GLP-1 Market
LLY $1136.11 ▼ -0.2% NVO $42.53 ▼ -2.1% PFE $27.55 ▼ -0.6% VKTX $29.95 ▼ -5.0% KLRA $13.45 ▼ -2.2% GPCR $38.95 ▲ +1.3% RHHBY $54.90 ▲ +0.2%
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About this data Sourced primarily from ClinicalTrials.gov — a listing isn't proof of safety or FDA approval.

Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.

Not yet reported

Eplerenone

Company
Brigham and Women's Hospital
Mechanism
Mechanism not yet reported
Route
Route not yet reported
Recruiting trials
13 recruiting

Efficacy results: Not yet reported

Find a Clinical Trial Near Me

13 recruiting studies currently listed on ClinicalTrials.gov.

Data source: ClinicalTrials.gov · trial data as of Sep 16, 2026

Find a Clinical Trial Near Me

See recruiting studies for Eplerenone and check eligibility with the study team.

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Treatment type

"Added to GLP-1" means the investigational treatment is being studied on top of an existing GLP-1-based therapy.

Your ZIP code is only used to calculate distance to trial sites — it isn't stored.

Trial details
  • Recruiting NCT NCT02901184

    Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

    Not yet reported Uppsala University 2000 participants Est. completion 2026-12 78 sites
    Heart failure
    View official trial listing →
  • Recruiting NCT NCT04450953

    The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients.

    Not yet reported Central Hospital, Nancy, France 36 participants Est. completion 2025-11 1 site
    Other conditions: Kidney Transplantation for More Than One Year, Patients with a Kidney Transplantation on Cyclosporine
    View official trial listing →
  • Recruiting NCT NCT05030545

    Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

    Not yet reported Brigham and Women's Hospital 40 participants Est. completion 2027-02-28 1 site Stand-alone
    Other conditions: Primary Aldosteronism, Hypertension
    View official trial listing →
  • Recruiting NCT NCT05198791

    Stratified Medicine of Eplerenone in Acute Myocardial Infarction or Injury and no Obstructive Coronary Arteries.

    Not yet reported NHS National Waiting Times Centre Board 400 participants Est. completion 2026-07-31 2 sites Stand-alone
    Cardiovascular disease Other conditions: Myocardial Injury
    View official trial listing →
  • Recruiting NCT NCT05593055

    Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

    Not yet reported Brigham and Women's Hospital 75 participants Est. completion 2027-12-31 1 site
    Other conditions: Hypertension, Left Ventricular Hypertrophy
    View official trial listing →
  • Recruiting NCT NCT05797558

    Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment

    Not yet reported Göteborg University 80 participants Est. completion 2028-05-28 3 sites
    Other conditions: Primary Hyperaldosteronism Due to Adrenal Adenoma
    View official trial listing →
  • Recruiting NCT NCT06091475

    Therapy to Maintain Remission in Dilated Cardiomyopathy

    Not yet reported Imperial College London 50 participants Est. completion 2026-09-15 1 site Stand-alone
    Heart failure Other conditions: Cardiomyopathy, Dilated, Cardiomyopathies, Heart Diseases
    View official trial listing →
  • Recruiting NCT NCT06749418

    Vascular Effects of High-Salt After Preeclampsia

    Not yet reported Anna Stanhewicz, PhD 40 participants Est. completion 2027-11-15 1 site Stand-alone
    Other conditions: Preeclampsia, Preeclampsia Postpartum
    View official trial listing →
  • Recruiting NCT NCT07029503

    Swedish Cardiac And Renal Failure Study-1

    Not yet reported Karolinska Institutet 40 participants Est. completion 2027-10 1 site Stand-alone
    Heart failureChronic kidney disease
    View official trial listing →
  • Recruiting NCT NCT07238400

    Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

    Not yet reported Massachusetts General Hospital 90 participants Est. completion 2029-03-30 2 sites
    Other conditions: Hypertension
    View official trial listing →
  • Recruiting NCT NCT07335900

    A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis

    Not yet reported RenJi Hospital 25 participants Est. completion 2027-05-30 1 site Stand-alone
    Other conditions: Severe Aortic Valve Stenosis
    View official trial listing →
  • Recruiting NCT NCT07513883

    The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart Failure in Remission.

    Not yet reported Ziekenhuis Oost-Limburg 100 participants Est. completion 2028-12 1 site
    Heart failure
    View official trial listing →
  • Recruiting NCT NCT07569640

    HFrEF Polypill in Sri Lanka RCT

    Not yet reported Washington University School of Medicine 1672 participants Est. completion 2029-04 11 sites Stand-alone
    Heart failure
    View official trial listing →
  • Completed NCT NCT00082589

    The Purpose of This Study is to Determine if Eplerenone is Effective in Treatment of Mild to Moderate Heart Failure

    Not yet reported Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 250 participants Est. completion 2006-03 53 sites
    Heart failure
    View official trial listing →
  • Completed NCT NCT00108251

    Aldosterone Antagonism in Diastolic Heart Failure

    Not yet reported US Department of Veterans Affairs 48 participants Est. completion 2007-10 1 site Stand-alone
    Heart failure Other conditions: Diastole
    View official trial listing →
  • Completed NCT NCT00132093

    Effects of Eplerenone on Left Ventricular Remodelling Following Heart Attack

    Not yet reported NHS Greater Glasgow and Clyde 100 participants 1 site
    Cardiovascular disease
    View official trial listing →
  • Completed NCT NCT00138944

    Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension

    Not yet reported University of Erlangen-Nürnberg Medical School 85 participants Est. completion 2008-07 1 site
    Other conditions: Essential Hypertension
    View official trial listing →
  • Completed NCT NCT00147563

    Compare Effectiveness of Eplerenone vs Atenolol in Reversing the Remodelling Resistance Arteries in Subjects With HT

    Not yet reported Pfizer 34 participants 1 site
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT00147589

    A Study to Evaluate the Efficacy and Safety of Eplerenone in the Treatment of Hypertension in Children.

