About this data
Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.
Cotadutide
- Company
- AstraZeneca
- Mechanism
- Mechanism not yet reported
- Route
- Route not yet reported
- Recruiting trials
- None currently listed
Efficacy results: Not yet reported
No recruiting studies currently listed
See all studies for this drugData source: ClinicalTrials.gov · trial data as of Sep 11, 2026
Trial details
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Completed NCT NCT02394314
A Phase 1, Single Dose Study to Evaluate the Safety and Pharmacokinetics of MEDI0382 in Healthy Volunteers
Not yet reported MedImmune LLC 362 participants Est. completion 2015-08 1 siteOther conditions: Healthy VolunteersView official trial listing → -
Completed NCT NCT02548585
A Multiple-ascending-dose Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus
Not yet reported, Not yet reported MedImmune LLC 113 participants Est. completion 2017-02-24 11 sitesType 2 diabetesView official trial listing → -
Completed NCT NCT03235050
A Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes
Not yet reported AstraZeneca 834 participants Est. completion 2019-06-14 119 sitesType 2 diabetesView official trial listing → -
Completed NCT NCT03235375
A Study to Evaluate Pharmacokinetics, Safety and Tolerability of MEDI0382 in Renal Impairment Subjects
Not yet reported MedImmune LLC 37 participants Est. completion 2018-04-24 4 sitesOther conditions: Renal InsufficiencyView official trial listing → -
Completed NCT NCT03244800
A Study to Investigate Different Doses of 0382 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.
Not yet reported MedImmune LLC 65 participants Est. completion 2018-01-23 5 sitesType 2 diabetesView official trial listing → -
Completed NCT NCT03347968
Study to Compare Pharmacokinetics & Pharmacodynamics of Warfarin & Esmolol in the Absence & Presence of MEDI0382
Not yet reported MedImmune LLC 22 participants Est. completion 2018-04-09 1 siteOther conditions: Healthy VolunteersView official trial listing → -
Completed NCT NCT03385369
A Study to Evaluate the Safety and Pharmacokinetics of MEDI0382 in Overweight/Obese Subjects of Japanese or Chinese Descent
Not yet reported MedImmune LLC 32 participants Est. completion 2018-04-12 1 siteOther conditions: Safety, Healthy SubjectsView official trial listing → -
Completed NCT NCT03444584
Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Participants With Type 2 Diabetes
Not yet reported MedImmune LLC 49 participants Est. completion 2018-12-06 8 sitesType 2 diabetesView official trial listing → -
Completed NCT NCT03550378
A Study to Look at the Effect MEDI0382 Has on Blood Sugar in People With Type 2 Diabetes and Kidney Problems and Also to Check That MEDI0382 is Well Tolerated
Not yet reported MedImmune LLC 41 participants Est. completion 2019-02-04 7 sitesOther conditions: Type II Diabetes Mellitus, Renal InsufficiencyView official trial listing → -
Completed NCT NCT03555994
A Study to Investigate the Effect of MEDI0382 on Hepatic Glycogen Metabolism in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.
Not yet reported MedImmune LLC 51 participants Est. completion 2021-04-14 3 sitesType 2 diabetesView official trial listing → -
Completed NCT NCT03596177
A Study to Evaluate the Effect of MEDI0382 on Energy Balance in Overweight and Obese Participants With Type 2 Diabetes Mellitus
Not yet reported MedImmune LLC 28 participants Est. completion 2019-12-22 1 siteOther conditions: Diabetes Mellitus, Type II, ObesityView official trial listing → -
Completed NCT NCT03625778
A Study to Assess Safety, Tolerability, and Pharmacokinetics of MEDI0382 in Non-diabetic Obese Participants
Not yet reported MedImmune LLC 51 participants Est. completion 2019-08-25 2 sitesOther conditions: ObesityView official trial listing → -
Completed NCT NCT03645421
Safety and Tolerability Study of MEDI0382 in Japanese Preobese or Obese Subjects With Type 2 Diabetes
Not yet reported AstraZeneca 61 participants Est. completion 2019-01-17 5 sitesType 2 diabetesView official trial listing → -
Completed NCT NCT03745937
A Study to Evaluate the Safety and Tolerability of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus
Not yet reported MedImmune LLC 20 participants Est. completion 2019-05-28 1 siteType 2 diabetesView official trial listing → -
Completed NCT NCT04019561
A Study to Evaluate Safety and Pharmacodynamic Efficacy of 0382 in Obese Subjects With NAFLD/NASH.
Not yet reported MedImmune LLC 74 participants Est. completion 2021-05-06 27 sitesMASLDMASHView official trial listing → -
Completed NCT NCT04091373
A Study Investigating the Pharmacokinetics of a Single Dose Administration of Cotadutide
Not yet reported MedImmune LLC 36 participants Est. completion 2020-03-06 1 site Stand-aloneType 2 diabetesView official trial listing → -
Completed NCT NCT04208620
Safety and Tolerability Study of Cotadutide in Japanese Obese Subjects With Type 2 Diabetes Melitus
Not yet reported AstraZeneca 16 participants Est. completion 2020-07-08 3 sites Stand-aloneType 2 diabetesView official trial listing → -
Completed NCT NCT04515849
A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus
Not yet reported AstraZeneca 248 participants Est. completion 2022-03-08 83 sites Stand-aloneType 2 diabetesChronic kidney diseaseView official trial listing → -
Completed NCT NCT05294458
A Randomised, Open-Label Study to Evaluate the Relative and Absolute Bioavailability of Cotadutide in Healthy Subjects
Not yet reported AstraZeneca 10 participants Est. completion 2022-09-12 1 site Stand-aloneType 2 diabetesChronic kidney disease Other conditions: Non-alcoholic SteatohepatitisView official trial listing → -
Completed NCT NCT05364931
A Study to Evaluate the Safety and Efficacy of Cotadutide Given by Subcutaneous Injection in Adult Participants With Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis
Not yet reported AstraZeneca 54 participants Est. completion 2024-04-19 115 sites Stand-aloneOther conditions: Non-cirrhotic Non-alcoholic Steatohepatitis With FibrosisView official trial listing → -
Completed NCT NCT05437848
Chinese Multiple Dose Escalation (MDE) High Dose Study
Not yet reported AstraZeneca 16 participants Est. completion 2022-12-12 2 sites Stand-aloneOther conditions: DiabetesView official trial listing → -
Terminated NCT NCT05517226
Pharmacokinetics of Cotadutide in Participants With Hepatic Impairment
Not yet reported AstraZeneca 24 participants Est. completion 2023-02-27 3 sites Stand-aloneOther conditions: Hepatic ImpairmentView official trial listing → -
Terminated NCT NCT05668936
A Thorough QTC Study to Assess the Effect of Cotadutide on Cardiac Repolarization in Healthy Participants
Not yet reported AstraZeneca 31 participants Est. completion 2023-03-10 1 site Stand-aloneOther conditions: Non-alcoholic SteatohepatitisView official trial listing →
Efficacy history
Not yet reported.
Safety
Not yet reported.
Sources
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This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.