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children
Not yet reported Sisters of Mercy University Hospital 300 participants Est. completion 2013-10 1 site Stand-aloneOther conditions: Abdominal Pain, Constipation - FunctionalView official trial listing → -
Status unknown NCT NCT01596192
PETCT for Diagnosing and Monitoring Acute GVHD
Rabin Medical Center 30 participants Est. completion 2013-06 1 siteOther conditions: Acute Graft Versus Host DiseaseView official trial listing → -
Completed NCT NCT01607060
Impact of Laxative Therapy With Lactulose in the Evolution of Organ Dysfunction in Critically Ill Patients.
Not yet reported Federal University of São Paulo 88 participants 1 siteOther conditions: ConstipationView official trial listing → -
Completed NCT NCT01641913
Intestinal Permeability in Response to Treatment in Eosinophilic Esophagitis Patients
Not yet reported Mayo Clinic 20 participants Est. completion 2014-02 1 site Stand-aloneOther conditions: Eosinophilic EsophagitisView official trial listing → -
Completed NCT NCT01650870
Safety, Efficacy, and Patient Preference of Split-Dose Crystalline Lactulose as a Preparation for Colonoscopy in Adults
Not yet reported Benaroya Research Institute 40 participants Est. completion 2012-09 1 site Stand-aloneOther conditions: ColonoscopyView official trial listing → -
Terminated NCT NCT01716052
Women's Mammography Study To Improve Comfort During Mammography
Not yet reported Kenneth A. Kist, 2 participants Est. completion 2013-06 1 siteOther conditions: PainView official trial listing → -
Completed NCT NCT01756040
Intestinal Permeability in Preterm Infants
Not yet reported University of Maryland, Baltimore 211 participants Est. completion 2021-08-31 1 siteOther conditions: Prematurity, Intestinal PermeabilityView official trial listing → -
Completed NCT NCT01773538
Diagnosis of Covert/Minimal Hepatic Encephalopathy by Means of Continuous Reaction Time Measurement
Not yet reported Mette Munk Lauridsen 136 participants Est. completion 2015-11 2 sitesOther conditions: Liver Cirrhosis, Hepatic EncephalopathyView official trial listing → -
Status unknown NCT NCT01803724
Lactulose and Glucose Breath Tests as Predictors of Clinical Benefit From Rifaximin in Irritable Bowel Syndrome
Pontificia Universidad Catolica de Chile 120 participants Est. completion 2014-12 1 siteOther conditions: Irritable Bowel SyndromeView official trial listing → -
Completed NCT NCT01811836
Zinc Resistant Starch Project
Not yet reported Washington University School of Medicine 20 participants Est. completion 2013-07 1 site Stand-aloneOther conditions: EnteropathyView official trial listing → -
Withdrawn NCT NCT01818648
Exenatide on GI Motor Function and Permeability in Short Bowel Syndrome
Not yet reported Mayo Clinic Est. completion 2014-01 Added to GLP-1Other conditions: Short Bowel SyndromeView official trial listing → -
Completed NCT NCT01829932
The Effect of Prebiotics on the Microbiome in Irritable Bowel Syndrome Patients: The Diet and Microbiome Study
Not yet reported Queen's University 30 participants Est. completion 2014-12 1 siteOther conditions: Irritable Bowel SyndromeView official trial listing → -
Terminated NCT NCT01842113
Quality of Life and Nutritional Improvements in Cirrhotic Patients
Not yet reported Tampa General Hospital 4 participants 1 siteOther conditions: Liver Cirrhosis, Hepatic Encephalopathy, Portal HypertensionView official trial listing → -
Completed NCT NCT01842581
The Safety/Efficacy of Rifaximin With/Without Lactulose in Participants With A History of Recurrent Hepatic Encephalopathy
Not yet reported Bausch Health Americas, Inc. 222 participants Est. completion 2014-12-17 43 sites Stand-aloneOther conditions: Hepatic Encephalopathy, CirrhosisView official trial listing → -
Completed NCT NCT01887470
2 Regimens of Lactulose for Colonoscopy Preparation in Adults
Not yet reported Cumberland Pharmaceuticals 55 participants Est. completion 2013-10 1 site Stand-aloneOther conditions: Colonoscopy PreparationView official trial listing → -
Withdrawn NCT NCT01923376
Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.)
Not yet reported New York Presbyterian Brooklyn Methodist Hospital Est. completion 2014-02 1 siteOther conditions: Hepatic Encephalopathy, HE, Cirrhosis, Altered Mental Status, AMSView official trial listing → -
Completed NCT NCT01956929
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.