    Not yet reported Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 320 participants Est. completion 2007-01 41 sites
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT00147615

    The Long-term Study to Evaluate the Safety of Eplerenone in the Treatment of Hypertension in Children Aged 6 to 16 Years

    Not yet reported Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 140 participants Est. completion 2006-06 21 sites
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT00187889

    EWISE: Study of Eplerenone in Women With Chest Pain, Coronary Vascular Dysfunction and Evidence of Myocardial Ischemia

    Not yet reported University of Florida 70 participants Est. completion 2011-12 1 site
    Other conditions: Ischemic Heart Disease
    View official trial listing →
  • Completed NCT NCT00214825

    Aldosterone and Vascular Disease in Diabetes Mellitus

    Not yet reported Brigham and Women's Hospital 46 participants Est. completion 2006-03 1 site Stand-alone
    Other conditions: Diabetes Mellitus, Endothelial Dysfunction, Albuminuria
    View official trial listing →
  • Completed NCT NCT00223717

    Treatment of Supine Hypertension in Autonomic Failure

    Not yet reported Vanderbilt University 152 participants Est. completion 2017-01 1 site Stand-alone
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT00232180

    A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines

    Not yet reported Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 2743 participants Est. completion 2012-01 307 sites
    Heart failure
    View official trial listing →
  • Terminated NCT NCT00293150

    Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure

    Not yet reported The Cleveland Clinic 11 participants Est. completion 2007-09 1 site
    Heart failure
    View official trial listing →
  • Completed NCT NCT00315016

    Eplerenone, ACE Inhibition and Albuminuria

    Not yet reported Radboud University Medical Center 30 participants Est. completion 2011-07 2 sites
    Chronic kidney disease
    View official trial listing →
  • Completed NCT NCT00391846

    Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone

    Not yet reported AstraZeneca 252 participants Est. completion 2009-01 39 sites
    Heart failure Other conditions: Ventricular Dysfunction, Left
    View official trial listing →
  • Completed NCT NCT00401856

    CMR to Assess Fibrosis in Cardiomyopathy Using Eplerenone

    Not yet reported Royal Brompton & Harefield NHS Foundation Trust 42 participants Est. completion 2013-04-02 1 site Stand-alone
    Other conditions: Cardiomyopathy
    View official trial listing →
  • Status unknown NCT NCT00407784

    Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives.

    Erasmus Medical Center 500 participants Est. completion 2009-11 13 sites
    Other conditions: Hyperaldosteronism, Hypertension
    View official trial listing →
  • Completed NCT NCT00427284

    Effect of Eplerenone on Endothelial Function in Patients With Stable Coronary Heart Disease

    University of Zurich 42 participants 1 site
    Cardiovascular disease
    View official trial listing →
  • Completed NCT NCT00430924

    Inhibition of Aldosterone in Patients With Chronic Renal Disease

    Not yet reported Lene Boesby 42 participants Est. completion 2009-08 2 sites
    Other conditions: Kidney Failure, Chronic
    View official trial listing →
  • Completed NCT NCT00505336

    The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure

    Not yet reported St Vincent's University Hospital, Ireland 43 participants Est. completion 2008-12 1 site Stand-alone
    Heart failure
    View official trial listing →
  • Completed NCT NCT00515021

    Diurnal Variation of Plasminogen Activator Inhibitor-1

    Not yet reported Vanderbilt University Medical Center 21 participants Est. completion 2010-04 1 site Stand-alone
    Metabolic syndrome
    View official trial listing →
  • Status unknown NCT NCT00553722

    Does Aldosterone Cause Hypertension by a Non-Renal Mechanism?

    Not yet reported Shaare Zedek Medical Center 27 participants Est. completion 2009-11 1 site Stand-alone
    Other conditions: Hypertension, Dialysis, Hyperaldosteronism
    View official trial listing →
  • Terminated NCT NCT00608465

    Defining Strategies for Improving Endothelial and Fibrinolytic Dysfunction in Obesity

    Not yet reported Vanderbilt University 4 participants Est. completion 2011-05 1 site
    Metabolic syndrome
    View official trial listing →
  • Terminated NCT NCT00647192

    EPLERAF-Study: Eplerenone in the Prevention of Atrial Fibrillation Recurrences After Cardioversion

    Not yet reported University Hospital, Saarland 38 participants Est. completion 2012-02 2 sites
    Other conditions: Atrial Fibrillation
    View official trial listing →
  • Terminated NCT NCT00649311

    A Study To Evaluate The Efficacy Of Eplerenone Compared With Losartan For The Treatment Of Patients With Mild To Moderate Hypertension

