GLP-1 Market
LLY $1150.99 ▼ -1.6% NVO $38.17 ▼ -3.1% PFE $28.18 ▲ +0.9% VKTX $41.65 ▲ +2.0% KLRA $13.13 ▲ +2.7% GPCR $35.95 ▼ -2.6% RHHBY $55.06 ▼ -0.9%
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About this data Sourced primarily from ClinicalTrials.gov — a listing isn't proof of safety or FDA approval.

Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.

Not yet reported

Denosumab

Company
Chrissy Kistler
Mechanism
Mechanism not yet reported
Route
Route not yet reported
Recruiting trials
31 recruiting

Efficacy results: Not yet reported

Find a Clinical Trial Near Me

31 recruiting studies currently listed on ClinicalTrials.gov.

Data source: ClinicalTrials.gov · trial data as of Sep 24, 2026

Find a Clinical Trial Near Me

See recruiting studies for Denosumab and check eligibility with the study team.

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Match
Treatment type

"Added to GLP-1" means the investigational treatment is being studied on top of an existing GLP-1-based therapy.

Your ZIP code is only used to calculate distance to trial sites — it isn't stored.

Trial details
  • Recruiting NCT NCT02150850

    Quebec Registry for Atypical Femur Fractures

    McGill University 150 participants Est. completion 2026-04 1 site
    Other conditions: Atypical Femur Fracture
    View official trial listing →
  • Recruiting NCT NCT03755193

    Examination of Efficacy and Safety of Other Anti-Resorption Drugs After 2-year-Denosumab Therapy in Japanese Osteoporosis Patients

    Not yet reported Shinshu University 90 participants Est. completion 2026-11-23 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Recruiting NCT NCT03921060

    Markers of Osteoporosis in Cystic Fibrosis

    Not yet reported University of Texas Southwestern Medical Center 100 participants Est. completion 2027-07 1 site Stand-alone
    Other conditions: Cystic Fibrosis
    View official trial listing →
  • Recruiting NCT NCT03958565

    Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.

    University of Colorado, Denver 100 participants Est. completion 2028-04-28 2 sites
    Other conditions: Carcinoma, Non-Small-Cell Lung
    View official trial listing →
  • Recruiting NCT NCT04547348

    The DENOCHARCOT Trial

    Not yet reported Ole Lander Svendsen 38 participants Est. completion 2026-10-01 8 sites Stand-alone
    Other conditions: Charcot Foot, Diabetes Mellitus
    View official trial listing →
  • Recruiting NCT NCT04608630

    Bone Loss Prevention With Zoledronic Acid or Denosumab in Critically Ill Adults

    Not yet reported Australian and New Zealand Intensive Care Research Centre 450 participants Est. completion 2027-02-28 22 sites
    Other conditions: Critical Illness, Osteoporosis
    View official trial listing →
  • Recruiting NCT NCT05334459

    Preoperative Radiotherapy and Systemic Therapy Following Surgery in 'de Novo' Metastatic Breast Cancer

    Ankara Oncology Research and Training Hospital 40 participants Est. completion 2028-03-31 1 site
    Other conditions: Metastatic Breast Cancer
    View official trial listing →
  • Recruiting NCT NCT05590949

    Observational Study of Bone Complications in People With Post-menopausal Breast Cancer Who Have Stopped Treatment With Denosumab and Aromatase Inhibitors

    Memorial Sloan Kettering Cancer Center 100 participants Est. completion 2026-10-18 7 sites
    Other conditions: Breast Cancer
    View official trial listing →
  • Recruiting NCT NCT05866029

    Study of the Key Techniques of Prevention and Treatment of Osteoporotic Refracture

    Not yet reported Peking Union Medical College Hospital 2478 participants Est. completion 2026-09-30 58 sites Stand-alone
    Other conditions: Osteoporotic Fractures
    View official trial listing →
  • Recruiting NCT NCT05966064

    DEnosumab for the Treatment of FIbrous Dysplasia/McCune-Albright Syndrome in Adults (DeFiD)

    Not yet reported Natasha Appelman-Dijkstra 82 participants Est. completion 2028-12 1 site
    Other conditions: Fibrous Dysplasia, McCune Albright Syndrome
    View official trial listing →
  • Recruiting NCT NCT06118905

    Preserving Geriatric Muscle With an Osteoporosis Medication

    Not yet reported Chrissy Kistler 155 participants Est. completion 2029-03-31 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Recruiting NCT NCT06164795

    Sequential Therapies After Osteoanabolic Treatment

    424 General Military Hospital 150 participants Est. completion 2027-12 8 sites
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Recruiting NCT NCT06357741

    Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis

    Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 30 participants Est. completion 2025-12-31 1 site
    Osteoarthritis
    View official trial listing →
  • Recruiting NCT NCT06374459

    Zunsemetinib in Combination With Capecitabine in Patients With Hormone Receptor-Positive and HER2-Negative Metastatic Breast Cancer With Bone Metastasis

    Not yet reported, Not yet reported Washington University School of Medicine 152 participants Est. completion 2032-05-31 3 sites
    Other conditions: Hormone Receptor Positive HER-2 Negative Metastatic Breast Cancer
    View official trial listing →
  • Recruiting NCT NCT06513624

    ETC-159 In Combination With Pembrolizumab In Advanced MSS/pMMR Ovarian Cancers

    Not yet reported National University Hospital, Singapore 16 participants Est. completion 2027-06-30 2 sites Stand-alone
    Other conditions: With MSS/pMMR Advanced, Platinum-resistant Ovarian Cancer
    View official trial listing →
  • Recruiting NCT NCT06524960

    Denosumab for Type 1 Diabetes

    Not yet reported, Not yet reported City of Hope Medical Center 45 participants Est. completion 2027-10-11 3 sites Stand-alone
    Other conditions: Type 1 Diabetes
    View official trial listing →
  • Recruiting NCT NCT06643780

    RANK-ligand Inhibition to Combat Sarcopenia With Underlying Osteoporosis

    Not yet reported Prince of Wales Hospital, Shatin, Hong Kong 120 participants Est. completion 2027-10 1 site
    Other conditions: Sarcopenia in Elderly
    View official trial listing →
  • Recruiting NCT NCT06728462

    A Study of Amorphous Calcium Carbonate in Postmenopausal Women

    Not yet reported Universal Integrated Corp. 205 participants Est. completion 2027-03-01 1 site
    Other conditions: Calcium, Osteoporosis, Bone Mineral Density, Bone Turnover Marker, Denosumab
    View official trial listing →
  • Recruiting NCT NCT06738160

    The Efficacy and Safety of Narlumosbart in Combination With Stereotactic Body Radiation Therapy to Improve the Efficacy of First-line Chemotherapy Combined With Immunotherapy in Patients With Bone Metastases From Advanced Non-small Cell Lung Cancer

    Not yet reported Fudan University 27 participants Est. completion 2028-12-30 1 site Stand-alone
    Other conditions: NSCLC, Stereotactic Body Radiation Therapy (SBRT), Immunotherapy
    View official trial listing →
  • Recruiting NCT NCT06749886

    An Exploratory Study of Tislelizumab in Combination with Chemotherapy in Immuno-experienced Patients with EGFR/ALK/ROS1-negative Advanced NSCLC in the Second-line Setting

    Not yet reported Shanghai Pulmonary Hospital, Shanghai, China 22 participants Est. completion 2027-06-30 1 site Stand-alone
    Other conditions: Lung Cancer
    View official trial listing →
  • Recruiting NCT NCT06767150

    StrAtegies For Zoledronic Acid Post-dEnosumab Discontinuation in Postmenopausal oSTeoporosis

    Not yet reported University Hospital, Toulouse 200 participants Est. completion 2030-10 17 sites Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Recruiting NCT NCT06938152

    Effects of Cycle Therapy vs Sequential Therapy With Romosozumab and Denosumab in Postmenopausal Osteoporosis Patients

    Not yet reported National Taiwan University Hospital 70 participants Est. completion 2029-12-31 1 site Stand-alone
    Other conditions: Osteoporosis, Osteoporosis Postmenopausal
    View official trial listing →
  • Recruiting NCT NCT07028268

    A Trial of SHR-2017 Injection in Patients With Bone Metastases From Solid Tumors

    Not yet reported Suzhou Suncadia Biopharmaceuticals Co., Ltd. 210 participants Est. completion 2027-05 1 site Stand-alone
    Other conditions: For Prevention of Bone Events in Patients With Bone Metastases From Solid Tumors
    View official trial listing →
  • Recruiting NCT NCT07034391

    A Study Evaluating the Efficacy of PD-1 Inhibitor Combined With Denosumab and Chemotherapy in Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer Patients With Driver Gene-Negative Status

    Not yet reported China Medical University, China 40 participants Est. completion 2027-10-31 1 site Stand-alone
    Other conditions: Non-Small Cell Lung Cancer
    View official trial listing →
  • Recruiting NCT NCT07043608

    Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone Metastases

    Not yet reported Kelly Fitzgerald, MD 20 participants Est. completion 2030-04-30 1 site
    Other conditions: Clear Cell Renal Cell Cancer (ccRCC), Clear Cell Renal Carcinoma, Clear Cell Renal Cell Carcinoma Metastatic, Clear Cell Renal Cancer, Bone Metastases of a Malignant Tumor, Clear Cell Renal Cell Carcinoma, Bone, Metastatic Cancer, Metastatic Cancer, Metastatic Renal Cell Carcinoma, Metastases to Bone
    View official trial listing →
  • Recruiting NCT NCT07062978

    A Comparative Study to Valuating the Efficacy and Safety of QL1206 and Prolia®

    Not yet reported Qilu Pharmaceutical Co., Ltd. 278 participants Est. completion 2027-01 1 site Stand-alone
    Other conditions: Postmenopausal Women With Osteoporosis at High Risk of Fracture
    View official trial listing →
  • Recruiting NCT NCT07271771

    The Effect of Denosumab on Muscle and Strength and Insulin Sensitivity

    Not yet reported Aarhus University Hospital 40 participants Est. completion 2027-03-01 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Recruiting NCT NCT07281586

    Step-down Therapy After Long-term Osteoporosis Treatment

    Not yet reported National Taiwan University Hospital 44 participants Est. completion 2028-12-31 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Recruiting NCT NCT07283887

    Romosozumab and Denosumab, Alone or Combined, in Postmenopausal Osteoporosis

    Not yet reported National Taiwan University Hospital 90 participants Est. completion 2026-07-31 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Recruiting NCT NCT07406685

    The Comparison of Ibandronate and Zoledronic Acid After Denosumab Discontinuation

    Not yet reported National Taiwan University Hospital 52 participants Est. completion 2030-10-31 1 site
    Other conditions: Postmenopausal Osteoporosis, Postmenopausal Osteopenia, Primary Osteoporosis, Osteoporosis
    View official trial listing →
  • Recruiting NCT NCT07546552

    Clinical Relevance of Modifying RANKL Signaling During Folliculogenesis

    Not yet reported Peter Humaidan 100 participants Est. completion 2028-03-15 1 site Stand-alone
    Other conditions: Female Infertility, NF-κB Ligand, RANKL, Osteoporosis, Follicle Development
    View official trial listing →
  • Completed NCT NCT00043186

    Determine the Efficacy, Safety and Tolerability of Denosumab (AMG 162) in the Treatment of Postmenopausal Women With Low Bone Mineral Density

    Not yet reported Amgen 412 participants Est. completion 2007-06 Stand-alone
    Other conditions: Low Bone Mineral Density
    View official trial listing →
  • Completed NCT NCT00089661

    AMG 162 in the Treatment of Bone Loss in Subjects Undergoing Aromatase Inhibitor Therapy for Non-metastatic Breast Cancer

    Not yet reported Amgen 252 participants Est. completion 2009-05-27 Stand-alone
    Other conditions: Breast Cancer, Low Bone Mineral Density, Osteopenia
    View official trial listing →
  • Completed NCT NCT00089674

    AMG 162 in the Treatment of Bone Loss in Subjects Undergoing Androgen-Deprivation Therapy for Non-metastatic Prostate Cancer

    Not yet reported Amgen 1468 participants Est. completion 2010-05-11
    Other conditions: Prostate Cancer
    View official trial listing →
  • Completed NCT NCT00089791

    A Study to Evaluate Denosumab in the Treatment of Postmenopausal Osteoporosis

    Not yet reported Amgen 7808 participants Est. completion 2008-06-17 Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT00091793

    Study to Evaluate AMG 162 in the Prevention of Postmenopausal Osteoporosis

    Not yet reported Amgen 332 participants Est. completion 2009-03 Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT00091832