Not yet reported Mayo Clinic 12 participants Est. completion 2016-03 1 siteOther conditions: Insulin Resistance, Prediabetic StateView official trial listing → -
Completed NCT NCT02017119
Comparison Between Lactulose and Lactulose-Paraffin in Cirrhotic Patients
Not yet reported Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran 40 participants Est. completion 2014-06 1 site Stand-aloneOther conditions: Cirrhosis, Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT02024425
Functional Bioactive Supplement Effect in Lost Weight Treatment
Not yet reported Instituto de Investigación Hospital Universitario La Paz 109 participants Est. completion 2014-01 1 siteOther conditions: Obesity and OverweightView official trial listing → -
Withdrawn NCT NCT02086825
A Randomized Comparison of Rifaximin Versus Lactulose in Hospitalized Cirrhotic Patients With Renal Failure
Not yet reported NYU Langone Health 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT02123017
Efficacy and Safety of Bisacodyl and Lactulose as a Preparation for Colonoscopy
Not yet reported Cumberland Pharmaceuticals 32 participants Est. completion 2014-08 1 site Stand-aloneOther conditions: Colonoscopy PreparationView official trial listing → -
Completed NCT NCT02158182
Lactulose, L-ornithine L-aspartate, or Rifaximin Versus Placebo for Preventing Hepatic Encephalopathy in Variceal Bleeding
Not yet reported Hospital General de Mexico 88 participants Est. completion 2016-06 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT02170467
Study of Intestinal Permeability in Patients With Anorexia Nervosa
Not yet reported University Hospital, Rouen 51 participants Est. completion 2018-05-03 2 sites Stand-aloneObstructive sleep apneaView official trial listing → -
Status unknown NCT NCT02216994
A New Scoring System Improves Diagnostic Accuracy of Intestinal Dysganglionosis --a Prospective Study
Not yet reported Tongji Hospital 80 participants Est. completion 2015-06 1 siteOther conditions: Hirschsprung DiseaseView official trial listing → -
Completed NCT NCT02228616
Efficacy and Safety of Prucalopride in Combination With Polyethylene Glycol or Lactulose in Women With Chronic Constipation
Not yet reported Xian-Janssen Pharmaceutical Ltd. 280 participants Est. completion 2016-09-28 9 sites Stand-aloneOther conditions: ConstipationView official trial listing → -
Completed NCT NCT02246647
Biomarkers for Intestinal Permeability in Patients With Constipation
Mayo Clinic 39 participants Est. completion 2016-12-08 1 siteOther conditions: Intestinal Diseases, Irritable Bowel Syndrome, ConstipationView official trial listing → -
Status unknown NCT NCT02255747
Anal Dilatation for Infants and Children With Constipation
Not yet reported Tongji Hospital 100 participants Est. completion 2016-10 1 siteOther conditions: ConstipationView official trial listing → -
Completed NCT NCT02265484
To Study the Efficacy of Bromocriptine in Patients With Hepatic/Cirrhosis Related Parkinsonism
Not yet reported Institute of Liver and Biliary Sciences, India 50 participants Est. completion 2015-01 1 site Stand-aloneOther conditions: Cirrhosis Related ParkinsonismView official trial listing → -
Terminated NCT NCT02313896
Cirrhosis Readmission Telehealth Project
Not yet reported Yale University 10 participants Est. completion 2016-06 1 site Stand-aloneOther conditions: CirrhosisView official trial listing → -
Completed NCT NCT02321371
Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encephalopathy.
Not yet reported Institute of Liver and Biliary Sciences, India 73 participants Est. completion 2016-01-31 1 site Stand-aloneOther conditions: Acute-On-Chronic Liver FailureView official trial listing → -
Status unknown NCT NCT02334163
The Effects of Nitazoxanide in Hepatic Encephalopathy
Not yet reported Ain Shams University 36 participants Est. completion 2015-04 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT02358564
Gut Permeability, Sensitivity and Symptomatology
Not yet reported Mayo Clinic 39 participants Est. completion 2021-03-11 2 sitesOther conditions: Irritable Bowel Syndrome, Visceral HypersensitivityView official trial listing → -
Completed NCT NCT02377947
A Retrospective, Open-label, Uncontrolled Cohort Study to Assess the Effectiveness and Safety of Lactulose Retention Enema in the Treatment of Cirrhotic Patients With Grade 3 or 4 (West Haven Criteria) Hepatic Encephalopathy (HE) [The RETRO Study]
Abbott 50 participants Est. completion 2016-03 3 sitesOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT02397512
Elucidating the Influence of Lactulose Intake on the Gut Microbiota Composition
Not yet reported University of Zurich 32 participants Est. completion 2015-10-01 1 site Stand-aloneOther conditions: Changes in Gut Microbiota Composition After Lactulose ExposureView official trial listing → -
Status unknown NCT NCT02464124
Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy
Not yet reported, Not yet reported Sherief Abd-Elsalam 120 participants Est. completion 2017-12 1 site Stand-aloneOther conditions: Encephalopathy, HepaticView official trial listing → -
Completed NCT NCT02520817
Antioxidants and Zinc Improving Minimal Hepatic Encephalopathy In Truck Drivers; a Pilot Study
Mansoura University 58 participants Est. completion 2013-10 1 siteOther conditions: Minimal Hepatic EncephalopathyView official trial listing → -
Status unknown NCT NCT02565654
Efficacy of Rifaximin to Treat Diarrhea-predominant Irritable Bowel Syndrome
First Affiliated Hospital, Sun Yat-Sen University 120 participants Est. completion 2017-12 1 siteOther conditions: Irritable Bowel SyndromeView official trial listing → -
Completed NCT NCT02603822
Performance of 13C Mannitol for in Vivo Measurement of Small Intestinal Permeability
Not yet reported Mayo Clinic 25 participants Est. completion 2018-07-17 1 site Stand-aloneOther conditions: Impaired Small Intestinal PermeabilityView official trial listing → -
Completed NCT NCT02608658
Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With Decompensated Cirrhosis With Ascites
Not yet reported St. Louis University 11 participants Est. completion 2017-04-27 1 site Stand-aloneOther conditions: Cirrhosis of the Liver, Ascites, Spontaneous Bacterial PeritonitisView official trial listing → -
Completed NCT NCT02650245
Breath and Blood Ammonia Response to an Oral Protein Challenge
Not yet reported St. Luke's Hospital and Health Network, Pennsylvania 12 participants Est. completion 2016-04 1 site Stand-aloneOther conditions: CirrhosisView official trial listing → -
Completed NCT NCT02896205
Study to Compare the Efficacy of Mycophenolate Mofetil in Systemic Sclerosis Related Early Interstitial Lung Disease
Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 41 participants Est. completion 2017-07-01 1 siteOther conditions: Systemic Sclerosis, Scleroderma, Interstitial Lung DiseaseView official trial listing → -
Status unknown NCT NCT02931123
A RCT COMPARING LACTULOSE AND RIFAXIMIN ASSOCIATED WITH A VEGETABLE DIET IN THE PREVENTION OF POST-TIPS OVERT HEPATIC ENCEPHALOPATHY
Not yet reported, Not yet reported University of Roma La Sapienza 58 participants Est. completion 2018-11 1 siteOther conditions: Cirrhotic Patients Undergoing TIPS PlacementView official trial listing → -
Completed NCT NCT02968498
Blood Glucose Response After Oral Intake of Lactulose in Healthy Volunteers
Not yet reported Fresenius Kabi 24 participants Est. completion 2017-02 1 siteOther conditions: Blood GlucoseView official trial listing → -
Status unknown NCT NCT03100513
PEG (Polyethylene Glycol)Versus Lactulose For Treatment Of Overt Hepatic Encephalopathy
Not yet reported Sherief Abd-Elsalam 100 participants Est. completion 2019-12 1 siteOther conditions: Hepatic EncephalopathyView official trial listing → -
Withdrawn NCT NCT03115697
High Volume Plasmapheresis for Refractory Hepatic Encephalopathy in Liver Intensive Care Unit.