    Not yet reported Pfizer 248 participants Est. completion 2003-09 2 sites Stand-alone
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT00684489

    Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension

    Not yet reported Medical University of South Carolina 52 participants Est. completion 2005-09
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT00703352

    Eplerenone in Systemic Right Ventricle

    Not yet reported Hospital Universitari Vall d'Hebron Research Institute 26 participants Est. completion 2010-12 1 site
    Other conditions: Transposition of Great Vessels, Atrial Switch Procedure
    View official trial listing →
  • Completed NCT NCT00749775

    Selara Drug Use Investigation (Regulatory Post Marketing Commitment Plan)

    Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 3338 participants Est. completion 2012-12
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT00758524

    A Study to Evaluate Efficacy and Safety of LCI699 in Participants With Essential Hypertension

    Not yet reported Novartis Pharmaceuticals 628 participants Est. completion 2009-07-02 1 site
    Other conditions: Essential Hypertension
    View official trial listing →
  • Completed NCT NCT00817635

    A Study to Evaluate the Efficacy and Safety of LCI699 Compared to Placebo in Participants With Resistant Hypertension

    Not yet reported Novartis 155 participants Est. completion 2009-10-13 38 sites
    Other conditions: Hypertension
    View official trial listing →
  • Terminated NCT NCT00825188

    A Study of the Effects of Eplerenone and Amlodipine on Blood Pressure and Basal Metabolic Rate in Obese Hypertensives

    Not yet reported University of Mississippi Medical Center 10 participants Est. completion 2014-03 1 site
    Other conditions: Obesity, Hypertension
    View official trial listing →
  • Completed NCT NCT00865176

    Comparative Bioavailability Study of Eplerenone 50 mg Tablets Under Fasting Conditions

    Not yet reported Sandoz 60 participants Est. completion 2006-07 Stand-alone
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT00865618

    Comparative Bioavailability Study of Eplerenone 50 mg Tablets Under Fed Conditions

    Not yet reported Sandoz 60 participants Est. completion 2006-07 Stand-alone
    Other conditions: Hypertension
    View official trial listing →
  • Terminated NCT NCT00980031

    Aldosterone Blockade to Prevent Myocardial Remodeling In Patients With Controlled Essential Hypertension

    Not yet reported Creighton University 20 participants Est. completion 2011-09 1 site
    Other conditions: Myocardial Remodeling
    View official trial listing →
  • Completed NCT NCT00990223

    Effects Of Eplerenone On Serum Aldesterone And Plasma Renin Activity

    Not yet reported Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 20 participants Est. completion 2009-11 2 sites Stand-alone
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Terminated NCT NCT01100203

    Aldosterone Blockade in Chronic Kidney Disease: Influence on Arterial Stiffness and Kidney Function

    Not yet reported Lene Boesby 54 participants Est. completion 2012-02 2 sites
    Chronic kidney disease
    View official trial listing →
  • Completed NCT NCT01115855

    Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart Failure

    Not yet reported Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 221 participants Est. completion 2015-09 54 sites Stand-alone
    Heart failure
    View official trial listing →
  • Completed NCT NCT01146197

    Input of the Use of Indometacin in Gitelman Syndrome as Compared to Potassium Sparing Diuretics

    Not yet reported, Not yet reported Assistance Publique - Hôpitaux de Paris 33 participants Est. completion 2013-01 1 site Stand-alone
    Other conditions: Gitelman Syndrome
    View official trial listing →
  • Completed NCT NCT01176968

    Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction

    Not yet reported Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 1012 participants Est. completion 2012-10 75 sites Stand-alone
    Cardiovascular disease
    View official trial listing →
  • Completed NCT NCT01237899

    Multiple Dose Study of the Safety, Tolerability, Pharmacokinetics and Effect on Renal Potassium Clearance

    Not yet reported Eli Lilly and Company 32 participants Est. completion 2011-01 1 site
    Chronic kidney disease
    View official trial listing →
  • Withdrawn NCT NCT01275352

    CLCNKA (Ka Renal Chloride Channel[ClC-Ka]) Polymorphism Effects on Hypertrophy Regression

    Not yet reported Washington University School of Medicine Est. completion 2015-06 2 sites
    Other conditions: Hypertension
    View official trial listing →
  • Withdrawn NCT NCT01302236

    Effect of Eplerenone in Elderly Hypertensive Early Stage Chronic Kidney Disease (CKD) Patients

    Not yet reported Jichi Medical University Est. completion 2012-07 Stand-alone
    Chronic kidney disease Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT01319344

    Effect of Eplerenone on Endothelial Function in Metabolic Syndrome

    Not yet reported University of Erlangen-Nürnberg Medical School 42 participants Est. completion 2013-04 2 sites Stand-alone
    Metabolic syndrome Other conditions: Endothelial Dysfunction
    View official trial listing →
  • Terminated NCT NCT01373086

    LFF269 Compared to Placebo After Treatment in Subjects With Essential Hypertension

    Not yet reported Novartis Pharmaceuticals 19 participants Est. completion 2011-10 11 sites Stand-alone
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT01394627

    Hypoglycemia and the Mineralocorticoid Receptor

    Not yet reported Brigham and Women's Hospital 21 participants Est. completion 2016-08 1 site Stand-alone
    Other conditions: Hypoglycemia
    View official trial listing →
  • Completed NCT NCT01405456

