About this data
Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.
Dorzagliatin
- Company
- Sun Yat-sen University
- Mechanism
- Mechanism not yet reported
- Route
- Route not yet reported
- Recruiting trials
- 2 recruiting
Efficacy results: Not yet reported
2 recruiting studies currently listed on ClinicalTrials.gov.
Data source: ClinicalTrials.gov · trial data as of Oct 17, 2026
Find a Clinical Trial Near Me
See recruiting studies for Dorzagliatin and check eligibility with the study team.
Trial details
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Recruiting NCT NCT06976658
Glucokinase Activator in Monogenic Diabetes
Not yet reported Chinese University of Hong Kong 44 participants Est. completion 2026-12-31 1 siteOther conditions: Diabetes Mellitus, Monogenic DiabetesView official trial listing → -
Recruiting NCT NCT06995651
Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis
Not yet reported Michael R. Rickels, MD, MS 15 participants Est. completion 2027-07 2 sites Stand-aloneOther conditions: Pancreatic Insufficiency, Cystic Fibrosis-related DiabetesView official trial listing → -
Completed NCT NCT01952535
A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of Oral HMS5552 in Healthy Volunteers
Not yet reported Hua Medicine Limited 60 participants Est. completion 2013-12 1 siteOther conditions: Type II Diabetes MellitusView official trial listing → -
Completed NCT NCT02077452
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HMS5552 in Patients With Type 2 Diabetes
Not yet reported Hua Medicine Limited 53 participants Est. completion 2014-10Type 2 diabetesView official trial listing → -
Completed NCT NCT02386982
Beta Cell Function and Related Pharmacodynamics of HMS5552 in T2DM Patients
Not yet reported Hua Medicine Limited 24 participants Est. completion 2015-05 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT02561338
A Multi-center 12-week Study of HMS5552 in T2DM
Not yet reported Hua Medicine Limited 258 participants Est. completion 2016-09 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT02597400
Drug-Drug Interaction Study of Glucokinase Activator HMS5552 and Metformin in T2DM
Not yet reported Hua Medicine Limited 12 participants Est. completion 2015-10 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT03141073
Long-term Efficacy and Safety of HMS5552 add-on to Metformin in T2DM Subjects
Not yet reported Hua Medicine Limited 767 participants Est. completion 2021-02-28 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT03158506
Human Mass Balance Study of HMS5552 in Healthy Subjects
Not yet reported Hua Medicine Limited 6 participants Est. completion 2017-04-06 1 siteOther conditions: Healthy SubjectView official trial listing → -
Completed NCT NCT03173391
Long-term Efficacy and Safety of HMS5552 in T2DM Subjects
Not yet reported Hua Medicine Limited 463 participants Est. completion 2020-11-30 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT03790787
Drug Interaction Study Between Dorzagliatin and Empagliflozin
Not yet reported Hua Medicine Limited 16 participants Est. completion 2020-03-15 1 site Stand-aloneOther conditions: PatientsView official trial listing → -
Completed NCT NCT03790839
Drug Interaction Study Between Dorzagliatin and Sitagliptin
Not yet reported Hua Medicine Limited 15 participants Est. completion 2019-08-30 1 site Stand-aloneOther conditions: PatientsView official trial listing → -
Completed NCT NCT04080596
DDI Study to Investigate the Impact of Itraconazole on the Pharmacokinetics of Dorzagliatin
Not yet reported Hua Medicine Limited 18 participants Est. completion 2017-12-05 1 site Stand-aloneOther conditions: Drug InteractionView official trial listing → -
Completed NCT NCT04080609
DDI Study Between Dorzagliatin and Rifampicin
Not yet reported Hua Medicine Limited 15 participants Est. completion 2018-04-17 1 site Stand-aloneOther conditions: Drug InteractionView official trial listing → -
Status unknown NCT NCT04091854
The Progress of Diabetes Mellitus After HMS5552 Treatment in Type 2 Diabetes Mellitus
Majianhua 24 participants Est. completion 2022-03 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT04324424
A Clinical Study to Access the Pharmacokinetics of HMS5552 in Renal Impaired Subjects and Healthy Volunteers
Not yet reported Hua Medicine Limited 17 participants Est. completion 2019-09-30 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT04426708
A Clinical Study to Access the Pharmacokinetics of HMS5552 in Hepatic Impaired Subjects and Healthy Volunteers
Not yet reported Hua Medicine Limited 25 participants Est. completion 2020-07-03 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT04531631
Effects of Dorzagliatin on 1st Phase Insulin and Beta-cell Glucose Sensitivity in T2D and Monogenic Diabetes
Not yet reported Chinese University of Hong Kong 18 participants Est. completion 2022-02-15 1 siteType 2 diabetesView official trial listing → -
Active, not recruiting NCT NCT05098470
Effects of Modulators of Gluconeogenesis, Glycogenolysis and Glucokinase Activity
Not yet reported University of Alabama at Birmingham 100 participants Est. completion 2026-07-29 2 sites Stand-aloneType 2 diabetesView official trial listing → -
Status unknown NCT NCT05468229
Dorzagliatin and 1st Phase Insulin and Beta-cell Glucose Sensitivity in IGT and NGT
Not yet reported, Not yet reported Chinese University of Hong Kong 20 participants Est. completion 2023-04Other conditions: Glucose IntoleranceView official trial listing → -
Status unknown NCT NCT06222476
Effect of Dorzagliatin on Renal Function Outcomes in People With Type 2 Diabetes: a Multicentric, Prospective, Randomized Study.
Not yet reported Yan Bi 106 participants Est. completion 2026-06-30 1 site Stand-aloneChronic kidney diseaseView official trial listing → -
Completed NCT NCT06263348
A Post-Marketing Safety Study of Dorzagliatin in Patients With Type 2 Diabetes
Not yet reported Hua Medicine Limited 2024 participants Est. completion 2026-04-30 1 site Stand-aloneOther conditions: Type2diabetesView official trial listing → -
Not yet recruiting NCT NCT06671340
Chronic Dorzagliatin on Insulin and Incretin Function in Intermediate Hyperglycemia and Type 2 Diabetes
Not yet reported Elaine Chow 30 participants Est. completion 2026-01-31 1 site Stand-aloneType 2 diabetesPrediabetes Other conditions: Diabetes MellitusView official trial listing → -
Withdrawn NCT NCT07786571
Study on Improving Blood Glucose Homeostasis With Dorzagliatin Tablets in the Treatment of Type 2 Diabetes Mellitus Patients With Moderate to Severe Chronic Renal Insufficiency
Not yet reported Sun Yat-sen University Est. completion 2029-07-01 1 site Stand-aloneType 2 diabetesChronic kidney disease Other conditions: Chronic Renal Insufficiency, Glucose HomeostasisView official trial listing →
Efficacy history
Not yet reported.
Safety
Not yet reported.
Sources
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This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.