Not yet reported Institute of Liver and Biliary Sciences, India Est. completion 2019-04-15 1 siteOther conditions: Refractory Hepatic EncephalopathyView official trial listing → -
Status unknown NCT NCT03141268
Rapid Orocecal Transit Time and Fermentation in IBS.
Uppsala University 1000 participants Est. completion 2019-07-01 1 siteOther conditions: Oro-cecal Transit TimeView official trial listing → -
Completed NCT NCT03148002
Peritoneal Dialysis Pilot Study: Evaluating Polyethylene Glycol (PEG) for Constipation
Not yet reported Nova Scotia Health Authority 25 participants Est. completion 2018-06-05 1 siteOther conditions: Constipation, Peritoneal Dialysis ComplicationView official trial listing → -
Withdrawn NCT NCT03161106
To Assess Efficacy of Nutritional Therapy in Secondary Prophylaxis of Hepatic Encephalopathy Versus Lactulose in Patients With Liver Cirrhosis.
Not yet reported Institute of Liver and Biliary Sciences, India Est. completion 2018-10-01 1 siteOther conditions: Liver CirrhosisView official trial listing → -
Withdrawn NCT NCT03162419
To Assess the Efficacy of High-Volume Plasma Exchange and GCSF Versus GCSF Alone in Patients of Acute on Chronic Liver Failure (ACLF).
Not yet reported Institute of Liver and Biliary Sciences, India Est. completion 2019-04-25 1 site Stand-aloneOther conditions: Acute-On-Chronic Liver FailureView official trial listing → -
Status unknown NCT NCT03177434
Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years.
Not yet reported Children's Memorial Health Institute, Poland 102 participants Est. completion 2018-05 3 sitesOther conditions: ConstipationView official trial listing → -
Terminated NCT NCT03242434
Investigation of Thermal Injury on Intestinal Permeability in Both Thermal Injury and Healthy Participants
Not yet reported GlaxoSmithKline 18 participants Est. completion 2018-03-26 1 siteOther conditions: BurnsView official trial listing → -
Completed NCT NCT03261570
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Not yet reported New York Medical College 51 participants Est. completion 2022-06-01 1 siteOther conditions: Postural Orthostatic Tachycardia Syndrome (POTS), POTS, Orthostatic IntoleranceView official trial listing → -
Status unknown NCT NCT03306498
Plasma Free Amino Acids in Patients With Hepatic Encephalopathy
Assiut University 100 participants Est. completion 2019-02-15Other conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT03384784
Effect of Galantamine on Inflammation and Cognition
Not yet reported University of Pennsylvania 63 participants Est. completion 2022-05-31 1 site Stand-aloneOther conditions: HIV Associated Cognitive Motor ComplexView official trial listing → -
Status unknown NCT NCT03415698
G-CSF in Decompensated Cirrhosis: an Open Label Trial
Not yet reported, Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 100 participants Est. completion 2018-12 1 siteOther conditions: Cirrhosis, LiverView official trial listing → -
Completed NCT NCT03420144
Growth Hormone Therapy in Liver Cirrhosis
Not yet reported, Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 76 participants Est. completion 2020-06-30 1 siteOther conditions: Cirrhosis, LiverView official trial listing → -
Completed NCT NCT03429257
Maternal EED and Aflatoxin Birth Outcomes Study Uganda
Tufts University 258 participants Est. completion 2017-12-01 1 siteOther conditions: Birth Weight, Pregnancy Preterm, Aflatoxins Toxicity, Inflammatory ResponseView official trial listing → -
Status unknown NCT NCT03448770
To Compare Efficacy and Safety of Lactulose Versus Polyethylene Glycol for Treatment of Overt Hepatic Encephalopathy in Cirrhotics.