    Eplerenone in HIV Associated Abdominal Fat Accumulation

    Not yet reported Massachusetts General Hospital 46 participants Est. completion 2017-11-01 1 site Stand-alone
    Other conditions: HIV
    View official trial listing →
  • Completed NCT NCT01427972

    A Study of LY2623091 in Male and Females With Chronic Kidney Disease

    Not yet reported Eli Lilly and Company 42 participants Est. completion 2013-03 4 sites
    Chronic kidney disease
    View official trial listing →
  • Completed NCT NCT01440049

    Patient's Management Receiving Eplerenone Therapy

    Pfizer 160 participants Est. completion 2010-12
    Cardiovascular disease
    View official trial listing →
  • Completed NCT NCT01473108

    Study to Investigate the Natriuretic Effects, Safety, Tolerability and Pharmacokinetics of BAY94-8862

    Not yet reported Bayer 67 participants Est. completion 2011-05-17 1 site Stand-alone
    Other conditions: Clinical Pharmacology
    View official trial listing →
  • Completed NCT NCT01521546

    Eplerenone for Subclinical Cardiomyopathy in Duchenne Muscular Dystrophy

    Not yet reported Subha Raman 42 participants Est. completion 2016-06 3 sites
    Other conditions: Duchenne Muscular Dystrophy
    View official trial listing →
  • Completed NCT NCT01541267

    The Effect of Various Types of the Renin-angiotensin-aldosterone System Blockade on Proteinuria

    Not yet reported Medical University of Gdansk 20 participants Est. completion 2011-11
    Chronic kidney disease Other conditions: Proteinuria
    View official trial listing →
  • Completed NCT NCT01586442

    Comparison of Eplerenone Versus Spironolactone in Heart Failure Patients With Glucose Intolerance or Type 2 Diabetes

    Not yet reported Montreal Heart Institute 62 participants Est. completion 2018-07-29 1 site Stand-alone
    Heart failureType 2 diabetes Other conditions: Glucose Intolerance
    View official trial listing →
  • Completed NCT NCT01650012

    Eplerenone in Hemodialysis Trial

    Not yet reported McMaster University 158 participants Est. completion 2013-12 5 sites Stand-alone
    Other conditions: Hemodialysis, End Stage Renal Disease
    View official trial listing →
  • Terminated NCT NCT01708798

    Study of the Effect of Eplerenone on Heart Function in Women Receiving Anthracycline Chemotherapy for Breast Cancer

    Not yet reported, Not yet reported University of British Columbia 44 participants Est. completion 2016-11 1 site Stand-alone
    Other conditions: Breast Cancer
    View official trial listing →
  • Completed NCT NCT01786551

    Effect of Eplerenone on Postprandial Inflammatory Response in Healthy Adults

    Not yet reported Brigham and Women's Hospital 16 participants Est. completion 2013-01 1 site Stand-alone
    Other conditions: Systemic Proinflammatory State
    View official trial listing →
  • Withdrawn NCT NCT01794091

    Detection of Diffuse Scar in Patients With Diabetes

    Not yet reported Brigham and Women's Hospital Est. completion 2017-08 1 site Stand-alone
    Other conditions: Diabetes Mellitus, Type II
    View official trial listing →
  • Withdrawn NCT NCT01801228

    Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis; a Study of Efficacy and Side Effects

    Not yet reported Emma Nilsson Est. completion 2015-10 1 site Stand-alone
    Other conditions: Ascites, Cirrhosis
    View official trial listing →
  • Completed NCT NCT01807221

    Phase IIb Safety and Efficacy Study of Different Oral Doses of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone

    Not yet reported Bayer 1066 participants Est. completion 2014-12-09 172 sites
    Heart failure
    View official trial listing →
  • Completed NCT NCT01822561

    Eplerenone for Central Serous Chorioretinopathy

    Not yet reported Tufts Medical Center 17 participants Est. completion 2017-12 1 site Stand-alone
    Other conditions: Central Serous Chorioretinopathy
    View official trial listing →
  • Status unknown NCT NCT01832558

    The EPOCH Study (Eplerenone on Top of ACE Inhibition in Chronic Kidney Disease Patients With Hypertension)

    Not yet reported Medical University of Vienna 24 participants Est. completion 2021-12-31 1 site Stand-alone
    Chronic kidney disease
    View official trial listing →
  • Status unknown NCT NCT01834768

    EPLErenone in CsA-Treated Recipients (EpleCsAT): Safety

    Not yet reported CHU de Reims 31 participants Est. completion 2013-12 1 site Stand-alone
    Other conditions: Chronic Kidney Insufficiency, Kidney Transplantation
    View official trial listing →
  • Completed NCT NCT01837108

    Eplerenone and Extracellular Adenosine Formation

    Not yet reported Radboud University Medical Center 14 participants Est. completion 2014-01 1 site Stand-alone
    Other conditions: Pharmacodynamics
    View official trial listing →
  • Completed NCT NCT01857856

    PHOspholamban RElated CArdiomyopathy STudy - Intervention

    Not yet reported M.p. van den Berg, MD, PhD, professor in Cardiology 84 participants Est. completion 2021-10 4 sites
    Other conditions: Phospholamban R14del Mutation-related Cardiomyopathy
    View official trial listing →
  • Completed NCT NCT01882179

    Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size

    Not yet reported University College, London 61 participants Est. completion 2016-05 4 sites
    Cardiovascular disease
    View official trial listing →
  • Terminated NCT NCT01887119

    Aldosterone Antagonism and Microvascular Function

    Not yet reported Maastricht University Medical Center 25 participants Est. completion 2018-11 1 site
    Metabolic syndrome Other conditions: Insulin Resistance, Hypertension
    View official trial listing →
  • Status unknown NCT NCT01893788

    Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy

    Not yet reported Nagoya University 100 participants 1 site
    Other conditions: Hypertensive Left Ventricular Hypertrophy
    View official trial listing →
  • Completed NCT NCT01955694

    Phase IIb Safety and Efficacy Study of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease Alone

    Not yet reported Bayer 72 participants Est. completion 2015-02-20 29 sites
    Heart failure
    View official trial listing →
  • Terminated NCT NCT01971593

    The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease

    Not yet reported Washington University School of Medicine 26 participants Est. completion 2016-06 1 site
    Other conditions: Tetralogy of Fallot, Transposition of the Great Vessels With an Arterial Switch, Single Ventricle With a Fontan Palliation
    View official trial listing →
  • Completed NCT NCT01990677

    Eplerenone for the Treatment of Central Serous Chorioretinopathy

    Not yet reported Wills Eye 108 participants Est. completion 2015-05 10 sites
    Other conditions: Central Serous Chorioretinopathy
    View official trial listing →
  • Completed NCT NCT01996449

    The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension

    Not yet reported University of Texas Southwestern Medical Center 14 participants Est. completion 2021-04 1 site
    Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT02034435

    Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism

    Not yet reported Vanderbilt University Medical Center 44 participants Est. completion 2019-12 1 site
    Metabolic syndrome
    View official trial listing →
  • Completed NCT NCT02118753

    The Effect of EPLerenone on Ischemia Reperfusion Injury in Human myoCARDium

    Not yet reported Radboud University Medical Center 24 participants Est. completion 2016-01 1 site Stand-alone
    Other conditions: Ischemia-reperfusion Injury
    View official trial listing →
  • Status unknown NCT NCT02153125

    Eplerenone For the Treatment of Chronic Central Serous Chorioretinopathy

    Not yet reported Tel-Aviv Sourasky Medical Center 30 participants 1 site Stand-alone
    Other conditions: Central Serous Chorioretinopathy
    View official trial listing →
  • Completed NCT NCT02200822

    Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients

    Not yet reported Hasselt University 80 participants Est. completion 2019-02 1 site
    Heart failure
    View official trial listing →
  • Status unknown NCT NCT02215330

    A Study of the Beneficial Effects of Eplerenone on Central Serous Chorioretinopathy

    Not yet reported, Not yet reported Prim. Prof. Dr. Oliver Findl, MBA 60 participants Est. completion 2017-09 1 site Stand-alone
    Other conditions: Central Serous Chorioretinopathy
    View official trial listing →
  • Completed NCT NCT02344199

    Eplerenone in Heart Failure Treatment

    Elpen Pharmaceutical Co. Inc. 450 participants Est. completion 2016-04 3 sites
    Heart failureCardiovascular disease Other conditions: Hypertension
    View official trial listing →
  • Completed NCT NCT02345044

    A Study to Evaluate Efficacy and Safety of CS-3150 in Japanese Hypertensive Subjects

    Not yet reported Daiichi Sankyo 426 participants Est. completion 2015-10 1 site
    Other conditions: Essential Hypertension
    View official trial listing →
  • Status unknown NCT NCT02345590

    Eplerenone in the Management of Abdominal Aortic Aneurysms

    Not yet reported Bayside Health 172 participants Est. completion 2019-12 2 sites Stand-alone
    Other conditions: Aortic Aneurysm, Abdominal
    View official trial listing →
  • Completed NCT NCT02354352

    Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular Dystrophy

    Not yet reported Ohio State University 52 participants Est. completion 2018-05 6 sites
    Other conditions: Duchenne Muscular Dystrophy
    View official trial listing →
  • Completed NCT NCT02362308

    Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas

    Vanderbilt University 10 participants Est. completion 2020-01 1 site
    Other conditions: Primary Aldosteronism
    View official trial listing →
  • Completed NCT NCT02363725

    Interest of COLchicine in the Treatment of Patients With Acute Myocardial INfarction and With Inflammatory Response

    Not yet reported University Hospital, Montpellier 44 participants Est. completion 2016-08 1 site
    Cardiovascular disease
    View official trial listing →
  • Completed NCT NCT02462499

    Eplerenone Treatment for Chronic Central Serous Chorioretinopathy in Hungarian Population

    Not yet reported Semmelweis University 28 participants Est. completion 2016-09 1 site Stand-alone
    Other conditions: Chronic Central Serous Chorioretinopathy
    View official trial listing →
  • Active, not recruiting NCT NCT02490904

    Eplerenone in Patients Undergoing REnal Transplant (EPURE TRANSPLANT)

    Not yet reported Central Hospital, Nancy, France 132 participants Est. completion 2031-08 7 sites Stand-alone
    Other conditions: End-stage Renal Disease
    View official trial listing →
  • Completed NCT NCT02525796

    Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism

    Not yet reported, Not yet reported Brigham and Women's Hospital 69 participants Est. completion 2021-10-02 1 site Stand-alone
    Other conditions: Primary Hyperparathyroidism
    View official trial listing →
  • Completed NCT NCT02532998

    A Study to Assess the Pharmacodynamic Effect of Single Doses of AZD9977 in Healthy Male Subjects

    Not yet reported AstraZeneca 40 participants Est. completion 2015-12 1 site Stand-alone
    Other conditions: Pharmacodynamics, Healthy Subjects
    View official trial listing →
  • Withdrawn NCT NCT02607657

    Pharmacokinetics of Eplerenone Tablet

    Not yet reported Biolab Sanus Farmaceutica Stand-alone
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Terminated NCT NCT02629094

    Cardiometabolic Effects of Eplerenone in HIV Infection

    Not yet reported National Institute of Allergy and Infectious Diseases (NIAID) 5 participants Est. completion 2017-09-11 1 site Stand-alone
    Other conditions: Cardiac Steatosis, Hepatic Steatosis
    View official trial listing →
  • Completed NCT NCT02740179

    Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study)

    Not yet reported Massachusetts General Hospital 40 participants Est. completion 2022-03-17 1 site Stand-alone
    Other conditions: HIV
    View official trial listing →
  • Completed NCT NCT02809963

    Mineralocorticoid Receptor Antagonists in Type 2 Diabetes

    Not yet reported Herlev Hospital 140 participants Est. completion 2017-11 1 site
    Other conditions: Diabetes Type 2
    View official trial listing →
  • Completed NCT NCT02871648

    The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production

    Not yet reported Brigham and Women's Hospital 23 participants Est. completion 2019-12 1 site
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT02890173

    Study of CS-3150 in Patients With Essential Hypertension

    Not yet reported Daiichi Sankyo Co., Ltd. 1001 participants Est. completion 2017-07-11 1 site
    Other conditions: Essential Hypertension
    View official trial listing →
  • Withdrawn NCT NCT02957435

    Pharmacokinetics Study of Eplerenone Coated Tablets

    Not yet reported Biolab Sanus Farmaceutica Est. completion 2017-12 1 site Stand-alone
    Other conditions: Pharmacokinetics, Healthy Subjects, Fasting
    View official trial listing →
  • Completed NCT NCT03017703

    The Role of Aldosterone in Circulatory Disorders Within Type 2 Diabetes

    Not yet reported University of Southern Denmark 27 participants Est. completion 2019-12-15 1 site Stand-alone
    Other conditions: Endothelial Dysfunction, Insulin Resistance
    View official trial listing →
  • Status unknown NCT NCT03079141

    Photodynamic Therapy Versus Eplerenone: Treatment Trial for Chronic Central Serous Chorioretinopathy

    Not yet reported Leiden University Medical Center 107 participants Est. completion 2021-08 3 sites
    Other conditions: Chronic Central Serous Chorioretinopathy
    View official trial listing →
  • Completed NCT NCT03122834

    Effect of Genetic Polymorphism on the Clinical Outcome of Patients With Heart Failure

    Ain Shams University 246 participants Est. completion 2024-06-14 1 site
    Heart failure
    View official trial listing →
  • Completed NCT NCT03165240

    This International Study Tests BI 690517 in Patients With Diabetic Kidney Disease. The Study Tests How 3 Different Doses of BI 690517 Are Taken up in the Body and How Well They Are Tolerated

    Not yet reported Boehringer Ingelheim 62 participants Est. completion 2020-05-07 40 sites Stand-alone
    Other conditions: Diabetic Nephropathies
    View official trial listing →
  • Completed NCT NCT03174847

    Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism

    Changi General Hospital 57 participants Est. completion 2020-09-20 1 site
    Other conditions: Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
    View official trial listing →
  • Completed NCT NCT03186742

    Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy

    Not yet reported Poznan University of Medical Sciences 125 participants Est. completion 2017-06-01 Stand-alone
    Obstructive sleep apnea Other conditions: Hypertension,Essential, Left Ventricular Hypertrophy
    View official trial listing →
  • Completed NCT NCT03342690

    Drug Use Investigation of Selara Tablets (an Investigation for Chronic Heart Failure)

    Pfizer's Upjohn has merged with Mylan to form Viatris Inc. 1165 participants Est. completion 2020-07-15 1 site
    Heart failure
    View official trial listing →
  • Withdrawn NCT NCT03418649

    Eplerenone as a Supplement to Epidural Steroid Injections

    Not yet reported University of Cincinnati Est. completion 2026-06 2 sites Stand-alone
    Other conditions: Degenerative Intervertebral Discs, Sciatic Radiculopathy, Low Back Pain
    View official trial listing →
  • Completed NCT NCT03476616

    Antihypertensive Pharmacological Therapy With Mineralocorticoid Receptor Antagonists in Obese Hypertensive Patients

    Not yet reported Hippocration General Hospital 198 participants Est. completion 2025-06-30 1 site
    Other conditions: Hypertension, Obesity
    View official trial listing →
  • Completed NCT NCT03683069

    Mineralocorticoid Receptor (MR) Antagonist (Eplerenone) vs Amlodipine and STRIATIN

    Not yet reported Brigham and Women's Hospital 90 participants Est. completion 2024-01-31 1 site Stand-alone
    Other conditions: Hypertension, Genetics Hypertension
    View official trial listing →
  • Completed NCT NCT03888066

    Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)

    Not yet reported Vifor Pharma, Inc. 1195 participants Est. completion 2021-09-02 415 sites
    Other conditions: Hyperkalemia
    View official trial listing →
  • Completed NCT NCT03923530

    Pressure Assessment to Improve Outcomes After TAVR: a Registry

    Not yet reported North Florida Foundation for Research and Education 12 participants Est. completion 2020-02-27 1 site Stand-alone
    Heart failure Other conditions: Hypertension, Aortic Stenosis, Calcific, Quality of Life
    View official trial listing →
  • Enrolling by invitation NCT NCT03984591

    A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure

    Not yet reported Bispebjerg Hospital 7200 participants Est. completion 2028-12-31 1 site
    Heart failure
    View official trial listing →
  • Terminated NCT NCT04142788

    RELieving Increasing oEdema Due to Heart Failure

    Not yet reported NHS Greater Glasgow and Clyde 19 participants Est. completion 2022-12-20 11 sites Stand-alone
    Heart failure
    View official trial listing →
  • Status unknown NCT NCT04143412

    Efficacy of ACE Inhibitors, MRAs and ACE Inhibitor/ MRA Combination

    Not yet reported Beni-Suef University 75 participants Est. completion 2020-03 1 site
    Chronic kidney diseaseType 2 diabetes
    View official trial listing →
  • Completed NCT NCT04251780

    Tissue K+ in Primary Hyperaldosteronism

    University of Erlangen-Nürnberg Medical School 21 participants Est. completion 2024-04-24 2 sites
    Other conditions: Primary Hyperaldosteronism, Electrolyte Disturbance
    View official trial listing →
  • Terminated NCT NCT04300881

    Treatment of Post-Ocriplasmin Therapy Vitreolysis Induced Subretinal Fluid With Eplerenone (Mineralocorticoid Antagonists)

    Not yet reported Wagner Macula & Retina Center 2 participants Est. completion 2021-01-05 1 site Stand-alone
    Other conditions: Vitreomacular Traction, Subretinal Edema
    View official trial listing →
  • Completed NCT NCT04467931

    ACEI or ARB and COVID-19 Severity and Mortality in US Veterans

    University of Utah 22213 participants Est. completion 2020-12-31 1 site
    Other conditions: Hypertension, COVID
    View official trial listing →
  • Completed NCT NCT04519164

    Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity

    Not yet reported Brigham and Women's Hospital 79 participants Est. completion 2025-09-17 1 site Stand-alone
    Metabolic syndrome Other conditions: Hypertension, Overweight and Obesity
    View official trial listing →
  • Completed NCT NCT04575675

    Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy

    Not yet reported Cheng-Hsin General Hospital 78 participants Est. completion 2020-12-30 1 site Stand-alone
    Heart failure Other conditions: Hypotension
    View official trial listing →
  • Withdrawn NCT NCT04697485

    Polydiuretic Therapy for Heart Failure With Preserved Ejection Fraction and Diabetes Mellitus

    Not yet reported Northwestern University Est. completion 2022-03-30 1 site Stand-alone
    Heart failure Other conditions: Diabetes Mellitus
    View official trial listing →
  • Withdrawn NCT NCT04746495

    Effect of Eplerenone on Novel Biomarkers of Mineralocorticoid Receptor Activation (ENOVA)

    Not yet reported University of Michigan Est. completion 2023-12-01 1 site Stand-alone
    Other conditions: Hypertension
    View official trial listing →
  • Active, not recruiting NCT NCT04789239

    OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart Failure

    Not yet reported Michael Fu 110 participants Est. completion 2025-12-31 2 sites
    Heart failure Other conditions: Hyperkalemia
    View official trial listing →
  • Active, not recruiting NCT NCT04840342

    MR Antagonist and LSD1

    Not yet reported Brigham and Women's Hospital 300 participants Est. completion 2026-06 1 site Stand-alone
    Other conditions: Hypertension, Mineralocorticoid Excess
    View official trial listing →
  • Completed NCT NCT05104138

    Eplerenone Versus PDT: Comparative Study by OCTA

    Federico II University 30 participants Est. completion 2017-11-30
    Other conditions: Central Serous Chorioretinopathy
    View official trial listing →
  • Terminated NCT NCT05129722

    Polydiuretic Therapy for HFpEF, a Randomised Controlled Trial

    Not yet reported The George Institute 3 participants Est. completion 2024-05-01 2 sites Stand-alone
    Heart failure
    View official trial listing →
  • Status unknown NCT NCT05580510

    " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD "

    Not yet reported, Not yet reported Instituto Nacional de Cardiologia Ignacio Chavez 160 participants Est. completion 2024-03-29 1 site Stand-alone
    Heart failure Other conditions: Congenital Heart Disease
    View official trial listing →
  • Active, not recruiting NCT NCT05637853

    Telemonitored Fast Track Medical Sequencing for Heart Failure With Reduced Ejection Fraction

    Not yet reported Göteborg University 60 participants Est. completion 2026-08-26 1 site Stand-alone
    Heart failure
    View official trial listing →
  • Completed NCT NCT05663372

    Bioequivalence Study of Test and Reference 50 mg Eplerenone Film-coated Tablets in Healthy Volunteers

