GLP-1 Market
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About this data Sourced primarily from ClinicalTrials.gov — a listing isn't proof of safety or FDA approval.

Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.

Not yet reported

Droxidopa Product

Company
Stephen G. Kaler
Mechanism
Mechanism not yet reported
Route
Oral
Recruiting trials
5 recruiting

Efficacy results: Not yet reported

Find a Clinical Trial Near Me

5 recruiting studies currently listed on ClinicalTrials.gov.

Data source: ClinicalTrials.gov · trial data as of Oct 6, 2026

Find a Clinical Trial Near Me

See recruiting studies for Droxidopa Product and check eligibility with the study team.

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Treatment type

"Added to GLP-1" means the investigational treatment is being studied on top of an existing GLP-1-based therapy.

Your ZIP code is only used to calculate distance to trial sites — it isn't stored.

Trial details
  • Recruiting NCT NCT02897063

    Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

    Not yet reported Vanderbilt University Medical Center 34 participants Est. completion 2026-12 1 site
    Other conditions: Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease, Orthostatic Hypotension
    View official trial listing →
  • Recruiting NCT NCT05839652

    Treatment of Orthostatic Hypotension in SCI

    Not yet reported James J. Peters Veterans Affairs Medical Center 25 participants Est. completion 2027-06-30 2 sites
    Other conditions: Hypotension
    View official trial listing →
  • Recruiting NCT NCT06289413

    Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study

    Kansas City Heart Rhythm Research Foundation 400 participants Est. completion 2025-12 8 sites
    Other conditions: Autonomic Dysfunction, Orthostatic Intolerance
    View official trial listing →
  • Recruiting NCT NCT06937307

    Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury

    Not yet reported Giuseppe Cullaro, MD 75 participants Est. completion 2028-12-31 1 site
    Other conditions: Acute Kidney Injury, Cirrhosis, Decompensated Cirrhosis of Liver
    View official trial listing →
  • Recruiting NCT NCT07398508

    NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease

    Not yet reported, Not yet reported Stephen G. Kaler 6 participants Est. completion 2030-06-30 1 site Stand-alone
    Other conditions: Menkes Disease
    View official trial listing →
  • Completed NCT NCT00004478

    Droxidopa in Treating Patients With Neurogenic Hypotension

    Not yet reported Icahn School of Medicine at Mount Sinai Est. completion 2006-03 1 site
    Other conditions: Shy-Drager Syndrome, Orthostatic Hypotension
    View official trial listing →
  • Terminated NCT NCT00547911

    Augmenting Effects of L-DOPS With Carbidopa and Entacapone

    Not yet reported, Not yet reported National Institute of Neurological Disorders and Stroke (NINDS) 14 participants Est. completion 2013-04 1 site
    Other conditions: Parkinson Disease, Multiple System Atrophy, Autonomic Nervous System Diseases
    View official trial listing →
  • Terminated NCT NCT00581477

    Treatment of Orthostatic Hypotension

    Not yet reported, Not yet reported Vanderbilt University 8 participants Est. completion 2020-12 1 site Stand-alone
    Other conditions: Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance
    View official trial listing →
  • Completed NCT NCT00633880

    Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)

    Not yet reported Chelsea Therapeutics 181 participants Est. completion 2009-09 54 sites
    Other conditions: Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy, Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency
    View official trial listing →
  • Completed NCT NCT00657046

    Safety and Benefit Study of Droxidopa to Treat Patients With Intradialytic Hypotension

    Not yet reported Chelsea Therapeutics 85 participants Est. completion 2009-01 1 site
    Other conditions: Intradialytic Hypotension
    View official trial listing →
  • Completed NCT NCT00738062

    Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)

    Not yet reported Chelsea Therapeutics 103 participants Est. completion 2010-12 54 sites
    Other conditions: Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy, Multiple System Atrophy, Dopamine Beta Hydroxylase Deficiency
    View official trial listing →
  • Completed NCT NCT00782340

    A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa

    Not yet reported Chelsea Therapeutics 263 participants Est. completion 2010-09 21 sites
    Other conditions: Symptomatic Neurogenic Orthostatic Hypotension (NOH), Non-diabetic Neuropathy, Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency
    View official trial listing →
  • Approved For Marketing NCT NCT00889135

    Long Term Treatment With L-DOPS

    Vanderbilt University Est. completion 2015-06 1 site
    Other conditions: Dopamine Beta Hydroxylase (DBH) Deficiency
    View official trial listing →
  • Terminated NCT NCT00977171

    Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome

    Not yet reported Chelsea Therapeutics 3 participants Est. completion 2011-10 1 site
    Other conditions: Chronic Fatigue Syndrome, Orthostatic Hypotension, Neurally Mediated Hypotension, Neurogenic Orthostatic Hypotension
    View official trial listing →
  • Completed NCT NCT00983814

    Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa

    Not yet reported Chelsea Therapeutics 20 participants Est. completion 2011-07 1 site
    Other conditions: Attention Deficit Hyperactivity Disorder
    View official trial listing →
  • Completed NCT NCT01132326

    Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304)

    Not yet reported Chelsea Therapeutics 350 participants Est. completion 2013-02
    Other conditions: Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency, Non-Diabetic Neuropathy, Neurogenic Orthostatic Hypotension
    View official trial listing →
  • Completed NCT NCT01149629

    Study of the Fed-Fast Pharmocokinetics and Bioequivalance of 300mg Capsules of Droxidopa

    Not yet reported Chelsea Therapeutics 24 participants Est. completion 2010-08 1 site
    Other conditions: Symptomatic Neurogenic Orthostatic Hypotension
    View official trial listing →
  • Completed NCT NCT01176240

    A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease

    Not yet reported Chelsea Therapeutics 225 participants Est. completion 2012-11 60 sites
    Other conditions: Orthostatic Hypotension, Parkinson's Disease
    View official trial listing →
  • Completed NCT NCT01323374

    Study To Assess The Clinical Benefit Of Droxidopa And Droxidopa/Carbidopa In Subjects With Fibromyalgia

    Not yet reported Chelsea Therapeutics 122 participants Est. completion 2011-10 7 sites
    Other conditions: Fibromyalgia
    View official trial listing →
  • Completed NCT NCT01327066

    Electrocardiographic (ECG) Safety Study of Droxidopa at Clinical and Supratherapeutic Dose

    Not yet reported Chelsea Therapeutics 52 participants Est. completion 2011-06 1 site
    Other conditions: QTc Interval
    View official trial listing →
  • Withdrawn NCT NCT01331122

    Study to Assess Droxidopa in the Treatment of Freezing Of Gait Symptoms in Patients With Parkinson's Disease

    Not yet reported, Not yet reported Chelsea Therapeutics Est. completion 2012-12 2 sites Stand-alone
    Other conditions: Gait Disorders, Neurologic
    View official trial listing →
  • Completed NCT NCT01354158

    A Dose Titration of Droxidopa in Patients With Spinal Cord Injury

    Not yet reported Bronx VA Medical Center 11 participants Est. completion 2013-05 1 site
    Other conditions: Spinal Cord Injury, Hypotension
    View official trial listing →
  • Enrolling by invitation NCT NCT01370512

    Droxidopa / Pyridostigmine in Orthostatic Hypotension

    Not yet reported Mayo Clinic 30 participants Est. completion 2027-05 1 site
    Other conditions: Orthostatic Hypotension
    View official trial listing →
  • Withdrawn NCT NCT01468259

    A Multi-Center, Open-Label Study

    Not yet reported Chelsea Therapeutics Est. completion 2012-12 1 site
    Other conditions: Renal Disease, End Stage Renal Disease
    View official trial listing →
  • Terminated NCT NCT01612078

    Phase 3 Study to Evaluate the Efficacy and Safety of Droxidopa on Orthostatic Hypotension Treatment in Hemodialysis Patients

    Not yet reported TSH Biopharm Corporation Limited 25 participants 1 site
    Other conditions: Orthostatic Hypotension
    View official trial listing →
  • Terminated NCT NCT01927055

    A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy

    Not yet reported Chelsea Therapeutics 61 participants Est. completion 2015-02 3 sites
    Other conditions: Symptomatic Neurogenic Orthostatic Hypotension, Parkinson's Disease, Multiple Systems Atrophy, Pure Autonomic Failure, Dopamine Beta Hydroxylase Deficiency
    View official trial listing →
  • Status unknown NCT NCT02066571

    Study to Assess the Clinical Benefit and Safety of Droxidopa in Parkinson's Disease

    Not yet reported Henry Ford Health System 20 participants Est. completion 2017-12 2 sites
    Other conditions: Parkinson's Disease, Freezing of Gait, Cognitive Ability, General
    View official trial listing →
  • Completed NCT NCT02071459

    Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA

    Not yet reported, Not yet reported University Hospital, Toulouse 107 participants Est. completion 2019-10-28 13 sites
    Other conditions: Multiple System Atrophy
    View official trial listing →
  • Terminated NCT NCT02558972

    Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS)

    Not yet reported New York Medical College 30 participants Est. completion 2022-12 1 site
    Other conditions: Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS), Fainting
    View official trial listing →
  • Completed NCT NCT02586623

    Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension

    Not yet reported H. Lundbeck A/S 453 participants Est. completion 2022-09-09 168 sites
    Other conditions: Symptomatic Neurogenic Orthostatic Hypotension
    View official trial listing →
  • Withdrawn NCT NCT02624310

    A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis

    Not yet reported NYU Langone Health Est. completion 2019-01
    Other conditions: HSAN Type IV
    View official trial listing →
  • Status unknown NCT NCT02812147

    Effect of L-Dihydoxyphenylserine on Locomotion, Postural Stability, and Fall Risk Reduction in Parkinson Disease

    Not yet reported St. Joseph's Hospital and Medical Center, Phoenix 20 participants Est. completion 2019-06 1 site
    Other conditions: Parkinson Disease
    View official trial listing →
  • Terminated NCT NCT03034564

    A Randomized, Double-Blind, Placebo-Controlled Study of Droxidopa for Fatigue in Parkinson's Disease

    Not yet reported The Cooper Health System 1 participants Est. completion 2018-09-30 1 site
    Other conditions: Parkinson Disease, Fatigue, Parkinsonism
    View official trial listing →
  • Terminated NCT NCT03070730

    Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist

    Not yet reported, Not yet reported Beth Israel Deaconess Medical Center 8 participants Est. completion 2014-07-28 2 sites
    Other conditions: Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
    View official trial listing →
  • Completed NCT NCT03115827

    Norepinephrine-targeted Therapy for Action Control in Parkinson Disease

    Not yet reported Vanderbilt University Medical Center 15 participants Est. completion 2018-12-21 1 site
    Other conditions: Parkinson Disease
    View official trial listing →
  • Completed NCT NCT03173781

    Effects of Droxidopa When Measuring Gait Speed, Kyphosis, and Functional Reach in Parkinson's Disease

    Not yet reported Colorado Springs Neurological Associates 21 participants Est. completion 2017-10 1 site
    Other conditions: Parkinson's Disease
    View official trial listing →
  • Completed NCT NCT03229174

    Brain Perfusion & Oxygenation in Parkinson's Disease With NOH

    Not yet reported William Ondo, MD 17 participants Est. completion 2022-02-02 1 site
    Other conditions: Parkinson Disease, Neurogenic Orthostatic Hypotension
    View official trial listing →
  • Withdrawn NCT NCT03446807

    Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism

    Not yet reported Loma Linda University Est. completion 2023-07-01 1 site
    Other conditions: Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
    View official trial listing →
  • Status unknown NCT NCT03567447

    Effect of L-Dihydroxyphenylserine (L-DOPS) on Falls in Patients With Neurogenic Orthostatic Hypotension (NOH)

    Not yet reported St. Joseph's Hospital and Medical Center, Phoenix 10 participants Est. completion 2020-03-01 1 site
    Other conditions: Parkinson Disease, Falls Patient
    View official trial listing →
  • Completed NCT NCT03602014

    Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury

    Not yet reported James J. Peters Veterans Affairs Medical Center 22 participants Est. completion 2021-12-31 2 sites Stand-alone
    Other conditions: Hypotension, Orthostatic, Hypotension, Spinal Cord Injuries
    View official trial listing →
  • Completed NCT NCT04510922

    Lundbeck TOMs Orthostatic Hypotension

    Not yet reported Alberto Espay, MD, MSc 9 participants Est. completion 2020-12-31 1 site Stand-alone
    Other conditions: Orthostatic Hypotension, Idiopathic Parkinson Disease
    View official trial listing →
  • Completed NCT NCT04977388

    NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Occipital Horn Syndrome

    Not yet reported, Not yet reported Stephen G. Kaler, MD 3 participants Est. completion 2024-06-29 1 site
    Other conditions: Menkes Disease, Occipital Horn Syndrome
    View official trial listing →
Efficacy history

Not yet reported.

Safety

Not yet reported.

Sources

Also known as: Droxidopa Product, Droxidopa Oral Product, NORTHERA

Related On The Pen coverage

No related coverage yet.

This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.