About this data
Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.
Guideline Directed Medical Therapy for Heart Failure
- Company
- University Medical Centre Ljubljana
- Mechanism
- Mechanism not yet reported
- Route
- Route not yet reported
- Recruiting trials
- 40 recruiting
Efficacy results: Not yet reported
40 recruiting studies currently listed on ClinicalTrials.gov.
Data source: ClinicalTrials.gov · trial data as of Sep 23, 2026
Find a Clinical Trial Near Me
See recruiting studies for Guideline Directed Medical Therapy for Heart Failure and check eligibility with the study team.
Trial details
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Recruiting NCT NCT04768322
LVAD Versus GDMT in Ambulatory Advanced Heart Failure Patients
Not yet reported Hospices Civils de Lyon 92 participants Est. completion 2029-02 8 sitesHeart failureView official trial listing → -
Recruiting NCT NCT05180773
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
Not yet reported Dennis M. McNamara, MD, MS 250 participants Est. completion 2028-12-31 64 sitesOther conditions: Peripartum Cardiomyopathy, PostpartumView official trial listing → -
Recruiting NCT NCT05433220
PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure at Inova
Not yet reported Inova Health Care Services 5000 participants Est. completion 2027-08-25 1 siteHeart failureView official trial listing → -
Recruiting NCT NCT05828719
Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction
Not yet reported Samsung Medical Center 900 participants Est. completion 2030-12-31 1 siteHeart failure Other conditions: Ischemic CardiomyopathyView official trial listing → -
Recruiting NCT NCT05831085
Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease
Not yet reported Duk-Woo Park, MD 1500 participants Est. completion 2029-12-31 39 sites Stand-aloneOther conditions: Coronary Artery StenosisView official trial listing → -
Recruiting NCT NCT05960721
Low-dose NOAC Versus GDMT After LAAO
Not yet reported Xijing Hospital 4220 participants Est. completion 2028-07-30 1 siteOther conditions: Atrial FibrillationView official trial listing → -
Recruiting NCT NCT06128980
Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy
Not yet reported, Not yet reported Herlev and Gentofte Hospital 348 participants Est. completion 2032-01 1 siteHeart failure Other conditions: Heart Rhythm DisorderView official trial listing → -
Recruiting NCT NCT06241430
The CardioClip Study
Not yet reported Columbia University 60 participants Est. completion 2030-06 1 site Stand-aloneHeart failure Other conditions: Mitral RegurgitationView official trial listing → -
Recruiting NCT NCT06250257
Bromocriptine in Dilated Cardiomyopathy Among Women of Reproductive Age
Not yet reported Jimma University 112 participants Est. completion 2026-11-30 1 site Stand-aloneOther conditions: Dilated CardiomyopathyView official trial listing → -
Recruiting NCT NCT06405555
Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension
Not yet reported, Not yet reported Ottawa Heart Institute Research Corporation 56 participants Est. completion 2028-06-01 1 siteHeart failure Other conditions: Hypotension, LV DysfunctionView official trial listing → -
Recruiting NCT NCT06526195
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Not yet reported Abbott Medical Devices 850 participants Est. completion 2032-09 68 sitesHeart failureCardiovascular disease Other conditions: Heart Diseases, Pulmonary HypertensionView official trial listing → -
Recruiting NCT NCT06526988
Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure
Not yet reported University of Colorado, Denver 2200 participants Est. completion 2028-09-01 5 sites Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT06552637
Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
Not yet reported VisCardia Inc. 270 participants Est. completion 2029-12 3 sites Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT06580392
CCM and Implementation of Guideline-Directed Medical Therapy in Patients With Heart Failure (Fix-GDMT-HF)
Impulse Dynamics 200 participants Est. completion 2027-12 2 sitesHeart failureView official trial listing → -
Recruiting NCT NCT06742567
Apixaban Prophylaxis for Prevention of Left Ventricular Thrombus Following Anterior Myocardial Infarction
Not yet reported National Institute of Cardiovascular Diseases, Pakistan 472 participants Est. completion 2025-11-30 1 site Stand-aloneCardiovascular disease Other conditions: Left Ventricular Thrombus, ProphylaxisView official trial listing → -
Recruiting NCT NCT06813820
RELIVE (Randomized Evaluation of Less Invasive Ventricular Enhancement) Trial
Not yet reported BioVentrix 135 participants Est. completion 2032-08 6 sites Stand-aloneOther conditions: Left Ventricle Remodeling, Left Ventricle Dilated, CHFView official trial listing → -
Recruiting NCT NCT06818084
TRanscAtheter TreatMent of PurE Aortic Regurgitation With VitaFlow Liberty System
Not yet reported Ruijin Hospital 120 participants Est. completion 2027-11-30 4 sites Stand-aloneOther conditions: AORTIC VALVE DISEASES, Aortic Regurgitation, Transcatheter Aortic Valve Replacement (TAVR)View official trial listing → -
Recruiting NCT NCT06868797
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
Not yet reported Central Hospital, Nancy, France 103 participants Est. completion 2027-09-12 11 sitesHeart failureView official trial listing → -
