Daridorexant

• Recruiting NCT NCT05924425

  Daridorexant to Treat Insomnia in Patients With Mild Cognitive Impairment and Mild to Moderate Alzheimer Disease

  Not yet reported University Hospital, Montpellier 62 participants Est. completion 2028-03-13 1 site Stand-alone
  Other conditions: Alzheimer Disease, Insomnia Disorder, Sleep
  View official trial listing →
• Recruiting NCT NCT06498128

  Registry to Collect Information on Pregnancy, Neonatal, and Infant Outcomes in Pregnant Women Exposed to QUVIVIQ®

  Idorsia Pharmaceuticals Ltd. 785 participants Est. completion 2033-03 7 sites
  Other conditions: Insomnia
  View official trial listing →
• Recruiting NCT NCT07136415

  Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms

  Not yet reported Brigham and Women's Hospital 1000 participants Est. completion 2031-02 5 sites
  Other conditions: Menopausal Women, Insomnia
  View official trial listing →
• Recruiting NCT NCT07213349

  Daridorexant for Alzheimer Disease Prevention

  Not yet reported Douglas Mental Health University Institute 240 participants Est. completion 2029-12 1 site Stand-alone
  Other conditions: Alzheimer Disease (AD)
  View official trial listing →
• Recruiting NCT NCT07217912

  Daridorexant to Prevent Post-cardiotomy Delirium

  Not yet reported University of Rochester 80 participants Est. completion 2027-11-01 1 site Stand-alone
  Other conditions: Postoperative Cognitive Decline, Postoperative Delirium
  View official trial listing →
• Recruiting NCT NCT07267559

  Dual Orexin Antagonism and Emotion and Affective Processing Study

  Not yet reported University of Oxford 62 participants Est. completion 2026-10-01 1 site Stand-alone
  Other conditions: Learning, Cognitive Functioning, Emotional Processing
  View official trial listing →
• Completed NCT NCT02526888

  Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 14 participants Est. completion 2015-11-01 1 site
  Other conditions: Healthy Subjects
  View official trial listing →
• Completed NCT NCT02571855

  A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of ACT-541468 in Healthy Young Adults and Elderly Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 85 participants Est. completion 2016-02-01 1 site
  Other conditions: Healthy Subjects
  View official trial listing →
• Completed NCT NCT02839200

  Efficacy and Safety of ACT-541468 in Adult Subjects With Insomnia Disorder

  Not yet reported Idorsia Pharmaceuticals Ltd. 360 participants Est. completion 2017-06-20 35 sites
  Other conditions: Insomnia Disorder
  View official trial listing →
• Completed NCT NCT02841709

  Efficacy and Safety of ACT-541468 in Elderly Subjects With Insomnia Disorder

  Not yet reported Idorsia Pharmaceuticals Ltd. 58 participants Est. completion 2017-06-29 10 sites
  Other conditions: Insomnia Disorder
  View official trial listing →
• Completed NCT NCT02919319

  A Single Ascending Dose Study of ACT-541468 in Healthy Male Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 40 participants Est. completion 2015-05-01 1 site
  Other conditions: Healthy Subjects
  View official trial listing →
• Completed NCT NCT03017495

  A Clinical Study to Investigate the Potential Interactions Between Food and ACT-541468 and Between ACT-541468 and Midazolam

  Not yet reported Idorsia Pharmaceuticals Ltd. 20 participants Est. completion 2017-02-01 1 site
  Other conditions: Healthy Subjects
  View official trial listing →
• Completed NCT NCT03101189

  A Study of ACT-541468 in Healthy Japanese and Caucasian Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 40 participants Est. completion 2017-04-26 1 site
  Other conditions: Healthy Subjects
  View official trial listing →
• Completed NCT NCT03339752

  A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-541468 Can Affect the Fate in the Body (Amount and Time of Presence in the Blood) of Rosuvastatin

