About this data Sourced primarily from ClinicalTrials.gov — a listing isn't proof of safety or FDA approval.

Pipeline and clinical trial information here comes primarily from ClinicalTrials.gov. A listing on ClinicalTrials.gov means a study has been registered — not that a treatment is proven safe, effective, or FDA-approved. Investigational treatments may never be approved. Who can join a trial is decided only by that trial's own study team.

Not yet reported

Apelin

Company: Cambridge University Hospitals NHS Foundation Trust
Mechanism: Mechanism not yet reported
Route: Route not yet reported
Recruiting trials: 1 recruiting

Efficacy results: Not yet reported

Find a Clinical Trial Near Me

1 recruiting study currently listed on ClinicalTrials.gov.

Data source: ClinicalTrials.gov · trial data as of Oct 1, 2026

Trial details

Recruiting NCT NCT07703345

Salivary Apelin, Chemerin, Ghrelin, and Lipocalin-2 Levels in Diabetic Patients With Periodontitis

Necmettin Erbakan University 88 participants Est. completion 2026-08-01 1 site

Type 2 diabetes Other conditions: Periodontitis
View official trial listing →
Withdrawn NCT NCT00730067

Sildenafil for Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension

Not yet reported University of Aarhus Est. completion 2012-12 2 sites

Other conditions: COPD, Pulmonary Hypertension
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Completed NCT NCT00901719

Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation

Not yet reported University of Edinburgh 12 participants Est. completion 2010-05 1 site Stand-alone

Heart failure Other conditions: Heart Disease, Vasodilatation
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Completed NCT NCT00901745

Interaction of Apelin and Angiotensin in the Human Forearm Circulation

Not yet reported University of Edinburgh 12 participants Est. completion 2010-04 1 site Stand-alone

Other conditions: Heart Disease, Vasodilation
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Completed NCT NCT00901888

Interaction of Apelin and Angiotensin in the Human Forearm Circulation

Not yet reported University of Edinburgh 12 participants Est. completion 2010-05 1 site Stand-alone

Other conditions: Heart Disease, Vasodilation
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Completed NCT NCT01049646

Interaction of Apelin and Angiotensin in the Systemic Circulation

Not yet reported University of Edinburgh 12 participants Est. completion 2010-04 1 site

Other conditions: Renin Angiotensin System
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Completed NCT NCT01121172

Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)

Aristotle University Of Thessaloniki 180 participants Est. completion 2014-01 1 site

Type 2 diabetes Other conditions: Obesity, Insulin Resistance
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Completed NCT NCT01179061

Investigating the Inotropic Potential of Apelin

Not yet reported University of Edinburgh 24 participants Est. completion 2012-07 3 sites Stand-alone

Heart failure
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Status unknown NCT NCT01457170

Effects of Apelin on the Lung Circulation in Pulmonary Hypertension

Not yet reported Golden Jubilee National Hospital 63 participants Est. completion 2014-01 3 sites Stand-alone

Heart failure Other conditions: Pulmonary Arterial Hypertension
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Completed NCT NCT01590108

The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects

Not yet reported Imperial College London 12 participants Est. completion 2014-09 2 sites Stand-alone

Other conditions: Idiopathic Pulmonary Arterial Hypertension
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Completed NCT NCT01613391

Effect of Roux-en-Y Gastric Bypass Versus Laparoscopic Adjustable Gastric Band Operations on Resistin, Apelin and Visfatin Peptides

Istanbul University 30 participants 1 site

Other conditions: Morbid Obesity
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Completed NCT NCT02033473

Effect of Apelin on Insulin Sensitivity: Proof of Concept in Healthy Volunteers

Not yet reported University Hospital, Toulouse 16 participants Est. completion 2014-10 1 site Stand-alone

Other conditions: Healthy
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Completed NCT NCT02129309

Haemodynamic Effects of Apelin Agonists and Antagonists in Man in COPD With Raised Pulmonary Artery Pressures

Not yet reported Cambridge University Hospitals NHS Foundation Trust 20 participants Est. completion 2014-12 1 site Stand-alone

Other conditions: COPD, Pulmonary Hypertension
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Completed NCT NCT02150694

Local Haemodynamic Effects of Apelin Agonists and Antagonists in Man in Vivo

Not yet reported University of Cambridge 52 participants Est. completion 2013-08 1 site Stand-alone

Cardiovascular disease
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Completed NCT NCT02259686

Cardiovascular Effects of Apelin In Healthy Volunteers

Not yet reported University of Edinburgh 14 participants Est. completion 2015-05 2 sites Stand-alone

Other conditions: Healthy
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Status unknown NCT NCT02264600

Apelin in Willis Ekbom Disease

Acibadem University 30 participants Est. completion 2015-04

Other conditions: Restless Legs Syndrome
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Completed NCT NCT02378675

Adipocytokines, Gestational Diabetes Mellitus and Lipid Metabolism

Medical University of Vienna 300 participants Est. completion 2013-12 1 site

Other conditions: Gestational Diabetes Mellitus
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Completed NCT NCT02516475

Effects of Zinc Supplementation on Anthropometric Factors, Apelin and Inflammatory Markers in Obese Individuals

Not yet reported, Not yet reported National Nutrition and Food Technology Institute 50 participants Est. completion 2015-06

Other conditions: Obesity
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Completed NCT NCT02574234

Influence of Apelin Levels on Postoperative Cognitive Disorders After Orthopedic Surgery in Elderlies (APOCOGNIT)

Not yet reported University Hospital, Toulouse 88 participants Est. completion 2018-03-12 1 site Stand-alone

Other conditions: Delirium
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Completed NCT NCT02696967

A Study of CLR325 in Chronic Stable Heart Failure Patients.