    Not yet reported Darnitsa Pharmaceutical Company 36 participants Est. completion 2021-12-28 1 site Stand-alone
    Other conditions: Bioequivalence, Healthy Subjects
    View official trial listing →
  • Completed NCT NCT05847049

    Eplerenone, Aflibercept and Topical Nepafenac Serous Foveal Deta Chment in Central Serous Chorioretinopathy

    Dar El Oyoun Hospital 16 participants Est. completion 2023-04-06 1 site
    Other conditions: Central Serous Chorioretinopathy
    View official trial listing →
  • Status unknown NCT NCT05924958

    Clinical Study on the Immunomodulatory Effect of Eprolidone on Patients With Chronic Heart Failure

    Not yet reported Cheng LuFeng,Principal Investigator 800 participants Est. completion 2026-09-01 Stand-alone
    Heart failure
    View official trial listing →
  • Status unknown NCT NCT05974566

    Efficacy and Safety of Finerenone in Heart Failure With Reduced Ejection Fraction

    Chongqing Medical University 60 participants Est. completion 2023-10-30
    Heart failure Other conditions: Diabetes Mellitus, Diabetic Nephropathies
    View official trial listing →
  • Status unknown NCT NCT06117722

    TorasEmide Induced Effect on QoL and Clinical parameterS in paTients With chronIc heArt Failure Receiving Eplerenone.

    Elpen Pharmaceutical Co. Inc. 210 participants Est. completion 2025-12-31 1 site
    Heart failure
    View official trial listing →
  • Not yet recruiting NCT NCT06168994

    Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease

    Not yet reported Assiut University 100 participants Est. completion 2027-05-20 Stand-alone
    Other conditions: Paroxysmal Atrial Fibrillation
    View official trial listing →
  • Status unknown NCT NCT06208072

    The Predictive Role of Urinary Proteomics in Blood Pressure Response of Obese Hypertensive Treated With Irbesartan or Eplerenone.

    Not yet reported Hippocration General Hospital 50 participants Est. completion 2025-02-01 1 site
    Other conditions: Primary Hypertension, Obesity
    View official trial listing →
  • Completed NCT NCT06233695

    Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure

    Alexandria University 100 participants Est. completion 2023-12-01 1 site
    Heart failure
    View official trial listing →
  • Status unknown NCT NCT06275763

    Optimal Medical Treatment of Difficult-to-treat Hypertension

    Not yet reported National Institute of Cardiology, Warsaw, Poland 2500 participants Est. completion 2025-12-31 1 site Stand-alone
    Other conditions: Hypertension
    View official trial listing →
  • Status unknown NCT NCT06556732

    Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patients With Structural Heart Disease

    Not yet reported Assiut University 100 participants Est. completion 2024-08-31 1 site
    Other conditions: Atrial Fibrillation
    View official trial listing →
  • Completed NCT NCT06649409

    Evaluation of Vamorolone Mineralocorticoid Receptor Antagonism in Healthy Subjects

    Not yet reported Santhera Pharmaceuticals 30 participants Est. completion 2024-07-06 1 site Stand-alone
    Other conditions: Pharmacodynamic
    View official trial listing →
  • Completed NCT NCT06697353

    An Observational Study to Learn More About the Real-world Outcomes in Patients With Heart Failure Who Initiate Treatment With Vericiguat in Japan

    Bayer 4936 participants Est. completion 2025-09-19 1 site
    Heart failure
    View official trial listing →
  • Completed NCT NCT06831864

    Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy in Sri Lanka

    Not yet reported Washington University School of Medicine 40 participants Est. completion 2025-05-05 2 sites Stand-alone
    Heart failure
    View official trial listing →
  • Not yet recruiting NCT NCT07235891

    Retinal Protective Effects of Novel Finerenone in Patients With Chronic Kidney Disease

    Not yet reported Alexandria University 40 participants Est. completion 2027-03-20 1 site Stand-alone
    Chronic kidney disease Other conditions: Retinal Nerve Fiber Layer Thickness
    View official trial listing →
  • Active, not recruiting NCT NCT07345845

    MR and Inflammation After Preeclampsia

    Not yet reported Anna Stanhewicz, PhD 40 participants Est. completion 2029-02-01 1 site Stand-alone
    Other conditions: Preeclampsia, Preeclampsia Postpartum
    View official trial listing →
  • Not yet recruiting NCT NCT07727252

    Early Aldo Blockade in Subclinical PA

    Not yet reported, Not yet reported Xinjiang Medical University 880 participants Est. completion 2029-08-01 Stand-alone
    Other conditions: Subclinical Primary Aldosteronism
    View official trial listing →
  • Completed NCT NCT07781826

    Influence of Neurohormonal Blockade on Natriuresis in Heart Failure Patients

    Not yet reported Wroclaw Medical University 80 participants Est. completion 2025-12-31 1 site Stand-alone
    Heart failure
    View official trial listing →
  • Not yet recruiting NCT NCT07795762

    Eplerenone and IOP in Healthy Adults

    Not yet reported University of Florida 30 participants Est. completion 2027-04-01 1 site Stand-alone
    Other conditions: Intraocular Pressure (IOP), Healthy Adult
    View official trial listing →
Efficacy history

Not yet reported.

Safety

Not yet reported.

Sources

Also known as: Eplerenone, Inspra

Related On The Pen coverage

No related coverage yet.

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