Recruiting NCT NCT06906640
Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)
Not yet reported Duke University 420 participants Est. completion 2027-04-01 7 sitesChronic kidney diseaseType 2 diabetes Other conditions: Type 2 DMView official trial listing → -
Recruiting NCT NCT07009418
Smart Angioplasty Research Team-Coronary CT Angiography Versus Standard Care as Follow-up Strategies in High-Risk Patients After PCI (SMART-CARE)
Not yet reported Samsung Medical Center 3500 participants Est. completion 2032-12-31 22 sitesCardiovascular disease Other conditions: Ischemic Heart DiseaseView official trial listing → -
Recruiting NCT NCT07023666
Early Screening and Treatment of Heart Complication in Sickle Cell Disease
Not yet reported Inova Health Care Services 100 participants Est. completion 2027-12-30 2 sites Stand-aloneOther conditions: Sickle Cell DiseaseView official trial listing → -
Recruiting NCT NCT07107971
Drug-Eluting Balloon Treatment vs. Guideline-Directed Medical Therapy for the Treatment of Lipid-Rich Plaques
Not yet reported Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 400 participants Est. completion 2033-01 1 site Stand-aloneCardiovascular disease Other conditions: Atheroscleroses, Vulnerable Coronary Plaques, Vulnerable Plaque, Lipid-Rich Atherosclerosis of Coronary Artery, Acute Coronary Syndromes (ACS)View official trial listing → -
Recruiting NCT NCT07154758
Registry BAsed Optimization Of Therapy in Heart Failure
Not yet reported Region Stockholm 1000 participants Est. completion 2026-06-30 6 sites Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT07214376
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
Not yet reported Pulnovo Medical, Inc. 750 participants Est. completion 2031-12-31 6 sites Stand-aloneHeart failureCardiovascular disease Other conditions: Pulmonary Hypertension, Hypertension, Vascular DiseasesView official trial listing → -
Recruiting NCT NCT07337577
Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failure (TAILOR-HF)
Not yet reported Brigham and Women's Hospital 500 participants Est. completion 2027-12-01 1 site Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT07349875
Colchicine Treatment for Non-Flow-Limiting Coronary Plaque by Coronary CTA: A Randomized Controlled Trial
Not yet reported Nanjing First Hospital, Nanjing Medical University 3826 participants Est. completion 2030-06-30 1 site Stand-aloneCardiovascular diseaseView official trial listing → -
Recruiting NCT NCT07352891
Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)
Not yet reported Beijing Anzhen Hospital 252 participants Est. completion 2026-07 6 sites Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT07391683
Telemedically Assisted Optimization for Heart Failure Patients Before Cardiac Surgery to Improve Perioperative Outcome
Not yet reported Medical University Innsbruck 162 participants Est. completion 2034-01-01 1 site Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT07405944
Vericiguat and Reverse Remodeling Indices in Heart Failure
Not yet reported University Medical Centre Ljubljana 60 participants Est. completion 2027-12-31 4 sites Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT07414225
Safety and Efficacy of Transcatheter Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation
Not yet reported Beijing Anzhen Hospital 400 participants Est. completion 2030-02-25 1 site Stand-aloneOther conditions: Atrial Functional Mitral RegurgitationView official trial listing → -
Recruiting NCT NCT07433504
A Prospective, Multicenter, Randomized Controlled Clinical Trial of Transcatheter Tricuspid Valve Clipping Systems.
Not yet reported Shanghai Huihe Medical Technology Co., Ltd 132 participants Est. completion 2031-12-31 1 site Stand-aloneOther conditions: Severe or Greater Tricuspid RegurgitationView official trial listing → -
Recruiting NCT NCT07489547
Medication Withdrawal in Stable HF With Improved LVEF
Not yet reported, Not yet reported Hospital de Clinicas de Porto Alegre 90 participants Est. completion 2026-12-31 1 siteHeart failureView official trial listing → -
Recruiting NCT NCT07492524
Novel Model of Integrated Care of Older Patients With Atrial Fibrillation and Heart Failure in Rural China (MIRACLE-AFHF)
Not yet reported Jiangsu Taizhou People's Hospital 942 participants Est. completion 2029-12-30 3 sites Stand-aloneHeart failure Other conditions: Atrial FibrillationView official trial listing → -
Recruiting NCT NCT07518030
Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure
Not yet reported Azienda Unita Sanitaria Locale di Piacenza 80 participants Est. completion 2028-06-01 1 site Stand-aloneHeart failureView official trial listing → -
Recruiting NCT NCT07543562
Selenium Intervention Registry Randomized Trial in Heart Failure
Not yet reported Skane University Hospital 4326 participants Est. completion 2031-03 11 sitesHeart failure Other conditions: Selenium Supplementation, Selenium, Cognitive FunctioningView official trial listing → -
Recruiting NCT NCT07560982
Evaluating Adherence to Guideline-Directed Medical Therapy in Patients With Advanced Heart Failure
Università Vita-Salute San Raffaele 300 participants Est. completion 2036-07-01 2 sitesHeart failureView official trial listing → -
Recruiting NCT NCT07572032
Delayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology (DELAY-HF), Pilot Study