Not yet reported Novartis Pharmaceuticals 26 participants Est. completion 2019-01-14 11 sites

Heart failure
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Completed NCT NCT02724566

Effect of Apelin on Insulin Sensitivity in Type 2 Diabetic Volunteers

Not yet reported University Hospital, Toulouse 9 participants Est. completion 2017-04 1 site

Other conditions: Diabetes
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Completed NCT NCT02796456

Determination of Maternal and Neonatal Apelinemia in Obese Women During Pregnancy

University Hospital, Lille 135 participants Est. completion 2018-04 1 site

Other conditions: Obesity, Pregnancy, Gestational Diabetes
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Completed NCT NCT02807532

Relationship Between Apelin and New-onset Atrial Fibrillation After Coronary Artery Bypass Grafting

General Hospital of Shenyang Military Region 120 participants Est. completion 2015-06

Other conditions: Coronary Atherosclerotic Heart Disease
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Completed NCT NCT03366389

Serum Levels of Apelin, Chemerin and Adiponectin Adipokines in Irritable Bowel Syndrome and Healthy Subjects

Amir Abbasnezhad 114 participants Est. completion 2017-10-20 1 site

Other conditions: Irritable Bowel Syndrome
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Active, not recruiting NCT NCT03449251

A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin

Not yet reported Cambridge University Hospitals NHS Foundation Trust 170 participants Est. completion 2026-12 1 site Stand-alone

Cardiovascular diseaseType 2 diabetes
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Status unknown NCT NCT03855540

Atrial Fibrillation in Relationship to Sleep Quality and Plasma Biomarkers

Premedix Academy 200 participants Est. completion 2019-12-31 4 sites

Other conditions: Atrial Fibrillation
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Completed NCT NCT03956576

Apelin as a Potential Treatment for Chronic Kidney Disease

Not yet reported University of Edinburgh 46 participants Est. completion 2022-12-14 1 site

Chronic kidney diseaseCardiovascular disease Other conditions: Endothelial Dysfunction
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Completed NCT NCT04380584

Relation Between Plasma Apelin Level and Diabetic Nephropathy in Type 2 Diabetes Patients.

Cairo University 90 participants Est. completion 2020-03-29 1 site

Other conditions: Diabetic Nephropathies
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Completed NCT NCT04632732

Apelin; ACE2 and Biomarkers of Alveolar-capillary Permeability in SARS-cov-2 (COVID-19).

Centre de recherche du Centre hospitalier universitaire de Sherbrooke 140 participants Est. completion 2021-10-01 1 site

Other conditions: Covid19
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Completed NCT NCT04663919

Comparison of the Effects of Weight Changes on Serum Adipokines in Patients Diagnosed With Anorexia Nervosa and Morbid Obesity

Not yet reported Istanbul University 55 participants Est. completion 2015-01-01

Obstructive sleep apnea Other conditions: Bariatric Surgery, Weight Change, Body
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Status unknown NCT NCT04710745

Atrial Fibrillation in Relationship to Plasma Biomarkers

Premedix Academy 300 participants Est. completion 2024-12 6 sites

Other conditions: Atrial Fibrillation
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Completed NCT NCT05562687

Association Between Some Polymorphisms in Apelin/ Apelin Receptor Genes and Coronary Artery Disease in Syrian Patients

Damascus University 223 participants Est. completion 2022-08-18 1 site

Cardiovascular disease Other conditions: Hypertension
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Status unknown NCT NCT05738577

Apelin as a Marker of Early Complications in Type 1 Diabetes Mellitus

Assiut University 90 participants Est. completion 2025-12-01

Other conditions: Diabetes Mellitus, Type 1
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Completed NCT NCT06141889

Pharmacokinetics Study of Azelaprag (BGE-105) in Older Adult Healthy Volunteers

Not yet reported BioAge Labs, Inc. 16 participants Est. completion 2024-02-02 1 site Stand-alone

Other conditions: Healthy Volunteer Study
View official trial listing →
Completed NCT NCT06277336

Effects of Intravenous [Pyr1]Apelin-13 on Healthy Volunteers With Artificially Induced SIAD

Not yet reported University Hospital, Basel, Switzerland 15 participants Est. completion 2025-03-18 1 site Stand-alone

Other conditions: SIAD - Syndrome of Inappropriate Antidiuresis, Hyponatremia
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Completed NCT NCT06850987

Effect of Nonsurgical Periodontal Treatment on Apelin and Oxidative Stress Levels

Hatice Yemenoğlu 60 participants Est. completion 2025-06-14 1 site

Other conditions: Periodontitis
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Active, not recruiting NCT NCT07449663

SPORT-SPECIFIC HIIT IN ELITE KICKBOXERS

Not yet reported Adiyaman University 40 participants Est. completion 2026-03-15 1 site

Other conditions: Exercise Training Adaptation, Exercise Physiology, High-Intensity Interval Training
View official trial listing →
Not yet recruiting NCT NCT07793656

mRNA Therapy to Restore Lymphatic Flow in Secondary Lymphedema

Not yet reported, Not yet reported University Hospital, Toulouse 9 participants Est. completion 2028-04 1 site Stand-alone

Other conditions: Secondary Lymphedema
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Efficacy history

Not yet reported.

Safety

Not yet reported.

Sources

ClinicalTrials.gov — NCT03449251

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This drug may be investigational and not yet approved for any use. Whether someone can join a clinical trial is determined only by that trial's own study team — On The Pen does not determine eligibility. Information here can change; always confirm current details on the official ClinicalTrials.gov listing or with the sponsor.