Hyperglycemic clamp

• Recruiting NCT NCT01803451

  Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass

  Not yet reported The University of Texas Health Science Center at San Antonio 80 participants Est. completion 2027-08 2 sites Stand-alone
  Other conditions: Post-bariatric Surgery
  View official trial listing →
• Recruiting NCT NCT05777330

  Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes

  Not yet reported Universitair Ziekenhuis Brussel 75 participants Est. completion 2027-11-30 6 sites
  Other conditions: Type1 Diabetes Mellitus
  View official trial listing →
• Recruiting NCT NCT07224334

  Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.

  Not yet reported David D'Alessio, M.D. 30 participants Est. completion 2027-12 1 site Stand-alone
  Other conditions: Diabetes (DM)
  View official trial listing →
• Recruiting NCT NCT07398300

  Insulin-Mediated Glucose Uptake and Organ Perfusion Assessed by Total-Body PET During GIP and GLP-1 Infusion

  Not yet reported Copenhagen University Hospital, Rigshospitalet 36 participants Est. completion 2027-05 1 site Stand-alone
  Type 2 diabetes Other conditions: Healhty
  View official trial listing →
• Recruiting NCT NCT07778524

  Alpelisib Challenge Test (ACT)

  Not yet reported Columbia University 15 participants Est. completion 2028-08-31 1 site Stand-alone
  Type 2 diabetes Other conditions: Insulin Resistance, Obesity & Overweight, Healthy Adult Participants
  View official trial listing →
• Completed NCT NCT00325559

  The Effect of Hyperglycaemia on Local Energy Stores in the Working Muscle in Patients With Type 1 Diabetes Mellitus

  Not yet reported Insel Gruppe AG, University Hospital Bern 10 participants 1 site
  Other conditions: Diabetes Mellitus, Type 1, Exercise
  View official trial listing →
• Completed NCT NCT00469833

  Insulin Secretion in Diabetes Before and After Glycemic Control

  Not yet reported US Department of Veterans Affairs 17 participants Est. completion 2012-09 1 site Stand-alone
  Other conditions: Diabetes, Hyperglycemia
  View official trial listing →
• Completed NCT NCT00488423

  Glucose Metabolism in the Immediate and Short Term Follow up After Bariatric Surgery

  Not yet reported The Cleveland Clinic 21 participants Est. completion 2008-11 1 site
  Other conditions: Diabetes, Gastric Bypass
  View official trial listing →
• Status unknown NCT NCT00525239

  HIV Antiretroviral Drugs and Metabolism

  Not yet reported National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 60 participants Est. completion 2010-12 1 site
  Other conditions: HIV Infections
  View official trial listing →
• Completed NCT NCT00574665

  Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 1

  Not yet reported Vanderbilt University 32 participants Est. completion 2010-12 1 site Stand-alone
  Type 2 diabetes
  View official trial listing →
• Status unknown NCT NCT00618761

  Insulin Secretory Capacity in Insulin-independent Pancreas-Kidney Recipients Compared to Controls

  Not yet reported University Hospital, Gasthuisberg 40 participants Est. completion 2014-01 1 site Stand-alone
  Other conditions: Kidney Transplantation, Pancreas Transplantation
  View official trial listing →
• Completed NCT NCT00747968

  The Effect of the GLP-1 Analogue Exenatide on Type 2 Diabetes in CNS and Heart During Hyperglycemia Assessed by PET

  Not yet reported, Not yet reported University of Aarhus 8 participants Est. completion 2011-03 4 sites
  Type 2 diabetes
  View official trial listing →
• Status unknown NCT NCT00800085

  Beta Cell Function in (Pre) Type 1 Diabetes

  Not yet reported, Not yet reported Universitair Ziekenhuis Brussel 200 participants Est. completion 2015-10 4 sites
  Other conditions: Type 1 Diabetes
  View official trial listing →
• Completed NCT NCT00888238

  A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)

  Not yet reported Merck Sharp & Dohme LLC 12 participants Est. completion 2009-07-21 Stand-alone
  Type 2 diabetes
  View official trial listing →
• Completed NCT NCT01160991