Not yet reported Institute of Liver and Biliary Sciences, India 110 participants Est. completion 2018-07-31 1 siteOther conditions: CirrhosisView official trial listing → -
Terminated NCT NCT03462966
Rifaximin on Visceral Hypersensitivity
Not yet reported Cedars-Sinai Medical Center 4 participants Est. completion 2021-11-19 1 site Stand-aloneOther conditions: Visceral Hypersensitivity, Irritable Bowel SyndromeView official trial listing → -
Completed NCT NCT03515044
Rifaximin Soluble Solid Dispersion (SSD) Tablets Plus Lactulose for the Treatment of Overt Hepatic Encephalopathy (OHE)
Not yet reported Bausch Health Americas, Inc. 71 participants Est. completion 2020-03-12 34 sites Stand-aloneOther conditions: Overt Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT03577938
Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment
Not yet reported Beijing 302 Hospital 516 participants Est. completion 2021-06-30 15 sites Stand-aloneOther conditions: Acute on Chronic Liver Failure, Traditional Chinese Medicine, Hepatitis BView official trial listing → -
Status unknown NCT NCT03659175
Characteristic of Intestinal Flora in Male Elderly With Small Intestinal Bacterial Overgrowth
Chinese PLA General Hospital 40 participants Est. completion 2020-05-10 1 siteOther conditions: Small Intestinal Bacterial Overgrowth, Elderly, Male, 16s rRNAView official trial listing → -
Completed NCT NCT03666546
Blood Glucose Response After Oral Intake of Lactulose in Mildly Constipated Patients With Diabetes Mellitus Type 2
Not yet reported Fresenius Kabi 24 participants Est. completion 2019-03-08 1 site Stand-aloneType 2 diabetesView official trial listing → -
Completed NCT NCT03667963
Effect of Genetic Variation in Starch-digesting Enzymes on Digestibility and Glycemic Index of Cold and Hot Rice
Not yet reported University of Toronto 40 participants Est. completion 2018-12-21 1 siteOther conditions: Carbohydrate IntoleranceView official trial listing → -
Completed NCT NCT03729271
Hydrogen Breath Test an Instrument to Predict Rifaximin-Response in Irritable Bowel Syndrome Predominant Diarrhea
Not yet reported University of Michigan 148 participants Est. completion 2026-01-01 1 site Stand-aloneOther conditions: Irritable Bowel Syndrome, Irritable Bowel Syndrome With DiarrheaView official trial listing → -
Completed NCT NCT03833999
Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea
Not yet reported University of Nottingham 16 participants Est. completion 2019-06-27 1 site Stand-aloneOther conditions: Motility Disorder of Intestine, Ondansetron, Small Bowel WaterView official trial listing → -
Status unknown NCT NCT03841578
Dark Chocolate and Intestinal Motility
Not yet reported University of Bari 10 participants Est. completion 2020-03-01 1 site Stand-aloneOther conditions: Gastrointestinal MotilityView official trial listing → -
Completed NCT NCT03846843
OCR002-SP103 - Oral Immediate Release Study
Not yet reported Ocera Therapeutics, Inc. 30 participants Est. completion 2017-12-31 1 site Stand-aloneOther conditions: CirrhosisView official trial listing → -
Status unknown NCT NCT03864978
Safety and Efficacy of Rifaximin in Patients With Papulopustular Rosacea and Positive Lactulose Breath Test
Not yet reported Alfasigma S.p.A. 236 participants Est. completion 2020-10 12 sitesObstructive sleep apneaView official trial listing → -
Completed NCT NCT03898856
Yield of Diagnostic Tests and Effects of Crofelemer for Chronic Idiopathic Diarrhea In Non-HIV Patients
Not yet reported The University of Texas Health Science Center, Houston 93 participants Est. completion 2025-01-30 1 site Stand-aloneOther conditions: Chronic Diarrhea of Unknown OriginView official trial listing → -
Status unknown NCT NCT03911037
GCSF Therapy in Decompensated Cirrhosis - A Double Blinded RCT
Not yet reported, Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 70 participants Est. completion 2020-06-30 1 siteOther conditions: Decompensated Cirrhosis of LiverView official trial listing → -
Status unknown NCT NCT03957668
Efficacy and Safety of PEG 3350 for Treatment of Chronic Constipation
Not yet reported Fakultas Kedokteran Universitas Indonesia 184 participants Est. completion 2020-10-31 3 sitesOther conditions: Constipation - FunctionalView official trial listing → -
Completed NCT NCT03962998
Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability
Not yet reported MediBeacon 22 participants Est. completion 2021-10-05 1 siteOther conditions: Crohn DiseaseView official trial listing → -
Status unknown NCT NCT03987893
PEG3350 in ACLF With Hepatic Encephalopathy
Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 60 participants Est. completion 2020-08-20 1 site Stand-aloneOther conditions: Hepatic Encephalopathy, Acute-On-Chronic Liver FailureView official trial listing → -
Status unknown NCT NCT04013113
Efficacy and Safety of Hemoperfusion or Plasma Exchange Compared to Standard Medical Therapy in Patients With Acute on Chronic Liver Failure
Not yet reported Institute of Liver and Biliary Sciences, India 250 participants Est. completion 2020-07-31 1 site Stand-aloneOther conditions: Acute-On-Chronic Liver FailureView official trial listing → -
Completed NCT NCT04094558
Validation of the Small Intestine Microbiome Aspiration (SIMBA) Capsule
Not yet reported University of Calgary 30 participants Est. completion 2022-06-16 1 siteOther conditions: Proof of Concept, Irritable Bowel SyndromeView official trial listing → -
Withdrawn NCT NCT04128462
MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function
Not yet reported Mallinckrodt Est. completion 2025-07 Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Status unknown NCT NCT04157413
Food-based Approach Development to Fulfil Amino Acid Gap by Considering the Intestinal Permeability of Children
Nia Novita Wirawan 172 participants Est. completion 2020-04-30Other conditions: StuntingView official trial listing → -
Status unknown NCT NCT04159181
The Endocrine Colon in Humans
