About this data
Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.
Cysteamine
- Company
- National Human Genome Research Institute (NHGRI)
- Mechanism
- Mechanism not yet reported
- Route
- Route not yet reported
- Recruiting trials
- 4 recruiting
Efficacy results: Not yet reported
4 recruiting studies currently listed on ClinicalTrials.gov.
Data source: ClinicalTrials.gov · trial data as of Oct 14, 2026
Find a Clinical Trial Near Me
See recruiting studies for Cysteamine and check eligibility with the study team.
Trial details
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Recruiting NCT NCT00359684
Use of Cysteamine in the Treatment of Cystinosis
National Human Genome Research Institute (NHGRI) 330 participants 1 siteOther conditions: CystinosisView official trial listing → -
Recruiting NCT NCT02735707
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
Not yet reported UMC Utrecht 20000 participants Est. completion 2028-02 408 sitesOther conditions: Community-acquired Pneumonia, Influenza, COVID-19View official trial listing → -
Recruiting NCT NCT06910813
DFT383 in Pediatric Participants With Nephropathic Cystinosis
Not yet reported, Not yet reported Novartis Pharmaceuticals 30 participants Est. completion 2044-05-28 6 sitesOther conditions: Nephropathic CystinosisView official trial listing → -
Recruiting NCT NCT07319091
Cystinosis and Mitochondrial Metabolism
Not yet reported Hospices Civils de Lyon 25 participants Est. completion 2028-07 9 sitesOther conditions: Cystinosis, Native KidneyView official trial listing → -
Completed NCT NCT00001213
Cysteamine Eye Drops to Treat Corneal Crystals in Cystinosis
Not yet reported National Eye Institute (NEI) 328 participants Est. completion 2013-07 1 site Stand-aloneOther conditions: CystinosisView official trial listing → -
Completed NCT NCT00001736
New Cysteamine Eye Drops Formulation to Treat Corneal Crystals in Cystinosis
Not yet reported National Eye Institute (NEI) 51 participants Est. completion 2001-03 1 siteOther conditions: CystinosisView official trial listing → -
Completed NCT NCT00002110
A Phase II/III Study of Cysteamine (Mercaptoethylamine) and Zidovudine for the Treatment of HIV Disease
Not yet reported Mylan Laboratories 300 participants 6 sitesOther conditions: HIV InfectionsView official trial listing → -
Completed NCT NCT00010426
Randomized Study of New Formulation Ophthalmic Cysteamine Hydrochloride for Corneal Cystine Accumulation in Patients With Cystinosis
Not yet reported FDA Office of Orphan Products Development 30 participants Est. completion 2001-02Other conditions: CystinosisView official trial listing → -
Completed NCT NCT00028262
Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis
Not yet reported Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 10 participants Est. completion 2013-11 1 site Stand-aloneOther conditions: Infantile Neronal Ceroid LipofuscinosisView official trial listing → -
Completed NCT NCT00074516
Kidney Transplantation in Patients With Cystinosis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 11 participants Est. completion 2014-06-11 1 siteOther conditions: CystinosisView official trial listing → -
Terminated NCT NCT00715559
Cysteamine Therapy for Major Depressive Disorder
Not yet reported Icahn School of Medicine at Mount Sinai 3 participants Est. completion 2009-05 1 site Stand-aloneOther conditions: Major Depressive DisorderView official trial listing → -
Completed NCT NCT00799578
A Preliminary Study to Evaluate Cysteamine Therapy in Human Subjects With Non-Alcoholic Steatohepatitis (NASH)
Not yet reported, Not yet reported Joel Lavine 13 participants Est. completion 2010-01 1 site Stand-aloneOther conditions: Fatty LiverView official trial listing → -
Completed NCT NCT00872729
Pilot Study of Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of RP103 Compared to Cystagon® in Patients With Cystinosis
Not yet reported, Not yet reported Amgen 9 participants Est. completion 2009-10 1 site Stand-aloneOther conditions: CystinosisView official trial listing → -
Completed NCT NCT01000961
Phase 3 Study of Cysteamine Bitartrate Delayed-release (RP103) Compared to Cystagon® in Patients With Cystinosis
