β-hydroxy-β-methylbutyrate

• Recruiting NCT NCT05869812

  Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes

  Not yet reported University of Kansas Medical Center 30 participants Est. completion 2029-12 1 site
  Other conditions: Atrophy
  View official trial listing →
• Recruiting NCT NCT06050668

  Essential Amino Acid Supplementation for Femoral Fragility Fractures

  Not yet reported Michael C Willey 60 participants Est. completion 2026-12 2 sites
  Other conditions: Femoral Fracture, Fragility Fracture, Muscle Atrophy
  View official trial listing →
• Recruiting NCT NCT07419633

  This Study Investigates β-hydroxy-β-methylbutyrate (HMB) and 2-hydroxybenzylamine (2-HOBA), When Administered Either Individually or in Combination Contributes to an Increased Quality of Health, Specifically Improving Muscular Strength and Cognitive Functioning in Adults Over the Age of 65.

  Not yet reported McGill University Health Centre/Research Institute of the McGill University Health Centre 120 participants Est. completion 2027-02-05 1 site
  Other conditions: Muscle, Cognitive Functioning, Geriatric, Ageing and Geriatric Health, Ageing
  View official trial listing →
• Recruiting NCT NCT07534852

  NIMA-Colon Cancer Study

  Not yet reported Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud 120 participants Est. completion 2027-12 1 site
  Other conditions: Colon Cancer
  View official trial listing →
• Recruiting NCT NCT07675421

  Impact of HMB Supplementation on Inflammation and Outcomes in Head and Neck Cancer

  Not yet reported Federal University of Minas Gerais 66 participants Est. completion 2027-11-30 1 site
  Other conditions: Head and Neck Cancers
  View official trial listing →
• Recruiting NCT NCT07773142

  Skeletal Muscle Adaptations to Peptide-Supplemented Resistance Exercise Training

  Not yet reported University of Birmingham 24 participants Est. completion 2027-12 1 site
  Other conditions: Supplement, Resistance Training Adaptation
  View official trial listing →
• Completed NCT NCT01607879

  Use of β-hydroxy-β-methylbutyrate to Counteract Muscle Loss in Men With Prostate Cancer on Androgen Ablation

  Not yet reported Medical College of Wisconsin 48 participants Est. completion 2021-02-16 1 site
  Other conditions: Prostate Cancer
  View official trial listing →
• Completed NCT NCT01941368

  The Effects of β-Hydroxy-β-methylbutyrate Free Acid and High-Intensity Interval Training

  Not yet reported Metabolic Technologies Inc. 40 participants Est. completion 2013-12 1 site
  Other conditions: Exercise
  View official trial listing →
• Completed NCT NCT02118181

  Assessment of Physical Performance With A Supplementation Containing HMB in a Sample of Old Women in Good Health

  Not yet reported University of Padova 80 participants Est. completion 2014-06 1 site
  Other conditions: Age Related Muscle Loss
  View official trial listing →
• Completed NCT NCT02679742

  Postacute Sarcopenia: Supplementation With β-hydroxyMethylbutyrate After Resistance Training

  Not yet reported Parc de Salut Mar 32 participants Est. completion 2021-02-06 1 site
  Other conditions: Sarcopenia
  View official trial listing →
• Completed NCT NCT02885337

  Fit-Joints: Getting Fit for Hip or Knee Replacement

  Not yet reported McMaster University 41 participants Est. completion 2022-12-31 2 sites
  Osteoarthritis
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• Completed NCT NCT03028649

  The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes

  Not yet reported Poznan University of Medical Sciences 58 participants Est. completion 2014-02 1 site
  Other conditions: Sport, Supplements, Supplementation
  View official trial listing →
• Status unknown NCT NCT03151291

  Effects of WB-EMS and Specific Dietary Supplements on Cancer Patients

  Not yet reported University of Erlangen-Nürnberg Medical School 200 participants Est. completion 2019-04 1 site
  Other conditions: Cancer, Cancer Cachexia, Weight Loss, Muscle Loss, Muscle Weakness
  View official trial listing →
• Completed NCT NCT03511092

  The Effects of Leucine Metabolites in Performance, Body Composition and Biochemical Markers of Muscle Damage