Not yet reported University of Copenhagen 10 participants Est. completion 2020-07-01 2 sites Stand-aloneOther conditions: HealthyView official trial listing → -
Completed NCT NCT04205045
Identification of Physiological Biomarkers of Gastro-intestinal Discomforts Induced by Milk Consumption
Paola Vitaglione 40 participants Est. completion 2020-01-24 1 siteOther conditions: Healthy SubjectsView official trial listing → -
Completed NCT NCT04238416
Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF
Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 70 participants Est. completion 2021-12-30 1 site Stand-aloneOther conditions: Hepatic Encephalopathy, Acute-On-Chronic Liver FailureView official trial listing → -
Completed NCT NCT04243681
Combination of Autologous MSC and HSC Infusion in Patients With Decompensated Cirrhosis
Not yet reported Asian Institute of Gastroenterology, India 5 participants Est. completion 2020-09-01 1 siteOther conditions: Cirrhosis, LiverView official trial listing → -
Status unknown NCT NCT04436601
Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;(PEGHE Trial)
Not yet reported Aga Khan University 102 participants Est. completion 2023-12-30 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT04462211
Constipation Bundle/Protocol and the Effect of Adherence in the Incidence of Constipation in Critically Ill Patients
Not yet reported University of Chile 66 participants Est. completion 2020-03-01 1 site Stand-aloneOther conditions: Constipation, Critical Illness, Constipation Drug InducedView official trial listing → -
Completed NCT NCT04578886
The Effect of Guanfacine on Delirium in Critically Ill Patients
Not yet reported University of Alabama at Birmingham 100 participants Est. completion 2023-04-01 1 siteOther conditions: DeliriumView official trial listing → -
Completed NCT NCT04582942
Improved Bowel Preparation Method for Colonoscopy Based on Different Risk Stratification
Not yet reported Renmin Hospital of Wuhan University 2028 participants Est. completion 2021-08-15 1 site Stand-aloneOther conditions: Bowel Preparation Before ColonoscopyView official trial listing → -
Status unknown NCT NCT04585672
Ammonia Metabolism Assessed by Ammonia Infusion
Not yet reported Aarhus University Hospital 20 participants Est. completion 2022-12-31 1 siteOther conditions: Ammonia; Metabolic Disorder, Liver Failure, ChronicView official trial listing → -
Completed NCT NCT04619875
A Clinical Study to Assess the Effect of Increasing Intake Amounts of Two Novel Glycans on the Gut Microbiota of Healthy Subjects
Not yet reported Kaleido Biosciences 36 participants Est. completion 2017-11-21 1 siteOther conditions: HealthyView official trial listing → -
Status unknown NCT NCT04621617
Midodrine and Albumin in Patients With Refractory Ascites
Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 114 participants Est. completion 2022-04Other conditions: Refractory AscitesView official trial listing → -
Completed NCT NCT04667169
Bleeding in Laser Haemorrhoidoplasty
Not yet reported University of Malaya 76 participants Est. completion 2018-10 1 site Stand-aloneOther conditions: HemorrhoidsView official trial listing → -
Completed NCT NCT04705662
GI Effects of Iron in Healthy Volunteers
Not yet reported Dr Anthony Hobson 48 participants Est. completion 2022-06-30 2 sitesOther conditions: Iron Deficiency Anemia Treatment, Microbial Colonization, Iron-deficiency, Iron Deficiency AnemiaView official trial listing → -
Completed NCT NCT04736836
Microbial Resistance of Rifaximin in Hepatic Encephalopathy
Not yet reported National Hepatology & Tropical Medicine Research Institute 100 participants Est. completion 2019-06Other conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT04787276
Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy
Not yet reported Bogomolets National Medical University 42 participants Est. completion 2020-03-15Other conditions: Hepatic Encephalopathy, Liver Cirrhosis, End Stage Liver DIseaseView official trial listing → -
Status unknown NCT NCT04794049
Comparison of Oral Lactulose Versus Polyethylene Glycol for Bowel Preparation
Not yet reported First People's Hospital of Hangzhou 800 participants Est. completion 2021-12-31 Stand-aloneOther conditions: Colon DiseaseView official trial listing → -
Completed NCT NCT04821323
A Study Exploring the Use of Challenge Agents in Healthy Volunteers - Intervention Specific Appendix
Not yet reported Janssen Research & Development, LLC 10 participants Est. completion 2021-05-07 1 site Stand-aloneOther conditions: HealthyView official trial listing → -
Status unknown NCT NCT04867512
Botanical Blend on the Gut Microbiome and Gut-Skin-Axis in Small Intestinal Bacterial Overgrowth (SIBO)
Not yet reported Integrative Skin Science and Research 35 participants Est. completion 2022-02-01 1 site Stand-aloneOther conditions: Small Intestinal Bacterial Overgrowth (SIBO)View official trial listing → -
Status unknown NCT NCT05004207
Study of Oro-cecal Transit Time in Healthy Subjects Using Scintigraphy and Lactulose Hydrogen Breath Test.
Asian Institute of Gastroenterology, India 50 participants Est. completion 2022-01-31 1 siteOther conditions: Small Bowel Disease, Motility Disorder, Irritable Bowel SyndromeView official trial listing → -
Completed NCT NCT05061992
A Trial to Improve Quality of Life in People With Cirrhosis
Not yet reported, Not yet reported University of Michigan 56 participants Est. completion 2022-11-01 1 site Stand-aloneOther conditions: CirrhosisView official trial listing → -
Completed NCT NCT05076799
Effect of Lactulose and/or Polyethylene Glycol Solution for Bowel Preparation for Colonscopy Procedures
Not yet reported Sichuan University 200 participants Est. completion 2022-11-30 1 site Stand-aloneOther conditions: ColonoscopyView official trial listing → -
Status unknown NCT NCT05134584
Efficacy of Linaclotide in Patients With Overlapping Functional Gastrointestinal Disorders