Not yet reported Kyungsub Song 80 participants Est. completion 2028-12-20 4 sitesCardiovascular diseaseHeart failure Other conditions: Valvular CardiomyopathyView official trial listing → -
Recruiting NCT NCT07741383
A Study on the Efficacy and Safety of TEER Combined With Electrical Cardioversion in Patients With Severe Mitral Regurgitation and Atrial Fibrillation
Not yet reported Second Affiliated Hospital, Zhejiang University, School of Medicine 570 participants Est. completion 2029-12-31 1 site Stand-aloneOther conditions: Atrial Fibrillation Mitral Valve InsufficiencyView official trial listing → -
Recruiting NCT NCT07814612
Clinical Efficacy and Safety of Left Bundle Branch Area Pacing Using Quantitative Guidance of Multimodal Data in the Treatment of Heart Failure
Not yet reported Second Affiliated Hospital of Nanchang University 100 participants Est. completion 2027-12 1 siteHeart failure Other conditions: Left Bundle Branch Block, Non-ischemic CardiomyopathyView official trial listing → -
Recruiting NCT NCT07820410
Atrial Shunt for the Treatment of Heart Failure With Reduced Ejection Fraction
Not yet reported, Not yet reported Beijing Anzhen Hospital 208 participants Est. completion 2027-12-31 1 site Stand-aloneHeart failureView official trial listing → -
Active, not recruiting NCT NCT01471834
Verification of the Efficacy and Safety of the BAROSTIM NEO System in the Treatment of Drug Resistant Hypertension
Not yet reported CVRx, Inc. 40 participants Est. completion 2026-12 9 sites Stand-aloneOther conditions: High Blood PressureView official trial listing → -
Withdrawn NCT NCT02590601
Bromocriptine in the Treatment of Peripartum Cardiomyopathy
Not yet reported Montreal Heart Institute Est. completion 2023-01-01 1 siteOther conditions: Peripartum CardiomyopathyView official trial listing → -
Completed NCT NCT02627196
Baroreflex Activation Therapy for Heart Failure
Not yet reported CVRx, Inc. 1090 participants Est. completion 2023-10 92 sites Stand-aloneHeart failureView official trial listing → -
Terminated NCT NCT02656329
International Study to Determine if AdreView Heart Function Scan Can be Used to Identify Patients With Mild or Moderate Heart Failure (HF) That Benefit From Implanted Medical Device
Not yet reported GE Healthcare 395 participants Est. completion 2018-05-04 94 sites Stand-aloneHeart failureView official trial listing → -
Active, not recruiting NCT NCT02931240
BioVentrix Revivent TC™ System Clinical Study
Not yet reported BioVentrix 126 participants Est. completion 2027-06-30 30 sitesOther conditions: Ventricular Dysfunction, LeftView official trial listing → -
Withdrawn NCT NCT02985268
Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF
Not yet reported Montreal Heart Institute Est. completion 2020-02Heart failure Other conditions: Functional Mitral RegurgitationView official trial listing → -
Completed NCT NCT03016754
Heart Failure Optimization Study
Zoll Medical Corporation 602 participants Est. completion 2022-06-01 67 sitesSubstance use disorderHeart failureView official trial listing → -
Terminated NCT NCT03016975
Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)
Not yet reported Edwards Lifesciences 12 participants Est. completion 2022-09-20 24 sites Stand-aloneOther conditions: Functional Mitral Regurgitation, Mitral Regurgitation, Mitral InsufficiencyView official trial listing → -
Withdrawn NCT NCT03845127
Randomized Evaluation and Verification of Ventricular Enhancement
Not yet reported BioVentrix Est. completion 2024-12-31 1 site Stand-aloneHeart failure Other conditions: Ischemic CardiomyopathyView official trial listing → -
Active, not recruiting NCT NCT04089059
PROACTIVE-HF IDE Trial Heart Failure NYHA Class III
Not yet reported Endotronix, Inc. 738 participants Est. completion 2028-04 74 sitesHeart failureView official trial listing → -
Status unknown NCT NCT04191330
Artificial Intelligence Mobile Health Trial Of A Digital Platform To Optimize GDMT Using Wearable Sensors
Not yet reported Biofourmis Inc. 122 participants Est. completion 2024-08-31 14 sites Stand-aloneHeart failureView official trial listing → -
Suspended NCT NCT04331769
Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study
Not yet reported Ancora Heart, Inc. 400 participants Est. completion 2030-12-21 122 sitesHeart failure Other conditions: Dilated CardiomyopathyView official trial listing → -
Withdrawn NCT NCT04376424
Ultra-sound Assisted Management of Heart Failure
Not yet reported The University of Texas Medical Branch, Galveston Est. completion 2021-11-17 1 site Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT04633005
Polypill Strategy for Heart Failure With Reduced Ejection Fraction
Not yet reported University of Texas Southwestern Medical Center 212 participants Est. completion 2025-10-31 1 siteHeart failureView official trial listing → -
Withdrawn NCT NCT04872959
TRANSFORM Heart Failure with Reduced Ejection Fraction
Not yet reported Massachusetts General Hospital Est. completion 2024-05 Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT05077293
Building Electronic Tools To Enhance and Reinforce Cardiovascular Recommendations - Heart Failure
NYU Langone Health 596 participants Est. completion 2022-01-01 1 siteHeart failureView official trial listing → -
Active, not recruiting NCT NCT05149755
Evolut™ EXPAND TAVR II Pivotal Trial