  Not yet reported Faculdade de Motricidade Humana 53 participants Est. completion 2017-10-28 1 site
  Other conditions: Resistance Training
  View official trial listing →
• Status unknown NCT NCT03605147

  The Effect of Calcium β-hydroxy-β-methylbutyrate (CaHMB) Supplementation in Sarcopenia in Liver Cirrhosis

  Not yet reported Shanghai Zhongshan Hospital 120 participants Est. completion 2019-07 1 site
  Other conditions: Sarcopenia, Cirrhosis, Liver
  View official trial listing →
• Status unknown NCT NCT03679273

  Nutritional Supplement on Wound Healing in Diabetic Foot

  Not yet reported Chang Gung Memorial Hospital 70 participants Est. completion 2020-05-15 1 site
  Other conditions: Diabetic Foot
  View official trial listing →
• Status unknown NCT NCT03692507

  Effects of Nutritional Preconditioning on the Patient's Outcomes After Surgery

  Not yet reported University of California, San Francisco 20 participants Est. completion 2022-12-30 1 site
  Other conditions: Major Abdominal/GI Surgery
  View official trial listing →
• Completed NCT NCT03792711

  The Effects of the Oral Nutritional Supplement With β-hydroxy-β-methylbutyrate in Lean Body Mass Among Taiwan Elderly

  Not yet reported National Yang Ming Chiao Tung University 70 participants Est. completion 2020-12-30 1 site
  Other conditions: Frail Elderly Syndrome, Nutrition Disorders in Old Age, Muscle Loss
  View official trial listing →
• Completed NCT NCT03827499

  HMB Supplementation in Addition to Multicomponent Exercise in Old Adults

  Not yet reported Universidad de Murcia 104 participants Est. completion 2023-04-30 1 site
  Other conditions: Aging, Frail Elderly Syndrome, Physical Activity
  View official trial listing →
• Status unknown NCT NCT03848741

  Independent and Combined Effects of Resistance Exercise Training and β-hydroxy β-methylbutyrate Plus Vitamin D

  Not yet reported University of Illinois at Urbana-Champaign 48 participants Est. completion 2021-04 1 site
  Other conditions: Aging, Skeletal Muscle
  View official trial listing →
• Status unknown NCT NCT04001907

  Effect of Exercise With and Without HMB on Body Composition and Muscle Strength in Sickle Cell Anaemia

  Not yet reported The University of The West Indies 24 participants Est. completion 2019-11-15
  Other conditions: Sickle Cell Anemia
  View official trial listing →
• Status unknown NCT NCT04549610

  HMB and Exercise-induced Muscle Damage

  Not yet reported, Not yet reported Poznan University of Physical Education 30 participants Est. completion 2025-01-01 1 site
  Other conditions: Supplementation, Sport, Sports Nutrition, Muscle Damage, Recovery
  View official trial listing →
• Completed NCT NCT04859400

  Influence of a Home-based Nutrition and Exercise Program on Quality of Life of Palliative Cancer Outpatients

  Not yet reported Kantonsspital Winterthur KSW 72 participants Est. completion 2024-11-06 3 sites
  Other conditions: Cancer, Gastrointestinal, Cancer, Lung, Malnutrition
  View official trial listing →
• Status unknown NCT NCT04953936

  β-hydroxy-β-methylbutyrate-enriched Nutritional Supplements for Obesity Adults

  Not yet reported West China Hospital 72 participants Est. completion 2021-12-31 1 site
  Other conditions: Obesity
  View official trial listing →
• Status unknown NCT NCT05384951

  HMB Cerebral Palsy Pilot Study

  Not yet reported Gillette Children's Specialty Healthcare 7 participants Est. completion 2024-05-31 1 site
  Other conditions: Cerebral Palsy
  View official trial listing →
• Status unknown NCT NCT05435534

  Effect of a Multicomponent Intervention on Functional Capacity After Hip Fracture

  Not yet reported Fundacion Miguel Servet 174 participants Est. completion 2024-05 1 site
  Other conditions: Hip Fractures, Osteoporosis, Fall, Frailty Syndrome, Rehabilitation
  View official trial listing →
• Completed NCT NCT05525039

  RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration

  Not yet reported Chinese University of Hong Kong 200 participants Est. completion 2026-05-04 3 sites
  Other conditions: Sarcopenia, Connective Tissue Diseases in Old Age, Musculoskeletal Abnormalities
  View official trial listing →
• Completed NCT NCT05767112

  Pharmacokinetic Profile of the Calcium-salt and Free Acid Forms of β-hydroxy-β-methylbutyrate in Humans

  Not yet reported University of Sao Paulo 16 participants Est. completion 2021-12-20 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT05951439

  Effect of Creatine+HMB Supplementation in Physically Active Older Adults

  Not yet reported Universidad de Burgos 30 participants Est. completion 2025-02-22 1 site
  Other conditions: Aging, Sarcopenia, Nutrition, Healthy
  View official trial listing →
• Completed NCT NCT06287502

  Efficacy of Structured Exercise-Nutritional Intervention on Sarcopenia in Patients With Osteoporosis

  Not yet reported Kowloon Hospital, Hong Kong 13 participants Est. completion 2024-06-30 1 site
  Other conditions: Sarcopenia, Osteoporosis
  View official trial listing →
• Status unknown NCT NCT06429410

  Effects of Milk Powder Intervention on Body Composition and Physical Performance in Middle-aged and Older Adults

  Not yet reported Huilian Zhu 200 participants Est. completion 2026-07
  Other conditions: Healthy
  View official trial listing →
• Not yet recruiting NCT NCT07142941

  Exercise and/or HMB in Older Diabetes With Low Muscle Mass

  Not yet reported Wu Shangling 120 participants Est. completion 2027-12-31
  Other conditions: Diabetes, Low Muscle Mass
  View official trial listing →
• Active, not recruiting NCT NCT07275996

  Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Muscle Function in Sarcopenic Frailty

  Not yet reported Universidad de Burgos 50 participants Est. completion 2027-05-30 1 site
  Other conditions: Frailty, Sarcopenia, Aging, Malnutrition Elderly
  View official trial listing →
• Completed NCT NCT07343999

  EFICAC-TTR Trial: Exercise and Nutritional Supplementation in Transthyretin Cardiac Amyloidosis

  Not yet reported Universidad de Burgos 47 participants Est. completion 2026-09-10 3 sites
  Other conditions: Transthyretin Cardiac Amyloidosis
  View official trial listing →
• Not yet recruiting NCT NCT07589764

  Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS

  Not yet reported Duke University 100 participants Est. completion 2027-10-01 2 sites
  Other conditions: Amyotrophic Lateral Sclerosis ALS
  View official trial listing →
• Not yet recruiting NCT NCT07722806

  A Nutrition and Exercise Program With Olanzapine Compared to Olanzapine Alone: A Trial in Patients With Advanced Tumors

  Not yet reported Kantonsspital Winterthur KSW 130 participants Est. completion 2028-12 1 site
  Other conditions: Cancer, Advanced Solid Tumors, Malnutrition
  View official trial listing →
• Not yet recruiting NCT NCT07731048

  High-Protein Diet and HMB Supplementation in Patients With Heart Failure

  Not yet reported Hospital de Clinicas de Porto Alegre 84 participants Est. completion 2027-11-30 1 site
  Heart failure
  View official trial listing →
• Not yet recruiting NCT NCT07780006

  Efficacy of Oral Nutritional Supplement in Femoral Neck Fracture Patients Undergoing Hip Arthroplasty

  Not yet reported Thammasat University 60 participants Est. completion 2027-12 1 site
  Other conditions: Femoral Neck Fractures, Geriatric Hip Fracture, Hip Fracture, Post Surgery Recovery, Muscle Resilience
  View official trial listing →
• Not yet recruiting NCT NCT07905755

  Effect of HMB Supplementation and Vivifrail Exercise on Body Composition, Handgrip Strength and Physical Performance in Women Over 60 Years of Age

  Not yet reported Universidad Autónoma del Estado de Hidalgo 44 participants Est. completion 2027-04 1 site
  Other conditions: Aging, Muscle Strength, Physical Functional Performance, Body Composition
  View official trial listing →

Not yet reported.

Not yet reported.

• ClinicalTrials.gov — NCT07589764

Also known as: β-hydroxy-β-methylbutyrate, β-hydroxy-β-methylbutyrate (HMB)

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