Not yet reported RenJi Hospital 78 participants Est. completion 2022-02 1 siteOther conditions: Functional Dyspepsia, Constipation-predominant Irritable Bowel SyndromeView official trial listing → -
Completed NCT NCT05144295
Lubiprostone for Functional Constipation in the Under 18 Years Patients
Not yet reported Alexandria University 274 participants Est. completion 2022-11-01 2 sitesOther conditions: Clinical Efficacy, Treatment Efficacy, Drug Side EffectView official trial listing → -
Status unknown NCT NCT05229289
Efficacy and Safety of Fecal Microbiota Transplant for Secondary Prophylaxis of Hepatic Encephalopathy
Not yet reported Institute of Liver and Biliary Sciences, India 66 participants Est. completion 2022-12-31 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT05253287
Growth Hormone in Decompensated Liver Cirrhosis
Not yet reported, Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 96 participants Est. completion 2024-12-31 1 siteOther conditions: Liver Cirrhosis, Fibrosis, End Stage Liver Disease, Digestive System Disease, Physiological Effect of Drugs, Growth Hormone Treatment, SarcopeniaView official trial listing → -
Status unknown NCT NCT05279586
Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhotic Patients
Not yet reported Madonna Magdy Fahmy 316 participants Est. completion 2023-03Other conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT05341180
Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial
Not yet reported, Not yet reported All India Institute of Medical Sciences, Bhubaneswar 144 participants Est. completion 2023-07-22 1 siteOther conditions: Anal Fissure, ConstipationView official trial listing → -
Completed NCT NCT05397158
Optimization of Intestinal Preparation in Older Patients
Not yet reported Beijing Tongren Hospital 312 participants Est. completion 2022-07-31 1 site Stand-aloneOther conditions: Colonoscopy, Older AdultsView official trial listing → -
Completed NCT NCT05428072
Alcohol, Gut Leakiness, & Liver Disease
Not yet reported Rush University Medical Center 195 participants Est. completion 2015-03 1 site Stand-aloneOther conditions: Alcoholic Liver DiseaseView official trial listing → -
Status unknown NCT NCT05498714
Improved Bowel Cleansing Method for Colonoscopy Based on High Risk Population of Bowel Preparation
Not yet reported Renmin Hospital of Wuhan University 150 participants Est. completion 2023-06-30 1 site Stand-aloneOther conditions: Bowel Preparation Before ColonoscopyView official trial listing → -
Completed NCT NCT05526404
Prevention of Hepatic Encephalopathy With Mobile Application Based Lactulose Titration
Not yet reported Mayo Clinic 50 participants Est. completion 2023-07-08 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT05604274
Longitudinal Monitoring of Stool Characteristics
Hunter Holmes Mcguire Veteran Affairs Medical Center 60 participants Est. completion 2023-10-28 1 siteOther conditions: Cirrhosis, LiverView official trial listing → -
Completed NCT NCT05648318
Comparison of Oral Lactulose Versus Polyethylene Glycol for Bowel Preparation in Low-risk Patients
Not yet reported Zhang Xiaofeng,MD 255 participants Est. completion 2022-09-12 1 site Stand-aloneOther conditions: Colonic NeoplasmsView official trial listing → -
Completed NCT NCT05687409
Synbiotics Interventions for Managing Cirrhosis and Its Complications
Not yet reported First Affiliated Hospital of Zhejiang University 120 participants Est. completion 2022-10-24 1 site Stand-aloneOther conditions: Cirrhosis, Liver, MetagonimiasisView official trial listing → -
Completed NCT NCT05700695
Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)
Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 114 participants Est. completion 2025-06-05 1 site Stand-aloneOther conditions: Hepatic Encephalopathy, Acute-On-Chronic Liver FailureView official trial listing → -
Completed NCT NCT05726344
Lactulose vs. Polyethylene Glycol as Bowel Preparation for Colonoscopy in Adults
Not yet reported Hospital de Clínicas Dr. Manuel Quintela 150 participants Est. completion 2023-12-13 1 site Stand-aloneOther conditions: Lactulose, Polyethylene Glycol, Bowel Preparation, Colonoscopy, BisacodylView official trial listing → -
Completed NCT NCT05754996
Efficacy and Safety of Nifuroxazide in the Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis
Not yet reported Cairo University 80 participants Est. completion 2025-07-29 1 site Stand-aloneOther conditions: Hepatic EncephalopathyView official trial listing → -
Status unknown NCT NCT05788627
Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy
Not yet reported Khyber Medical College, Peshawar 100 participants Est. completion 2023-11 Stand-aloneOther conditions: Hepatic Encephalopathy, Chronic Liver DiseaseView official trial listing → -
Completed NCT NCT05794555
LiveSMART Trial to Prevent Falls in Patients With Cirrhosis
Not yet reported University of Michigan 233 participants Est. completion 2025-03-07 3 sites Stand-aloneOther conditions: Cirrhosis, Liver, Portal HypertensionView official trial listing → -
Status unknown NCT NCT05854043
Modified Enhanced Recovery After Oblique Lateral Interbody Fusion Surgery
Not yet reported Xuanwu Hospital, Beijing 96 participants Est. completion 2025-04-01 1 site Stand-aloneOther conditions: Lumbar Spondylosis, Lumbar Spinal Stenosis, Lumbar Disc HerniationView official trial listing → -
Completed NCT NCT05859919
Conducting Clinical Trials of the Medicine "Rutan Tablets 0.1g" No. 10 in the Complex Therapy of COVID-19
Not yet reported Research Institute of Virology, Ministry of Health of the Republic of Uzbekistan 57 participants Est. completion 2021-09-30 1 site Stand-aloneOther conditions: Patients With COVID-19View official trial listing → -
Completed NCT NCT05862883
Studying the Efficiency of the Natural Preparation Rutan in Children in the Treatment of COVID-19, ARVI