Not yet reported Amgen 43 participants Est. completion 2011-08 8 sites Stand-aloneOther conditions: CystinosisView official trial listing → -
Terminated NCT NCT01139125
An Open Trial of Cysteamine Treatment in Schizophrenia
Not yet reported Augusta University 3 participants Est. completion 2012-06 2 sites Stand-aloneOther conditions: Schizophrenia, SchizoaffectiveView official trial listing → -
Completed NCT NCT01197378
Long-Term Safety Follow-up Study of Cysteamine Bitartrate Delayed-release Capsules (RP103)
Not yet reported Amgen 60 participants Est. completion 2017-06-26 10 sites Stand-aloneOther conditions: CystinosisView official trial listing → -
Completed NCT NCT01432561
Study in Healthy Adults to Determine the Effect That Food Has on the Absorption and Delivery of the Drug Cystagon™
Not yet reported University of California, San Diego 8 participants Est. completion 2011-12 1 site Stand-aloneOther conditions: Cystinosis, Nephropathic CystinosisView official trial listing → -
Completed NCT NCT01529268
Cysteamine Bitartrate Delayed-Release for the Treatment of NAFLD in Children
Not yet reported, Not yet reported National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 169 participants Est. completion 2015-09 10 sitesMASLDView official trial listing → -
Completed NCT NCT01733316
Open-Label, Safety and Superior Effectiveness Study of Cysteamine Bitartrate Delayed-Release Capsules (RP103) in Cystinosis
Not yet reported Amgen 41 participants Est. completion 2017-07-10 14 sites Stand-aloneOther conditions: CystinosisView official trial listing → -
Completed NCT NCT01744782
Safety/Effectiveness Study of Cysteamine Bitartrate Delayed-release Capsules (RP103) in Cysteamine Treatment Naive Patients With Cystinosis
Not yet reported Amgen 17 participants Est. completion 2016-12-13 2 sites Stand-aloneOther conditions: CystinosisView official trial listing → -
Completed NCT NCT02012114
A Cohort of Patients With Cystinosis : Compliance to Cysteamine and Neurological Complications
Not yet reported Hospices Civils de Lyon 65 participants Est. completion 2021-12-14 1 siteOther conditions: CystinosisView official trial listing → -
Completed NCT NCT02023866
Open-Label, Dose-Escalating Study Assessing Safety, Tolerability, Efficacy, of RP103 in Mitochondrial Disease
Not yet reported Amgen 36 participants Est. completion 2016-10 5 sites Stand-aloneOther conditions: Inherited Mitochondrial Disease, Including Leigh SyndromeView official trial listing → -
Status unknown NCT NCT02101957
Multicentric Trial of the Treatment of Huntington's Disease by Cysteamine (RP103)
Not yet reported, Not yet reported University Hospital, Angers 96 participants 1 siteOther conditions: Huntington's DiseaseView official trial listing → -
Completed NCT NCT02212431
First Study of Oral Cysteamine in Cystic Fibrosis
Not yet reported, Not yet reported University of Aberdeen 10 participants Est. completion 2015-04 1 site Stand-aloneOther conditions: Cystic FibrosisView official trial listing → -
Terminated NCT NCT02473445
A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease
Not yet reported Amgen 22 participants Est. completion 2017-03-06 5 sites Stand-aloneOther conditions: Mitochondrial DiseasesView official trial listing → -
Completed NCT NCT02766855
Efficacy of Topical Cysteamine in Nephropathic Cyctinosis
Not yet reported The Eye Center and The Eye Foundation for Research in Ophthalmology 26 participants Est. completion 2016-03 Stand-aloneOther conditions: Nephropathic Cyctinosis, Corneal Cystine CrystalsView official trial listing → -
Completed NCT NCT03000348
A Study of the Dosing, Efficacy, and Safety of Oral Cysteamine in Adult Patients With Cystic Fibrosis Exacerbations
Not yet reported NovaBiotics Ltd. 91 participants Est. completion 2018-04 17 sitesOther conditions: Cystic FibrosisView official trial listing → -
Completed NCT NCT03883984
Cysteamine for Asthma
Not yet reported Children's Hospital Medical Center, Cincinnati 60 participants Est. completion 2021-02-10 1 site Stand-aloneOther conditions: AsthmaView official trial listing → -
Status unknown NCT NCT03919981
CYSTEA-BONE Clinical Study