Not yet reported Medtronic Cardiovascular 650 participants Est. completion 2034-12 94 sites Stand-aloneOther conditions: Moderate Aortic Valve StenosisView official trial listing → -
Status unknown NCT NCT05170165
A Pilot Study to Increase Utilization of GDMT in Patients With HFrEF
Cedars-Sinai Medical Center 50 participants Est. completion 2023-09-25 1 siteHeart failureView official trial listing → -
Completed NCT NCT05212649
Optimized Peak VO2 in Predicting Advanced HF
Chang Gung Memorial Hospital 377 participants Est. completion 2021-07-30 1 siteHeart failure Other conditions: Morality, Transplant; Failure, HeartView official trial listing → -
Completed NCT NCT05275920
Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure (BETTER CARE-HF)
Not yet reported NYU Langone Health 2211 participants Est. completion 2022-10-26 1 siteHeart failureView official trial listing → -
Completed NCT NCT05413447
Assessment of Digital Consultations on Clinical Impact and Efficiency
Not yet reported Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 150 participants Est. completion 2024-06-06 5 sitesHeart failureView official trial listing → -
Completed NCT NCT05531214
Creating A Cardiorenal Multidisciplinary Team for Management HF and CKD Patients
Not yet reported George Washington University 96 participants Est. completion 2024-06-01 1 siteHeart failureChronic kidney diseaseView official trial listing → -
Active, not recruiting NCT NCT05534932
Guideline-directed Management and Therapy (GDMT) for the Prevention of Postpartum Cardiac Dysfunction in Preeclamptic African American Women
Not yet reported University of Chicago 20 participants Est. completion 2026-11-01 1 siteOther conditions: Preeclampsia PostpartumView official trial listing → -
Status unknown NCT NCT05572814
Transform: Teaching, Technology, and Teams
Not yet reported American College of Cardiology 750 participants Est. completion 2023-12-31 1 siteHeart failureType 2 diabetes Other conditions: Atrial FibrillationView official trial listing → -
Active, not recruiting NCT NCT05572957
LBBP as Initial Therapy in Patients With Non-ischemic Heart Failure and LBBB
Not yet reported The First Affiliated Hospital with Nanjing Medical University 50 participants Est. completion 2027-10 6 sites Stand-aloneHeart failure Other conditions: Non-ischemic Cardiomyopathy, Left Bundle-Branch BlockView official trial listing → -
Status unknown NCT NCT05591443
Artificial Intelligence and Smart Wearable Technologies for Early Detection of Acute Heart Failure
Centro Cardiologico Monzino 120 participants Est. completion 2026-05Heart failureView official trial listing → -
Status unknown NCT NCT05606718
Dapagliflozin Effect on FunctiOnal Mitral Regurgitation and Myocardial Remodeling
Not yet reported Sun Yat-sen University 98 participants Est. completion 2023-07-31 3 sites Stand-aloneOther conditions: Functional Mitral RegurgitationView official trial listing → -
Active, not recruiting NCT NCT05637853
Telemonitored Fast Track Medical Sequencing for Heart Failure With Reduced Ejection Fraction
Not yet reported Göteborg University 60 participants Est. completion 2026-08-26 1 site Stand-aloneHeart failureView official trial listing → -
Status unknown NCT NCT05770648
A Prospective, Multicenter, Randomized Controlled Trial to Evaluate the Efficacy and Safety of the Transcatheter Tricuspid Valvuloplasty System in Patients With Severe or Above Tricuspid Regurgitation
Not yet reported Shanghai Huihe Medical Technology Co., Ltd 64 participants Est. completion 2024-12 Stand-aloneOther conditions: Tricuspid RegurgitationView official trial listing → -
Completed NCT NCT05792085
Heart Failure Optimization at Home to Improve Outcomes (Hozho): A Pragmatic Clinical Trial in Navajo Nation
Not yet reported University of Pennsylvania 103 participants Est. completion 2023-08-01 2 sitesHeart failureView official trial listing → -
Completed NCT NCT05799638
Strategy, Efficacy and Safety of Medication Usage in Heart Failure Patients Who Were Intolerable to GDMT
Chongqing Medical University 263 participants Est. completion 2024-06-30 1 siteHeart failureView official trial listing → -
Withdrawn NCT NCT05806970
Email Nudges to Improve GDMT (MRA) Adherence in Heart Failure
Not yet reported University of California, Los Angeles Est. completion 2023-07 1 site Stand-aloneHeart failureView official trial listing → -
Active, not recruiting NCT NCT05824923
A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure
Not yet reported Pulnovo Medical (Wuxi) Co., Ltd. 264 participants Est. completion 2027-02 1 site Stand-aloneHeart failureCardiovascular disease Other conditions: Pulmonary Hypertension, Hypertension, Vascular DiseasesView official trial listing → -
Terminated NCT NCT05834673
VICTORION-ASCERTAIN: Implementation Study (v-ASCERTAIN)
Not yet reported Monash University 6 participants Est. completion 2024-12-19 1 siteCardiovascular disease Other conditions: Coronary Heart Disease (CHD), Cerebrovascular Disease, Peripheral Arterial Disease (PAD)View official trial listing → -
Status unknown NCT NCT05848102
Dapagliflozin Effect on FunctiOnal Mitral Regurgitation and Myocardial Fibrosis (DEFORM)
Not yet reported Sun Yat-sen University 166 participants Est. completion 2025-04-23 3 sitesOther conditions: Functional Mitral RegurgitationView official trial listing → -
Completed NCT NCT05906745
Guideline Directed Medical Therapy (GDMT) Optimization and Adherence Longitudinal Study for Heart Failure.