  Effect of Atypical Antipsychotic Drugs Olanzapine and Amisulpride on Glucose Metabolism

  Not yet reported Central Institute of Mental Health, Mannheim 10 participants Est. completion 2006-10 1 site Stand-alone
  Other conditions: Schizophrenia, Diabetes, Insulin Resistance
  View official trial listing →
• Completed NCT NCT01185119

  Effect of GLP-1 on Glucose Metabolism in CNS Assessed by PET

  Not yet reported, Not yet reported University of Aarhus 10 participants Est. completion 2011-03 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT01375270

  Glucolipotoxicity and Type 2 Diabetes

  Not yet reported Copenhagen University Hospital, Rigshospitalet 30 participants Est. completion 2014-12 1 site Stand-alone
  Type 2 diabetes
  View official trial listing →
• Status unknown NCT NCT01402037

  Beta Cell Function in (Pre)Type 1 Diabetes

  Not yet reported Universitair Ziekenhuis Brussel 100 participants Est. completion 2016-07 3 sites
  Other conditions: Type 1 Diabetes
  View official trial listing →
• Terminated NCT NCT01409993

  Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis

  Not yet reported Vanderbilt University 78 participants Est. completion 2016-11 1 site Stand-alone
  Prediabetes
  View official trial listing →
• Completed NCT NCT01481623

  Identification and Characterization of Monogenic Diabetes

  Not yet reported Assistance Publique - Hôpitaux de Paris 127 participants Est. completion 2018-07-21 1 site
  Other conditions: Diabetes
  View official trial listing →
• Completed NCT NCT01517100

  The Role of Endocannabinoids in Insulin Production and Action

  Not yet reported National Institute on Aging (NIA) 45 participants Est. completion 2014-10-06 1 site
  Other conditions: Healthy Volunteers
  View official trial listing →
• Completed NCT NCT01621516

  Measurement of the Pancreas Function in Patients With More Than One Pancreas After Liver and Small Bowel Transplantation

  KU Leuven 6 participants Est. completion 2015-11
  Other conditions: Diabetes, Insulin Resistance, Liver/Small Bowel Transplant
  View official trial listing →
• Status unknown NCT NCT01660386

  Study of Comparing the Different Effect of DPP-4 Inhibitors and Sulfonylurea by Using "Biphase-Hyperglycemic Clamp"

  Not yet reported Shanghai Jiao Tong University School of Medicine 12 participants Est. completion 2013-03 1 site
  Type 2 diabetes
  View official trial listing →
• Completed NCT NCT01759823

  Bone Marrow Derived Stem Cell Transplantation in T2DM

  Not yet reported, Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 30 participants Est. completion 2015-10 1 site Stand-alone
  Type 2 diabetes
  View official trial listing →
• Completed NCT NCT01823406

  Tissue-Specific Metabolic Reprogramming in Diabetic Complications

  Not yet reported University of Michigan 35 participants Est. completion 2017-08 1 site Stand-alone
  Other conditions: Type 1 Diabetes Mellitus
  View official trial listing →
• Completed NCT NCT01975259

  Investigating the Incretin Effect in Cystic Fibrosis

  Liverpool Heart and Chest Hospital NHS Foundation Trust 50 participants Est. completion 2015-07 1 site
  Other conditions: Cystic Fibrosis
  View official trial listing →
• Completed NCT NCT02053935

  Impact of Dopamine Infusion on Insulin Secretion in Healthy Subjects

  Not yet reported Albert Einstein College of Medicine 15 participants Est. completion 2016-01 1 site
  Other conditions: Hyperglycemia, Sepsis
  View official trial listing →
• Completed NCT NCT02237521

  The Effect of the Incretin Hormones on the Endocrine Pancreatic Function During Hyperglycemia in End-stage Renal Disease

  Bo Feldt-Rasmussen 24 participants Est. completion 2016-04-28 1 site
  Other conditions: End-stage Renal Disease
  View official trial listing →
• Completed NCT NCT02272556