    Denosumab (AMG 162) in Bisphosphonate Naive Metastatic Breast Cancer

    Not yet reported Amgen 255 participants Est. completion 2006-10 Stand-alone
    Other conditions: Breast Cancer, Metastases, Bone Metastases in Subjects With Advanced Breast Cancer
    View official trial listing →
  • Completed NCT NCT00095498

    Efficacy, Safety and Tolerability of Denosumab in the Treatment of Rheumatoid Arthritis

    Not yet reported Amgen 227 participants Est. completion 2007-04-01 Stand-alone
    Other conditions: Rheumatoid Arthritis
    View official trial listing →
  • Completed NCT NCT00104650

    Study of AMG 162 in Subjects With Advanced Cancer Currently Being Treated With Intravenous (IV) Bisphosphonates

    Not yet reported Amgen 111 participants Est. completion 2010-03
    Other conditions: Bone Metastases in Men With Hormone-Refractory Prostate Cancer, Bone Metastases in Subjects With Advanced Breast Cancer, Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma
    View official trial listing →
  • Completed NCT NCT00259740

    Open-Label, Phase 2, Proof of Concept Study in Multiple Myeloma - Denosumab

    Not yet reported Amgen 96 participants Est. completion 2011-12 Stand-alone
    Other conditions: Relapsed or Plateau-Phase Multiple Myeloma
    View official trial listing →
  • Completed NCT NCT00286091

    Study on Prolonging Bone Metastasis-Free Survival in Men With Hormone Refractory Prostate Cancer

    Not yet reported Amgen 1435 participants Est. completion 2014-04-09 Stand-alone
    Other conditions: Hormone Refractory Prostate Cancer
    View official trial listing →
  • Completed NCT NCT00293813

    A Multicenter, Randomized Placebo Controlled Pilot MicroCT Study to Estimate the Effect of Treatment With Denosumab (AMG 162) and Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density

    Not yet reported Amgen 247 participants Est. completion 2008-08 Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT00306189

    A Randomized, Double-blind, Placebo-controlled, Dose Response Study of AMG 162 (Denosumab) in Japanese Postmenopausal Osteoporotic Subjects

    Not yet reported Amgen 212 participants Est. completion 2007-11
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT00321464

    A Study Comparing Denosumab vs. Zoledronic Acid for the Treatment of Bone Metastases in Breast Cancer Subjects.

    Not yet reported Amgen 2049 participants Est. completion 2012-04-04 Stand-alone
    Other conditions: Bone Metastases
    View official trial listing →
  • Completed NCT NCT00321620

    Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Men With Hormone-refractory Prostate Cancer

    Not yet reported Amgen 1904 participants Est. completion 2012-02-24 Stand-alone
    Other conditions: Bone Metastases
    View official trial listing →
  • Completed NCT NCT00325468

    An Open-label, Single-arm Extension Study to Evaluate the Long-term Safety of Denosumab Administration in Postmenopausal Women With Low Bone Mineral Density

    Not yet reported Amgen 200 participants Est. completion 2012-08-02 Stand-alone
    Other conditions: Low Bone Mineral Density
    View official trial listing →
  • Completed NCT NCT00330460

    A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density.

    Not yet reported Amgen 1189 participants Est. completion 2008-01 Stand-alone
    Other conditions: Osteoporosis, Osteopenia
    View official trial listing →
  • Completed NCT NCT00330759

    Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.

    Not yet reported Amgen 1779 participants Est. completion 2011-10-01 Stand-alone
    Other conditions: Bone Metastases
    View official trial listing →
  • Completed NCT NCT00377819

    Study of Transitioning From Alendronate to Denosumab

    Not yet reported Amgen 504 participants Est. completion 2008-07 Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT00396279

    Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone

    Not yet reported Amgen 37 participants Est. completion 2011-02-01 Stand-alone
    Other conditions: GCT, Giant Cell Tumor of Bone
    View official trial listing →
  • Completed NCT NCT00515463

    A Multi-Center, Randomized, Open-Label Study to Assess the Immunogenicity and Safety of Denosumab in Pre-filled Syringe Compared to Vial in Subjects With Low Bone Mineral Density

    Not yet reported Amgen 311 participants Est. completion 2009-03 Stand-alone
    Other conditions: Low Bone Mineral Density, Osteopenia, Osteoporosis
    View official trial listing →
  • Completed NCT NCT00518531

    Denosumab Adherence Preference Satisfaction Study

    Not yet reported Amgen 250 participants Est. completion 2010-06-01
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT00523341

    Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis

    Not yet reported Amgen 4550 participants Est. completion 2015-07-19 Stand-alone
    Other conditions: Osteopenia, Osteoporosis
    View official trial listing →
  • Completed NCT NCT00556374

    Study to Determine Treatment Effects of Denosumab in Patients With Breast Cancer Receiving Aromatase Inhibitor Therapy

    Not yet reported Amgen 3420 participants Est. completion 2022-07-26 46 sites Stand-alone
    Other conditions: Breast Cancer
    View official trial listing →
  • Completed NCT NCT00680953

    Denosumab Fracture Intervention Randomized Placebo Controlled Trial in Japanese Patients With Osteoporosis

    Not yet reported Daiichi Sankyo Co., Ltd. 1262 participants Est. completion 2012-07 4 sites Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT00680992

    Study of Denosumab in Subjects With Giant Cell Tumor of Bone

    Not yet reported Amgen 535 participants Est. completion 2018-05-17 33 sites Stand-alone
    Other conditions: Cancer, Giant Cell Tumors, Giant Cell Tumor of Bone, Benign Giant Cell Tumors
    View official trial listing →
  • Completed NCT NCT00838201

    Extension Study to Evaluate Long Term Safety of Denosumab in Subjects Undergoing ADT for Non-Metastatic Prostate Cancer

    Not yet reported Amgen 384 participants Est. completion 2012-05-03 74 sites Stand-alone
    Other conditions: Cancer, Carcinoma, Castrate-Resistant Prostate Cancer, Prostate Cancer, Tumors
    View official trial listing →
  • Completed NCT NCT00887965

    A Transiliac Crest Bone Histology and Histomorphometry Study in Postmenopausal Women With Low Bone Mass or Osteoporosis Previously Treated With Denosumab

    Not yet reported Amgen 15 participants Est. completion 2010-08
    Other conditions: Low Bone Mass, Low Bone Mineral Density, Osteoporosis, Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT00890981

    A High-resolution Peripheral Quantitative Computed Tomography Study in Postmenopausal Women Previously Treated With Denosumab

    Not yet reported Amgen 79 participants Est. completion 2010-08
    Other conditions: Low Bone Mass, Low Bone Mineral Density, Osteoporosis, Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT00896454

    Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium

    Not yet reported Amgen 33 participants Est. completion 2013-08-21 24 sites Stand-alone
    Other conditions: Breast Cancer, Hypercalcemia of Malignancy, Colon Cancer, Endocrine Cancer, Head and Neck Cancer, Kidney Cancer, Lung Cancer, Lymphoma, Metastatic Cancer, Multiple Myeloma, Parathyroid Neoplasms, Renal Cancer, Thyroid Cancer, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Non-Small Cell Lung Cancer
    View official trial listing →
  • Completed NCT NCT00896532

    Romosozumab (AMG 785) in Postmenopausal Women With Low Bone Mineral Density

    Not yet reported Amgen 419 participants Est. completion 2016-02-18 Stand-alone
    Other conditions: Low Bone Mineral Density, Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT00919711

    Study to Evaluate the Safety and Efficacy of Denosumab and Actonel® in Post Menopausal Women Transitioned From Alendronate Therapy

    Not yet reported Amgen 870 participants Est. completion 2012-03-05 Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT00925600

    Evaluation of New or Worsening Lens Opacifications in Men With Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss

    Not yet reported Amgen 769 participants Est. completion 2016-05-12 172 sites Stand-alone
    Other conditions: Cancer, Cataract, Low Bone Mineral Density, Osteopenia, Osteoporosis, Prostate Cancer
    View official trial listing →
  • Completed NCT NCT00926380

    Denosumab, Teriparatide or Both for the Treatment of Postmenopausal Osteoporosis

    Not yet reported Massachusetts General Hospital 94 participants Est. completion 2016-12 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT00936897

    A Study to Evaluate the Safety and Efficacy of Denosumab and Ibandronate in Postmenopausal Women Sub-Optimally Treated With Daily or Weekly Bisphosphonates

    Not yet reported Amgen 833 participants Est. completion 2012-01 Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT00950911

    Open Label Extension to SRE Studies in United Kingdom and Czech Republic Only

    Not yet reported Amgen 35 participants Est. completion 2012-04 17 sites Stand-alone
    Other conditions: Bone Metastases in Men With Hormone-Refractory Prostate Cancer, Bone Metastases in Subjects With Advanced Breast Cancer, Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma
    View official trial listing →
  • Completed NCT NCT00980174

    Study to Compare the Efficacy and Safety of DenosumAb Versus Placebo in Males With Osteoporosis

    Not yet reported Amgen 242 participants Est. completion 2012-05-23 Stand-alone
    Other conditions: Low Bone Mass, Low Bone Mineral Density, Males With Osteoporosis, Osteopenia, Osteoporosis
    View official trial listing →
  • Terminated NCT NCT01077154

    Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE)

    Not yet reported Amgen 4509 participants Est. completion 2018-03-26 459 sites Stand-alone
    Other conditions: Breast Cancer
    View official trial listing →
  • Completed NCT NCT01221727

    The Effects of Denosumab on the Pharmacokinetics (PK) of Midazolam

    Not yet reported Amgen 30 participants Est. completion 2011-07
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Terminated NCT NCT01294397

    Effects of Denosumab on the Pharmacokinetics of Etanercept

    Not yet reported Amgen 19 participants Est. completion 2016-01 2 sites Stand-alone
    Other conditions: Postmenopausal, Osteopenia, Rheumatoid Arthritis, Osteoporosis
    View official trial listing →
  • Completed NCT NCT01345019

    Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma

    Not yet reported Amgen 1718 participants Est. completion 2019-03-29 309 sites Stand-alone
    Other conditions: Cancer, Hematologic Malignancies, Multiple Myeloma, Oncology, Bone Metastases, Multiple Myeloma Bone Lesions
    View official trial listing →
  • Completed NCT NCT01358669

    Effect of Denosumab on Inflammatory Osteolytic Lesion Activity in Total Hip Arthroplasty

    Not yet reported Sheffield Teaching Hospitals NHS Foundation Trust 24 participants Est. completion 2021-12-31 1 site
    Other conditions: Revision Surgery of Total Hip Arthroplasty
    View official trial listing →
  • Completed NCT NCT01377467

    Denosumab for Prevention of Osteoporosis in Renal Transplant Recipients

    Not yet reported Rudolf Wuethrich 90 participants Est. completion 2015-10 1 site Stand-alone
    Chronic kidney disease Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT01419717

    Open-Label Access Protocol of Denosumab for Subjects With Advanced Cancer

    Not yet reported Amgen 129 participants Est. completion 2018-08-10 64 sites Stand-alone
    Other conditions: Bone Metastases in Men With Hormone-Refractory Prostate Cancer, Bone Metastases in Subjects With Advanced Breast Cancer
    View official trial listing →
  • Completed NCT NCT01457950

    A Study in Korean Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab

    Not yet reported GlaxoSmithKline 135 participants Est. completion 2013-06 10 sites Stand-alone
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Completed NCT NCT01464931

    Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis

    Not yet reported Amgen 32 participants Est. completion 2013-03 7 sites Stand-alone
    Other conditions: Renal Impairment
    View official trial listing →
  • Completed NCT NCT01465568

    Denosumab in Current Users of Bisphosphonates for Glucocorticoid-induced Osteoporosis

    Not yet reported Tuen Mun Hospital 40 participants Est. completion 2014-06 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT01495000

    A Study in Indian Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab

    Not yet reported GlaxoSmithKline 250 participants Est. completion 2013-02 11 sites Stand-alone
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Terminated NCT NCT01545648

    Pilot Study to Evaluate the Impact of Denosumab on Disseminated Tumor Cells (DTC) in Patients With Early Stage Breast Cancer

    Not yet reported Hope Rugo, MD 4 participants Est. completion 2016-06-09 1 site Stand-alone
    Other conditions: Early Stage Breast Cancer
    View official trial listing →
  • Terminated NCT NCT01558115

    Denosumab in Primary Hyperparathyroidism

    Not yet reported Columbia University 8 participants Est. completion 2014-10 1 site Stand-alone
    Other conditions: Primary Hyperparathyroidism
    View official trial listing →
  • Completed NCT NCT01572545

    Comparative Effect of Zoledronic Acid Versus Denosumab on Serum Sclerostin of Postmenopausal Women With Low Bone Mass