  Not yet reported Idorsia Pharmaceuticals Ltd. 20 participants Est. completion 2017-12-02 1 site
  Other conditions: Healthy Subjects
  View official trial listing →
• Completed NCT NCT03545191

  Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects With Insomnia Disorder

  Not yet reported Idorsia Pharmaceuticals Ltd. 930 participants Est. completion 2020-02-25 81 sites Stand-alone
  Other conditions: Insomnia Disorder
  View official trial listing →
• Completed NCT NCT03575104

  Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep

  Not yet reported Idorsia Pharmaceuticals Ltd. 924 participants Est. completion 2020-05-14 86 sites Stand-alone
  Other conditions: Insomnia Disorder
  View official trial listing →
• Completed NCT NCT03609775

  A Study to Investigate the Drug-drug Interactions Between ACT-541468 and Ethanol in Healthy Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 22 participants Est. completion 2018-10-09 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT03646864

  A Study to Evaluate the Effects of ACT-541468 on Respiration in Patients With Moderate Chronic Obstructive Pulmonary Disease

  Not yet reported Idorsia Pharmaceuticals Ltd. 28 participants Est. completion 2019-09-19 5 sites
  Other conditions: Chronic Obstructive Pulmonary Disease
  View official trial listing →
• Completed NCT NCT03657355

  Study to Evaluate the Abuse Potential of ACT-541468 in Healthy Recreational Drug Users

  Not yet reported Idorsia Pharmaceuticals Ltd. 63 participants Est. completion 2019-08-08 2 sites
  Other conditions: Healthy Recreational Drug Users
  View official trial listing →
• Completed NCT NCT03679884

  Study to Assess the Long Term Safety and Tolerability of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep

  Not yet reported Idorsia Pharmaceuticals Ltd. 804 participants Est. completion 2021-02-22 106 sites Stand-alone
  Other conditions: Insomnia Disorder
  View official trial listing →
• Completed NCT NCT03713242

  A Study to Evaluate the Pharmacokinetics of ACT-541468 in Subjects With Mild, Moderate, and Severe Hepatic Impairment

  Not yet reported Idorsia Pharmaceuticals Ltd. 32 participants Est. completion 2020-02-27 1 site
  Other conditions: Hepatic Impairment
  View official trial listing →
• Completed NCT NCT03765294

  A Study to Investigate the Effects of ACT-541468 on Nighttime Respiratory Function in Patients With Mild to Moderate Obstructive Sleep Apnea

  Not yet reported Idorsia Pharmaceuticals Ltd. 28 participants Est. completion 2019-11-05 1 site
  Obstructive sleep apnea
  View official trial listing →
• Completed NCT NCT03799978

  A Clinical Study to Investigate the Food Effect on the Pharmacokinetics of ACT-541468 in Healthy Male Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 20 participants Est. completion 2019-03-18 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT03892902

  A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 56 participants Est. completion 2019-10-10 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT03907215

  A Clinical Study to Examine the Drug-drug Interactions Between ACT-541468 and Citalopram in Healthy Male and Female Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 24 participants Est. completion 2019-06-26 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT04024332

  Study of the Way the Body Takes up, Distributes, and Gets Rid of ACT-541468 in Subjects With Abnormal Kidney Function Compared to Healthy Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 16 participants Est. completion 2020-08-14 1 site
  Other conditions: Renal Insufficiency, Healthy
  View official trial listing →
• Completed NCT NCT04250506

  A Study to Assess the Effect of Single Doses of Daridorexant on Electrocardiogram Parameters in Healthy Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 36 participants Est. completion 2020-07-22 1 site Stand-alone
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT04390334

  A Study in Healthy Male Subjects to Investigate the Effect of Famotidine and Efavirenz on the Way the Body Takes up, Distributes, and Gets Rid of Daridorexant.