Tricog Health Inc 52 participants Est. completion 2024-09-27 4 sitesHeart failureView official trial listing → -
Status unknown NCT NCT05931900
The JensClip Transcatheter Valve Repair System for Treating Functional Mitral Regurgitation
Not yet reported Jenscare Scientific 129 participants Est. completion 2025-08 1 site Stand-aloneOther conditions: Functional Mitral RegurgitationView official trial listing → -
Status unknown NCT NCT05973591
The Impact of Ivabradine on Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy (NIDCM) on Current Medical Therapy Era
Yonsei University 500 participants Est. completion 2024-12-31 1 siteHeart failure Other conditions: Dilated Cardiomyopathy, Ventricular RemodelingView official trial listing → -
Completed NCT NCT05974189
The VERIFY Study: An Observational Study Called VERIFY to Learn More About the Use of Vericiguat in People With Chronic Heart Failure With Reduced Ejection Fraction
Bayer 1391 participants Est. completion 2024-10-08 1 siteHeart failureView official trial listing → -
Completed NCT NCT05990296
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Not yet reported Geisinger Clinic 4306 participants Est. completion 2025-05-17 1 site Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT06003972
Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failure
Not yet reported Hadassah Medical Organization 14 participants Est. completion 2023-03-12 1 siteHeart failure Other conditions: Cytokine Storm, Inflammatory ResponseView official trial listing → -
Completed NCT NCT06029712
Heart Failure Polypill at a Safety Net Hospital
Not yet reported University of California, San Francisco 35 participants Est. completion 2025-01-29 1 site Stand-aloneHeart failure Other conditions: HIV InfectionsView official trial listing → -
Completed NCT NCT06068166
Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Reduced Ejection Fraction
Not yet reported First Affiliated Hospital of Harbin Medical University 1840 participants Est. completion 2023-08-31 Stand-aloneHeart failure Other conditions: Thoracic Epidural AnesthesiaView official trial listing → -
Status unknown NCT NCT06099808
Veterans Affairs Pharmacist Heart Failure Medication Titration Project 1
Not yet reported Stanford University 110 participants Est. completion 2024-09-30 1 site Stand-aloneHeart failureView official trial listing → -
Not yet recruiting NCT NCT06102031
Clinical Study on the Noninvasive Lung Fluid Monitoring System in Guiding the Treatment of Heart Failure
Not yet reported Shanghai Zhongshan Hospital 1000 participants Est. completion 2026-12 Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT06103565
EHR Nudges to Improve Quality of Care in HF
Not yet reported Northwestern University 3 participants Est. completion 2025-08-13 1 siteHeart failureView official trial listing → -
Active, not recruiting NCT NCT06126081
Clinical Efficacy of Early Left Bundle Branch Pacing for Cardiac Resynchronization Therapy
Not yet reported Fu Wai Hospital, Beijing, China 36 participants Est. completion 2026-06 2 sites Stand-aloneHeart failure Other conditions: Left Bundle Branch PacingView official trial listing → -
Status unknown NCT NCT06192524
OPTImal PHARMacological Therapy for Patients With Heart Failure: The OPTIPHARM-HF Registry
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 2000 participants Est. completion 2025-10-01 1 siteHeart failureView official trial listing → -
Status unknown NCT NCT06273085
Intensive Education Versus Usual Education of Patients for Improving Guideline Directed Medical Therapy (GDMT) Prescription in Heart Failure With Reduced Ejection Fraction
Not yet reported Medstar Health Baltimore 500 participants Est. completion 2025-02 4 sitesHeart failure Other conditions: Patient Acceptance of Health CareView official trial listing → -
Status unknown NCT NCT06273280
Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction.