    Not yet reported Aristotle University Of Thessaloniki 91 participants Est. completion 2013-01 3 sites Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT01575834

    Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis

    Not yet reported Amgen 7180 participants Est. completion 2016-12-28 218 sites Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT01575873

    Efficacy and Safety of Denosumab Compared With Risedronate in Individuals Taking Glucocorticoids

    Not yet reported Amgen 795 participants Est. completion 2017-06-29 99 sites Stand-alone
    Other conditions: Steroid-induced Osteopor, Glucocorticoid-induced Ostepor
    View official trial listing →
  • Completed NCT NCT01624766

    Everolimus and Anakinra or Denosumab in Treating Participants With Relapsed or Refractory Advanced Cancers

    Not yet reported M.D. Anderson Cancer Center 57 participants Est. completion 2021-02-24 1 site Stand-alone
    Other conditions: Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm, Recurrent Malignant Neoplasm, Refractory Malignant Neoplasm
    View official trial listing →
  • Completed NCT NCT01630941

    Effects of Denosumab on Periprosthetic Bone After Total Hip Arthroplasty

    Not yet reported Hans Mallmin 64 participants Est. completion 2017-03-30 1 site
    Osteoarthritis Other conditions: Ambulation Difficulty
    View official trial listing →
  • Completed NCT NCT01652690

    Prospective Observational Study to Describe Characteristics and Management of Patients Treated With Denosumab (Prolia®) in Routine Clinical Practice

    Amgen 600 participants Est. completion 2015-05-15 29 sites
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Completed NCT NCT01668589

    Observational Study of Denosumab (Prolia®) in Postmenopausal Women With Osteoporosis

    Amgen 1501 participants Est. completion 2015-08-31 144 sites
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT01732770

    Safety and Efficacy Study to Evaluate Denosumab Compared With Zoledronic Acid in Postmenopausal Women With Osteoporosis

    Not yet reported Amgen 643 participants Est. completion 2015-01-07 45 sites Stand-alone
    Other conditions: Post Menopausal Osteoporosis
    View official trial listing →
  • Suspended NCT NCT01734824

    Treatment of Atraumatic Bone Marrow Edema With Denosumab and Teriparatide vs Placebo

    Not yet reported Medical University of Vienna 90 participants Est. completion 2015-09 1 site
    Other conditions: Bone Marrow Oedema Syndrome, High Turnover Bone Disease, Quality of Life
    View official trial listing →
  • Completed NCT NCT01750086

    Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption

    Not yet reported Massachusetts General Hospital 27 participants Est. completion 2014-08 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT01753856

    Effects of Teriparatide or Denosumab on Bone in Postmenopausal Women With Osteoporosis

    Not yet reported Eli Lilly and Company 69 participants Est. completion 2014-06 6 sites
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT01770106

    RA Denosumab on Bone Microstructure Study

    Not yet reported Chinese University of Hong Kong 40 participants Est. completion 2014-06 1 site Stand-alone
    Other conditions: Rheumatoid Arthritis
    View official trial listing →
  • Completed NCT NCT01799798

    Translational Therapy in Patients With Osteogenesis Imperfecta - A Pilot Trial on Treatment With the Rankl-Antibody Denosumab

    Not yet reported University of Cologne 10 participants Est. completion 2015-01 1 site Stand-alone
    Other conditions: Osteogenesis Imperfecta
    View official trial listing →
  • Completed NCT NCT01824342

    Denosumab for Prolonging Bone Metastasis-Free Survival in Men With Hormone-Refractory Prostate Cancer

    Not yet reported Amgen 18 participants Est. completion 2014-02 9 sites Stand-alone
    Other conditions: Castrate-resistant Prostate Cancer
    View official trial listing →
  • Terminated NCT NCT01864798

    A Study to Evaluate Denosumab in Young Patients With Primary Breast Cancer

    Not yet reported Jules Bordet Institute 27 participants Est. completion 2017-01 6 sites Stand-alone
    Other conditions: Breast Neoplasms
    View official trial listing →
  • Completed NCT NCT01869686

    Study to Evaluate the Concentration of Denosumab in Seminal Fluid in Healthy Men After a Single Subcutaneous Dose

    Not yet reported Amgen 12 participants Est. completion 2013-09 1 site Stand-alone
    Other conditions: Healthy Volunteer
    View official trial listing →
  • Completed NCT NCT01920568

    A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors

    Not yet reported GlaxoSmithKline 487 participants Est. completion 2016-04 25 sites Stand-alone
    Other conditions: Fractures, Bone
    View official trial listing →
  • Completed NCT NCT01926158

    Denosumab in Enhancement of Bone Bonding of Hip Prosthesis in Postmenopausal Women

    Not yet reported Turku University Hospital 65 participants Est. completion 2017-12-31 1 site Stand-alone
    Osteoarthritis
    View official trial listing →
  • Completed NCT NCT01951586

    Denosumab in Combination With Chemotherapy as First-line Treatment of Metastatic Non-small Cell Lung Cancer

    Not yet reported Amgen 226 participants Est. completion 2017-11-28 74 sites Stand-alone
    Other conditions: Non-Small Cell Lung Cancer
    View official trial listing →
  • Terminated NCT NCT01952054

    Denosumab for Breast Cancer With Bone Mets

    Not yet reported M.D. Anderson Cancer Center 7 participants Est. completion 2018-10-10 1 site Stand-alone
    Other conditions: Breast Cancer
    View official trial listing →
  • Completed NCT NCT01967160

    Osteonecrosis of the Jaw (ONJ) and Infection Among Nordic Cancer Patients Treated With XGEVA™ or Zoledronic Acid

    Amgen 2560 participants Est. completion 2019-08-05
    Other conditions: Osteonecrosis of the Jaw, Infection Leading to Hospitalization
    View official trial listing →
  • Completed NCT NCT01973569

    AMG 162 (Denosumab) Phase 3 Study (DESIRABLE Study) in Participants With Rheumatoid Arthritis on Disease-modifying Antirheumatic Drugs (DMARDs) Treatment

    Not yet reported Daiichi Sankyo 679 participants Est. completion 2017-09-19 1 site Stand-alone
    Other conditions: Rheumatoid Arthritis
    View official trial listing →
  • Completed NCT NCT01978483

    Effect of RANKL Inhibition on UV-induced Immunosuppression

    Not yet reported Innovaderm Research Inc. 31 participants Est. completion 2014-06 1 site Stand-alone
    Other conditions: Ultraviolet Rays, Immunosuppression, Hypersensitivity, Delayed, Immune Tolerance/Drug Effects
    View official trial listing →
  • Status unknown NCT NCT01983475

    Denosumab Administration After Spinal Cord Injury

    Not yet reported James J. Peters Veterans Affairs Medical Center 24 participants Est. completion 2020-05 2 sites Stand-alone
    Other conditions: Osteoporosis, Spinal Cord Injury
    View official trial listing →
  • Completed NCT NCT01998607

    Survey of XGEVA® Presrcibers in Europe to Evaluate Their Knowledge of the Summary of Product Characteristics Pertaining to Osteonecrosis of the Jaw

    Amgen 420 participants Est. completion 2015-05-15
    Other conditions: Solid Tumours, Bone Metastasis
    View official trial listing →
  • Completed NCT NCT02014467

    Denosumab China Phase III Study

    Not yet reported GlaxoSmithKline 486 participants Est. completion 2015-08 8 sites Stand-alone
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Completed NCT NCT02049866

    Denosumab for Prevention of Post-Teriparatide Bone Loss in Premenopausal Women With IOP

    Not yet reported Elizabeth Shane 33 participants Est. completion 2021-12-23 2 sites Stand-alone
    Other conditions: Adult Idiopathic Generalized Osteoporosis
    View official trial listing →
  • Active, not recruiting NCT NCT02051218

    Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks

    Not yet reported Swiss Cancer Institute 1380 participants Est. completion 2028-12-31 50 sites Stand-alone
    Other conditions: Metastatic Breast Cancer, Metastatic Prostate Cancer, Bone Metastases
    View official trial listing →
  • Completed NCT NCT02053753

    Bioequivalence Study of Denosumab CP4 Drug Product and Commercially Available Denosumab CP2 Drug Product

    Not yet reported Amgen 146 participants Est. completion 2014-08 2 sites Stand-alone
    Other conditions: Healthy Volunteer
    View official trial listing →
  • Completed NCT NCT02066805

    Estimation of Off-Label Use of XGEVA® (Denosumab) Using Population-Based Databases in Denmark

    Amgen 142 participants Est. completion 2015-02
    Other conditions: XGEVA Off-label Use
    View official trial listing →
  • Completed NCT NCT02099461

    Effect of Denosumab on Cellular Biomarkers in the Human Breast

    Not yet reported Amgen 82 participants Est. completion 2014-07 3 sites Stand-alone
    Other conditions: Healthy Volunteer, Female, Breast
    View official trial listing →
  • Withdrawn NCT NCT02101164

    Evaluate Time Associated With the Preparation & Administration of Denosumab/Pamidronate in Patients With Solid Tumors and Metastatic Bone Disease

    Not yet reported Amgen Est. completion 2014-11
    Other conditions: Solid Tumor, Metastatic Bone Disease
    View official trial listing →
  • Terminated NCT NCT02129699

    Survival imProvement in Lung cancEr iNduced by DenOsUmab theRapy

    Not yet reported ETOP IBCSG Partners Foundation 595 participants Est. completion 2020-02-29 66 sites Stand-alone
    Other conditions: Lung Cancer Non-small Cell Stage IV
    View official trial listing →
  • Status unknown NCT NCT02130973

    The Treatment of Osteoporosis Using a Combination of Teriparatide (Forteo) and Denosumab

    Not yet reported Health Research, Inc. 60 participants Est. completion 2018-08 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT02132026

    Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis.

    Not yet reported University of Edinburgh 152 participants Est. completion 2019-11-28 1 site
    Other conditions: Calcific Aortic Stenosis
    View official trial listing →
  • Completed NCT NCT02135640

    China HVT Safety, PK, PD

    Not yet reported GlaxoSmithKline 64 participants Est. completion 2015-02-17 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT02156960

    Changes of Bone Metabolic Markers and Bone Mineral Density After Denosumab and/or Teriparatide Treatment in Japanese Osteoporotic Patients

    Not yet reported Shinshu University 100 participants Est. completion 2022-11 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT02157948

    A Double-blind Study to Assess the Efficacy and Safety of Denosumab Produced by Two Different Processes in Postmenopausal Women With Osteoporosis

    Not yet reported Amgen 394 participants Est. completion 2015-07 23 sites Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT02166437

    Clinical Results of Bisphosphonate and Denosumab Therapy Following Teriparatide Therapy for Japanese

    Tomidahama Hospital 500 participants Est. completion 2018-11 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT02176382

    Denosumab and Teriparatide Study (DATA-HD and DATA-EX)

    Not yet reported Massachusetts General Hospital 76 participants Est. completion 2020-02 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT02239523

    Effectiveness or Orthopedic Intervention in Osteoporosis Management After a Fracture of the Hip With Cost-Benefit Analysis

    Not yet reported Shaare Zedek Medical Center 200 participants Est. completion 2019-02-28 1 site
    Other conditions: Osteoporotic Fracture
    View official trial listing →
  • Completed NCT NCT02274623

    Effect of CTAP101 Capsules on Ca/iPTH in Advanced Breast/Prostate Cancer Patients Treated With Denosumab/Zoledronic Acid

    Not yet reported OPKO Health, Inc. 33 participants Est. completion 2017-03-17 6 sites
    Other conditions: Breast Cancer, Prostate Cancer, Bone Neoplasms, Hypocalcemia, Hyperparathyroidism, Secondary
    View official trial listing →
  • Status unknown NCT NCT02299817

    Denosumab for Treating Periprosthetic Osteolysis.