  Not yet reported Idorsia Pharmaceuticals Ltd. 24 participants Est. completion 2020-06-26 1 site Stand-alone
  Other conditions: Healthy
  View official trial listing →
• Suspended NCT NCT05422612

  Department of Defense PTSD Adaptive Platform Trial - Master Protocol

  Not yet reported Global Coalition for Adaptive Research 800 participants Est. completion 2029-07 9 sites Stand-alone
  Other conditions: Post Traumatic Stress Disorder
  View official trial listing →
• Completed NCT NCT05423717

  Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder

  Not yet reported Idorsia Pharmaceuticals Ltd. 166 participants Est. completion 2026-02-05 35 sites Stand-alone
  Other conditions: Insomnia
  View official trial listing →
• Completed NCT NCT05458193

  A Study to Investigate the Effects of Daridorexant on Nighttime Breathing in Patients With Shallow or Paused Breath During Sleep

  Not yet reported Idorsia Pharmaceuticals Ltd. 20 participants Est. completion 2023-02-28 1 site Stand-alone
  Obstructive sleep apnea
  View official trial listing →
• Completed NCT NCT05480475

  A Study to Examine the Effect of Daridorexant on the Way the Body Absorbs, Distributes, and Gets Rid of Dabigatran and Rosuvastatin in Healthy Male Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 24 participants Est. completion 2022-09-17 1 site Stand-alone
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT05480488

  A Study to Examine the Effect of Daridorexant on the Way the Body Absorbs, Distributes, and Gets Rid of Midazolam and Warfarin in Healthy Male Subjects

  Not yet reported Idorsia Pharmaceuticals Ltd. 18 participants Est. completion 2022-10-06 1 site
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT05597020

  A Study to Find Out if Daridorexant is Safe and Efficacious in Patients With Insomnia and Comorbid Nocturia

  Not yet reported Idorsia Pharmaceuticals Ltd. 60 participants Est. completion 2024-04-18 16 sites Stand-alone
  Other conditions: Insomnia Disorder, Nocturia
  View official trial listing →
• Completed NCT NCT05632393

  A Study to Measure Daridorexant in Breast Milk of Healthy Lactating Women

  Not yet reported Idorsia Pharmaceuticals Ltd. 10 participants Est. completion 2023-04-30 1 site Stand-alone
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT05702177

  A Study of the Effect of Daridorexant on Nighttime Body Posture, the Noise Level Required to Wake up, and the Ability to Remember Words Previously Presented

  Not yet reported Idorsia Pharmaceuticals Ltd. 36 participants Est. completion 2023-04-25 1 site Stand-alone
  Other conditions: Healthy
  View official trial listing →
• Completed NCT NCT05877222

  A Phase 1 Trial to Investigate the Biological Equivalence of 5 × 10 mg Tablets and 2 × 25 mg Tablets of Daridorexant in Healthy Male and Female Japanese Participants

  Not yet reported Idorsia Pharmaceuticals Ltd. 38 participants Est. completion 2023-08-04 1 site Stand-alone
  Other conditions: Healthy
  View official trial listing →
• Suspended NCT NCT05948540

  Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant

  Not yet reported Global Coalition for Adaptive Research 200 participants Est. completion 2029-07 9 sites Stand-alone
  Other conditions: Post Traumatic Stress Disorder
  View official trial listing →
• Completed NCT NCT06010693

  A Study of Daridorexant in Chinese Patients With Insomnia Disorder

  Not yet reported Jiangsu Simcere Pharmaceutical Co., Ltd. 206 participants Est. completion 2024-05-10 33 sites Stand-alone
  Other conditions: Insomnia Disorder
  View official trial listing →
• Completed NCT NCT06311864

  Real-World Observational Study on Patient-Reported Outcomes in the Treatment of Insomnia With Daridorexant in Canada

  PeriPharm 90 participants Est. completion 2026-05-19 1 site
  Other conditions: Insomnia
  View official trial listing →
• Completed NCT NCT06326723

  Investigate the PK, Safety, and Tolerability After Single and Multiple Dose Daridorexant in Chinese Healthy Subjects