Not yet reported Research Institute of Virology, Ministry of Health of the Republic of Uzbekistan 301 participants Est. completion 2022-07-01 1 site Stand-aloneOther conditions: COVID-19 Respiratory InfectionView official trial listing → -
Completed NCT NCT05878639
Efficacy and Safety of Lactulose for Bowel Preparation in Patients With Inflammatory Bowel Disease
Not yet reported Second Affiliated Hospital of Wenzhou Medical University 140 participants Est. completion 2023-07-01 1 site Stand-aloneOther conditions: IBDView official trial listing → -
Status unknown NCT NCT05920213
Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy
Not yet reported Jinnah Postgraduate Medical Centre 360 participants Est. completion 2024-04 6 sites Stand-aloneOther conditions: Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3, Hepatic Encephalopathy Stage 4View official trial listing → -
Status unknown NCT NCT05934552
Assesment of Lactulose vs Lactobacillus Acidophilus Effect in CKD Patients
Assiut University 150 participants Est. completion 2024-12Chronic kidney diseaseView official trial listing → -
Status unknown NCT NCT05949411
Development of Non-invasive Methods to Study Gut Microbiome - Nutrition - Host Interactions
Not yet reported Université Catholique de Louvain 100 participants Est. completion 2024-12-31 3 sitesOther conditions: HealthyView official trial listing → -
Completed NCT NCT06123195
Effects of Constipation Treatment in Chronic Kidney Disease: A Pilot Feasibility Trial
Not yet reported University of Tennessee 14 participants Est. completion 2025-11-17 1 site Stand-aloneChronic kidney disease Other conditions: ConstipationView official trial listing → -
Completed NCT NCT06248736
Description of Lactulose Administration by Balloon Rectal Tube in Severe Hepatic Encephalopathy
University Hospital, Grenoble 25 participants Est. completion 2024-08-27 1 siteOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT06282367
Bowel Preparation for Colonoscopy With Oral Lactulose
Josue Aliaga 222 participants Est. completion 2023-04-01 1 siteOther conditions: Colonoscopy, Colonoscopy PreparationView official trial listing → -
Status unknown NCT NCT06328088
Vegetarian Versus Non Vegetarian Based Diet in the Recurrence of Hepatic Encephalopathy in Patients With Cirrhosis: An Open Label Pilot Study
Sir Ganga Ram Hospital 40 participants Est. completion 2024-10-16 1 siteOther conditions: Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT06368895
Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment
Not yet reported Fondazione Policlinico Universitario Agostino Gemelli IRCCS 33 participants Est. completion 2024-10-31 1 site Stand-aloneOther conditions: Hepatic Encephalopathy, DysbiosisView official trial listing → -
Completed NCT NCT06411314
Efficacy and Safety of Natamycin and Lactulose Vaginal Suppositories in Treatment of Vulvovaginal Candidiasis
Not yet reported Avva Rus, JSC 218 participants Est. completion 2023-09-22 1 site Stand-aloneOther conditions: Vulvovaginal Candidiasis, GenitalView official trial listing → -
Completed NCT NCT06543498
The Effect of Dietary Supplementation on Intestinal Barrier Function in IBS-D
Not yet reported Dr Anthony Hobson 32 participants Est. completion 2025-01-13 2 sitesOther conditions: Irritable Bowel Syndrome With DiarrheaView official trial listing → -
Completed NCT NCT06666556
Bowel Preparation in Colonoscopy: Lactulose vs Polyethyleneglycol, Randomized Double-blind Comparative Clinical Trial, Multicenter Study.
Not yet reported Hospital Civil de Guadalajara 449 participants Est. completion 2025-08-14 3 sitesOther conditions: Colorectal Cancer ScreeningView official trial listing → -
Enrolling by invitation NCT NCT06738550
Effect of Agave Inulin on Constipation and Quality of Life in Peritoneal Dialysis Patients.
Not yet reported NIN Institute 45 participants Est. completion 2025-08-31 1 siteChronic kidney disease Other conditions: Constipation, Peritoneal Dialysis (PD), Quality of Life (QOL)View official trial listing → -
Enrolling by invitation NCT NCT06748638
Clinical Study on the Application of Lactulose Combined with Linaclotide in Bowel Preparation for Colonoscopy
Not yet reported Haifeng Lan 444 participants Est. completion 2025-10-01 1 site Stand-aloneOther conditions: Lactulose, Bowel PreparationView official trial listing → -
Not yet recruiting NCT NCT06808009
Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial)
Not yet reported Institute of Liver and Biliary Sciences, India 90 participants Est. completion 2026-02-28 1 site Stand-aloneOther conditions: Acute on Chronic Liver FailureView official trial listing → -
Completed NCT NCT06862986
Ear Massage Effect on Bowel Activity After Surgery
Not yet reported Mersin University 40 participants Est. completion 2025-12-04 1 siteOther conditions: Constipation, Lower Extremity SurgeryView official trial listing → -
Not yet recruiting NCT NCT06876064
National Cohort of Subjects at Risk of Developing Rheumatoid Arthritis
University Hospital, Montpellier 150 participants Est. completion 2027-12 1 siteOther conditions: Rheumatoid Arthritis (RA)View official trial listing → -
Not yet recruiting NCT NCT06995586
Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.
Not yet reported Nicosia General Hospital 108 participants Est. completion 2028-12-01 1 site Stand-aloneCardiovascular disease Other conditions: Cardio-pulmonary Bypass, Omega-3 Polyunsaturated Fatty Acids, Omega-3 Supplementation, Vitamin C, Supplements, Postoperative Depression, Antioxidants, Lactulose, Postoperative, Optimal Medical Therapy, CABG, Coronary Artery Bypass Grafting, PrebioticsView official trial listing → -
Completed NCT NCT07037394
A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy.
Not yet reported Qurratul Ain Jamil 252 participants Est. completion 2025-04-30 1 site Stand-aloneOther conditions: Overt Hepatic EncephalopathyView official trial listing → -
Completed NCT NCT07066176
Establishing and Validating a Meal-provoked Intestinal Permeability Test for Nutritional and Metabolic Health Clinical Research.