Not yet reported Ziekenhuis Oost-Limburg 345 participants Est. completion 2026-03 1 site Stand-aloneHeart failureView official trial listing → -
Status unknown NCT NCT06278727
Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University 270 participants Est. completion 2025-12-31 1 siteHeart failure Other conditions: Mitral RegurgitationView official trial listing → -
Completed NCT NCT06300086
Nationwide Utilization of Danish Government Electronic Letter System for Increasing Guideline-directed Medical Therapy in Chronic Kidney Disease
Not yet reported Tor Biering-Sørensen 28388 participants Est. completion 2025-02-19 1 site Stand-aloneChronic kidney disease Other conditions: Behavior and Behavior MechanismsView official trial listing → -
Status unknown NCT NCT06344910
PRagmatic Study Of Messaging to Providers of Patients With Heart Failure in Amsterdam UMC
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 900 participants Est. completion 2025-12 2 sitesHeart failureView official trial listing → -
Active, not recruiting NCT NCT06386042
Guideline Implementation and Quality of Care in Patients With Heart Failure: the TITRATE-HF Registry
Erasmus Medical Center 4289 participants Est. completion 2029-04 1 siteHeart failureView official trial listing → -
Active, not recruiting NCT NCT06416813
Preventive Intervention Value of DCB in Vulnerable Coronary Atherosclerotic Plaques
Not yet reported Yong He 140 participants Est. completion 2027-12-01 1 site Stand-aloneOther conditions: Acute Coronary SyndromeView official trial listing → -
Withdrawn NCT NCT06433687
Evaluation of the HekaHeart Platform in Medication Management for Heart Failure Patients
Yale University Est. completion 2026-10 2 sitesHeart failureView official trial listing → -
Suspended NCT NCT06566183
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Left Ventricular Dysfunction Trial
Not yet reported NYU Langone Health 1200 participants Est. completion 2032-12 6 sites Stand-aloneCardiovascular diseaseHeart failure Other conditions: Cognitive ImpairmentView official trial listing → -
Enrolling by invitation NCT NCT06635863
Comparing Immune System Suppression to Medication for Unexplained Heart Function and Irregular Heartbeat
Not yet reported Roderick Tung 40 participants Est. completion 2027-10 1 site Stand-aloneOther conditions: Ventricular Arrythmia, Non-ischemic Cardiomyopathy, Arrhythmogenic Inflammatory CardiomyopathyView official trial listing → -
Completed NCT NCT06641284
Gender-Based Differences in Heart Failure Hospitalizations Among Patients With Heart Failure Treated With Spironolactone
Ahmad Abdullah Salawi 509 participants Est. completion 2024-10-15 1 siteHeart failureView official trial listing → -
Completed NCT NCT06641921
Strategy TO Prevent Decompensated Heart Failure
Not yet reported Seerlinq s. r. o. 330 participants Est. completion 2025-11-01 1 site Stand-aloneHeart failure Other conditions: Remote MonitoringView official trial listing → -
Not yet recruiting NCT NCT06667128
Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)
Not yet reported IRCCS Ospedale San Raffaele 160 participants Est. completion 2026-02-01 1 site Stand-aloneHeart failure Other conditions: Valvulopathy, Aortic Stenosis, Aortic Regurgitation Disease, Mitral Regurgitation, Tricuspid Regurgitation, Brain Natriuretic Peptide, Mitraclip, TAVI(Transcatheter Aortic Valve Implantation)View official trial listing → -
Active, not recruiting NCT NCT06675552
Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany
AstraZeneca 338 participants Est. completion 2027-06-30 6 sitesHeart failureCardiovascular disease Other conditions: Heart DiseaseView official trial listing → -
Completed NCT NCT06700213
Guideline Directed Medical Therapy in Patients With Heart Failure
Massachusetts General Hospital 300 participants Est. completion 2025-09-22 1 siteHeart failureView official trial listing → -
Terminated NCT NCT06702527
Optimizing Clinical Outcomes in Patients Undergoing Mitral Transcatheter Edge-to-edge Repair (M-TEER) for Severe Functional Mitral Regurgitation Towards Improved Guideline-directed Medical Therapy
Institut für Pharmakologie und Präventive Medizin 9 participants Est. completion 2026-03-01 2 sitesHeart failure Other conditions: Mitral Regurgitation Functional, M-TEERView official trial listing → -
Enrolling by invitation NCT NCT06844006
Investigating the Impact of Nudging Cardiologists to Prescribe Guideline-directed Medical Therapy in Heart Failure Patients
Not yet reported Medisch Spectrum Twente 1320 participants Est. completion 2028-08-31 5 sitesHeart failureView official trial listing → -
Completed NCT NCT06847438
Tailored Electronic Intervention to Improve Therapy in a Diverse Cohort of Patients With Heart Failure
Not yet reported Emory University 3966 participants Est. completion 2026-06-15 4 sitesHeart failureView official trial listing → -
Not yet recruiting NCT NCT06928883
Ticin Pilot Study: Sirolimus-Eluting Balloon for Stabilization and Regression of Non-Obstructive Coronary Plaques.
Not yet reported Cardiocentro Ticino 24 participants Est. completion 2028-12-31 1 siteCardiovascular disease Other conditions: Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Coronary Vessel, Acute Coronary Syndromes (ACS)View official trial listing → -
Not yet recruiting NCT NCT06965504
INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
Not yet reported Abiomed Inc. 250 participants Est. completion 2029-06-01 15 sitesHeart failure Other conditions: Cardiogenic ShockView official trial listing → -
Completed NCT NCT07130175
Radiofrequency Ablation for Polymorphic Ventricular Tachycardia With Heart Failure (RFCA for PMVT-HF)
Not yet reported Qian Feng 118 participants Est. completion 2024-12-31 1 site Stand-aloneHeart failure Other conditions: Polymorphic Ventricular TachycardiaView official trial listing → -
Not yet recruiting NCT NCT07197021
TEER In dynaMic sEvere Functional Mitral Regurgitation (TIMER)
Not yet reported Sun Yat-sen University 540 participants Est. completion 2034-12-31 1 site Stand-aloneOther conditions: Mitral Regurgitation FunctionalView official trial listing → -
Not yet recruiting NCT NCT07211724
Methamphetamine Use Disorder Support in Heart Failure Pilot Study
Not yet reported University of Southern California 50 participants Est. completion 2027-07 2 sitesHeart failure Other conditions: Methamphetamine Use DisorderView official trial listing → -
Completed NCT NCT07217106
A Study of Accelerated Guideline-Directed Medical Therapy for Heart Failure
Novartis Pharmaceuticals 342 participants Est. completion 2024-07-01 1 siteHeart failureView official trial listing → -
Not yet recruiting NCT NCT07230756
Coronary Heart Disease Complicated With Ischemic Mitral Regurgitation in China
China National Center for Cardiovascular Diseases 6000 participants Est. completion 2029-12-31Other conditions: Ischemic Mitral Regurgitation, Coronary Heart Disease (CHD)View official trial listing → -
Enrolling by invitation NCT NCT07252310
Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App)
Not yet reported Weill Medical College of Cornell University 5 participants Est. completion 2027-08 1 site Stand-aloneHeart failure Other conditions: Heart DiseasesView official trial listing → -
Not yet recruiting NCT NCT07295522
Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?