  Investigating the Role of the Polyol Pathway in the Central Nervous System

  Not yet reported Yale University 138 participants Est. completion 2022-05-18 1 site
  Other conditions: Hyperglycemia
  View official trial listing →
• Status unknown NCT NCT02386943

  Study on Exploring the Effect of DPP-4 Inhibitors on β-cell Function by Using the Two-step Hyperglycemic Clamp

  Not yet reported Shanghai Jiao Tong University School of Medicine 12 participants Est. completion 2015-03 1 site
  Type 2 diabetes
  View official trial listing →
• Status unknown NCT NCT02518932

  The Effect of VTC-G15 (a Pentapeptide Cleavage Product og GLP-1) on Whole Body Glucose Metabolism in Man

  Not yet reported Elahi, Dariush, PhD 20 participants Est. completion 2016-03 1 site Stand-alone
  Other conditions: Insulin Resistance
  View official trial listing →
• Completed NCT NCT02550548

  Incretin Action in Physiology and Diabetes

  Not yet reported David D'Alessio, M.D. 39 participants Est. completion 2021-04-16 1 site Stand-alone
  Other conditions: Insulin Secretion
  View official trial listing →
• Completed NCT NCT02591849

  GLP-1 Effects on Insulin and Glucagon in PTDM

  Not yet reported Oslo University Hospital 24 participants Est. completion 2015-03 1 site
  Other conditions: Post-transplant Diabetes Mellitus
  View official trial listing →
• Completed NCT NCT02662400

  Assessment of Insulin Sensitivity and β Cell Function by Clamps Studies

  Not yet reported, Not yet reported Post Graduate Institute of Medical Education and Research, Chandigarh 7 participants Est. completion 2016-12 Stand-alone
  Other conditions: Diabetes Mellitus, Non-Insulin-Dependent
  View official trial listing →
• Completed NCT NCT02669732

  An Exploratory Study of DS-8500a on Beta Cell Function Using Hyperglycemic Clamp

  Not yet reported Daiichi Sankyo Co., Ltd. 21 participants Est. completion 2016-10 1 site
  Type 2 diabetes
  View official trial listing →
• Completed NCT NCT02673554

  The Reduced Insulinotropic Effect of a Continuous Infusion Relative to a Bolus Injection of GIP

  Not yet reported Diabeteszentrum Bad Lauterberg im Harz 30 participants
  Type 2 diabetes
  View official trial listing →
• Terminated NCT NCT02844907

  Regulation of Insulin Secretion by the GLP-1 Receptor

  Not yet reported VA Office of Research and Development 6 participants Est. completion 2021-12-31 1 site Stand-alone
  Other conditions: Insulin Secretion
  View official trial listing →
• Completed NCT NCT03195400

  Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes

  Yale University 100 participants Est. completion 2022-08-12 1 site
  PrediabetesType 2 diabetes
  View official trial listing →
• Status unknown NCT NCT03415139

  Finding the Cause for Post-Transplant Diabetes Mellitus After Allogeneic Hematopoietic Cell Transplant

  Vanderbilt-Ingram Cancer Center 120 participants Est. completion 2025-04 1 site
  Other conditions: Diabetes Mellitus, Cancer
  View official trial listing →
• Completed NCT NCT03461510

  Type 2 Diabetes and the Brain in Adolescents

  Not yet reported Nemours Children's Clinic 18 participants Est. completion 2019-01-30 1 site Stand-alone
  Type 2 diabetes Other conditions: Obesity, Pediatric Obesity, Insulin Resistance, Dysglycemia, Hyperglycemia
  View official trial listing →
• Withdrawn NCT NCT03520153

  Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome

  Yale University Est. completion 2021-08 1 site
  Other conditions: McCune-Albright Syndrome, Fibrous Dysplasia, Intraductal Papillary Mucinous Neoplasm, Diabetes Mellitus
  View official trial listing →
• Completed NCT NCT03956173

  Hypoglycemia and Cardiac Arrhythmias in Type 1 Diabetes

  Steno Diabetes Center Copenhagen 24 participants Est. completion 2021-12-01 1 site
  Other conditions: Diabetes type1, Hypoglycemia, Arrhythmias, Cardiac
  View official trial listing →
• Completed NCT NCT03972215