  Not yet reported Jiangsu Simcere Pharmaceutical Co., Ltd. 32 participants Est. completion 2024-02-05 1 site Stand-alone
  Other conditions: Healthy Volunteer
  View official trial listing →
• Active, not recruiting NCT NCT06393504

  Database Study to Provide Information on Pregnancy and Infant Outcomes Among Women Exposed to QUVIVIQ (Daridorexant)

  Idorsia Pharmaceuticals Ltd. 2095 participants Est. completion 2028-04 1 site
  Other conditions: Insomnia Disorder
  View official trial listing →
• Completed NCT NCT06630390

  Daridorexant to Prevent Delirium After Heart Surgery

  Not yet reported University of Rochester 11 participants Est. completion 2025-02-16 1 site Stand-alone
  Other conditions: POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
  View official trial listing →
• Completed NCT NCT07028697

  A Study to Evaluate the Efficacy and Safety of Daridorexant in Participants With Insomnia Disorder

  Not yet reported Nxera Pharma Korea Co., Ltd. 164 participants Est. completion 2025-10-21 17 sites Stand-alone
  Other conditions: Insomnia Disorder
  View official trial listing →
• Completed NCT NCT07132086

  Prospective Observational Study on the Effectiveness of Daridorexant in Chronic Insomnia in a Real-World Setting

  Azienda Ospedaliero, Universitaria Pisana 31 participants Est. completion 2025-06-30 1 site
  Other conditions: Insomnia Chronic
  View official trial listing →
• Not yet recruiting NCT NCT07328594

  Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking

  Not yet reported Legacy Health System 44 participants Est. completion 2027-09-30 1 site
  Substance use disorder Other conditions: Smoking, Nicotine, Tobacco, Addiction, Insomnia, Sleep
  View official trial listing →
• Not yet recruiting NCT NCT07532252

  Daridorexant for Alcohol Use Disorder

  Not yet reported Johns Hopkins University 150 participants Est. completion 2031-02-01 Stand-alone
  Alcohol use disorder
  View official trial listing →
• Not yet recruiting NCT NCT07555743

  Efficacy and Safety of Daridorexant in Patients With Major Depressive Disorder and Insomnia

  Not yet reported Institut d'Investigació Biomèdica de Bellvitge 134 participants Est. completion 2028-10 1 site Stand-alone
  Other conditions: Insomnia, Major Depressive Disorder
  View official trial listing →
• Not yet recruiting NCT NCT07701928

  Daridorexant for People With Insomnia and Alcohol Use Disorder Study

  Not yet reported Sterling McPherson 205 participants Est. completion 2031-12 1 site Stand-alone
  Alcohol use disorder Other conditions: Insomnia
  View official trial listing →
• Not yet recruiting NCT NCT07733414

  Evaluating the Efficacy and Safety of Daridorexant Transition From BZRAs in Insomnia Patients（EASY-TIP）

  Not yet reported Xuanwu Hospital, Beijing 156 participants Est. completion 2030-12-01 1 site Stand-alone
  Other conditions: Insomnia Disorders
  View official trial listing →
• Not yet recruiting NCT NCT07743931

  Study on the Management of COMISA

  Not yet reported University Hospital, Grenoble 150 participants Est. completion 2029-02 4 sites
  Obstructive sleep apnea Other conditions: Insomnia, COMISA
  View official trial listing →
• Not yet recruiting NCT NCT07830303

  Daridorexant for Sleep Disturbance in Adults With Liver Cirrhosis

  Not yet reported Wang Fengmei 180 participants Est. completion 2029-02 3 sites Stand-alone
  Other conditions: Liver Cirrhosis, Sleep Disturbance, Hepatic Encephalopathy
  View official trial listing →

Not yet reported.

Not yet reported.

• ClinicalTrials.gov — NCT07830303

Also known as: Daridorexant, QUVIVIQ

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