Not yet reported IRCCS Policlinico S. Donato 368 participants Est. completion 2028-06-08 13 sites Stand-aloneHeart failureView official trial listing → -
Not yet recruiting NCT NCT07331220
Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction
Not yet reported Nanjing First Hospital, Nanjing Medical University 310 participants Est. completion 2028-12-30 1 site Stand-aloneHeart failureView official trial listing → -
Not yet recruiting NCT NCT07332494
Digital Remote Management for Care and Continuous Optimization Versus Usual Care in Patients With Coronary Heart Disease (DigiCare-CHD)
Not yet reported Beijing Anzhen Hospital 792 participants Est. completion 2027-07 4 sitesOther conditions: Coronary Heart Disease, Percutaneous Coronary InterventionView official trial listing → -
Not yet recruiting NCT NCT07349888
Combined Mitral and Tricuspid Versus Isolated Mitral Transcatheter Edge-to-Edge Repair for Mitral Regurgitation With Tricuspid Regurgitation (DUAL-TEER Trial)
Not yet reported Nanjing First Hospital, Nanjing Medical University 404 participants Est. completion 2031-08-31 Stand-aloneOther conditions: Mitral Regurgitation, Tricuspid RegurgitationView official trial listing → -
Not yet recruiting NCT NCT07349979
PCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEF
Not yet reported Nanjing First Hospital, Nanjing Medical University 1154 participants Est. completion 2028-01-30 1 siteHeart failureCardiovascular disease Other conditions: Stable GDMTView official trial listing → -
Not yet recruiting NCT NCT07411287
Gut Microbiota Modulation With Synbiotics After Acute Coronary Syndrome
Not yet reported Centre Hospitalier de Bienne 80 participants Est. completion 2028-05-31 Stand-aloneOther conditions: Atheroscleroses, Coronary, MicrobiotaView official trial listing → -
Not yet recruiting NCT NCT07412626
Evaluation of the HeartLogic Diagnostic in Optimizing Guideline-directed Medical Therapy in Patients With Congestive Heart Failure and Chronically Low Ejection Fractions (EFs)
Not yet reported Robert Pickett 135 participants Est. completion 2028-03 2 sitesHeart failure Other conditions: Low Ejection FractionView official trial listing → -
Not yet recruiting NCT NCT07430930
Pragmatic Trial of Messaging to Providers About Treatment of Chronic Kidney Disease
Not yet reported Yale University 1000 participants Est. completion 2028-09 1 site Stand-aloneChronic kidney diseaseView official trial listing → -
Not yet recruiting NCT NCT07505511
Visualization of the Effects of Guideline-directed Medical Therapy (GDMT) on Improving Adherence and Quality of Life in Heart Failure With Reduced Ejection Fraction (HFrEF)
Not yet reported University of Giessen 100 participants Est. completion 2028-03-01Heart failure Other conditions: Adherence, Medication, Adherence, TreatmentView official trial listing → -
Not yet recruiting NCT NCT07532317
Comparison of Myval THV Series With Guideline-Directed Medical Therapy in Participants With Moderate Aortic Stenosis
Not yet reported Meril Life Sciences Pvt. Ltd. 778 participants Est. completion 2041-05-12Other conditions: Moderate Aortic StenosisView official trial listing → -
Not yet recruiting NCT NCT07547449
Bachmann Bundle Pacing for Prevention of New-Onset Atrial Fibrillation in Patients With Heart Failure
Not yet reported Fu Wai Hospital, Beijing, China 140 participants Est. completion 2028-04 1 siteHeart failure Other conditions: Atrial Fibrillation (AF), Cardiac InsufficiencyView official trial listing → -
Not yet recruiting NCT NCT07558902
RDN for Heart Failure
Not yet reported Shanghai Golden Leaf MedTec Co. Ltd 20 participants Est. completion 2027-09-13 1 site Stand-aloneHeart failureView official trial listing → -
Not yet recruiting NCT NCT07578129
PASCAL Precision-GDMT Registry
Ceric Sàrl 50 participants Est. completion 2027-08-31Other conditions: Tricuspid Insufficiency, Tricuspid Regurgitation (TR), Left Ventricular Cardiac Dysfunction, Left Ventricular (LV) Systolic Dysfunction, Left Ventricular Dysfunction, Left Ventricular Ejection FractionView official trial listing → -
Completed NCT NCT07582094
Exercise-induced Epigenetic Adaptations
Not yet reported Chang Gung Memorial Hospital 40 participants Est. completion 2023-07-31 1 site Stand-aloneHeart failureView official trial listing → -
Not yet recruiting NCT NCT07670845
Implementation of an Encounter-based Patient Decision Aid for Heart Failure Medications in Heart Function Clinics: the SHARE-HF Pragmatic, Stepped-wedge Trial