  Berberine Hyperglycemic Clamp

  Not yet reported Jin-Kui Yang 15 participants Est. completion 2020-02-17 1 site
  Other conditions: Diabetes Mellitus
  View official trial listing →
• Withdrawn NCT NCT03998709

  Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion

  Not yet reported Mayo Clinic Est. completion 2022-07-31 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT04459338

  A Dose-response Study Examining the Contribution of GLP-1 Receptor Signaling to Glucagon-stimulated Insulin Secretion

  Not yet reported Adrian Vella 11 participants Est. completion 2022-06-14 1 site Stand-alone
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT04782999

  Effect of RYGB on Alpha- and Beta Cell Function and Sensitivity to Incretins in Patients With Type 2 Diabetes

  Not yet reported Hvidovre University Hospital 9 participants Est. completion 2022-03 1 site
  Type 2 diabetes Other conditions: Obesity, Morbid
  View official trial listing →
• Completed NCT NCT05355285

  Type 1 Diabetes and Depression: Role of Brain Glutamate

  Not yet reported Beth Israel Deaconess Medical Center 68 participants Est. completion 2014-11 Stand-alone
  Other conditions: Type1diabetes, Depressive Symptoms, Major Depressive Disorder
  View official trial listing →
• Completed NCT NCT05417646

  Impact of SGLT2 on Glucosuria in HNF1A-MODY

  Not yet reported Steno Diabetes Center Copenhagen 21 participants Est. completion 2023-06-14 1 site
  Type 2 diabetes Other conditions: Maturity-Onset Diabetes of the Young, Type 3
  View official trial listing →
• Withdrawn NCT NCT05456854

  Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp

  Not yet reported Massachusetts General Hospital Est. completion 2024-08-01 1 site Stand-alone
  Other conditions: Metabolic Disease
  View official trial listing →
• Not yet recruiting NCT NCT05499702

  The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction

  Not yet reported Adrian Vella 20 participants Est. completion 2029-12-31 1 site Stand-alone
  Other conditions: Type2diabetes
  View official trial listing →
• Completed NCT NCT05500586

  The Effects of Glucagon on Hepatic Metabolism

  Not yet reported, Not yet reported Adrian Vella 21 participants Est. completion 2026-03-31 1 site Stand-alone
  MASLD Other conditions: Obesity, Type2diabetes
  View official trial listing →
• Status unknown NCT NCT05575206

  The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans

  University Hospital Tuebingen 20 participants Est. completion 2025-03-01 1 site
  Type 2 diabetes Other conditions: Impaired Insulin Secretion
  View official trial listing →
• Withdrawn NCT NCT05794776

  Effect of Spinal Cord Stimulation (SCS) on Insulin Secretion in Humans

  Not yet reported University Hospital Tuebingen Est. completion 2023-10-01 1 site Stand-alone
  Other conditions: Spinal Cord Stimulation, Insulin Secretion
  View official trial listing →
• Completed NCT NCT06194955

  The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function

  Not yet reported University of Copenhagen 50 participants Est. completion 2026-04-01 1 site
  Other conditions: Incretin Effect
  View official trial listing →
• Not yet recruiting NCT NCT06727071

  Using Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes

  Not yet reported University of California, San Diego 20 participants Est. completion 2026-06-30 1 site
  Other conditions: Type 1 Diabetes Mellitus
  View official trial listing →
• Not yet recruiting NCT NCT06972407

  The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans

  Not yet reported Mayo Clinic 80 participants Est. completion 2029-03-01 1 site
  Other conditions: Genetic Predisposition, Type2diabetes
  View official trial listing →
• Not yet recruiting NCT NCT07670871

  Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology

  Fondazione Policlinico Universitario Agostino Gemelli IRCCS 440 participants Est. completion 2031-09
  Type 2 diabetesPrediabetes Other conditions: Chronic Pancreatitis, Pancreatic Neoplasms
  View official trial listing →

Not yet reported.

Not yet reported.

• ClinicalTrials.gov — NCT05499702

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