    Not yet reported Olof Skoldenberg 20 participants Est. completion 2021-02 1 site
    Other conditions: Osteolysis
    View official trial listing →
  • Status unknown NCT NCT02304887

    The Relationship Between the Residual Renal Function and Osteoporosis Treatment

    Toshihiko Kono 1000 participants Est. completion 2019-01 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT02321280

    The Efficacy of Denosumab in Active Crohn's Disease

    Not yet reported, Not yet reported University of Manitoba 2 participants Est. completion 2018-04-20 1 site Stand-alone
    Other conditions: Crohn Disease
    View official trial listing →
  • Completed NCT NCT02347865

    Characteristics and Management of Postmenopausal Women With Osteoporosis Treated With Prolia® in France

    Amgen 777 participants Est. completion 2018-09-27 1 site
    Other conditions: Post Menopausal Osteoporosis
    View official trial listing →
  • Terminated NCT NCT02352753

    Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI

    Not yet reported Amgen 153 participants Est. completion 2022-03-26 49 sites Stand-alone
    Other conditions: Osteogenesis Imperfecta
    View official trial listing →
  • Completed NCT NCT02366130

    Trial of Ra-223 Dichloride in Combination With Hormonal Therapy and Denosumab in the Treatment of Patients With Hormone-Positive Bone-Dominant Metastatic Breast Cancer

    Not yet reported M.D. Anderson Cancer Center 45 participants Est. completion 2020-12-16 1 site Stand-alone
    Other conditions: Breast Cancer
    View official trial listing →
  • Withdrawn NCT NCT02418273

    Denosumab for Glucocorticoid-treated Children With Rheumatic Disorders

    Not yet reported, Not yet reported Indiana University Est. completion 2021-06 1 site Stand-alone
    Other conditions: Osteoporosis, Juvenile Rheumatoid Arthritis, Dermatomyositis, Polyarthritis, Systemic Lupus Erythematosis, Vasculitis, Glucocorticoid-induced Osteoporosis
    View official trial listing →
  • Completed NCT NCT02422108

    TNFSF11 Inhibition and Fertility: a Prospective Study

    Not yet reported Martin Blomberg Jensen 12 participants Est. completion 2019-01 1 site Stand-alone
    Other conditions: Testis, Infertility, Sperm
    View official trial listing →
  • Completed NCT NCT02435147

    Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index

    HealthEast Care System 86 participants Est. completion 2016-06 1 site
    Other conditions: Osteoporosis, Bone Fracture
    View official trial listing →
  • Withdrawn NCT NCT02444585

    Longjohn Amgen Study - Effect of Denosumab...

    Not yet reported University of Southern California Est. completion 2019-12 1 site Stand-alone
    Other conditions: Arthroplasty, Replacement, Hip
    View official trial listing →
  • Completed NCT NCT02470091

    Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma

    Not yet reported Children's Oncology Group 56 participants Est. completion 2023-12-31 141 sites Stand-alone
    Obstructive sleep apnea
    View official trial listing →
  • Status unknown NCT NCT02491515

    Effects of Denosumab Therapy for Japanese

    Tomidahama Hospital 500 participants Est. completion 2020-12 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT02499237

    Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation

    Not yet reported 424 General Military Hospital 57 participants Est. completion 2018-11-26 2 sites Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT02520362

    Denosumab Safety Assessment in Multiple Observational Databases

    Amgen 517991 participants Est. completion 2023-07-21
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT02554695

    Osteoclast Inhibition and Bone Formation

    Not yet reported Mayo Clinic 81 participants Est. completion 2016-10-25 1 site
    Other conditions: Bone Loss, Aging
    View official trial listing →
  • Completed NCT NCT02559648

    Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis

    Not yet reported Ersi Voskaridou 63 participants Est. completion 2017-12 1 site
    Other conditions: Thalassemia Major, Osteoporosis
    View official trial listing →
  • Terminated NCT NCT02567279

    Impact of Denosumab in the Prevention of Bone Loss in Non-menopausal Women With Anorexia Nervosa

    Not yet reported University Hospital, Montpellier 2 participants Est. completion 2019-01-03 1 site
    Obstructive sleep apnea
    View official trial listing →
  • Completed NCT NCT02576652

    Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement

    Not yet reported Amgen 6 participants Est. completion 2017-12-18 2 sites
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT02613416

    Denosumab and MRI Breast Imaging

    Not yet reported Alison Stopeck 42 participants Est. completion 2021-08-20 1 site Stand-alone
    Other conditions: Breast Cancer
    View official trial listing →
  • Completed NCT NCT02632916

    Denosumab for the Treatment of Osteoporosis in Children: A Pilot Study

    Not yet reported Children's Hospital of Eastern Ontario 10 participants Est. completion 2020-02-03 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT02637180

    Secondary Prevention of Osteoporotic Fractures: a Multiple Center Fracture Liaison Service in Greece

    Hellenic Society for the Study of Bone Metabolism 397 participants Est. completion 2017-12-07 4 sites
    Other conditions: Osteoporosis
    View official trial listing →
  • Withdrawn NCT NCT02677246

    Denosumab for Prevention of Bone Complications After Bone Marrow Transplantation in Children

    Not yet reported St. Justine's Hospital Est. completion 2018-09-04 1 site Stand-alone
    Other conditions: Disorder Related to Bone Marrow Transplantation
    View official trial listing →
  • Completed NCT NCT02682693

    Denosumab as an add-on Neoadjuvant Treatment (GeparX)

    Not yet reported GBG Forschungs GmbH 780 participants Est. completion 2020-12-31 1 site Stand-alone
    Other conditions: Breast Cancer Female NOS, Tubular Breast Cancer Stage II, Mucinous Breast Cancer Stage II, Invasive Ductal Breast Cancer, HER2 Positive Breast Cancer, Inflammatory Breast Cancer, Tubular Breast Cancer Stage III
    View official trial listing →
  • Completed NCT NCT02721433

    4-weekly Versus 12-weekly Administration of Bone-targeted Agents in Patients With Bone Metastases

    Not yet reported Ottawa Hospital Research Institute 263 participants Est. completion 2020-04 1 site
    Other conditions: Breast Cancer, Prostate Cancer, Metastasis
    View official trial listing →
  • Completed NCT NCT02732210

    Persistence With Prolia® (Denosumab) in Postmenopausal Women With Osteoporosis

    Amgen 935 participants Est. completion 2014-04-14 89 sites
    Other conditions: Osteoporosis, Age-Related
    View official trial listing →
  • Completed NCT NCT02753283

    Preventing Osteoporosis Using Denosumab

    Not yet reported Susan L. Greenspan 201 participants Est. completion 2023-08 1 site Stand-alone
    Other conditions: Osteoporosis, Postmenopausal, Osteoporosis, Osteoporotic Fractures
    View official trial listing →
  • Terminated NCT NCT02758132

    Denosumab Plus Enzalutamide, Abiraterone and Prednisone Compared to Denosumab Plus Enzalutamide Alone for Men With Castrate Resistant Prostate Cancer (CRPC) With Bone Metastases

    Not yet reported University of Hawaii 1 participants Est. completion 2016-09-06 1 site
    Other conditions: Prostate Cancer
    View official trial listing →
  • Completed NCT NCT02760979

    The Efficacy of Denosumab in Decreasing Periprosthetic Bone Loss in Patients With Total Knee Arthroplasty

    Not yet reported Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 60 participants Est. completion 2015-06
    Other conditions: Bone Resorption
    View official trial listing →
  • Completed NCT NCT02771860

    RANKL-blockade for the Treatment of Erosive Osteoarthritis (OA) of Interphalangeal Finger Joints

    Not yet reported University Hospital, Ghent 100 participants Est. completion 2021-04-28 1 site
    Osteoarthritis
    View official trial listing →
  • Terminated NCT NCT02792413

    Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease

    Not yet reported University Hospital, Montpellier 4 participants Est. completion 2020-12-10 9 sites Stand-alone
    Chronic kidney disease
    View official trial listing →
  • Completed NCT NCT02833610

    A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency

    Not yet reported Massachusetts General Hospital 55 participants Est. completion 2023-03-20 7 sites Stand-alone
    Other conditions: Multiple Myeloma
    View official trial listing →
  • Completed NCT NCT02853539

    Denosumab in Metabolic Bone Disease in Chronic Intestinal Failure Patients

    Not yet reported Stanley Dudrick's Memorial Hospital 32 participants Est. completion 2016-07 1 site Stand-alone
    Other conditions: Metabolic Bone Disease
    View official trial listing →
  • Withdrawn NCT NCT02864784

    Investigating the Safety, Tolerability and Efficacy of Amorphous Calcium Carbonate (ACC) on the Treatment of Subjects With CRPC

    Not yet reported Amorphical Ltd. Est. completion 2023-12 1 site Stand-alone
    Other conditions: Castrate Resistant Prostate Cancer With Bone Metastasis
    View official trial listing →
  • Completed NCT NCT02900469

    Presurgical Trial of Denosumab in Breast Cancer

    Not yet reported NYU Langone Health 44 participants Est. completion 2020-01-03 1 site Stand-alone
    Other conditions: Breast Cancer
    View official trial listing →
  • Completed NCT NCT02903446

    Denosumab In Addition To Intense Urate-Lowering Therapy for Bone Erosions

    Not yet reported University of Alabama at Birmingham 20 participants Est. completion 2020-03-01 1 site
    Other conditions: Gout
    View official trial listing →
  • Status unknown NCT NCT02932501

    Medication-related Osteonecrosis of the Jaw (MRONJ) Registry

    AO Clinical Investigation and Publishing Documentation 518 participants Est. completion 2024-04 14 sites
    Other conditions: Medication-related Osteonecrosis of the Jaw, Bisphosphonate-Associated Osteonecrosis of the Jaw
    View official trial listing →
  • Completed NCT NCT02996734

    Giant Cell Tumor of the Extremities Treated With Surgery and/or Medical Treatment

    Istituto Ortopedico Rizzoli 412 participants Est. completion 2016-12
    Other conditions: Giant Cell Tumor of Bone
    View official trial listing →
  • Completed NCT NCT03005678

    Denosumab Versus Bisphosphonates (Alendronate) in GIOP

    Not yet reported Tuen Mun Hospital 140 participants Est. completion 2020-02-01 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT03027557

    Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet.

    Not yet reported Peter Vestergaard 46 participants Est. completion 2019-09-12 1 site Stand-alone
    Other conditions: Primary Hyperparathyroidism, Parathyroid Adenoma, Parathyroid Hyperplasia
    View official trial listing →
  • Terminated NCT NCT03029442

    The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury

    Not yet reported James J. Peters Veterans Affairs Medical Center 5 participants Est. completion 2022-10-06 2 sites Stand-alone
    Other conditions: Secondary Osteoporosis, Spinal Cord Injury
    View official trial listing →
  • Completed NCT NCT03030196

    Denosumab and Male Infertility: a RCT

    Not yet reported Martin Blomberg Jensen 95 participants Est. completion 2023-05 1 site
    Other conditions: Infertility, Male
    View official trial listing →
  • Terminated NCT NCT03040765

    Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosis

    Not yet reported Hamad Medical Corporation 17 participants Est. completion 2019-04-08 1 site
    Other conditions: Thalassemia Majors (Beta-Thalassemia Major), Osteoporosis
    View official trial listing →
  • Terminated NCT NCT03070002

    Denosumab in Treating Patients With ER and/or PR Positive, HER2 Negative Metastatic Breast Cancer With Bone Metastases and Detectable Circulating Tumor Cells

    Not yet reported Northwestern University 1 participants Est. completion 2018-04-24 2 sites Stand-alone
    Other conditions: Breast Carcinoma Metastatic in the Bone, Circulating Tumor Cell Count, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Positive, Stage IV Breast Cancer
    View official trial listing →
  • Completed NCT NCT03087851

    Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis

    Not yet reported Aarhus University Hospital 61 participants Est. completion 2020-08-01 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT03161756

    Evaluation of Denosumab in Combination With Immune Checkpoint Inhibitors in Patients With Unresectable or Metastatic Melanoma

    Not yet reported, Not yet reported Melanoma and Skin Cancer Trials Limited 72 participants Est. completion 2023-12 10 sites Stand-alone
    Other conditions: Melanoma Stage Iv, Melanoma Stage Iii, Melanoma
    View official trial listing →
  • Completed NCT NCT03164928

    Safety and Efficiency of Denosumab in Pediatric Subjects With Glucocorticoid-induced Osteoporosis

    Not yet reported Amgen 24 participants Est. completion 2023-12-20 38 sites Stand-alone
    Other conditions: Evaluate the Safety and Efficacy of Denosumab in Pediatric Subjects With, Glucocorticoid-induced Osteoporosis
    View official trial listing →
  • Completed NCT NCT03174366

    Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy

    Not yet reported Western University of Health Sciences 7 participants Est. completion 2019-03-06 1 site Stand-alone
    Other conditions: Charcot Joint of Foot
    View official trial listing →
  • Withdrawn NCT NCT03217513

    Knee Osteoarthritis Outcome Measures in Arthritic Patients With Osteoporosis

    Edward Fox Est. completion 2024-12-31 1 site
    Osteoarthritis Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT03239080

    Effect of Denosumab in Erosion Healing in RA

    Not yet reported Chinese University of Hong Kong 110 participants Est. completion 2020-05-24 1 site
    Other conditions: Rheumatoid Arthritis
    View official trial listing →
  • Status unknown NCT NCT03259152

    Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone

    Not yet reported Hebei Medical University Third Hospital 30 participants Est. completion 2019-05-01 1 site Stand-alone
    Other conditions: Giant Cell Tumor of Bone
    View official trial listing →
  • Completed NCT NCT03270020

    Denosumab for the Treatment of Adult LCH

    Not yet reported Hellenic Society for the Study of Bone Metabolism 10 participants Est. completion 2025-01-14 1 site Stand-alone
    Other conditions: Langerhans Cell Histiocytosis
    View official trial listing →
  • Status unknown NCT NCT03280667

    Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma

    Not yet reported Australian and New Zealand Urogenital and Prostate Cancer Trials Group 59 participants Est. completion 2023-06-04 16 sites Stand-alone
    Other conditions: Renal Cell Carcinoma, Clear Cell, Metastatic Kidney Cancer
    View official trial listing →
  • Completed NCT NCT03292146

    Effects of Denosumab on Bone Mineral Density in Women With Anorexia Nervosa: A Pilot Study

    Not yet reported Massachusetts General Hospital 30 participants Est. completion 2021-07-22 1 site Stand-alone
    Obstructive sleep apnea Other conditions: Bone Density, Bone Loss, Eating Disorder
    View official trial listing →
  • Status unknown NCT NCT03293108

    Comparing Efficacy and Safety of AryoGen Pharmed Biosimilar Denosumab 60 mg (Arylia) Versus Prolia® in Improvement of Bone Mineral Densitometry (BMD) Among Osteoporotic Postmenopausal Women

    Not yet reported AryoGen Pharmed Co. 190 participants Est. completion 2020-09-30 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT03301857

    Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004

    Not yet reported Amgen 85 participants Est. completion 2023-07-27 14 sites Stand-alone
    Other conditions: Giant Cell Tumor of Bone
    View official trial listing →
  • Active, not recruiting NCT NCT03324932

    Efficacy of Denosumab on Normal BMD in Women Receiving Adjuvant Aromatase Inhibitors for Early Breast Cancer

    Not yet reported Kyoto Prefectural University of Medicine 160 participants Est. completion 2027-12 1 site
    Other conditions: Breast Cancer
    View official trial listing →
  • Status unknown NCT NCT03358212

    Safety and Efficacy of Post-operative Denosumab Strategy for Giant Cell Tumor of Bone Treatment in China

    Peking University People's Hospital 100 participants Est. completion 2021-06-01
    Other conditions: Giant Cell Tumor of Bone
    View official trial listing →
  • Terminated NCT NCT03382574

    Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy

    Not yet reported National Cancer Institute (NCI) 2 participants Est. completion 2021-10-22 6 sites Stand-alone
    Other conditions: Ovarian Carcinoma
    View official trial listing →
  • Completed NCT NCT03396315

    Bisphosphonates for Prevention of Post-Denosumab Bone Loss

    Not yet reported Columbia University 24 participants Est. completion 2023-06-09 2 sites
    Other conditions: IOP, Osteoporosis
    View official trial listing →
  • Completed NCT NCT03401060

    Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis

    Not yet reported Assistance Publique - Hôpitaux de Paris 24 participants Est. completion 2024-03-11 11 sites Stand-alone
    Other conditions: Osteoporosis, Systemic Mastocytosis
    View official trial listing →
  • Terminated NCT NCT03408652

    Efficacy and Safety of Systemic Treatments of Bone Metastases From Kidney Cancer in Patients Treated With Targeted Therapies

    Not yet reported Centre Leon Berard 1 participants Est. completion 2020-06-22 1 site Stand-alone
    Other conditions: Metastatic Renal Cell Carcinoma
    View official trial listing →
  • Completed NCT NCT03415477

    Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts

    Not yet reported, Not yet reported Peking University People's Hospital 6 participants Est. completion 2017-12-31 Stand-alone
    Other conditions: Bone Cyst Aneurysmal, Pathological Fracture, Recurrent Disease, Refractory Tumor
    View official trial listing →
  • Status unknown NCT NCT03427853

    A Study to Evaluate the Denosumab in Healthy Adults

    Not yet reported Luye Pharma Group Ltd. 32 participants Est. completion 2019-12-28 1 site
    Other conditions: Healthy Adults
    View official trial listing →
  • Terminated NCT NCT03457818

    Therapy of the Skeletal Disease of Type 2 Diabetes With Denosumab

    Not yet reported Mishaela Rubin 8 participants Est. completion 2020-06-10 1 site Stand-alone
    Type 2 diabetes Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT03472846

    MiDeTe - microRNA Levels Under Denosumab and Teriparatide Therapy in Postmenopausal Osteoporosis

    Not yet reported Medical University of Vienna 26 participants Est. completion 2022-09-30 1 site
    Other conditions: Postmenopausal Osteoporosis, Diabetes Type 2
    View official trial listing →
  • Completed NCT NCT03520231

    Study Comparing Denosumab With Standard Treatment in Urothelial Cancer Patients With Bone Metastases

    Not yet reported University Health Network, Toronto 6 participants Est. completion 2020-12-01 1 site Stand-alone
    Other conditions: Urothelial Carcinoma, Kidney Cancer, Ureter Cancer, Bladder Cancer
    View official trial listing →
  • Withdrawn NCT NCT03532087

    Study to Identify the Impact of Denosumab on the Immune System in Patients With HER2 Negative Breast Cancer

    Not yet reported Borstkanker Onderzoek Groep Est. completion 2023-06 8 sites Stand-alone
    Other conditions: Breast Neoplasms
    View official trial listing →
  • Active, not recruiting NCT NCT03571191

    Denosumab Treatment for Fibrous Dysplasia

    Not yet reported National Institute of Dental and Craniofacial Research (NIDCR) 9 participants Est. completion 2030-03-15 1 site Stand-alone
    Other conditions: Bone Diseases, Pain
    View official trial listing →
  • Completed NCT NCT03603444

    Reliability of Serum Calcium to Phosphorus (Ca/P) Ratio as an Accurate and Inexpensive Tool to Define Disorders of Ca-P Metabolism

    Azienda Ospedaliero-Universitaria di Modena 606 participants Est. completion 2018-01-01 1 site
    Other conditions: Phosphorus and Calcium Disorders
    View official trial listing →
  • Status unknown NCT NCT03605199

    Denosumab in Subjects With Giant Cell Rich Tumors of Bone

    Not yet reported Leiden University Medical Center 60 participants Est. completion 2023-06 3 sites Stand-alone
    Other conditions: Aneurysmal Bone Cysts, Giant Cell Granuloma, Osteoblastoma, Chondroblastoma, Chondromyxoid Fibroma
    View official trial listing →
  • Completed NCT NCT03620019

    Denosumab + PD-1 in Subjects With Stage III/ IV Melanoma

    Not yet reported UNC Lineberger Comprehensive Cancer Center 25 participants Est. completion 2023-08-15 2 sites Stand-alone
    Other conditions: Melanoma Stage Iii, Melanoma Stage Iv, Melanoma, Melanoma (Skin), Cutaneous Melanoma
    View official trial listing →
  • Terminated NCT NCT03620149

    Reduced Dose-density of Denosumab for Unresectable GCTB

    Not yet reported European Organisation for Research and Treatment of Cancer - EORTC 2 participants Est. completion 2020-07-30 8 sites Stand-alone
    Other conditions: Bone Giant Cell Tumor
    View official trial listing →
  • Active, not recruiting NCT NCT03623633

    Comparative Antiresorptive Efficacy Discontinuation of Denosumab

    Not yet reported Massachusetts General Hospital 51 participants Est. completion 2023-08-01 1 site
    Other conditions: Osteoporosis, Postmenopausal, Osteoporosis
    View official trial listing →
  • Completed NCT NCT03629717

    RANKL Inhibition and Breast Tissue Biomarkers

    Not yet reported Washington University School of Medicine 10 participants Est. completion 2018-12-03 1 site Stand-alone
    Other conditions: Breast Cancer Prevention, Mammographic Density
    View official trial listing →
  • Terminated NCT NCT03638128

    Open-label Extension of Study 20130173 of Denosumab in Children and Young Adults With Osteogenesis Imperfecta

    Not yet reported Amgen 75 participants Est. completion 2022-03-28 22 sites Stand-alone
    Other conditions: Osteogenesis Imperfecta (OI)
    View official trial listing →
  • Completed NCT NCT03651947

    Comparing of the Pharmacokinetic, Safety and Pharmacodynamic of QL1206 and Xgeva® in Healthy Adults

    Not yet reported Qilu Pharmaceutical Co., Ltd. 168 participants Est. completion 2019-05-22 1 site
    Other conditions: Healthy People
    View official trial listing →
  • Completed NCT NCT03669523

    Denosumab and Nivolumab Combination As 2d-line Therapy in Stage IV NSC Lung Cancer with Bone Metastases (DENIVOS)

    Not yet reported Centre Hospitalier Annecy Genevois 82 participants Est. completion 2023-10-19 27 sites Stand-alone
    Other conditions: Carcinoma, Non-Small-Cell Lung, Bone Metastases
    View official trial listing →
  • Status unknown NCT NCT03691311

    Biomarker Study of the Antitumoral Activity of Denosumab in the Pre- Operative Setting of Early Breast Cancer

    Not yet reported Institut Català d'Oncologia 60 participants Est. completion 2023-02-05 1 site Stand-alone
    Other conditions: Breast Neoplasm Female, Stage I Breast Cancer, Stage II Breast Cancer, Hormone Receptor Negative Neoplasm, Hormone Receptor Positive Tumor
    View official trial listing →
  • Status unknown NCT NCT03702140

    Examination How the Administration Period of Teriparatide Affects Bone Metabolism and Bone Mineral Density Prior to Denosumab Therapy

    Not yet reported Shinshu University 90 participants Est. completion 2025-10-08 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT03732495

    Study of the Efficacy of Lenvatinib Combined With Denosumab in the Treatment of Patients With Predominant Bone Metastatic Radioiodine Refractory Differentiated Thyroid Carcinomas

    Not yet reported Centre Leon Berard 35 participants Est. completion 2023-01-15 14 sites Stand-alone
    Other conditions: Thyroid Cancer Metastatic
    View official trial listing →
  • Completed NCT NCT03792763

    Denosumab for High Risk SMM and SLiM CRAB Positive, Early Myeloma Patients

    Not yet reported Arbeitsgemeinschaft medikamentoese Tumortherapie 8 participants Est. completion 2023-09-14 10 sites Stand-alone
    Other conditions: Multiple Myeloma
    View official trial listing →
  • Completed NCT NCT03808285

    Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection

    Hospices Civils de Lyon 13 participants Est. completion 2018-12-31 1 site
    Other conditions: Bone and Joint Infection, Osteomyelitis, Adverse Drug Event
    View official trial listing →
  • Status unknown NCT NCT03811509

    Breast Cancer Women on Aromatase Inhibitors Treatment

    Not yet reported Parc de Salut Mar 1000 participants Est. completion 2022-12-31 1 site
    Other conditions: Osteoporosis, Osteoporosis Fracture, Arthralgia Generalized
    View official trial listing →
  • Withdrawn NCT NCT03812367

    Activity of Pre-Osteoclasts and Osteoclasts Over Time in Postmenopausal Women Treated With Denosumab or Zoledronic Acid

    University of California, Davis Est. completion 2021-12-31 1 site
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Completed NCT NCT03822078

    Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Denosumab (AMG 162) in Japanese Postmenopausal Women

    Not yet reported Amgen 45 participants Est. completion 2004-12-24 Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT03839459

    Denosumab for Smoldering Multiple Myeloma

    Not yet reported University of Rochester 20 participants Est. completion 2025-01-30 1 site Stand-alone
    Other conditions: Smoldering Multiple Myeloma
    View official trial listing →
  • Completed NCT NCT03868033

    Denosumab Sequential Therapy

    Not yet reported National Taiwan University Hospital 101 participants Est. completion 2023-12-31 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Terminated NCT NCT03869762

    Denosumab in Combination With Enzalutamide in Progressive Metastatic Castrate-resistant Prostate Cancer and Bone Metastases.