Not yet reported Laval University 10 participants Est. completion 2025-08-15 1 site Stand-aloneOther conditions: Intestinal PermeabilityView official trial listing → -
Not yet recruiting NCT NCT07075315
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial
Not yet reported Institute of Liver and Biliary Sciences, India 100 participants Est. completion 2031-12 3 sitesOther conditions: Acute-On-Chronic Liver FailureView official trial listing → -
Completed NCT NCT07084350
Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients
Not yet reported General Hospital of Shenyang Military Region 300 participants Est. completion 2026-05-18 1 site Stand-aloneOther conditions: Type II Diabetes MellitusView official trial listing → -
Not yet recruiting NCT NCT07131306
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial
Not yet reported Institute of Liver and Biliary Sciences, India 100 participants Est. completion 2031-08 1 siteOther conditions: Acute-On-Chronic Liver FailureView official trial listing → -
Active, not recruiting NCT NCT07140120
LiveSMART Trial to Prevent Falls in Patients With Cirrhosis - Supplementary Study
University of Michigan 52 participants Est. completion 2026-10 3 sitesOther conditions: Cirrhosis, Liver, Portal HypertensionView official trial listing → -
Completed NCT NCT07145580
Combined Lactulose H2-breath Test With Abdominal Imaging
Klinik Arlesheim 510 participants Est. completion 2026-07-31 1 siteOther conditions: Food Intolerance Syndromes, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Breath TestsView official trial listing → -
Not yet recruiting NCT NCT07178366
Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial)
Not yet reported Institute of Liver and Biliary Sciences, India 56 participants Est. completion 2027-10 Stand-aloneOther conditions: Acute-on-Chronic Liver Failure (ACLF)View official trial listing → -
Not yet recruiting NCT NCT07273734
UDCA to Prevent Post-TIPS Hepatic Encephalopathy
Not yet reported West China Hospital 270 participants Est. completion 2027-12-31 1 site Stand-aloneOther conditions: Hepatic Encephalopathy (HE), TIPSView official trial listing → -
Not yet recruiting NCT NCT07337707
New Microbiota-endocrine Axis in Fructose Malabsorption-caused Visceral Hypersensitivity in Irritable Bowel Syndrome.
Not yet reported University Hospital, Rouen 60 participants Est. completion 2027-08 1 site Stand-aloneOther conditions: Irritable Bowel Syndrome (IBS)View official trial listing → -
Completed NCT NCT07360535
Effect of Probiotic on Gut Microbiota in Young Children With Functional Constipation
Not yet reported Min-Tze LIONG 84 participants Est. completion 2026-02-28 2 sitesOther conditions: Functional Constipation in ChildrenView official trial listing → -
Not yet recruiting NCT NCT07422948
Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure.
Not yet reported Institute of Liver and Biliary Sciences, India 113 participants Est. completion 2027-08-30 1 site Stand-aloneOther conditions: Acute on Chronic Liver FailureView official trial listing → -
Not yet recruiting NCT NCT07454408
Evaluation of the Outcome of Fecal Microbiota Transplantation
Not yet reported, Not yet reported Air Force Military Medical University, China 40 participants Est. completion 2028-06-30 1 site Stand-aloneOther conditions: Hepatic Encephalopathy, Fecal Microbiota Transplantation, TIPSView official trial listing → -
Not yet recruiting NCT NCT07479238
Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 100 participants Est. completion 2028-04-26 1 siteOther conditions: SIBO, Pancreatic Insufficiency, Chronic Pancreatitis, Pancreatic SurgeyView official trial listing → -
Not yet recruiting NCT NCT07528690
Microbiota trAnSplant ThERaPy In hEpatiC Encephalopathy (MASTERPIECE)
Not yet reported VA Office of Research and Development 162 participants Est. completion 2031-03-03 3 sitesOther conditions: Hepatic Encephalopathy, CirrhosisView official trial listing → -
Not yet recruiting NCT NCT07534995
A Prospective, Multicenter, Randomized, Parallel-controlled, Superiority Trial
Not yet reported First Teaching Hospital of Tianjin University of Traditional Chinese Medicine 270 participants Est. completion 2027-12-30Other conditions: OICView official trial listing → -
Completed NCT NCT07600281
Ultra-Processed Foods, Palatability, Appetite, and Gastrointestinal Transit
Not yet reported Purdue University 40 participants Est. completion 2026-04-30 1 siteOther conditions: Appetite, Gastrointestinal Transit, Food Processing, Food Palatability, Eating BehaviorView official trial listing → -
Not yet recruiting NCT NCT07648394
Research on the Efficacy and Mechanism of Shouhui Tongbian Capsules in Treating Postoperative Constipation of Benign Anal and Rectal Diseases Based on Gut Microbiota Analysis
Not yet reported, Not yet reported China-Japan Friendship Hospital 120 participants Est. completion 2027-06-30 1 siteOther conditions: Intestinal Flora, Anorectal Diseases, Surgery, ConstipationView official trial listing → -
Not yet recruiting NCT NCT07667049
Gut Permeability and Microbiome in Preterm Infants
Not yet reported University of Maryland, Baltimore 150 participants Est. completion 2027-12-30Other conditions: Prematurity ComplicationsView official trial listing → -
Completed NCT NCT07751224
Auricular Acupuncture for Post-Stroke Constipation
Not yet reported Ho Chi Minh City Orthopedics and Rehabilitation Hospital 60 participants Est. completion 2025-07-01 1 site Stand-aloneCardiovascular disease Other conditions: ConstipationView official trial listing → -
Not yet recruiting NCT NCT07768267
Herbal Supplement (Biocidin REMOVE) for Bacterial Overgrowth in Irritable Bowel Syndrome
Not yet reported Johns Hopkins University 40 participants Est. completion 2027-12-31 1 siteOther conditions: Irritable Bowel Syndrome (IBS), Small Intestinal Bacterial Overgrowth Syndrome (SIBO)View official trial listing → -
Completed NCT NCT07787897
Ultra-low Split-dose Oral Lactulose vs High-volume Split-dose Polyethylene Glycol as Bowel Preparation for Outpatient Colonoscopies.
Not yet reported National Institute of Medical Sciences and Nutrition, Salvador Zubiran 200 participants Est. completion 2025-12-31 1 site Stand-aloneOther conditions: ColonoscopyView official trial listing → -
Active, not recruiting NCT NCT07797491
Breath Gases, Gut Flora, and Immunity in Children With Constipation
Ruijin Hospital 200 participants Est. completion 2027-12-31 1 siteOther conditions: Constipation - FunctionalView official trial listing →
Efficacy history
Not yet reported.
Safety
Not yet reported.
Sources
Also known as: Lactulose, Lactulose Solution
Related On The Pen coverage
No related coverage yet.
This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.