Not yet reported University of British Columbia 1350 participants Est. completion 2030-10-31Heart failureView official trial listing → -
Not yet recruiting NCT NCT07687862
Wearable Device-Assisted Remote Management to Improve Prognosis in Patients With Acute Heart Failure Complicated by Atrial Fibrillation: WARM-HF Trial (Stage 2)
Not yet reported Beijing Anzhen Hospital 818 participants Est. completion 2028-12-30 Stand-aloneHeart failure Other conditions: Atrial Fibrillation (AF)View official trial listing → -
Not yet recruiting NCT NCT07693049
Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving Heart Failure With Preserved Ejection Fraction
Not yet reported Peking University Third Hospital 192 participants Est. completion 2028-04-30 12 sites Stand-aloneHeart failureView official trial listing → -
Completed NCT NCT07697365
Vericiguat and Exercise Hemodynamics in Patients With HFrEF
Argyrios Ntalianis 40 participants Est. completion 2025-12-31 1 siteHeart failureView official trial listing → -
Not yet recruiting NCT NCT07709208
Mitral Valve Edge-to-Edge Repair in Patients With Exercise-Induced Severe Mitral Regurgitation
Not yet reported Jena University Hospital 246 participants Est. completion 2030-06 2 sites Stand-aloneHeart failure Other conditions: Mitral Regurgitation FunctionalView official trial listing → -
Not yet recruiting NCT NCT07714239
Pharmacist-Assisted Titration of Rx to Implement Optimal Medical Therapy for Heart Failure
Not yet reported VA Office of Research and Development 585 participants Est. completion 2030-09-30 1 site Stand-aloneHeart failureView official trial listing → -
Not yet recruiting NCT NCT07718724
Impact of GDMT in Uncontrolled Asthma Patients Receiving MHD Inhaled Corticosteroids + Long-acting β2 Agonist
Not yet reported AstraZeneca 540 participants Est. completion 2028-04-30 1 site Stand-aloneOther conditions: Uncontrolled AsthmaView official trial listing → -
Not yet recruiting NCT NCT07741253
PRECISE-AFMR I: Transcatheter Mitral Valve Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation in Patients at High Surgical Risk
Not yet reported China National Center for Cardiovascular Diseases 182 participants Est. completion 2027-12 1 site Stand-aloneOther conditions: Atrial Functional, Mitral Regurgitation (MR)View official trial listing → -
Not yet recruiting NCT NCT07758023
Achieving Optimal Medical Therapy Through Percutaneous Treatment of Secondary Mitral Regurgitation to Improve Outcome in Patients With HFrEF
Not yet reported University Medical Center Mainz 520 participants Est. completion 2030-09-30 Stand-aloneHeart failure Other conditions: Mitral Regurgitation FunctionalView official trial listing → -
Not yet recruiting NCT NCT07811427
Heart-Kidney-Diabetes Multidisciplinary Care MOdels for CardiovascuLar Health In Patients With Chronic Kidney DiSease and Diabetes: A PragmaTIC Cluster Randomized Controlled Trial (HOLISTIC)
Not yet reported Baim Institute for Clinical Research 570 participants Est. completion 2029-05Chronic kidney disease Other conditions: Type II DiabetesView official trial listing → -
Not yet recruiting NCT NCT07820800
NMR Metabolomics-Based Risk Assessment and Stratified Digital Health Interventions in Middle-Aged Adults (PREMAP)
Not yet reported University of Eastern Finland 1400 participants Est. completion 2028-03 Stand-aloneType 2 diabetesCardiovascular diseaseChronic kidney disease Other conditions: Coronary Heart Disease, Cerebrovascular Disease, Fatty Liver DiseaseView official trial listing → -
Not yet recruiting NCT NCT07821801
Short-Term Outcomes of HFrEF Patients on Guideline-Directed Medical Therapy
Assiut University 250 participants Est. completion 2028-03-20Heart failureView official trial listing → -
Not yet recruiting NCT NCT07828834
Utilization of Guided Point of Care Ultrasound in Heart Failure Diagnosis Pilot Trial
Not yet reported Corewell Health West 100 participants Est. completion 2028-09-30 1 siteHeart failureView official trial listing → -
Not yet recruiting NCT NCT07831538
Digital Outreach for Heart Failure Adherence
Not yet reported Kaiser Permanente 13714 participants Est. completion 2028-03 1 site Stand-aloneHeart failureView official trial listing →
Efficacy history
Not yet reported.
Safety
Not yet reported.
Sources
Also known as: Guideline Directed Medical Therapy for Heart Failure, Guideline Directed Medical Therapy for Heart Failure (GDMT), GDMT
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