    Not yet reported Cancer Trials Ireland 7 participants Est. completion 2019-01-12 7 sites Stand-alone
    Other conditions: Castration-resistant Prostate Cancer, Metastatic Cancer, Bone Metastases
    View official trial listing →
  • Status unknown NCT NCT03923842

    Denosumab In Ebv Nasopharyngeal Carcinoma As A Model For RankMediated Immunologic Modulation Of Virus-Related Tumours

    Not yet reported Gruppo Oncologico del Nord-Ovest 45 participants Est. completion 2022-10-30 2 sites Stand-alone
    Other conditions: Nasopharyngeal Carcinoma, EBV Related Carcinoma
    View official trial listing →
  • Completed NCT NCT03925051

    Phase 1 Study to Compare CMAB807 Injection to Prolia® in Healthy Volunteers

    Not yet reported Shanghai Biomabs Pharmaceutical Co., Ltd. 132 participants Est. completion 2020-06-18 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT03925532

    Denosumab in Treating Patients With Bone Loss Due to Donor Stem Cell Transplant

    Not yet reported Roswell Park Cancer Institute 30 participants Est. completion 2022-11-16 2 sites Stand-alone
    Other conditions: Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Osteopenia, Osteoporosis
    View official trial listing →
  • Terminated NCT NCT03960554

    The Effects of 12-months of Denosumab on Bone Density in Prevalent Kidney Transplant Recipients

    Not yet reported Thomas Nickolas, MD MS 8 participants Est. completion 2021-12-02 3 sites
    Other conditions: Osteoporosis, Renal Osteodystrophy, Kidney Transplant; Complications
    View official trial listing →
  • Completed NCT NCT03974100

    Study Investigating PK, PD, Efficacy, Safety, and Immunogenicity of Biosimilar Denosumab (GP2411) in Patients With Postmenopausal Osteoporosis

    Not yet reported Sandoz 527 participants Est. completion 2022-04-22 42 sites
    Other conditions: Postmenopausal Women With Osteoporosis
    View official trial listing →
  • Completed NCT NCT04026256

    Bone Modeling Effects of Combined Anabolic/Antiresorptive Administration

    Not yet reported Massachusetts General Hospital 37 participants Est. completion 2022-04-18 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT04034199

    Treating Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density With Denosumab or Zoledronic Acid

    Not yet reported Kwong Wah Hospital 40 participants Est. completion 2021-03-31 1 site Stand-alone
    Other conditions: Idiopathic Inflammatory Myopathies, Osteoporosis, Osteopenia
    View official trial listing →
  • Active, not recruiting NCT NCT04067726

    RANKL Inhibition and Mammographic Breast Density

    Not yet reported Washington University School of Medicine 210 participants Est. completion 2026-08-31 1 site Stand-alone
    Other conditions: Dense Breasts
    View official trial listing →
  • Status unknown NCT NCT04085419

    Osteoporosis in Primary Hyperparathyroidism

    Not yet reported University Medical Centre Ljubljana 40 participants Est. completion 2023-05 1 site
    Other conditions: Primary Hyperparathyroidism, Osteoporosis
    View official trial listing →
  • Completed NCT NCT04087096

    Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery

    Not yet reported Massachusetts General Hospital 36 participants Est. completion 2024-08-06 2 sites Stand-alone
    Other conditions: Bariatric Surgery Candidate, Bone Loss
    View official trial listing →
  • Completed NCT NCT04091243

    Romosozumab Versus Denosumab for Osteoporosis in Long-term Glucocorticoid Users

    Not yet reported Tuen Mun Hospital 70 participants Est. completion 2023-11-15 1 site
    Other conditions: Glucocorticoid-induced Osteoporosis
    View official trial listing →
  • Completed NCT NCT04169698

    Alendronate Versus Denosumab in Kidney Transplant Patients

    Not yet reported, Not yet reported Ain Shams University 90 participants Est. completion 2021-05-01 1 site Stand-alone
    Other conditions: Osteoporosis, Osteopenia, Renal Transplant Recipient
    View official trial listing →
  • Completed NCT NCT04177940

    Denosumab (DMAB) Discontinuation And Switching In Glucocorticoid-Induced Osteoporosis (GIOP): A Pilot Study

    Not yet reported University of Alabama at Birmingham 45 participants Est. completion 2025-01-14 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT04198636

    A Study to Evaluate LY01011 and Xgeva® in Healthy Adults

    Not yet reported Luye Pharma Group Ltd. 168 participants Est. completion 2021-06-30
    Other conditions: Healthy Adults
    View official trial listing →
  • Completed NCT NCT04206618

    Circulating Myokine Levels and Bone Metabolism

    424 General Military Hospital 220 participants Est. completion 2020-11-10 1 site
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Status unknown NCT NCT04213105

    Comparing of the Pharmacokinetic, Safety and Pharmacodynamic of QL1206 and Prolia® in Healthy Adults

    Not yet reported Qilu Pharmaceutical Co., Ltd. 144 participants Est. completion 2020-10-31 1 site
    Other conditions: Healthy People
    View official trial listing →
  • Withdrawn NCT NCT04231682

    A Study to Evaluate Efficacy and Safety of Denosumab for Prevention and Treatment of Osteoporosis in 1st Time Liver Transplant Recipients.

    Not yet reported Albert Einstein Healthcare Network Est. completion 2025-01-01 Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT04232657

    Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI

    Not yet reported VA Office of Research and Development 36 participants Est. completion 2026-08-24 2 sites
    Other conditions: Spinal Cord Injury (=3 Years), Sublesional Bone Loss Secondary to SCI
    View official trial listing →
  • Status unknown NCT NCT04241211

    Comparative Study for Incidence of Proximal Junctional Kyphosis Between Parathyroid Hormone and Denosumab Following Adult Spinal Deformity Surgery : A Prospective, Randomized Controlled Trial

    Not yet reported Seoul National University Bundang Hospital 64 participants Est. completion 2020-12-31 1 site
    Other conditions: Spine Deformity
    View official trial listing →
  • Completed NCT NCT04338529

    Alendronate in an Weekly Effervescent Tablet Formulation Following Denosumab Discontinuation

    251 Hellenic Air Force & VA General Hospital 92 participants Est. completion 2024-11-01 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT04403698

    The Use of Steovess/Binosto After Denosumab Discontinuation to Prevent Increase in Bone Turnover

    Not yet reported University Hospital, Ghent 30 participants Est. completion 2022-03-09 1 site Stand-alone
    Osteoarthritis
    View official trial listing →
  • Active, not recruiting NCT NCT04467983

    Abaloparatide Added to Ongoing Denosumab vs Continued Denosumab Alone

    Not yet reported Hospital for Special Surgery, New York 70 participants Est. completion 2026-12-01 1 site
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Status unknown NCT NCT04494373

    Comparing of the Pharmacokinetic, Pharmacodynamic, Safety and Immunogenicity of HS-20090 and Xgeva® in Healthy Adults

    Not yet reported Jiangsu Hansoh Pharmaceutical Co., Ltd. 154 participants Est. completion 2021-06-30
    Other conditions: Bone Metastasis From Solid Tumors
    View official trial listing →
  • Completed NCT NCT04512872

    A Phase I Study to Evaluate the Safety and Pharmacokinetics of CT-P41 and EU-approved Prolia in Healthy Male Subjects

    Not yet reported Celltrion 30 participants Est. completion 2021-05-04 1 site
    Other conditions: Healthy Male Subjects
    View official trial listing →
  • Completed NCT NCT04534582

    Pharmacokinetic, Safety and Immunogenicity Phase I Study of HLX14 Versus Prolia® in Healthy Male Subjects

    Not yet reported Shanghai Henlius Biotech 252 participants Est. completion 2023-09-12 1 site
    Other conditions: Healthy Male Volunteers
    View official trial listing →
  • Completed NCT NCT04540601

    Antiresorptive Drug Continuation Compared With Drug Holiday in Cancer Patients Needing Tooth Extraction

    Not yet reported University of Copenhagen 30 participants Est. completion 2020-08-19 2 sites
    Other conditions: Osteonecrosis Due to Drugs, Jaw
    View official trial listing →
  • Active, not recruiting NCT NCT04549207

    Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer

    Not yet reported Ottawa Hospital Research Institute 240 participants Est. completion 2026-09 5 sites
    Other conditions: Breast Cancer, Castration-resistant Prostate Cancer
    View official trial listing →
  • Status unknown NCT NCT04550949

    To Evaluate the Efficacy and Safety of QL1206 and Xgeva in Patients With Bone Metastases From Solid Tumors

    Not yet reported Qilu Pharmaceutical Co., Ltd. 700 participants Est. completion 2022-06-10 2 sites
    Other conditions: Bone Metastases
    View official trial listing →
  • Active, not recruiting NCT NCT04586660

    Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone

    Not yet reported Amgen 36 participants Est. completion 2028-03-07 10 sites
    Other conditions: Giant Cell Tumor of Bone
    View official trial listing →
  • Completed NCT NCT04591275

    Clinical Efficacy and Safety Comparative Study Between CMAB807 Injection and Prolia® .

    Not yet reported Shanghai Biomabs Pharmaceutical Co., Ltd. 278 participants Est. completion 2024-11-01 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT04621318

    Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity Study of SB16 in Healthy Male Subjects

    Not yet reported Samsung Bioepis Co., Ltd. 168 participants Est. completion 2022-11-09 2 sites Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT04664959

    A Study to Compare SB16 (Proposed Denosumab Biosimilar) to Prolia® in Postmenopausal Women With Osteoporosis

    Not yet reported Samsung Bioepis Co., Ltd. 457 participants Est. completion 2023-01-03 5 sites Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT04673799

    Comparing of the Pharmacokinetics, Immunogenicity and Safety of MV088 and Prolia® in Healthy Adults.

    Not yet reported Kunming Pharmaceuticals, Inc. 144 participants Est. completion 2021-10-18
    Other conditions: Healthy
    View official trial listing →
  • Completed NCT NCT04702204

    Efficacy of Denosumab Treatment in Bisphosphonate Unresponsive Patients

    Nigde Omer Halisdemir University 73 participants Est. completion 2021-08-15 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Active, not recruiting NCT NCT04711109

    Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation

    Not yet reported Alliance for Clinical Trials in Oncology 300 participants Est. completion 2033-12 47 sites Stand-alone
    Other conditions: BRCA1 Mutation, Breast Cancer, Breast Diseases, Breast Neoplasms, Breast Carcinoma, Neoplasms
    View official trial listing →
  • Status unknown NCT NCT04719572

    Intervention Study of Drugs in Patients Osteopenia and Osteoporosis

    Not yet reported Chinese PLA General Hospital 180 participants Est. completion 2023-01 1 site
    Other conditions: Osteoporosis, Osteopenia, Osteoporosis
    View official trial listing →
  • Completed NCT NCT04729621

    A Study to Test if TVB-009P is Effective in Relieving Postmenopausal Osteoporosis

    Not yet reported Teva Pharmaceuticals USA 332 participants Est. completion 2023-06-19 78 sites Stand-alone
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Status unknown NCT NCT04741906

    Outcome of Dental Implant Therapy in Patients Treated With Antiresorptive Medication

    Copenhagen University Hospital at Herlev 225 participants Est. completion 2025-12-31 1 site
    Other conditions: Missing Teeth, Implants, Cancer, Osteoporosis
    View official trial listing →
  • Completed NCT NCT04757376

    A Phase 3 Study to Compare Between CT-P41 and US-licensed Prolia in Postmenopausal Women With Osteoporosis

    Not yet reported Celltrion 479 participants Est. completion 2023-11-16 20 sites
    Other conditions: Postmenopausal Women With Osteoporosis
    View official trial listing →
  • Completed NCT NCT04798313

    Comparing of the Pharmacokinetic, Pharmacodynamic, Safety and Immunogenicity of MW031 and Prolia® in Healthy Adults

    Not yet reported Mabwell (Shanghai) Bioscience Co., Ltd. 120 participants Est. completion 2020-12-31 1 site
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Completed NCT NCT04798326

    Comparing of the Pharmacokinetic, Pharmacodynamic, Safety and Immunogenicity of MW032 and Xgeva® in Healthy Adults

    Not yet reported Mabwell (Shanghai) Bioscience Co., Ltd. 120 participants Est. completion 2020-02-26 1 site
    Other conditions: Bone Tumor
    View official trial listing →
  • Active, not recruiting NCT NCT04800367

    Romosozumab/Denosumab Study for Premenopausal IOP

    Not yet reported Columbia University 30 participants Est. completion 2028-03 1 site Stand-alone
    Other conditions: Premenopausal Idiopathic Osteoporosis
    View official trial listing →
  • Completed NCT NCT04812509

    Efficacy and Safety of MW032 and Xgeva® in Subjects With Bone Metastases From Solid Tumors

    Not yet reported Mabwell (Shanghai) Bioscience Co., Ltd. 708 participants Est. completion 2022-01-28 1 site
    Other conditions: Bone Metastases
    View official trial listing →
  • Status unknown NCT NCT04859569

    Efficacy and Safety of LY01011 and Xgeva® in Patients With Bone Metastases From Solid Tumors