Hospices Civils de Lyon 50 participants Est. completion 2026-10-05 13 sitesOther conditions: Nephropathic CystinosisView official trial listing → -
Completed NCT NCT04125927
Cystadrops in Pediatric Cystinosis Patients From Six Months to Less Than Two Years Old (SCOB2)
Not yet reported RECORDATI GROUP 5 participants Est. completion 2022-12-23 6 sitesOther conditions: CystinosisView official trial listing → -
Status unknown NCT NCT04246060
Observational Study to Assess the Quality of Life in Nephropathic Cystinosis Patients
Chiesi SA/NV 31 participants Est. completion 2026-07-01 7 sitesOther conditions: Nephropathic CystinosisView official trial listing → -
Withdrawn NCT NCT04262895
TTI-0102 for Veterans With TBI
Not yet reported, Not yet reported VA Office of Research and Development Est. completion 2021-10-15 1 site Stand-aloneOther conditions: Mild to Moderate TBI, Posttraumatic Stress DisorderView official trial listing → -
Status unknown NCT NCT05206318
Efficacy and Safety of Topical Cysteamine for Postinflammatory Hyperpigmentation
Not yet reported Chang Gung Memorial Hospital 40 participants Est. completion 2022-12-10 1 site Stand-aloneOther conditions: Hyperpigmentation; PostinflammatoryView official trial listing → -
Withdrawn NCT NCT05212662
Study of Cysteamine-pantetheine Disulfide (TTI-0102) in Mild to Moderate COVID-19
Not yet reported Thiogenesis Therapeutics, Inc. Est. completion 2024-09-27 Stand-aloneOther conditions: COVID-19, COVID-19 Acute Respiratory Distress SyndromeView official trial listing → -
Status unknown NCT NCT05656833
Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial Melasma
Not yet reported UnionDerm 20 participants Est. completion 2023-07 1 siteOther conditions: MelasmaView official trial listing → -
Completed NCT NCT05969587
Cysteamine Compared to Hydroquinone in Melasma
Not yet reported China Medical University Hospital 28 participants Est. completion 2020-11-11 1 site Stand-aloneOther conditions: MelasmaView official trial listing → -
Completed NCT NCT05994534
PK and PD Study of NPI-001 and Cysteamine Bitartrate
Not yet reported, Not yet reported Nacuity Pharmaceuticals, Inc. 8 participants Est. completion 2026-05-26 1 site Stand-aloneOther conditions: CystinosisView official trial listing → -
Status unknown NCT NCT06278948
Efficacy and Tolerability of Test Product Versus Cysteamine 5% in Treatment of Facial Epidermal Melasma
Not yet reported Cosmetique Active International 140 participants Est. completion 2024-06 1 siteOther conditions: MelasmaView official trial listing → -
Completed NCT NCT06644534
A Study to Assess TTI-0102 vs Placebo in MELAS Patients
Not yet reported Thiogenesis Therapeutics, Inc. 9 participants Est. completion 2026-01-12 2 sites Stand-aloneCardiovascular disease Other conditions: MELAS SyndromeView official trial listing → -
Not yet recruiting NCT NCT06990984
A Dose-ranging Study of TTI-0102 in Adults and Children With Leigh Syndrome Spectrum (LSS)
Not yet reported Thiogenesis Therapeutics, Inc. 18 participants Est. completion 2027-09 Stand-aloneOther conditions: Leigh SyndromeView official trial listing → -
Completed NCT NCT07477288
Effectiveness of a Bilayering Serum and Cream Containing GABA, DMAE, Cysteamine, and Bakuchiol for Skin Whitening and Anti-Aging
Not yet reported Hasanuddin University 44 participants Est. completion 2025-12-29 1 site Stand-aloneOther conditions: Skin AgingView official trial listing → -
Not yet recruiting NCT NCT07680751
European Cystinosis Cohort 2
Institut National de la Santé Et de la Recherche Médicale, France 250 participants Est. completion 2028-03-01 1 siteOther conditions: CystinosisView official trial listing → -
Not yet recruiting NCT NCT07837726
Pilot Study of TTI-0102 in Cystinosis
Not yet reported Thiogenesis Therapeutics, Inc. 6 participants Est. completion 2027-03 Stand-aloneOther conditions: Nephropathic Cystinosis, CystinosisView official trial listing →
Efficacy history
Not yet reported.
Safety
Not yet reported.
Sources
Also known as: Cysteamine, CYSTADROPS, CYSTARAN, PROCYSBI, Cystagon, Cysteamine Bitartrate
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This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.