    Not yet reported Luye Pharma Group Ltd. 850 participants Est. completion 2023-06-30 1 site
    Other conditions: Bone Metastases From Solid Tumors
    View official trial listing →
  • Status unknown NCT NCT04861142

    Osteoporosis Treatment Protocol in Patients With Fragility Fractures: Application and Efficacy

    University General Hospital of Heraklion 350 participants Est. completion 2024-10 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT04907539

    A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer After Progression on Standard of Care (SOC)

    Not yet reported Redx Pharma Ltd 25 participants Est. completion 2024-04-02 22 sites Stand-alone
    Other conditions: Colorectal Cancer
    View official trial listing →
  • Completed NCT NCT04907851

    A Study to Assess RXC004 Efficacy in Advanced Solid Tumours After Progression on Standard of Care (SoC) Therapy (PORCUPINE2)

    Not yet reported Redx Pharma Ltd 45 participants Est. completion 2023-11-30 13 sites Stand-alone
    Other conditions: Advanced Solid Tumours
    View official trial listing →
  • Completed NCT NCT04934072

    A Study to Evaluate the Efficacy, Pharmacodynamics, Safety, and Immunogenicity of FKS518 in Postmenopausal Women With Osteoporosis

    Not yet reported Fresenius Kabi SwissBioSim GmbH 553 participants Est. completion 2023-08-07 76 sites
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT04940845

    Comparing of the Pharmacokinetic, Safety and Immunogenicity of HS-20090-2 Injection and Prolia® in Healthy Adults

    Not yet reported Shanghai Hansoh Biomedical Co., Ltd 174 participants Est. completion 2022-06 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT04973722

    A Study to Evaluate LY06006 and Prolia in Healthy Adults

    Not yet reported Luye Pharma Group Ltd. 168 participants Est. completion 2021-12-31 1 site
    Other conditions: Healthy Adults
    View official trial listing →
  • Active, not recruiting NCT NCT05010590

    Anabolic Therapy in Postmenopausal Osteoporosis

    Not yet reported Massachusetts General Hospital 50 participants Est. completion 2027-11-01 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT05058443

    Denosumab and Osteoporotic Vertebral Compression Fracture

    Not yet reported, Not yet reported Shenzhen People's Hospital 90 participants Est. completion 2022-08-10 1 site Stand-alone
    Other conditions: Osteoporotic Vertebral Compression Fracture
    View official trial listing →
  • Withdrawn NCT NCT05065164

    Denosumab and Screw Fixation for Osteoporotic Compression Fracture

    Not yet reported, Not yet reported Shenzhen People's Hospital Est. completion 2023-09-25 1 site Stand-alone
    Other conditions: Denosumab Allergy
    View official trial listing →
  • Completed NCT NCT05087030

    Comparative Efficacy and Safety Study of RGB-14-P and Prolia® in Women With Postmenopausal Osteoporosis

    Not yet reported Gedeon Richter Plc. 473 participants Est. completion 2023-11-15 59 sites
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Active, not recruiting NCT NCT05091086

    The Optimal Long Term Treatment Strategy of Anti-resorptive Medications

    Not yet reported National Taiwan University Hospital 60 participants Est. completion 2030-12-31 1 site Stand-alone
    Other conditions: Osteoporosis, Bone Mineral Density
    View official trial listing →
  • Completed NCT NCT05091099

    The Optimal Sequential Therapy After Long Term Denosumab Treatment

    Not yet reported National Taiwan University Hospital 44 participants Est. completion 2025-11-14 1 site Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Active, not recruiting NCT NCT05096195

    PRevEnting FracturEs in REnal Disease - 1

    Not yet reported Western University, Canada 60 participants Est. completion 2025-12 6 sites Stand-alone
    Chronic kidney disease Other conditions: Kidney Diseases, Dialysis; Complications, Fragility Fracture
    View official trial listing →
  • Active, not recruiting NCT NCT05101018

    Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI

    Not yet reported James J. Peters Veterans Affairs Medical Center 40 participants Est. completion 2027-11-01 2 sites Stand-alone
    Other conditions: Osteoporosis, Spinal Cord Injuries
    View official trial listing →
  • Status unknown NCT NCT05106517

    Denosumab vs Zoledronic Acid and Osteoporotic Compression Fracture

    Not yet reported, Not yet reported Shenzhen People's Hospital 122 participants Est. completion 2023-03-11 1 site Stand-alone
    Other conditions: Denosumab vs Zoledronate
    View official trial listing →
  • Completed NCT NCT05126784

    AVT03 With Prolia in Healthy Male Subjects

    Not yet reported Alvotech Swiss AG 209 participants Est. completion 2023-10-16 4 sites Stand-alone
    Other conditions: Healthy Male Subjects
    View official trial listing →
  • Status unknown NCT NCT05203588

    Effects of Denosumab on Bone Fusion in Osteoporotic Patients After Lumbar Fusion

    Not yet reported Shanghai Changzheng Hospital 116 participants Est. completion 2023-10 1 site Stand-alone
    Other conditions: Osteoporosis, Fusion of Spine, Lumbar Region
    View official trial listing →
  • Active, not recruiting NCT NCT05212337

    FITMI - First In Treating Male Infertility

    Not yet reported Martin Blomberg Jensen 180 participants Est. completion 2025-09-30 1 site
    Other conditions: Infertility, Male
    View official trial listing →
  • Status unknown NCT NCT05234047

    Study Evaluating Denosumab on Vascular and Bone Metabolism in Osteoporotic Chronic Kidney Disease (HDENOBS)

    University Hospital, Montpellier 21 participants Est. completion 2025-02
    Chronic kidney disease Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT05245669

    Study to Compare the Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity of Biosimilar Denosumab With Prolia® in Healthy Adult Male Volunteers

    Not yet reported Enzene Biosciences Ltd. 207 participants Est. completion 2024-05-22 2 sites Stand-alone
    Other conditions: Healthy Male Subjects
    View official trial listing →
  • Status unknown NCT NCT05278338

    Efficacy and Safety of JMT103 in the Treatment of Postmenopausal Women With Osteoporosis

    Not yet reported Shanghai JMT-Bio Inc. 200 participants Est. completion 2024-03-31 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Completed NCT NCT05299073

    A Study Comparing the Pharmacokinetic Similarity of MB09 and EU/US-Sourced Xgeva

    Not yet reported mAbxience Research S.L. 257 participants Est. completion 2023-03-18 1 site Stand-alone
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT05323708

    Comparison of Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Bmab 1000 and Prolia® in Normal Healthy Volunteers: DENARIUS: DENosumab Pharmacokinetic equivAlence tRIal in Healthy volUnteerS

    Not yet reported Biocon Biologics UK Ltd 190 participants Est. completion 2023-10-06 1 site
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT05338086

    A Study to Compare Efficacy, PK, PD, Safety and IMM of MB09 to Prolia® [EU-sourced] in Postmenopausal Osteoporosis.

    Not yet reported mAbxience Research S.L. 558 participants Est. completion 2024-05-22 64 sites Stand-alone
    Other conditions: Postmenopausal Women With Osteoporosis
    View official trial listing →
  • Completed NCT NCT05345691

    Comparison of Efficacy, Pharmacodynamics, Safety, and Immunogenicity Between Bmab 1000 and Prolia® in Postmenopausal Women With Osteoporosis

    Not yet reported Biocon Biologics UK Ltd 479 participants Est. completion 2024-06-12 1 site
    Other conditions: Postmenopausal Women With Osteoporosis
    View official trial listing →
  • Completed NCT NCT05352516

    A Study to Evaluate the Efficacy and Safety of HLX14 vs. Denosumab Prolia® in Postmenopausal Women With Osteoporosis at High Risk of Fracture

    Not yet reported Shanghai Henlius Biotech 514 participants Est. completion 2024-07-03 38 sites
    Other conditions: Postmenopausal
    View official trial listing →
  • Completed NCT NCT05361408

    A Clinical Trial to Evaluate Efficacy of Once or Twice ZOledronic Acid After Different Duration of denOsumMab Administration in Postmenopausal Women With Osteoporosis (ZOOM Study)

    Not yet reported Yonsei University 114 participants Est. completion 2024-02-13 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT05366621

    Post-fracture Medication and Mortality

    National Cheng-Kung University Hospital 216155 participants Est. completion 2021-10-31 1 site
    Other conditions: Osteoporosis, Osteoporosis Fracture, Drug Therapy, Mortality, Adherence, Medication
    View official trial listing →
  • Completed NCT NCT05372224

    Effect of Vitamin D and Denosumab on Bone Remodelling in Women With Postmenopausal Osteoporosis

    Not yet reported Hospital Regional 1o de Octubre 55 participants Est. completion 2021-06-22 1 site
    Other conditions: Hypovitaminosis D, Osteoporosis, Postmenopausal, Menopause
    View official trial listing →
  • Completed NCT NCT05395091

    Multicenter Study in Postmenopausal Women With Osteoporosis, ALVOBOND

    Not yet reported Alvotech Swiss AG 532 participants Est. completion 2024-10-28 34 sites Stand-alone
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Completed NCT NCT05402865

    A Real-world Study on Patients of Unresectable Giant Cell Tumor of Bone

    Shanghai JMT-Bio Inc. 301 participants Est. completion 2022-02-18 3 sites
    Other conditions: Giant Cell Tumor of Bone
    View official trial listing →
  • Completed NCT NCT05405725

    A Phase 3 Study to Compare Biosimilar Denosumab With Prolia®

    Not yet reported Enzene Biosciences Ltd. 504 participants Est. completion 2024-07-18 48 sites Stand-alone
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT05405894

    Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation

    University of Calgary 20 participants Est. completion 2025-07-01 1 site
    Other conditions: Osteoporosis, Osteoporosis, Postmenopausal, Osteopenia, Bone Loss
    View official trial listing →
  • Completed NCT NCT05415657

    Denosumab Effect on Bone Quality and Function After Lumbar Fusion Surgery

    Not yet reported Shenzhen People's Hospital 76 participants Est. completion 2023-01-10 1 site Stand-alone
    Other conditions: Osteopenia, Spine Fusion, Denosumab Allergy
    View official trial listing →
  • Completed NCT NCT05419050

    Study of Denosumab for Prevention of Skeletal Disease Progression in Children With Fibrous Dysplasia

    Not yet reported National Institute of Dental and Craniofacial Research (NIDCR) 15 participants Est. completion 2026-01-09 1 site Stand-alone
    Other conditions: Fibrous Dysplasia
    View official trial listing →
  • Status unknown NCT NCT05419427

    Denosumab Biosimilar Injection in Post Menopausal Women With Osteoporosis

    Not yet reported Lambda Therapeutic Research Ltd. 552 participants Est. completion 2024-11-24 1 site Stand-alone
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Status unknown NCT NCT05435768

    PraG With RANKL Inhibitor for the Treatment of Advanced Multiple Metastatic Solid Tumors

    Second Affiliated Hospital of Soochow University 51 participants Est. completion 2025-08-15 1 site
    Other conditions: Metastatic Solid Tumor
    View official trial listing →
  • Completed NCT NCT05493761

    Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Disease

    Not yet reported Aristotle University Of Thessaloniki 72 participants Est. completion 2026-07-16 3 sites Stand-alone
    Other conditions: Nonalcoholic Fatty Liver, Osteoporosis, Postmenopausal
    View official trial listing →
  • Status unknown NCT NCT05559268

    Effects of Denosumab on Bone Microarchitecture After Total Knee Arthroplasty

    Not yet reported The Affiliated Hospital of Qingdao University 60 participants Est. completion 2023-12-31 Stand-alone
    Osteoarthritis
    View official trial listing →
  • Active, not recruiting NCT NCT05575167

    Single or Repeat Zoledronate Versus Alendronate Following Denosumab (EUROpean Denosumab Effects Consolidation Study)

    424 General Military Hospital 122 participants Est. completion 2027-11 9 sites
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Completed NCT NCT05598606

    Denosumab vs Zoledronate After Vertebroplasty

    Not yet reported Shenzhen People's Hospital 75 participants Est. completion 2023-01-14 1 site Stand-alone
    Other conditions: Denosumab Allergy, Zoledronic Acid Allergy
    View official trial listing →
  • Completed NCT NCT05630768

    Efficacy and Safety of Actonel® After Denosumab Discontinuation in Postmenopausal Osteoporosis Women

    Not yet reported Dong-A ST Co., Ltd. 149 participants Est. completion 2025-07-23 1 site
    Other conditions: Postmenopausal Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT05638399

    Denosumab vs Zoledronate After Lumbar Fusion

    Not yet reported Shenzhen People's Hospital 100 participants Est. completion 2023-02-28 1 site Stand-alone
    Other conditions: Osteopenia, Lumbar Spondylolisthesis
    View official trial listing →
  • Active, not recruiting NCT NCT05655013

    Treatment With Zoledronate Subsequent to Denosumab in Osteoporosis 2 (ZOLARMAB2)

    Not yet reported Aarhus University Hospital 200 participants Est. completion 2027-02-01 1 site
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Status unknown NCT NCT05662358

    Denosumab vs Alendronate After Vertebroplasty

    Not yet reported Shenzhen People's Hospital 90 participants Est. completion 2023-10-25 1 site Stand-alone
    Other conditions: Denosumab Allergy
    View official trial listing →
  • Active, not recruiting NCT NCT05666310

    Muscle Impact of Treating Osteoporosis

    Not yet reported Nami Safai Haeri 20 participants Est. completion 2026-09-05 1 site
    Other conditions: Sarcopenia, Osteoporosis
    View official trial listing →
  • Status unknown NCT NCT05692297

    Denosumab Treatment in CKD Patients at High Risk of Fracture

    Not yet reported Capital Medical University 102 participants Est. completion 2025-12-31 1 site Stand-alone
    Chronic kidney disease Other conditions: Fracture, Bone Density, Low, End Stage Renal Disease
    View official trial listing →
  • Completed NCT NCT05736640

    Osseointegrated Transdermal Femoral Amputation Prostheses

    Not yet reported University of Aarhus 6 participants Est. completion 2016-09-30
    Other conditions: Osseointegrated Implants, Bone Mineral Density
    View official trial listing →
  • Status unknown NCT NCT05777109

    Comparing of the PK, PD, Safety and Immunogenicity of HS-20090 and Xgeva® in Healthy Adults

    Not yet reported Jiangsu Hansoh Pharmaceutical Co., Ltd. 180 participants Est. completion 2024-04-05 1 site
    Other conditions: Healthy
    View official trial listing →
  • Withdrawn NCT NCT05808673

    Study of CMAB807X Pre- and Post-change in Manufacturing Site and Xgeva® in Healthy Volunteers

    Not yet reported Taizhou Mabtech Pharmaceutical Co.,Ltd Est. completion 2024-07 1 site
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Not yet recruiting NCT NCT05813665

    A Study to Evaluate the Efficacy and Safety of Narlumosbart (JMT103) in Patients With Giant Cell Tumor of Bone

    Not yet reported Shanghai JMT-Bio Inc. 146 participants Est. completion 2028-09 1 site
    Other conditions: Giant Cell Tumor of Bone
    View official trial listing →
  • Status unknown NCT NCT05853354

    Comparative Efficacy, Safety, PK, and Immunogenicity Study

    Not yet reported Luye Pharma Group Ltd. 392 participants Est. completion 2025-12-30 39 sites Stand-alone
    Other conditions: Osteoporosis, Postmenopausal
    View official trial listing →
  • Completed NCT NCT05876949

    AVT03 With Xgeva in Healthy Male Subjects

    Not yet reported Alvotech Swiss AG 208 participants Est. completion 2024-04-15 3 sites Stand-alone
    Other conditions: This is a Phase I Study Conducted in Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT05884372

    Efficacy and Safety of Combination Denosumab With Eldecalcitol for Postmenopausal Women With Osteoporosis.(ESCORT)

    Not yet reported Xi'an Honghui Hospital 100 participants Est. completion 2025-07-16 1 site Stand-alone
    Other conditions: Osteoporosis in Postmenopausal Women
    View official trial listing →
  • Completed NCT NCT06037395

    Phase I Study to Compare the Pharmacokinetics, Pharmacodynamics, and Safety Between CT-P41 and US-licensed Prolia in Healthy Male Subjects

    Not yet reported Celltrion 154 participants Est. completion 2022-10-20 2 sites
    Other conditions: Healthy Subject
    View official trial listing →
  • Not yet recruiting NCT NCT06076772

    Palbociclib Induced Neutropenia; Risk Factors and Treatment Outcome in Metastatic Breast Cancer Patients

    Assiut University 54 participants Est. completion 2026-12 1 site
    Other conditions: Metastatic Breast Cancer
    View official trial listing →
  • Completed NCT NCT06095427

    A Pharmacokinetic Similarity Study in Healthy Male Subjects to Evaluate Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of LY06006 Versus US-Prolia and EU-Prolia by Single-dose Subcutaneous Injection

    Not yet reported Luye Pharma Group Ltd. 300 participants Est. completion 2023-03-14 2 sites Stand-alone
    Other conditions: Healthy
    View official trial listing →
  • Status unknown NCT NCT06154707

    Clinical Controlled Study on the Efficacy of Denosumab in Treating Osteoporosis in the Domestic Population and Its Impact on Sarcopenia-related Outcomes

    Not yet reported Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 86 participants Est. completion 2025-03-01 1 site Stand-alone
    Other conditions: Sarcopenia, Osteoporosis, Denosumab
    View official trial listing →
  • Status unknown NCT NCT06272227

    Effect of Alfacalcidol on Muscle Function in Osteoporosis Patients

    Not yet reported Yonsei University 340 participants Est. completion 2025-09-01 1 site Stand-alone
    Other conditions: Sarcopenia
    View official trial listing →
  • Completed NCT NCT06300229

    NAPO - Novel Approach for Oligospermia

    Not yet reported, Not yet reported Martin Blomberg Jensen 42 participants Est. completion 2025-08-31 1 site
    Other conditions: Infertility, Male
    View official trial listing →
  • Completed NCT NCT06310824

    Single Dose, Three-arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia®

    Not yet reported Xentria, Inc. 225 participants Est. completion 2025-07-22 2 sites
    Other conditions: Healthy Participants
    View official trial listing →
  • Not yet recruiting NCT NCT06314698

    Narlumosbart Compared With Denosumab in Patients With Multiple Myeloma Bone Disease

    Not yet reported RenJi Hospital 478 participants Est. completion 2027-04-30
    Other conditions: Multiple Myeloma, Bone Diseases
    View official trial listing →
  • Active, not recruiting NCT NCT06332014

    Evaluation of Efficacy and Safety of Prolia in Subjects of Male Osteoporosis in Mainland China

    Not yet reported Amgen 102 participants Est. completion 2027-01-23 16 sites Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT06361355

    Study of CMAB807 Post-change in Manufacturing Site and Prolia in Healthy Volunteers

    Not yet reported Taizhou Mabtech Pharmaceutical Co.,Ltd 128 participants Est. completion 2024-07-05 1 site
    Other conditions: Healthy Volunteers
    View official trial listing →
  • Completed NCT NCT06414616

    Real-World Evidence of Adherence to Denosumab Therapy and Fracture Risk Associated With Drug Withdrawal: A Cross-sectional Study

    Trakya University 210 participants Est. completion 2024-03-01 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Completed NCT NCT06472050

    Romosozumab Versus Denosumab in Glucocorticoid-induced Osteoporosis: an Extended Observation of a Randomized Controlled Trial at 48 Months

    Not yet reported Tuen Mun Hospital 54 participants Est. completion 2026-04-30 1 site
    Other conditions: Osteoporosis, Glucocorticoids Toxicity
    View official trial listing →
  • Withdrawn NCT NCT06504966

    Study to Compare the Efficacy, Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of MAB-22 Versus Prolia®

    Not yet reported Xentria, Inc. Est. completion 2027-10 Stand-alone
    Other conditions: Osteoporosis
    View official trial listing →
  • Active, not recruiting NCT NCT06588153

    A Study for the Evaluation of Efficacy and Safety of Prolia® in Participants With Glucocorticoid-induced Osteoporosis in Mainland China

    Not yet reported Amgen 102 participants Est. completion 2027-04-27 16 sites Stand-alone
    Other conditions: Glucocorticoid-induced Osteoporosis
    View official trial listing →
  • Active, not recruiting NCT NCT06706414

    NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia

    Not yet reported, Not yet reported Martin Blomberg Jensen 16 participants Est. completion 2026-08 1 site Stand-alone
    Other conditions: Infertility, Male
    View official trial listing →
  • Not yet recruiting NCT NCT06720350

    Efficacy of Romosozumab and Denosumab Combined Treatment in Postmenopausal Osteoporosis Patients with Multiple Fragility Fractures

    Not yet reported Marmara University 60 participants Est. completion 2026-12-15 1 site Stand-alone
    Other conditions: Osteoporosis in Post-menopausal Women
    View official trial listing →
  • Completed NCT NCT06804590

    A Study on Efficacy, Safety and Immunogenicity of 9MW0311 in Postmenopausal Women With Osteoporosis

    Not yet reported Mabwell (Shanghai) Bioscience Co., Ltd. 280 participants Est. completion 2026-06-30 1 site Stand-alone
    Other conditions: Postmenopausal Women Osteoporosis
    View official trial listing →
  • Enrolling by invitation NCT NCT06811363

    Contribution of Bone to Urine Citrate

    University of Texas Southwestern Medical Center 25 participants Est. completion 2027-03 1 site
    Other conditions: Osteoporosis
    View official trial listing →
  • Not yet recruiting NCT NCT07056478

    RANKL Inhibition to Combat Sarcopenia in Hip Fracture Patients

    Not yet reported Prince of Wales Hospital, Shatin, Hong Kong 130 participants Est. completion 2030-01-01 1 site
    Other conditions: Sarcopenia in Elderly
    View official trial listing →
  • Not yet recruiting NCT NCT07063797

    Study on the Intervention Effect of Denosumab on High-Risk Patients With Osteoporotic Fractures in Type 2 Diabetes

    Not yet reported Peking Union Medical College Hospital 358 participants Est. completion 2027-07-31 4 sites Stand-alone
    Type 2 diabetes Other conditions: Osteoporosis, Fractures
    View official trial listing →
  • Not yet recruiting NCT NCT07085520

    A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches

    Not yet reported Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 12 participants Est. completion 2026-05-31 1 site Stand-alone
    Osteoarthritis Other conditions: Osteoporosis, Osteoporosis (Senile), Healthy
    View official trial listing →
  • Not yet recruiting NCT NCT07329543

    AGE Burden and Response to Antiresorptive Therapy in Osteoporosis

    Bursa City Hospital 240 participants Est. completion 2027-04-15
    Other conditions: Osteoporosis, Postmenopausal Osteoporosis
    View official trial listing →
  • Not yet recruiting NCT NCT07537972

    Denosumab Strategy for Liver Cancer With Bone Metastases

    Not yet reported Tongji Hospital 50 participants Est. completion 2029-06-30 1 site Stand-alone
    Other conditions: Hepatocellular Carcinoma (HCC), Bone Metastases
    View official trial listing →
  • Not yet recruiting NCT NCT07687225

    Surgery vs. No Surgery for Primary Tumor in De Novo Stage IV Breast Cancer With Solitary Bone Metastases

    Not yet reported West China Hospital 216 participants Est. completion 2036-12-31
    Other conditions: Breast Cancer, Stage IV Breast Cancer, Bone Metastases
    View official trial listing →
  • Not yet recruiting NCT NCT07691892

    Early Warning and Risk Prediction of Medication-Related Osteonecrosis of the Jaw

    Hospital of Stomatology, Wuhan University 310 participants Est. completion 2030-09-01
    Other conditions: Medication-related Osteonecrosis of the Jaw (MRONJ)
    View official trial listing →
  • Not yet recruiting NCT NCT07757373

    Romosozumab Versus Denosumab In Glucocorticoid-induced Osteoporosis: An Extended Observation Of a Clinical Trial at 6 Years

    Not yet reported Tuen Mun Hospital 54 participants Est. completion 2027-12-01 1 site
    Other conditions: Glucocorticoid-Associated Osteopenia and Osteoporosis
    View official trial listing →
  • Not yet recruiting NCT NCT07772609

    Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMD

    Not yet reported Sahlgrenska University Hospital 216 participants Est. completion 2031-12-31 9 sites Stand-alone
    Other conditions: Osteoporosis in Post-menopausal Women
    View official trial listing →
  • Not yet recruiting NCT NCT07806331

    Study of TST002 Injection in Postmenopausal Women With Osteoporosis or Low Bone Mass

    Not yet reported Transcenta Therapeutics (Hangzhou) Co., Ltd. 110 participants Est. completion 2028-10-31
    Other conditions: Postmenopausal Osteoporosis, Low Bone Mass
    View official trial listing →
Efficacy history

Not yet reported.

Safety

Not yet reported.

Sources

Also known as: Denosumab, Denosumab-BMWO, Denosumab 60 MG/ML, Prolia

Related On The Pen coverage

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